Experiment: 7H9 with Bedaquiline 0.15 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0110 and Rv0111 are separated by 180 nucleotides Rv0111 and Rv0112 are separated by 281 nucleotides
Rv0110: Rv0110 - Probable conserved integral membrane protein, at 133,020 to 133,769
Rv0110
Rv0111: Rv0111 - Possible transmembrane acyltransferase, at 133,950 to 136,007
Rv0111
Rv0112: Rv0112 - Possible GDP-mannose 4,6-dehydratase Gca (GDP-D-mannose dehydratase), at 136,289 to 137,245
Rv0112
Position (kb) 133
134
135
136
137 Strain fitness (log2 ratio) -2
-1
0
1
2
3 at 132.951 kb on + strand at 132.952 kb on - strand at 132.975 kb on + strand at 132.975 kb on + strand at 132.975 kb on + strand at 132.975 kb on + strand at 132.975 kb on + strand at 132.976 kb on - strand at 132.976 kb on - strand at 133.002 kb on + strand at 133.002 kb on + strand at 133.002 kb on + strand at 133.019 kb on + strand at 133.019 kb on + strand at 133.136 kb on + strand, within Rv0110 at 133.136 kb on + strand, within Rv0110 at 133.136 kb on + strand, within Rv0110 at 133.136 kb on + strand, within Rv0110 at 133.140 kb on + strand, within Rv0110 at 133.248 kb on + strand, within Rv0110 at 133.278 kb on + strand, within Rv0110 at 133.279 kb on - strand, within Rv0110 at 133.317 kb on + strand, within Rv0110 at 133.375 kb on - strand, within Rv0110 at 133.375 kb on - strand, within Rv0110 at 133.410 kb on + strand, within Rv0110 at 133.427 kb on + strand, within Rv0110 at 133.428 kb on - strand, within Rv0110 at 133.430 kb on + strand, within Rv0110 at 133.629 kb on + strand, within Rv0110 at 133.629 kb on + strand, within Rv0110 at 133.630 kb on - strand, within Rv0110 at 133.630 kb on - strand, within Rv0110 at 133.833 kb on + strand at 134.359 kb on + strand, within Rv0111 at 134.360 kb on - strand, within Rv0111 at 134.394 kb on - strand, within Rv0111 at 134.466 kb on + strand, within Rv0111 at 134.467 kb on - strand, within Rv0111 at 134.469 kb on + strand, within Rv0111 at 134.469 kb on + strand, within Rv0111 at 134.469 kb on + strand, within Rv0111 at 134.469 kb on + strand, within Rv0111 at 134.470 kb on - strand, within Rv0111 at 134.506 kb on + strand, within Rv0111 at 134.986 kb on + strand, within Rv0111 at 134.992 kb on - strand, within Rv0111 at 135.001 kb on - strand, within Rv0111 at 135.045 kb on - strand, within Rv0111 at 135.045 kb on - strand, within Rv0111 at 135.078 kb on - strand, within Rv0111 at 135.134 kb on + strand, within Rv0111 at 135.135 kb on - strand, within Rv0111 at 135.402 kb on + strand, within Rv0111 at 135.483 kb on + strand, within Rv0111 at 135.484 kb on - strand, within Rv0111 at 135.660 kb on + strand, within Rv0111 at 135.661 kb on - strand, within Rv0111 at 135.677 kb on - strand, within Rv0111 at 135.775 kb on - strand, within Rv0111 at 135.894 kb on + strand at 136.089 kb on + strand at 136.090 kb on - strand at 136.101 kb on - strand at 136.159 kb on + strand at 136.163 kb on + strand at 136.164 kb on - strand at 136.164 kb on - strand at 136.375 kb on + strand at 136.376 kb on - strand at 136.622 kb on - strand, within Rv0112 at 136.678 kb on + strand, within Rv0112 at 136.921 kb on + strand, within Rv0112
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL remove 132,951 + +0.2 132,952 - -0.1 132,975 + +1.2 132,975 + +0.2 132,975 + -0.5 132,975 + -0.5 132,975 + -1.0 132,976 - +1.2 132,976 - +0.9 133,002 + -2.4 133,002 + +0.1 133,002 + -0.2 133,019 + +0.1 133,019 + +0.1 133,136 + Rv0110 0.15 -1.2 133,136 + Rv0110 0.15 +0.2 133,136 + Rv0110 0.15 -0.2 133,136 + Rv0110 0.15 -0.2 133,140 + Rv0110 0.16 -0.6 133,248 + Rv0110 0.30 +0.3 133,278 + Rv0110 0.34 -0.5 133,279 - Rv0110 0.35 +0.9 133,317 + Rv0110 0.40 -0.1 133,375 - Rv0110 0.47 +0.2 133,375 - Rv0110 0.47 +0.0 133,410 + Rv0110 0.52 -0.2 133,427 + Rv0110 0.54 -2.2 133,428 - Rv0110 0.54 -0.7 133,430 + Rv0110 0.55 +0.0 133,629 + Rv0110 0.81 +0.0 133,629 + Rv0110 0.81 +1.9 133,630 - Rv0110 0.81 +0.3 133,630 - Rv0110 0.81 +0.7 133,833 + -0.0 134,359 + Rv0111 0.20 +0.7 134,360 - Rv0111 0.20 -0.4 134,394 - Rv0111 0.22 +0.1 134,466 + Rv0111 0.25 -1.3 134,467 - Rv0111 0.25 -0.5 134,469 + Rv0111 0.25 +2.5 134,469 + Rv0111 0.25 -0.7 134,469 + Rv0111 0.25 -0.2 134,469 + Rv0111 0.25 -0.4 134,470 - Rv0111 0.25 -0.5 134,506 + Rv0111 0.27 -0.3 134,986 + Rv0111 0.50 -1.2 134,992 - Rv0111 0.51 +0.5 135,001 - Rv0111 0.51 -0.3 135,045 - Rv0111 0.53 +0.0 135,045 - Rv0111 0.53 -0.7 135,078 - Rv0111 0.55 -0.8 135,134 + Rv0111 0.58 +0.1 135,135 - Rv0111 0.58 -0.9 135,402 + Rv0111 0.71 +0.1 135,483 + Rv0111 0.74 -1.3 135,484 - Rv0111 0.75 -0.2 135,660 + Rv0111 0.83 +0.1 135,661 - Rv0111 0.83 +0.3 135,677 - Rv0111 0.84 -0.6 135,775 - Rv0111 0.89 +0.0 135,894 + -0.5 136,089 + +0.1 136,090 - +0.1 136,101 - +1.5 136,159 + -0.1 136,163 + -1.2 136,164 - +0.4 136,164 - -0.7 136,375 + +2.9 136,376 - -0.1 136,622 - Rv0112 0.35 +0.7 136,678 + Rv0112 0.41 -0.4 136,921 + Rv0112 0.66 +0.2
Or see this region's nucleotide sequence