Experiment: Ying_Others16 rep B; time point 2
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt IAI47_21240 and IAI47_21245 are separated by 240 nucleotides IAI47_21245 and IAI47_21250 are separated by 104 nucleotides IAI47_21250 and IAI47_21255 are separated by 3 nucleotides
IAI47_21240: IAI47_21240 - hypothetical protein, at 505,444 to 505,953
_21240
IAI47_21245: IAI47_21245 - alcohol dehydrogenase catalytic domain-containing protein, at 506,194 to 507,273
_21245
IAI47_21250: IAI47_21250 - helix-turn-helix domain-containing protein, at 507,378 to 508,148
_21250
IAI47_21255: IAI47_21255 - TetR/AcrR family transcriptional regulator, at 508,152 to 508,721
_21255
Position (kb) 506
507
508 Strain fitness (log2 ratio) -3
-2
-1
0
1
2 at 505.205 kb on - strand at 505.209 kb on - strand at 505.332 kb on + strand at 505.354 kb on + strand at 505.355 kb on - strand at 505.387 kb on + strand at 505.387 kb on + strand at 505.387 kb on + strand at 505.388 kb on - strand at 505.399 kb on + strand at 505.424 kb on + strand at 505.428 kb on - strand at 505.428 kb on - strand at 505.430 kb on + strand at 505.441 kb on - strand at 505.441 kb on - strand at 505.485 kb on + strand at 505.485 kb on + strand at 505.485 kb on + strand at 505.486 kb on - strand at 505.488 kb on - strand at 505.488 kb on - strand at 505.563 kb on + strand, within IAI47_21240 at 505.563 kb on + strand, within IAI47_21240 at 505.563 kb on + strand, within IAI47_21240 at 505.564 kb on - strand, within IAI47_21240 at 505.566 kb on + strand, within IAI47_21240 at 505.567 kb on - strand, within IAI47_21240 at 505.581 kb on + strand, within IAI47_21240 at 505.581 kb on + strand, within IAI47_21240 at 505.584 kb on + strand, within IAI47_21240 at 505.585 kb on - strand, within IAI47_21240 at 505.656 kb on + strand, within IAI47_21240 at 505.657 kb on - strand, within IAI47_21240 at 505.692 kb on + strand, within IAI47_21240 at 505.693 kb on - strand, within IAI47_21240 at 505.693 kb on - strand, within IAI47_21240 at 505.693 kb on - strand, within IAI47_21240 at 505.693 kb on - strand, within IAI47_21240 at 505.699 kb on + strand, within IAI47_21240 at 505.700 kb on - strand, within IAI47_21240 at 505.713 kb on + strand, within IAI47_21240 at 505.713 kb on + strand, within IAI47_21240 at 505.729 kb on + strand, within IAI47_21240 at 505.767 kb on - strand, within IAI47_21240 at 505.838 kb on + strand, within IAI47_21240 at 505.838 kb on + strand, within IAI47_21240 at 505.839 kb on - strand, within IAI47_21240 at 505.839 kb on - strand, within IAI47_21240 at 505.852 kb on + strand, within IAI47_21240 at 505.853 kb on - strand, within IAI47_21240 at 505.855 kb on + strand, within IAI47_21240 at 505.864 kb on + strand, within IAI47_21240 at 505.865 kb on - strand, within IAI47_21240 at 505.881 kb on - strand, within IAI47_21240 at 505.899 kb on + strand, within IAI47_21240 at 505.899 kb on + strand, within IAI47_21240 at 505.899 kb on + strand, within IAI47_21240 at 505.899 kb on + strand, within IAI47_21240 at 505.900 kb on - strand, within IAI47_21240 at 505.900 kb on - strand, within IAI47_21240 at 505.907 kb on + strand at 505.922 kb on + strand at 505.962 kb on + strand at 505.975 kb on + strand at 505.975 kb on + strand at 505.979 kb on + strand at 505.979 kb on + strand at 505.979 kb on + strand at 505.980 kb on - strand at 505.980 kb on - strand at 505.980 kb on - strand at 505.980 kb on - strand at 