Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0973c

Experiment: 7H9 with Rifampicin 0.014 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0972c and Rv0973c overlap by 4 nucleotidesRv0973c and Rv0974c are separated by 5 nucleotides Rv0972c: Rv0972c - Acyl-CoA dehydrogenase FadE12, at 1,082,584 to 1,083,750 Rv0972c Rv0973c: Rv0973c - Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP), at 1,083,747 to 1,085,750 Rv0973c Rv0974c: Rv0974c - Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2, at 1,085,756 to 1,087,345 Rv0974c Position (kb) 1083 1084 1085 1086Strain fitness (log2 ratio) -1 0 1at 1082.777 kb on + strand, within Rv0972cat 1082.777 kb on + strand, within Rv0972cat 1082.778 kb on - strand, within Rv0972cat 1083.205 kb on + strand, within Rv0972cat 1083.543 kb on - strand, within Rv0972cat 1083.811 kb on - strandat 1084.519 kb on - strand, within Rv0973cat 1084.567 kb on + strand, within Rv0973cat 1084.567 kb on + strand, within Rv0973cat 1084.568 kb on - strand, within Rv0973cat 1084.912 kb on + strand, within Rv0973cat 1086.102 kb on + strand, within Rv0974cat 1086.214 kb on - strand, within Rv0974c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.014 ug/mL
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1,082,777 + Rv0972c 0.17 -1.4
1,082,777 + Rv0972c 0.17 +0.8
1,082,778 - Rv0972c 0.17 -0.4
1,083,205 + Rv0972c 0.53 +0.1
1,083,543 - Rv0972c 0.82 -0.3
1,083,811 - -0.1
1,084,519 - Rv0973c 0.39 -0.1
1,084,567 + Rv0973c 0.41 +1.2
1,084,567 + Rv0973c 0.41 +0.2
1,084,568 - Rv0973c 0.41 -1.2
1,084,912 + Rv0973c 0.58 +0.8
1,086,102 + Rv0974c 0.22 -0.1
1,086,214 - Rv0974c 0.29 +0.6

Or see this region's nucleotide sequence