Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0752c

Experiment: 7H9 with Rifampicin 0.00045 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0750 and Rv0751c are separated by 68 nucleotidesRv0751c and Rv0752c are separated by 10 nucleotidesRv0752c and Rv0753c are separated by 6 nucleotides Rv0750: Rv0750 - Conserved hypothetical protein, at 842,033 to 842,278 Rv0750 Rv0751c: Rv0751c - Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh), at 842,347 to 843,231 Rv0751c Rv0752c: Rv0752c - Probable acyl-CoA dehydrogenase FadE9, at 843,242 to 844,414 Rv0752c Rv0753c: Rv0753c - Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH), at 844,421 to 845,953 Rv0753c Position (kb) 843 844 845Strain fitness (log2 ratio) -1 0 1 2at 842.348 kb on + strandat 842.791 kb on + strand, within Rv0751cat 843.008 kb on + strand, within Rv0751cat 843.008 kb on + strand, within Rv0751cat 843.211 kb on + strandat 843.211 kb on + strandat 843.212 kb on - strandat 843.243 kb on + strandat 843.372 kb on + strand, within Rv0752cat 843.912 kb on + strand, within Rv0752cat 843.912 kb on + strand, within Rv0752cat 843.913 kb on - strand, within Rv0752cat 844.257 kb on + strand, within Rv0752cat 844.779 kb on + strand, within Rv0753cat 844.780 kb on - strand, within Rv0753cat 844.944 kb on + strand, within Rv0753cat 845.030 kb on - strand, within Rv0753cat 845.250 kb on + strand, within Rv0753cat 845.257 kb on - strand, within Rv0753cat 845.257 kb on - strand, within Rv0753c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.00045 ug/mL
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842,348 + -0.2
842,791 + Rv0751c 0.50 -1.5
843,008 + Rv0751c 0.75 +0.1
843,008 + Rv0751c 0.75 -0.2
843,211 + -0.3
843,211 + -0.2
843,212 - -0.5
843,243 + -0.8
843,372 + Rv0752c 0.11 -0.1
843,912 + Rv0752c 0.57 -0.7
843,912 + Rv0752c 0.57 +0.2
843,913 - Rv0752c 0.57 +0.9
844,257 + Rv0752c 0.87 -0.3
844,779 + Rv0753c 0.23 -0.1
844,780 - Rv0753c 0.23 +0.4
844,944 + Rv0753c 0.34 +1.3
845,030 - Rv0753c 0.40 +0.3
845,250 + Rv0753c 0.54 -0.3
845,257 - Rv0753c 0.55 -1.4
845,257 - Rv0753c 0.55 +1.9

Or see this region's nucleotide sequence