506.007 kb on + strand at 506.008 kb on - strand at 506.008 kb on - strand at 506.008 kb on - strand at 506.013 kb on + strand at 506.014 kb on - strand at 506.017 kb on + strand at 506.017 kb on + strand at 506.018 kb on - strand at 506.040 kb on + strand at 506.040 kb on + strand at 506.040 kb on + strand at 506.040 kb on + strand at 506.041 kb on - strand at 506.042 kb on + strand at 506.042 kb on + strand at 506.043 kb on - strand at 506.051 kb on + strand at 506.052 kb on - strand at 506.052 kb on - strand at 506.093 kb on - strand at 506.110 kb on + strand at 506.111 kb on - strand at 506.119 kb on - strand at 506.136 kb on + strand at 506.137 kb on - strand at 506.137 kb on - strand at 506.153 kb on + strand at 506.168 kb on + strand at 506.168 kb on + strand at 506.217 kb on + strand at 506.260 kb on - strand at 506.260 kb on - strand at 506.260 kb on - strand at 506.263 kb on - strand at 506.292 kb on - strand at 506.308 kb on + strand, within IAI47_21245 at 506.339 kb on + strand, within IAI47_21245 at 506.339 kb on + strand, within IAI47_21245 at 506.358 kb on - strand, within IAI47_21245 at 506.358 kb on - strand, within IAI47_21245 at 506.358 kb on - strand, within IAI47_21245 at 506.373 kb on + strand, within IAI47_21245 at 506.373 kb on + strand, within IAI47_21245 at 506.373 kb on + strand, within IAI47_21245 at 506.374 kb on - strand, within IAI47_21245 at 506.374 kb on - strand, within IAI47_21245 at 506.374 kb on - strand, within IAI47_21245 at 506.406 kb on - strand, within IAI47_21245 at 506.468 kb on + strand, within IAI47_21245 at 506.468 kb on + strand, within IAI47_21245 at 506.484 kb on + strand, within IAI47_21245 at 506.484 kb on + strand, within IAI47_21245 at 506.485 kb on - strand, within IAI47_21245 at 506.580 kb on + strand, within IAI47_21245 at 506.580 kb on + strand, within IAI47_21245 at 506.580 kb on + strand, within IAI47_21245 at 506.581 kb on - strand, within IAI47_21245 at 506.685 kb on + strand, within IAI47_21245 at 506.686 kb on - strand, within IAI47_21245 at 506.686 kb on - strand, within IAI47_21245 at 506.755 kb on + strand, within IAI47_21245 at 506.756 kb on - strand, within IAI47_21245 at 506.788 kb on + strand, within IAI47_21245 at 506.788 kb on + strand, within IAI47_21245 at 506.788 kb on + strand, within IAI47_21245 at 506.789 kb on - strand, within IAI47_21245 at 506.798 kb on + strand, within IAI47_21245 at 506.799 kb on - strand, within IAI47_21245 at 506.799 kb on - strand, within IAI47_21245 at 506.799 kb on - strand, within IAI47_21245 at 506.799 kb on - strand, within IAI47_21245 at 506.799 kb on - strand, within IAI47_21245 at 506.814 kb on + strand, within IAI47_21245 at 506.814 kb on + strand, within IAI47_21245 at 506.814 kb on + strand, within IAI47_21245 at 506.814 kb on + strand, within IAI47_21245 at 506.815 kb on - strand, within IAI47_21245 at 506.815 kb on - strand, within IAI47_21245 at 506.815 kb on - strand, within IAI47_21245 at 506.815 kb on - strand, within IAI47_21245 at 506.921 kb on + strand, within IAI47_21245 at 506.921 kb on + strand, within IAI47_21245 at 506.921 kb on + strand, within IAI47_21245 at 506.921 kb on + strand, within IAI47_21245 at 506.921 kb on + strand, within IAI47_21245 at 506.922 kb on - strand, within IAI47_21245 at 506.922 kb on - strand, within IAI47_21245 at 506.922 kb on - strand, within IAI47_21245 at 506.922 kb on - strand, within IAI47_21245 at 