Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3711c

Experiment: 7H9 with Rifampicin 0.00045 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3710 and Rv3711c are separated by 65 nucleotidesRv3711c and Rv3712 are separated by 251 nucleotides Rv3710: Rv3710 - 2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS), at 4,153,740 to 4,155,674 Rv3710 Rv3711c: Rv3711c - Probable DNA polymerase III (epsilon subunit) DnaQ, at 4,155,740 to 4,156,729 Rv3711c Rv3712: Rv3712 - Possible ligase, at 4,156,981 to 4,158,222 Rv3712 Position (kb) 4155 4156 4157Strain fitness (log2 ratio) -1 0 1 2at 4155.672 kb on + strandat 4155.672 kb on + strandat 4155.689 kb on - strandat 4155.689 kb on - strandat 4155.752 kb on + strandat 4155.752 kb on + strandat 4155.753 kb on - strandat 4155.753 kb on - strandat 4155.753 kb on - strandat 4155.876 kb on + strand, within Rv3711cat 4155.877 kb on - strand, within Rv3711cat 4155.877 kb on - strand, within Rv3711cat 4156.001 kb on + strand, within Rv3711cat 4156.002 kb on - strand, within Rv3711cat 4156.056 kb on + strand, within Rv3711cat 4156.057 kb on - strand, within Rv3711cat 4156.221 kb on - strand, within Rv3711cat 4156.566 kb on - strand, within Rv3711cat 4156.589 kb on + strand, within Rv3711cat 4156.590 kb on - strand, within Rv3711cat 4156.969 kb on + strandat 4156.970 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.00045 ug/mL
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4,155,672 + +0.4
4,155,672 + -0.7
4,155,689 - +1.3
4,155,689 - -0.6
4,155,752 + -0.2
4,155,752 + +0.0
4,155,753 - +0.1
4,155,753 - -1.3
4,155,753 - +0.4
4,155,876 + Rv3711c 0.14 +1.9
4,155,877 - Rv3711c 0.14 -0.5
4,155,877 - Rv3711c 0.14 -0.2
4,156,001 + Rv3711c 0.26 +0.9
4,156,002 - Rv3711c 0.26 +1.5
4,156,056 + Rv3711c 0.32 +0.7
4,156,057 - Rv3711c 0.32 -0.5
4,156,221 - Rv3711c 0.49 -0.7
4,156,566 - Rv3711c 0.83 -0.2
4,156,589 + Rv3711c 0.86 -0.1
4,156,590 - Rv3711c 0.86 +0.1
4,156,969 + -0.4
4,156,970 - +0.3

Or see this region's nucleotide sequence