Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2758c

Experiment: 7H9 with Rifampicin 0.014 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2756c and Rv2757c are separated by 86 nucleotidesRv2757c and Rv2758c overlap by 4 nucleotidesRv2758c and Rv2759c are separated by 25 nucleotidesRv2759c and Rv2760c overlap by 4 nucleotidesRv2760c and Rv2761c are separated by 9 nucleotides Rv2756c: Rv2756c - Possible type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase), at 3,068,461 to 3,070,083 Rv2756c Rv2757c: Rv2757c - Possible toxin VapC21, at 3,070,170 to 3,070,586 Rv2757c Rv2758c: Rv2758c - Possible antitoxin VapB21, at 3,070,583 to 3,070,849 Rv2758c Rv2759c: Rv2759c - Possible toxin VapC42. Contains PIN domain., at 3,070,875 to 3,071,270 Rv2759c Rv2760c: Rv2760c - Possible antitoxin VapB42, at 3,071,267 to 3,071,536 Rv2760c Rv2761c: Rv2761c - Possible type I restriction/modification system specificity determinant HsdS (S protein), at 3,071,546 to 3,072,640 Rv2761c Position (kb) 3070 3071Strain fitness (log2 ratio) -1 0 1at 3069.644 kb on + strand, within Rv2756cat 3069.645 kb on - strand, within Rv2756cat 3069.819 kb on - strand, within Rv2756cat 3069.936 kb on - strandat 3069.936 kb on - strandat 3069.972 kb on - strandat 3070.247 kb on - strand, within Rv2757cat 3070.390 kb on + strand, within Rv2757cat 3070.747 kb on + strand, within Rv2758cat 3070.826 kb on + strandat 3070.901 kb on + strandat 3070.961 kb on - strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.967 kb on - strand, within Rv2759cat 3070.967 kb on - strand, within Rv2759cat 3071.015 kb on - strand, within Rv2759cat 3071.158 kb on + strand, within Rv2759cat 3071.159 kb on - strand, within Rv2759cat 3071.159 kb on - strand, within Rv2759cat 3071.292 kb on + strandat 3071.293 kb on - strandat 3071.525 kb on - strandat 3071.525 kb on - strandat 3071.525 kb on - strandat 3071.525 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.014 ug/mL
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3,069,644 + Rv2756c 0.73 -0.7
3,069,645 - Rv2756c 0.73 +0.1
3,069,819 - Rv2756c 0.84 +1.3
3,069,936 - -0.9
3,069,936 - +0.6
3,069,972 - +0.7
3,070,247 - Rv2757c 0.18 +1.7
3,070,390 + Rv2757c 0.53 -0.7
3,070,747 + Rv2758c 0.61 +0.6
3,070,826 + -0.5
3,070,901 + -1.6
3,070,961 - Rv2759c 0.22 +0.1
3,070,966 + Rv2759c 0.23 +0.4
3,070,966 + Rv2759c 0.23 -1.3
3,070,966 + Rv2759c 0.23 -0.3
3,070,966 + Rv2759c 0.23 -0.5
3,070,966 + Rv2759c 0.23 -0.4
3,070,967 - Rv2759c 0.23 -0.2
3,070,967 - Rv2759c 0.23 -0.9
3,071,015 - Rv2759c 0.35 -0.0
3,071,158 + Rv2759c 0.71 -0.3
3,071,159 - Rv2759c 0.72 +1.0
3,071,159 - Rv2759c 0.72 +0.1
3,071,292 + -0.4
3,071,293 - +0.3
3,071,525 - -1.3
3,071,525 - -0.6
3,071,525 - -0.3
3,071,525 - -0.5

Or see this region's nucleotide sequence