Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0471c

Experiment: 7H9 with Rifampicin 0.014 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0470c and Rv0470A are separated by 142 nucleotidesRv0470A and Rv0471c overlap by 70 nucleotidesRv0471c and Rv0472c are separated by 9 nucleotidesRv0472c and Rv0473 are separated by 136 nucleotides Rv0470c: Rv0470c - Mycolic acid synthase PcaA (cyclopropane synthase), at 560,848 to 561,711 Rv0470c Rv0470A: Rv0470A - Hypothetical protein, at 561,854 to 562,294 Rv0470A Rv0471c: Rv0471c - Hypothetical protein, at 562,225 to 562,713 Rv0471c Rv0472c: Rv0472c - Probable transcriptional regulatory protein (possibly TetR-family), at 562,723 to 563,427 Rv0472c Rv0473: Rv0473 - Possible conserved transmembrane protein, at 563,564 to 564,934 Rv0473 Position (kb) 562 563Strain fitness (log2 ratio) -4 -3 -2 -1 0 1 2at 561.272 kb on + strand, within Rv0470cat 561.615 kb on - strand, within Rv0470cat 561.798 kb on + strandat 561.798 kb on + strandat 561.799 kb on - strandat 561.952 kb on + strand, within Rv0470Aat 561.953 kb on - strand, within Rv0470Aat 561.953 kb on - strand, within Rv0470Aat 562.091 kb on + strand, within Rv0470Aat 562.099 kb on + strand, within Rv0470Aat 562.100 kb on - strand, within Rv0470Aat 562.100 kb on - strand, within Rv0470Aat 562.100 kb on - strand, within Rv0470Aat 562.103 kb on + strand, within Rv0470Aat 562.103 kb on + strand, within Rv0470Aat 562.103 kb on + strand, within Rv0470Aat 562.103 kb on + strand, within Rv0470Aat 562.104 kb on - strand, within Rv0470Aat 562.104 kb on - strand, within Rv0470Aat 562.104 kb on - strand, within Rv0470Aat 562.104 kb on - strand, within Rv0470Aat 562.107 kb on + strand, within Rv0470Aat 562.160 kb on + strand, within Rv0470Aat 562.197 kb on + strand, within Rv0470Aat 562.219 kb on + strand, within Rv0470Aat 562.219 kb on + strand, within Rv0470Aat 562.302 kb on + strand, within Rv0471cat 562.303 kb on - strand, within Rv0471cat 562.303 kb on - strand, within Rv0471cat 562.303 kb on - strand, within Rv0471cat 562.303 kb on - strand, within Rv0471cat 562.305 kb on + strand, within Rv0471cat 562.305 kb on + strand, within Rv0471cat 562.305 kb on + strand, within Rv0471cat 562.306 kb on - strand, within Rv0471cat 562.306 kb on - strand, within Rv0471cat 562.306 kb on - strand, within Rv0471cat 562.306 kb on - strand, within Rv0471cat 562.359 kb on + strand, within Rv0471cat 562.359 kb on + strand, within Rv0471cat 562.359 kb on + strand, within Rv0471cat 562.360 kb on - strand, within Rv0471cat 562.360 kb on - strand, within Rv0471cat 562.360 kb on - strand, within Rv0471cat 562.360 kb on - strand, within Rv0471cat 562.360 kb on - strand, within Rv0471cat 562.360 kb on - strand, within Rv0471cat 562.361 kb on + strand, within Rv0471cat 562.361 kb on + strand, within Rv0471cat 562.361 kb on + strand, within Rv0471cat 562.361 kb on + strand, within Rv0471cat 562.362 kb on - strand, within Rv0471cat 562.362 kb on - strand, within Rv0471cat 562.362 kb on - strand, within Rv0471cat 562.362 kb on - strand, within Rv0471cat 562.362 kb on - strand, within Rv0471cat 562.403 kb on + strand, within Rv0471cat 562.404 kb on - strand, within Rv0471cat 562.418 kb on + strand, within Rv0471cat 562.418 kb on + strand, within Rv0471cat 562.451 kb on + strand, within Rv0471cat 562.452 kb on - strand, within Rv0471cat 562.464 kb on + strand, within Rv0471cat 562.464 kb on + strand, within Rv0471cat 562.464 kb on + strand, within Rv0471cat 562.464 