Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2427c

Experiment: 7H9 with Rifampicin 0.014 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2425c and Rv2426c overlap by 1 nucleotidesRv2426c and Rv2427c are separated by 46 nucleotidesRv2427c and Rv2427A are separated by 93 nucleotidesRv2427A and Rv2428 are separated by 105 nucleotides Rv2425c: Rv2425c - Conserved hypothetical protein, at 2,721,866 to 2,723,308 Rv2425c Rv2426c: Rv2426c - Conserved hypothetical protein, at 2,723,308 to 2,724,183 Rv2426c Rv2427c: Rv2427c - Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase), at 2,724,230 to 2,725,477 Rv2427c Rv2427A: Rv2427A - 'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11, at 2,725,571 to 2,726,087 Rv2427A Rv2428: Rv2428 - Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C), at 2,726,193 to 2,726,780 Rv2428 Position (kb) 2724 2725 2726Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2723.294 kb on - strandat 2723.309 kb on + strandat 2723.309 kb on + strandat 2723.309 kb on + strandat 2723.469 kb on + strand, within Rv2426cat 2723.469 kb on + strand, within Rv2426cat 2723.506 kb on + strand, within Rv2426cat 2723.507 kb on - strand, within Rv2426cat 2723.507 kb on - strand, within Rv2426cat 2723.597 kb on + strand, within Rv2426cat 2723.907 kb on + strand, within Rv2426cat 2723.925 kb on - strand, within Rv2426cat 2723.925 kb on - strand, within Rv2426cat 2723.925 kb on - strand, within Rv2426cat 2723.954 kb on + strand, within Rv2426cat 2724.218 kb on + strandat 2724.218 kb on + strandat 2724.587 kb on + strand, within Rv2427cat 2724.756 kb on + strand, within Rv2427cat 2724.756 kb on + strand, within Rv2427cat 2724.757 kb on - strand, within Rv2427cat 2724.963 kb on - strand, within Rv2427cat 2725.147 kb on + strand, within Rv2427cat 2725.147 kb on + strand, within Rv2427cat 2725.148 kb on - strand, within Rv2427cat 2725.150 kb on - strand, within Rv2427cat 2725.150 kb on - strand, within Rv2427cat 2725.150 kb on - strand, within Rv2427cat 2725.334 kb on + strand, within Rv2427cat 2725.562 kb on - strandat 2725.575 kb on + strandat 2725.628 kb on - strand, within Rv2427Aat 2725.655 kb on + strand, within Rv2427Aat 2725.656 kb on - strand, within Rv2427Aat 2725.845 kb on + strand, within Rv2427Aat 2726.098 kb on - strandat 2726.292 kb on + strand, within Rv2428at 2726.303 kb on + strand, within Rv2428

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.014 ug/mL
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2,723,294 - -0.1
2,723,309 + +1.7
2,723,309 + +1.0
2,723,309 + -0.9
2,723,469 + Rv2426c 0.18 +0.7
2,723,469 + Rv2426c 0.18 +0.5
2,723,506 + Rv2426c 0.23 -0.6
2,723,507 - Rv2426c 0.23 -1.0
2,723,507 - Rv2426c 0.23 -1.2
2,723,597 + Rv2426c 0.33 -0.2
2,723,907 + Rv2426c 0.68 -0.5
2,723,925 - Rv2426c 0.70 +0.0
2,723,925 - Rv2426c 0.70 +2.1
2,723,925 - Rv2426c 0.70 +1.3
2,723,954 + Rv2426c 0.74 -0.5
2,724,218 + -1.5
2,724,218 + -0.4
2,724,587 + Rv2427c 0.29 -0.9
2,724,756 + Rv2427c 0.42 +0.2
2,724,756 + Rv2427c 0.42 +0.8
2,724,757 - Rv2427c 0.42 +1.1
2,724,963 - Rv2427c 0.59 +1.2
2,725,147 + Rv2427c 0.73 -0.9
2,725,147 + Rv2427c 0.73 +1.1
2,725,148 - Rv2427c 0.74 -0.1
2,725,150 - Rv2427c 0.74 -1.7
2,725,150 - Rv2427c 0.74 +0.5
2,725,150 - Rv2427c 0.74 +0.0
2,725,334 + Rv2427c 0.88 +0.9
2,725,562 - -0.5
2,725,575 + -1.0
2,725,628 - Rv2427A 0.11 -0.5
2,725,655 + Rv2427A 0.16 -2.0
2,725,656 - Rv2427A 0.16 +0.0
2,725,845 + Rv2427A 0.53 +0.6
2,726,098 - -3.0
2,726,292 + Rv2428 0.17 +0.4
2,726,303 + Rv2428 0.19 +0.5

Or see this region's nucleotide sequence