Experiment: 7H9 with Bedaquiline 0.15 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0137c and Rv0138 are separated by 62 nucleotides Rv0138 and Rv0139 are separated by 0 nucleotides Rv0139 and Rv0140 are separated by 60 nucleotides Rv0140 and Rv0141c overlap by 20 nucleotides Rv0141c and Rv0142 are separated by 29 nucleotides
Rv0137c: Rv0137c - Probable peptide methionine sulfoxide reductase MsrA (protein-methionine-S-oxide reductase) (peptide met(O) reductase), at 164,712 to 165,260
Rv0137c
Rv0138: Rv0138 - Conserved hypothetical protein, at 165,323 to 165,826
Rv0138
Rv0139: Rv0139 - Possible oxidoreductase, at 165,827 to 166,849
Rv0139
Rv0140: Rv0140 - Conserved protein, at 166,910 to 167,290
Rv0140
Rv0141c: Rv0141c - Unknown protein, at 167,271 to 167,681
Rv0141c
Rv0142: Rv0142 - Conserved hypothetical protein, at 167,711 to 168,637
Rv0142
Position (kb) 165
166
167 Strain fitness (log2 ratio) -1
0
1
2
3 at 164.831 kb on - strand, within Rv0137c at 164.968 kb on + strand, within Rv0137c at 164.969 kb on - strand, within Rv0137c at 165.005 kb on + strand, within Rv0137c at 165.006 kb on - strand, within Rv0137c at 165.130 kb on + strand, within Rv0137c at 165.130 kb on + strand, within Rv0137c at 165.130 kb on + strand, within Rv0137c at 165.160 kb on + strand, within Rv0137c at 165.161 kb on - strand, within Rv0137c at 165.282 kb on + strand at 165.283 kb on - strand at 165.283 kb on - strand at 165.283 kb on - strand at 165.303 kb on - strand at 165.303 kb on - strand at 165.434 kb on + strand, within Rv0138 at 165.434 kb on + strand, within Rv0138 at 165.435 kb on - strand, within Rv0138 at 165.435 kb on - strand, within Rv0138 at 165.674 kb on + strand, within Rv0138 at 165.674 kb on + strand, within Rv0138 at 165.674 kb on + strand, within Rv0138 at 165.674 kb on + strand, within Rv0138 at 165.674 kb on + strand, within Rv0138 at 165.675 kb on - strand, within Rv0138 at 165.675 kb on - strand, within Rv0138 at 165.675 kb on - strand, within Rv0138 at 165.713 kb on + strand, within Rv0138 at 165.713 kb on + strand, within Rv0138 at 165.713 kb on + strand, within Rv0138 at 165.713 kb on + strand, within Rv0138 at 165.713 kb on + strand, within Rv0138 at 165.714 kb on - strand, within Rv0138 at 165.714 kb on - strand, within Rv0138 at 165.714 kb on - strand, within Rv0138 at 165.824 kb on + strand at 165.824 kb on + strand at 165.824 kb on + strand at 165.924 kb on + strand at 165.925 kb on - strand at 166.049 kb on + strand, within Rv0139 at 166.049 kb on + strand, within Rv0139 at 166.049 kb on + strand, within Rv0139 at 166.049 kb on + strand, within Rv0139 at 166.050 kb on - strand, within Rv0139 at 166.050 kb on - strand, within Rv0139 at 166.050 kb on - strand, within Rv0139 at 166.050 kb on - strand, within Rv0139 at 166.050 kb on - strand, within Rv0139 at 166.053 kb on - strand, within Rv0139 at 166.184 kb on + strand, within Rv0139 at 166.259 kb on + strand, within Rv0139 at 166.259 kb on + strand, within Rv0139 at 166.259 kb on + strand, within Rv0139 at 166.260 kb on - strand, within Rv0139 at 166.260 kb on - strand, within Rv0139 at 166.302 kb on - strand, within Rv0139 at 166.352 kb on + strand, within Rv0139 at 166.353 kb on - strand, within Rv0139 at 166.520 kb on + strand, within