kb on + strand, within Rv0471cat 562.464 kb on + strand, within Rv0471cat 562.465 kb on - strand, within Rv0471cat 562.465 kb on - strand, within Rv0471cat 562.465 kb on - strand, within Rv0471cat 562.670 kb on + strandat 562.671 kb on - strandat 562.724 kb on + strandat 562.724 kb on + strandat 562.724 kb on + strandat 562.841 kb on + strand, within Rv0472cat 562.923 kb on - strand, within Rv0472cat 563.050 kb on - strand, within Rv0472cat 563.102 kb on + strand, within Rv0472cat 563.102 kb on + strand, within Rv0472cat 563.103 kb on - strand, within Rv0472cat 563.244 kb on - strand, within Rv0472cat 563.278 kb on + strand, within Rv0472cat 563.415 kb on + strandat 563.464 kb on + strandat 563.464 kb on + strandat 563.534 kb on + strandat 563.535 kb on - strandat 563.535 kb on - strandat 563.535 kb on - strandat 563.575 kb on + strandat 563.575 kb on + strandat 563.575 kb on + strandat 563.575 kb on + strandat 563.575 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.014 ug/mL
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561,272 + Rv0470c 0.49 +0.5
561,615 - Rv0470c 0.89 +1.6
561,798 + +0.1
561,798 + -0.4
561,799 - -0.6
561,952 + Rv0470A 0.22 -0.5
561,953 - Rv0470A 0.22 -0.4
561,953 - Rv0470A 0.22 -0.7
562,091 + Rv0470A 0.54 -0.5
562,099 + Rv0470A 0.56 -1.1
562,100 - Rv0470A 0.56 -0.5
562,100 - Rv0470A 0.56 -1.9
562,100 - Rv0470A 0.56 -0.1
562,103 + Rv0470A 0.56 +1.8
562,103 + Rv0470A 0.56 +1.8
562,103 + Rv0470A 0.56 -0.0
562,103 + Rv0470A 0.56 -0.5
562,104 - Rv0470A 0.57 +0.2
562,104 - Rv0470A 0.57 -0.2
562,104 - Rv0470A 0.57 -0.0
562,104 - Rv0470A 0.57 -1.4
562,107 + Rv0470A 0.57 -0.5
562,160 + Rv0470A 0.69 -1.2
562,197 + Rv0470A 0.78 -0.5
562,219 + Rv0470A 0.83 -1.6
562,219 + Rv0470A 0.83 -0.0
562,302 + Rv0471c 0.16 +0.1
562,303 - Rv0471c 0.16 +0.2
562,303 - Rv0471c 0.16 +0.2
562,303 - Rv0471c 0.16 +0.2
562,303 - Rv0471c 0.16 -0.7
562,305 + Rv0471c 0.16 +1.8
562,305 + Rv0471c 0.16 -0.1
562,305 + Rv0471c 0.16 +0.1
562,306 - Rv0471c 0.17 +1.0
562,306 - Rv0471c 0.17 -1.0
562,306 - Rv0471c 0.17 +0.0
562,306 - Rv0471c 0.17 -0.6
562,359 + Rv0471c 0.27 -0.1
562,359 + Rv0471c 0.27 -0.4
562,359 + Rv0471c 0.27 -0.4
562,360 - Rv0471c 0.28 +1.2
562,360 - Rv0471c 0.28 +0.4
562,360 - Rv0471c 0.28 -0.3
562,360 - Rv0471c 0.28 +2.4
562,360 - Rv0471c 0.28 -0.2
562,360 - Rv0471c 0.28 +0.2
562,361 + Rv0471c 0.28 -0.9
562,361 + Rv0471c 0.28 -1.6
562,361 + Rv0471c 0.28 -0.7
562,361 + Rv0471c 0.28 -0.1
562,362 - Rv0471c 0.28 -0.8
562,362 - Rv0471c 0.28 -0.6
562,362 - Rv0471c 0.28 +0.5
562,362 - Rv0471c 0.28 -0.2
562,362 - Rv0471c 0.28 +0.4
562,403 + Rv0471c 0.36 +2.1
562,404 - Rv0471c 0.37 +2.2
562,418 + Rv0471c 0.39 +0.9
562,418 + Rv0471c 0.39 +0.2
562,451 + Rv0471c 0.46 -0.2
562,452 - Rv0471c 0.46 +0.1
562,464 + Rv0471c 0.49 +0.4
562,464 + Rv0471c 0.49 +0.1
562,464 + Rv0471c 0.49 +0.2
562,464 + Rv0471c 0.49 -0.3
562,464 + Rv0471c 0.49 +0.6
562,465 - Rv0471c 0.49 -0.3
562,465 - Rv0471c 0.49 +0.2
562,465 - Rv0471c 0.49 -0.4
562,670 + -0.6
562,671 - -0.4
562,724 + +0.8
562,724 + +0.0
562,724 + -0.8
562,841 + Rv0472c 0.17 -1.0
562,923 - Rv0472c 0.28 -2.3
563,050 - Rv0472c 0.46 -0.5
563,102 + Rv0472c 0.54 -2.4
563,102 + Rv0472c 0.54 -2.9
563,103 - Rv0472c 0.54 -1.6
563,244 - Rv0472c 0.74 -1.5
563,278 + Rv0472c 0.79 -1.7
563,415 + -3.9
563,464 + -1.4
563,464 + -0.5
563,534 + -1.1
563,535 - +0.8
563,535 - -0.6
563,535 - +0.1
563,575 + -1.3
563,575 + -1.3
563,575 + +0.6
563,575 + -1.3
563,575 + -1.0

Or see this region's nucleotide sequence