Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1398c

Experiment: 7H9 with Rifampicin 0.014 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1396c and Rv1397c are separated by 254 nucleotidesRv1397c and Rv1398c overlap by 4 nucleotidesRv1398c and Rv1399c are separated by 82 nucleotides Rv1396c: Rv1396c - PE-PGRS family protein PE_PGRS25, at 1,572,127 to 1,573,857 Rv1396c Rv1397c: Rv1397c - Possible toxin VapC10, at 1,574,112 to 1,574,513 Rv1397c Rv1398c: Rv1398c - Possible antitoxin VapB10, at 1,574,510 to 1,574,767 Rv1398c Rv1399c: Rv1399c - Probable non lipolytic carboxylesterase NlhH, at 1,574,850 to 1,575,809 Rv1399c Position (kb) 1574 1575Strain fitness (log2 ratio) -2 -1 0 1at 1573.598 kb on + strand, within Rv1396cat 1573.599 kb on - strand, within Rv1396cat 1573.673 kb on + strand, within Rv1396cat 1573.673 kb on + strand, within Rv1396cat 1573.674 kb on - strand, within Rv1396cat 1573.674 kb on - strand, within Rv1396cat 1573.674 kb on - strand, within Rv1396cat 1573.674 kb on - strand, within Rv1396cat 1573.913 kb on - strandat 1573.949 kb on + strandat 1574.082 kb on + strandat 1574.082 kb on + strandat 1574.082 kb on + strandat 1574.082 kb on + strandat 1574.082 kb on + strandat 1574.083 kb on - strandat 1574.229 kb on + strand, within Rv1397cat 1574.230 kb on - strand, within Rv1397cat 1574.230 kb on - strand, within Rv1397cat 1574.308 kb on - strand, within Rv1397cat 1574.308 kb on - strand, within Rv1397cat 1574.611 kb on + strand, within Rv1398cat 1574.612 kb on - strand, within Rv1398cat 1574.749 kb on - strandat 1574.767 kb on + strandat 1574.768 kb on - strandat 1574.775 kb on - strandat 1574.779 kb on + strandat 1574.780 kb on - strandat 1574.851 kb on + strandat 1574.935 kb on + strandat 1574.964 kb on + strand, within Rv1399cat 1575.004 kb on + strand, within Rv1399cat 1575.142 kb on + strand, within Rv1399cat 1575.142 kb on + strand, within Rv1399cat 1575.142 kb on + strand, within Rv1399cat 1575.142 kb on + strand, within Rv1399cat 1575.142 kb on + strand, within Rv1399cat 1575.143 kb on - strand, within Rv1399cat 1575.550 kb on + strand, within Rv1399cat 1575.595 kb on + strand, within Rv1399cat 1575.654 kb on + strand, within Rv1399cat 1575.749 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.014 ug/mL
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1,573,598 + Rv1396c 0.85 +0.5
1,573,599 - Rv1396c 0.85 -0.7
1,573,673 + Rv1396c 0.89 -0.1
1,573,673 + Rv1396c 0.89 +0.1
1,573,674 - Rv1396c 0.89 -0.9
1,573,674 - Rv1396c 0.89 +1.2
1,573,674 - Rv1396c 0.89 +0.4
1,573,674 - Rv1396c 0.89 +0.3
1,573,913 - +0.4
1,573,949 + -1.1
1,574,082 + -1.6
1,574,082 + -0.6
1,574,082 + -0.2
1,574,082 + -0.7
1,574,082 + -0.5
1,574,083 - -0.5
1,574,229 + Rv1397c 0.29 -0.5
1,574,230 - Rv1397c 0.29 -2.1
1,574,230 - Rv1397c 0.29 +1.7
1,574,308 - Rv1397c 0.49 -1.1
1,574,308 - Rv1397c 0.49 -0.3
1,574,611 + Rv1398c 0.39 +0.9
1,574,612 - Rv1398c 0.40 -0.3
1,574,749 - -1.0
1,574,767 + -0.1
1,574,768 - -1.1
1,574,775 - -0.3
1,574,779 + +1.7
1,574,780 - +0.1
1,574,851 + -1.4
1,574,935 + -0.6
1,574,964 + Rv1399c 0.12 +0.0
1,575,004 + Rv1399c 0.16 -0.3
1,575,142 + Rv1399c 0.30 +0.3
1,575,142 + Rv1399c 0.30 -0.4
1,575,142 + Rv1399c 0.30 +0.4
1,575,142 + Rv1399c 0.30 -0.1
1,575,142 + Rv1399c 0.30 -0.4
1,575,143 - Rv1399c 0.31 -0.2
1,575,550 + Rv1399c 0.73 -0.0
1,575,595 + Rv1399c 0.78 +0.0
1,575,654 + Rv1399c 0.84 +0.5
1,575,749 + -1.6

Or see this region's nucleotide sequence