Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3574

Experiment: 7H9 with Rifampicin 0.014 ug/mL

Add experiment(s):

Zoom: Pan:

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

download SVG
500 ntRv3573c and Rv3574 are separated by 271 nucleotidesRv3574 and Rv3575c are separated by 5 nucleotides Rv3573c: Rv3573c - Probable acyl-CoA dehydrogenase FadE34, at 4,014,077 to 4,016,212 Rv3573c Rv3574: Rv3574 - Transcriptional regulatory protein KstR (probably TetR-family), at 4,016,484 to 4,017,083 Rv3574 Rv3575c: Rv3575c - Transcriptional regulatory protein (probably LacI-family), at 4,017,089 to 4,018,168 Rv3575c Position (kb) 4016 4017 4018Strain fitness (log2 ratio) -2 -1 0 1 2at 4015.695 kb on - strand, within Rv3573cat 4016.101 kb on - strandat 4016.242 kb on + strandat 4016.243 kb on - strandat 4016.243 kb on - strandat 4016.282 kb on - strandat 4016.315 kb on + strandat 4016.316 kb on - strandat 4016.316 kb on - strandat 4016.316 kb on - strandat 4016.362 kb on + strandat 4016.362 kb on + strandat 4016.363 kb on - strandat 4016.418 kb on + strandat 4016.447 kb on + strandat 4016.492 kb on - strandat 4016.644 kb on - strand, within Rv3574at 4016.835 kb on + strand, within Rv3574at 4017.082 kb on - strandat 4017.179 kb on + strandat 4017.295 kb on - strand, within Rv3575cat 4017.316 kb on - strand, within Rv3575cat 4017.430 kb on - strand, within Rv3575cat 4017.489 kb on - strand, within Rv3575cat 4017.513 kb on - strand, within Rv3575cat 4017.513 kb on - strand, within Rv3575cat 4017.624 kb on + strand, within Rv3575cat 4017.744 kb on + strand, within Rv3575cat 4017.769 kb on - strand, within Rv3575cat 4017.931 kb on - strand, within Rv3575cat 4018.014 kb on + strand, within Rv3575cat 4018.052 kb on + strand, within Rv3575c

download strain data

Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.014 ug/mL
remove
4,015,695 - Rv3573c 0.76 -0.1
4,016,101 - +0.5
4,016,242 + -1.4
4,016,243 - -1.9
4,016,243 - -1.1
4,016,282 - +0.0
4,016,315 + +0.2
4,016,316 - +0.4
4,016,316 - -0.7
4,016,316 - +0.4
4,016,362 + -0.9
4,016,362 + +1.8
4,016,363 - +0.3
4,016,418 + -0.2
4,016,447 + -0.9
4,016,492 - +0.2
4,016,644 - Rv3574 0.27 +2.0
4,016,835 + Rv3574 0.58 +1.2
4,017,082 - -0.3
4,017,179 + -0.2
4,017,295 - Rv3575c 0.19 -0.3
4,017,316 - Rv3575c 0.21 +0.1
4,017,430 - Rv3575c 0.32 -0.5
4,017,489 - Rv3575c 0.37 -0.4
4,017,513 - Rv3575c 0.39 +0.3
4,017,513 - Rv3575c 0.39 +0.4
4,017,624 + Rv3575c 0.50 -0.4
4,017,744 + Rv3575c 0.61 -0.1
4,017,769 - Rv3575c 0.63 -0.7
4,017,931 - Rv3575c 0.78 -0.5
4,018,014 + Rv3575c 0.86 +1.3
4,018,052 + Rv3575c 0.89 -0.7

Or see this region's nucleotide sequence