Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2670c

Experiment: 7H9 with Rifampicin 0.00045 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2668 and Rv2669 are separated by 28 nucleotidesRv2669 and Rv2670c overlap by 23 nucleotidesRv2670c and Rv2671 overlap by 2 nucleotidesRv2671 and Rv2672 are separated by 66 nucleotides Rv2668: Rv2668 - Possible exported alanine and valine rich protein, at 2,984,733 to 2,985,254 Rv2668 Rv2669: Rv2669 - GCN5-related N-acetyltransferase, at 2,985,283 to 2,985,753 Rv2669 Rv2670c: Rv2670c - Conserved hypothetical protein, at 2,985,731 to 2,986,840 Rv2670c Rv2671: Rv2671 - Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase), at 2,986,839 to 2,987,615 Rv2671 Rv2672: Rv2672 - Possible secreted protease, at 2,987,682 to 2,989,268 Rv2672 Position (kb) 2985 2986 2987Strain fitness (log2 ratio) -1 0 1 2at 2984.875 kb on - strand, within Rv2668at 2984.934 kb on + strand, within Rv2668at 2984.935 kb on - strand, within Rv2668at 2984.936 kb on + strand, within Rv2668at 2985.082 kb on - strand, within Rv2668at 2985.750 kb on - strandat 2985.796 kb on - strandat 2985.990 kb on + strand, within Rv2670cat 2986.347 kb on - strand, within Rv2670cat 2986.375 kb on + strand, within Rv2670cat 2986.479 kb on + strand, within Rv2670cat 2986.479 kb on + strand, within Rv2670cat 2986.480 kb on - strand, within Rv2670cat 2986.902 kb on + strandat 2986.903 kb on - strandat 2986.933 kb on - strand, within Rv2671at 2987.115 kb on + strand, within Rv2671at 2987.115 kb on + strand, within Rv2671at 2987.411 kb on + strand, within Rv2671at 2987.491 kb on - strand, within Rv2671at 2987.586 kb on + strandat 2987.592 kb on + strandat 2987.593 kb on - strandat 2987.593 kb on - strandat 2987.601 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Rifampicin 0.00045 ug/mL
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2,984,875 - Rv2668 0.27 -0.2
2,984,934 + Rv2668 0.39 -0.3
2,984,935 - Rv2668 0.39 +0.1
2,984,936 + Rv2668 0.39 -0.2
2,985,082 - Rv2668 0.67 -0.6
2,985,750 - -0.5
2,985,796 - -0.2
2,985,990 + Rv2670c 0.23 +0.1
2,986,347 - Rv2670c 0.55 -0.4
2,986,375 + Rv2670c 0.58 +0.0
2,986,479 + Rv2670c 0.67 +0.8
2,986,479 + Rv2670c 0.67 -1.0
2,986,480 - Rv2670c 0.67 +1.3
2,986,902 + -0.1
2,986,903 - -0.2
2,986,933 - Rv2671 0.12 -0.3
2,987,115 + Rv2671 0.36 -0.6
2,987,115 + Rv2671 0.36 -0.1
2,987,411 + Rv2671 0.74 +2.0
2,987,491 - Rv2671 0.84 -0.6
2,987,586 + -0.5
2,987,592 + -0.5
2,987,593 - -0.3
2,987,593 - -0.5
2,987,601 + -0.2

Or see this region's nucleotide sequence