Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2140c

Experiment: 7H9 with Rifampicin 0.00045 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2139 and Rv2140c are separated by 4 nucleotidesRv2140c and Rv2141c are separated by 47 nucleotides Rv2139: Rv2139 - Probable dihydroorotate dehydrogenase PyrD, at 2,398,720 to 2,399,793 Rv2139 Rv2140c: Rv2140c - Conserved protein TB18.6, at 2,399,798 to 2,400,328 Rv2140c Rv2141c: Rv2141c - Conserved protein, at 2,400,376 to 2,401,722 Rv2141c Position (kb) 2399 2400 2401Strain fitness (log2 ratio) -3 -2 -1 0 1 2 3at 2399.791 kb on + strandat 2399.792 kb on - strandat 2399.792 kb on - strandat 2399.812 kb on - strandat 2399.868 kb on + strand, within Rv2140cat 2399.868 kb on + strand, within Rv2140cat 2399.931 kb on + strand, within Rv2140cat 2399.932 kb on - strand, within Rv2140cat 2400.129 kb on + strand, within Rv2140cat 2400.307 kb on - strandat 2400.401 kb on - strandat 2400.650 kb on + strand, within Rv2141cat 2400.650 kb on + strand, within Rv2141cat 2400.650 kb on + strand, within Rv2141cat 2400.650 kb on + strand, within Rv2141cat 2400.651 kb on - strand, within Rv2141cat 2400.794 kb on + strand, within Rv2141cat 2400.794 kb on + strand, within Rv2141cat 2400.814 kb on - strand, within Rv2141cat 2400.832 kb on + strand, within Rv2141cat 2400.832 kb on + strand, within Rv2141cat 2400.833 kb on - strand, within Rv2141cat 2401.119 kb on - strand, within Rv2141cat 2401.119 kb on - strand, within Rv2141cat 2401.215 kb on + strand, within Rv2141cat 2401.241 kb on + strand, within Rv2141cat 2401.241 kb on + strand, within Rv2141cat 2401.242 kb on - strand, within Rv2141c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.00045 ug/mL
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2,399,791 + -0.6
2,399,792 - -0.5
2,399,792 - -0.0
2,399,812 - -1.5
2,399,868 + Rv2140c 0.13 +0.2
2,399,868 + Rv2140c 0.13 -0.1
2,399,931 + Rv2140c 0.25 +2.8
2,399,932 - Rv2140c 0.25 +1.5
2,400,129 + Rv2140c 0.62 +0.8
2,400,307 - -1.0
2,400,401 - -3.0
2,400,650 + Rv2141c 0.20 -0.2
2,400,650 + Rv2141c 0.20 +1.6
2,400,650 + Rv2141c 0.20 +0.3
2,400,650 + Rv2141c 0.20 -0.9
2,400,651 - Rv2141c 0.20 -0.4
2,400,794 + Rv2141c 0.31 -1.0
2,400,794 + Rv2141c 0.31 +0.1
2,400,814 - Rv2141c 0.33 +0.4
2,400,832 + Rv2141c 0.34 -0.2
2,400,832 + Rv2141c 0.34 -0.4
2,400,833 - Rv2141c 0.34 +1.4
2,401,119 - Rv2141c 0.55 -0.0
2,401,119 - Rv2141c 0.55 +0.9
2,401,215 + Rv2141c 0.62 -0.2
2,401,241 + Rv2141c 0.64 -1.0
2,401,241 + Rv2141c 0.64 +1.5
2,401,242 - Rv2141c 0.64 -0.2

Or see this region's nucleotide sequence