Rv0139 at 166.520 kb on + strand, within Rv0139 at 166.521 kb on - strand, within Rv0139 at 166.521 kb on - strand, within Rv0139 at 166.521 kb on - strand, within Rv0139 at 166.676 kb on - strand, within Rv0139 at 166.863 kb on - strand at 166.986 kb on + strand, within Rv0140 at 167.065 kb on + strand, within Rv0140 at 167.085 kb on + strand, within Rv0140 at 167.120 kb on + strand, within Rv0140 at 167.121 kb on - strand, within Rv0140 at 167.148 kb on - strand, within Rv0140 at 167.148 kb on - strand, within Rv0140 at 167.150 kb on + strand, within Rv0140 at 167.201 kb on + strand, within Rv0140 at 167.202 kb on - strand, within Rv0140 at 167.308 kb on - strand at 167.308 kb on - strand at 167.335 kb on + strand, within Rv0141c at 167.398 kb on + strand, within Rv0141c at 167.570 kb on - strand, within Rv0141c at 167.839 kb on + strand, within Rv0142 at 167.839 kb on + strand, within Rv0142 at 167.840 kb on - strand, within Rv0142 at 167.840 kb on - strand, within Rv0142
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL remove 164,831 - Rv0137c 0.22 -1.6 164,968 + Rv0137c 0.47 -0.0 164,969 - Rv0137c 0.47 +0.1 165,005 + Rv0137c 0.53 +0.5 165,006 - Rv0137c 0.54 -0.0 165,130 + Rv0137c 0.76 +1.9 165,130 + Rv0137c 0.76 +0.0 165,130 + Rv0137c 0.76 -0.2 165,160 + Rv0137c 0.82 +1.5 165,161 - Rv0137c 0.82 -0.5 165,282 + -0.5 165,283 - +1.9 165,283 - -0.5 165,283 - -0.5 165,303 - +0.2 165,303 - -0.0 165,434 + Rv0138 0.22 +0.9 165,434 + Rv0138 0.22 +0.9 165,435 - Rv0138 0.22 -0.1 165,435 - Rv0138 0.22 +0.2 165,674 + Rv0138 0.70 -0.2 165,674 + Rv0138 0.70 -1.1 165,674 + Rv0138 0.70 +0.0 165,674 + Rv0138 0.70 -0.1 165,674 + Rv0138 0.70 -0.5 165,675 - Rv0138 0.70 +1.9 165,675 - Rv0138 0.70 -0.2 165,675 - Rv0138 0.70 +0.6 165,713 + Rv0138 0.77 -0.5 165,713 + Rv0138 0.77 -0.0 165,713 + Rv0138 0.77 -0.3 165,713 + Rv0138 0.77 +0.6 165,713 + Rv0138 0.77 -0.6 165,714 - Rv0138 0.78 +2.5 165,714 - Rv0138 0.78 -0.9 165,714 - Rv0138 0.78 +0.2 165,824 + -0.4 165,824 + +0.9 165,824 + -0.6 165,924 + -0.4 165,925 - -1.3 166,049 + Rv0139 0.22 -0.5 166,049 + Rv0139 0.22 +0.4 166,049 + Rv0139 0.22 +0.3 166,049 + Rv0139 0.22 +0.5 166,050 - Rv0139 0.22 +0.7 166,050 - Rv0139 0.22 +0.1 166,050 - Rv0139 0.22 +0.2 166,050 - Rv0139 0.22 +1.9 166,050 - Rv0139 0.22 -0.2 166,053 - Rv0139 0.22 +1.9 166,184 + Rv0139 0.35 -0.1 166,259 + Rv0139 0.42 +0.3 166,259 + Rv0139 0.42 -0.4 166,259 + Rv0139 0.42 -0.4 166,260 - Rv0139 0.42 +3.2 166,260 - Rv0139 0.42 -0.1 166,302 - Rv0139 0.46 +0.1 166,352 + Rv0139 0.51 -0.1 166,353 - Rv0139 0.51 +0.2 166,520 + Rv0139 0.68 +0.5 166,520 + Rv0139 0.68 +0.4 166,521 - Rv0139 0.68 +1.2 166,521 - Rv0139 0.68 -0.1 166,521 - Rv0139 0.68 -0.3 166,676 - Rv0139 0.83 -0.5 166,863 - -0.2 166,986 + Rv0140 0.20 -0.2 167,065 + Rv0140 0.41 +1.9 167,085 + Rv0140 0.46 -0.6 167,120 + Rv0140 0.55 +0.3 167,121 - Rv0140 0.55 +0.2 167,148 - Rv0140 0.62 -0.1 167,148 - Rv0140 0.62 +0.1 167,150 + Rv0140 0.63 -0.2 167,201 + Rv0140 0.76 -0.9 167,202 - Rv0140 0.77 -0.9 167,308 - +0.7 167,308 - +0.1 167,335 + Rv0141c 0.16 -0.5 167,398 + Rv0141c 0.31 +0.1 167,570 - Rv0141c 0.73 -0.3 167,839 + Rv0142 0.14 -0.1 167,839 + Rv0142 0.14 -0.9 167,840 - Rv0142 0.14 -0.0 167,840 - Rv0142 0.14 +0.3
Or see this region's nucleotide sequence