Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2334

Experiment: 7H9 with Rifampicin 0.00045 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2333c and Rv2334 are separated by 474 nucleotidesRv2334 and Rv2335 are separated by 3 nucleotides Rv2333c: Rv2333c - Integral membrane drug efflux protein Stp, at 2,606,708 to 2,608,321 Rv2333c Rv2334: Rv2334 - Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A), at 2,608,796 to 2,609,728 Rv2334 Rv2335: Rv2335 - Probable serine acetyltransferase CysE (sat), at 2,609,732 to 2,610,421 Rv2335 Position (kb) 2608 2609 2610Strain fitness (log2 ratio) -2 -1 0 1 2at 2607.825 kb on + strand, within Rv2333cat 2607.825 kb on + strand, within Rv2333cat 2607.825 kb on + strand, within Rv2333cat 2607.826 kb on - strand, within Rv2333cat 2607.826 kb on - strand, within Rv2333cat 2607.826 kb on - strand, within Rv2333cat 2607.826 kb on - strand, within Rv2333cat 2607.889 kb on + strand, within Rv2333cat 2608.063 kb on + strand, within Rv2333cat 2608.091 kb on + strand, within Rv2333cat 2608.091 kb on + strand, within Rv2333cat 2608.092 kb on - strand, within Rv2333cat 2608.171 kb on - strandat 2608.335 kb on + strandat 2608.335 kb on + strandat 2608.335 kb on + strandat 2608.335 kb on + strandat 2608.336 kb on - strandat 2608.370 kb on + strandat 2608.370 kb on + strandat 2608.370 kb on + strandat 2608.371 kb on - strandat 2608.485 kb on - strandat 2608.485 kb on - strandat 2608.514 kb on + strandat 2608.516 kb on + strandat 2608.539 kb on + strandat 2608.552 kb on + strandat 2609.503 kb on - strand, within Rv2334at 2609.727 kb on - strandat 2609.928 kb on + strand, within Rv2335at 2609.929 kb on - strand, within Rv2335at 2609.929 kb on - strand, within Rv2335at 2609.932 kb on + strand, within Rv2335at 2610.427 kb on + strandat 2610.486 kb on + strandat 2610.574 kb on + strandat 2610.574 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.00045 ug/mL
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2,607,825 + Rv2333c 0.69 -0.3
2,607,825 + Rv2333c 0.69 +0.0
2,607,825 + Rv2333c 0.69 -1.1
2,607,826 - Rv2333c 0.69 -0.5
2,607,826 - Rv2333c 0.69 -0.2
2,607,826 - Rv2333c 0.69 -0.4
2,607,826 - Rv2333c 0.69 -0.5
2,607,889 + Rv2333c 0.73 +1.8
2,608,063 + Rv2333c 0.84 -0.3
2,608,091 + Rv2333c 0.86 -0.2
2,608,091 + Rv2333c 0.86 -0.2
2,608,092 - Rv2333c 0.86 +0.3
2,608,171 - +0.2
2,608,335 + +0.1
2,608,335 + -1.8
2,608,335 + -0.7
2,608,335 + -0.1
2,608,336 - +1.4
2,608,370 + -0.3
2,608,370 + +0.7
2,608,370 + -0.3
2,608,371 - -0.0
2,608,485 - +0.2
2,608,485 - +1.8
2,608,514 + +0.8
2,608,516 + -0.4
2,608,539 + +0.0
2,608,552 + +0.6
2,609,503 - Rv2334 0.76 -0.5
2,609,727 - +0.8
2,609,928 + Rv2335 0.28 -0.5
2,609,929 - Rv2335 0.29 -0.3
2,609,929 - Rv2335 0.29 -2.0
2,609,932 + Rv2335 0.29 -0.9
2,610,427 + -0.0
2,610,486 + -1.6
2,610,574 + -0.3
2,610,574 + -0.3

Or see this region's nucleotide sequence