Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2044c

Experiment: 7H9 with Rifampicin 0.014 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2042c and Rv2043c overlap by 1 nucleotidesRv2043c and Rv2044c are separated by 40 nucleotidesRv2044c and Rv2045c are separated by 85 nucleotides Rv2042c: Rv2042c - Conserved protein, at 2,287,884 to 2,288,681 Rv2042c Rv2043c: Rv2043c - Pyrazinamidase/nicotinamidase PncA (PZase), at 2,288,681 to 2,289,241 Rv2043c Rv2044c: Rv2044c - Conserved hypothetical protein, at 2,289,282 to 2,289,599 Rv2044c Rv2045c: Rv2045c - Carboxylesterase LipT, at 2,289,685 to 2,291,220 Rv2045c Position (kb) 2289 2290Strain fitness (log2 ratio) -1 0 1 2 3at 2288.372 kb on - strand, within Rv2042cat 2288.376 kb on + strand, within Rv2042cat 2288.376 kb on + strand, within Rv2042cat 2288.846 kb on - strand, within Rv2043cat 2288.958 kb on + strand, within Rv2043cat 2289.141 kb on + strand, within Rv2043cat 2289.241 kb on + strandat 2289.241 kb on + strandat 2289.242 kb on - strandat 2289.252 kb on + strandat 2289.253 kb on - strandat 2289.306 kb on + strandat 2289.307 kb on - strandat 2289.391 kb on + strand, within Rv2044cat 2289.578 kb on - strandat 2289.612 kb on + strandat 2289.794 kb on + strandat 2289.926 kb on + strand, within Rv2045cat 2290.007 kb on + strand, within Rv2045cat 2290.013 kb on + strand, within Rv2045cat 2290.019 kb on + strand, within Rv2045cat 2290.020 kb on - strand, within Rv2045cat 2290.020 kb on - strand, within Rv2045cat 2290.175 kb on - strand, within Rv2045cat 2290.319 kb on + strand, within Rv2045cat 2290.556 kb on - strand, within Rv2045c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.014 ug/mL
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2,288,372 - Rv2042c 0.61 +1.7
2,288,376 + Rv2042c 0.62 -1.5
2,288,376 + Rv2042c 0.62 +3.3
2,288,846 - Rv2043c 0.29 -0.3
2,288,958 + Rv2043c 0.49 +0.5
2,289,141 + Rv2043c 0.82 -0.5
2,289,241 + -0.1
2,289,241 + -0.2
2,289,242 - -0.4
2,289,252 + -1.4
2,289,253 - +0.2
2,289,306 + -1.5
2,289,307 - +1.7
2,289,391 + Rv2044c 0.34 +1.4
2,289,578 - +0.6
2,289,612 + -0.9
2,289,794 + -0.3
2,289,926 + Rv2045c 0.16 -0.5
2,290,007 + Rv2045c 0.21 -0.6
2,290,013 + Rv2045c 0.21 -0.3
2,290,019 + Rv2045c 0.22 -1.6
2,290,020 - Rv2045c 0.22 -0.3
2,290,020 - Rv2045c 0.22 -0.1
2,290,175 - Rv2045c 0.32 -0.1
2,290,319 + Rv2045c 0.41 +0.4
2,290,556 - Rv2045c 0.57 -0.2

Or see this region's nucleotide sequence