506.994 kb on + strand, within IAI47_21245 at 506.995 kb on - strand, within IAI47_21245 at 506.995 kb on - strand, within IAI47_21245 at 507.042 kb on + strand, within IAI47_21245 at 507.043 kb on - strand, within IAI47_21245 at 507.116 kb on - strand, within IAI47_21245 at 507.116 kb on - strand, within IAI47_21245 at 507.122 kb on + strand, within IAI47_21245 at 507.122 kb on + strand, within IAI47_21245 at 507.123 kb on - strand, within IAI47_21245 at 507.123 kb on - strand, within IAI47_21245 at 507.142 kb on + strand, within IAI47_21245 at 507.142 kb on + strand, within IAI47_21245 at 507.259 kb on + strand at 507.260 kb on - strand at 507.260 kb on - strand at 507.273 kb on + strand at 507.273 kb on + strand at 507.273 kb on + strand at 507.279 kb on + strand at 507.279 kb on + strand at 507.279 kb on + strand at 507.279 kb on + strand at 507.279 kb on + strand at 507.279 kb on + strand at 507.279 kb on + strand at 507.279 kb on + strand at 507.279 kb on + strand at 507.279 kb on + strand at 507.280 kb on - strand at 507.280 kb on - strand at 507.280 kb on - strand at 507.280 kb on - strand at 507.280 kb on - strand at 507.280 kb on - strand at 507.280 kb on - strand at 507.280 kb on - strand at 507.296 kb on - strand at 507.308 kb on + strand at 507.308 kb on + strand at 507.309 kb on - strand at 507.310 kb on + strand at 507.310 kb on + strand at 507.310 kb on + strand at 507.310 kb on + strand at 507.311 kb on - strand at 507.340 kb on + strand at 507.341 kb on - strand at 507.346 kb on + strand at 507.346 kb on + strand at 507.347 kb on - strand at 507.347 kb on - strand at 507.347 kb on - strand at 507.354 kb on + strand at 507.354 kb on + strand at 507.354 kb on + strand at 507.355 kb on - strand at 507.355 kb on - strand at 507.355 kb on - strand at 507.355 kb on - strand at 507.356 kb on + strand at 507.356 kb on + strand at 507.356 kb on + strand at 507.356 kb on + strand at 507.356 kb on + strand at 507.356 kb on + strand at 507.357 kb on - strand at 507.357 kb on - strand at 507.357 kb on - strand at 507.372 kb on + strand at 507.372 kb on + strand at 507.397 kb on + strand at 507.398 kb on - strand at 507.398 kb on - strand at 507.398 kb on - strand at 507.398 kb on - strand at 507.398 kb on - strand at 507.398 kb on - strand at 507.451 kb on + strand at 507.451 kb on + strand at 507.452 kb on - strand at 507.452 kb on - strand at 507.452 kb on - strand at 507.452 kb on - strand at 507.521 kb on + strand, within IAI47_21250 at 507.522 kb on - strand, within IAI47_21250 at 507.531 kb on + strand, within IAI47_21250 at 507.532 kb on - strand, within IAI47_21250 at 507.534 kb on - strand, within IAI47_21250 at 507.611 kb on + strand, within IAI47_21250 at 507.611 kb on + strand, within IAI47_21250 at 507.612 kb on - strand, within IAI47_21250 at 507.612 kb on - strand, within IAI47_21250 at 507.641 kb on + strand, within IAI47_21250 at 507.641 kb on + strand, within IAI47_21250 at 507.691 kb on + strand, within IAI47_21250 at 507.758 kb on - strand, within IAI47_21250 at 507.803 kb on - strand, within IAI47_21250 at 507.881 kb on + strand, within IAI47_21250 at 507.881 kb on + strand, within IAI47_21250 at 507.882 kb on - strand, within IAI47_21250 at 507.921 kb on + strand, within IAI47_21250 at 507.922 kb on - strand, within IAI47_21250 at 507.922 kb on - strand, within IAI47_21250 at 508.018 kb on + strand, within IAI47_21250 at 508.019 kb on - strand, within IAI47_21250 at 508.019 kb on - strand, within IAI47_21250 at 508.019 kb on - strand, within IAI47_21250 at 508.083 kb on + strand at 508.083 kb on + strand at 508.131 kb on + strand at 508.131 kb on + strand at 508.131 kb on + strand at 508.132 kb on - strand at 508.132 kb on - strand at 508.146 kb on + strand at 508.146 kb on + strand at 508.146 kb on + strand at 508.147 kb on - strand at 508.186 kb on + strand at 508.186 kb on + strand at 508.186 kb on + strand at 508.187 kb on - strand at 508.187 kb on - strand at 508.187 kb on - strand at 508.187 kb on - strand at 508.187 kb on - strand at 508.193 kb on + strand at 508.193 kb on + strand at 508.194 kb on - strand at 508.194 kb on - strand at 508.214 kb on + strand, within IAI47_21255 at 508.215 kb on - strand, within IAI47_21255 at 508.217 kb on + strand, within IAI47_21255 at 508.217 kb on + strand, within IAI47_21255 at 508.218 kb on - strand, within IAI47_21255 at 508.218 kb on - strand, within IAI47_21255 at 508.239 kb on + strand, within IAI47_21255 at 508.264 kb on + strand, within IAI47_21255
Per-strain Table
Position Strand Gene LocusTag Fraction Ying_Others16 rep B; time point 2 remove 505,205 - -1.0 505,209 - -0.5 505,332 + -0.9 505,354 + -0.1 505,355 - -2.1 505,387 + +0.4 505,387 + +0.3 505,387 + -0.3 505,388 - +0.5 505,399 + -0.2 505,424 + +0.4 505,428 - +0.7 505,428 - -0.5 505,430 + +0.2 505,441 - -1.1 505,441 - +0.4 505,485 + +1.7 505,485 + -1.6 505,485 + -0.1 505,486 - -0.5 505,488 - +0.1 505,488 - +0.2 505,563 + IAI47_21240 0.23 +1.7 505,563 + IAI47_21240 0.23 -1.3 505,563 + IAI47_21240 0.23 -0.4 505,564 - IAI47_21240 0.24 +0.1 505,566 + IAI47_21240 0.24 +1.7 505,567 - IAI47_21240 0.24 -0.9 505,581 + IAI47_21240 0.27 +1.1 505,581 + IAI47_21240 0.27 -1.3 505,584 + IAI47_21240 0.27 +1.1 505,585 - IAI47_21240 0.28 +0.6 505,656 + IAI47_21240 0.42 -1.0 505,657 - IAI47_21240 0.42 +0.2 505,692 + IAI47_21240 0.49 +0.4 505,693 - IAI47_21240 0.49 +0.4 505,693 - IAI47_21240 0.49 -0.3 505,693 - IAI47_21240 0.49 +0.6 505,693 - IAI47_21240 0.49 -0.5 505,699 + IAI47_21240 0.50 +1.7 505,700 - IAI47_21240 0.50 -0.9 505,713 + IAI47_21240 0.53 -1.2 505,713 + IAI47_21240 0.53 +0.2 505,729 + IAI47_21240 0.56 -0.6 505,767 - IAI47_21240 0.63 -1.9 505,838 + IAI47_21240 0.77 -0.9 505,838 + IAI47_21240 0.77 -0.7 505,839 - IAI47_21240 0.77 +0.7 505,839 - IAI47_21240 0.77 -1.1 505,852 + IAI47_21240 0.80 -0.1 505,853 - IAI47_21240 0.80 -1.9 505,855 + IAI47_21240 0.81 +0.9 505,864 + IAI47_21240 0.82 +0.3 505,865 - IAI47_21240 0.83 +0.1 505,881 - IAI47_21240 0.86 +2.7 505,899 + IAI47_21240 0.89 +0.9 505,899 + IAI47_21240 0.89 +0.7 505,899 + IAI47_21240 0.89 +0.3 505,899 + IAI47_21240 0.89 +0.6 505,900 - IAI47_21240 0.89 -0.7 505,900 - IAI47_21240 0.89 +0.7 505,907 + +1.0 505,922 + -0.5 505,962 + +0.3 505,975 + -1.9 505,975 + -0.0 505,979 + -0.1 505,979 + +0.3 505,979 + +0.1 505,980 - +0.4 505,980 - -0.5 505,980 - -0.4 505,980 - +0.4 506,007 + -0.3 506,008 - +0.3 506,008 - +0.1 506,008 - +0.1 506,013 + -1.0 506,014 - +1.6 506,017 + +0.5 506,017 + +0.7 506,018 - +1.7 506,040 + -1.7 506,040 + -2.1 506,040 + +0.5 506,040 + +0.1 506,041 - +0.4 506,042 + -0.3 506,042 + -1.1 506,043 - +0.7 506,051 + -1.4 506,052 - +0.3 506,052 - -1.1 506,093 - -0.1 506,110 + +0.3 506,111 - -0.0 506,119 - -0.5 506,136 + -1.9 506,137 - +0.6 506,137 - +0.7 506,153 + +2.3 506,168 + +1.1 506,168 + +0.0 506,217 + -0.3 506,260 - -0.7 506,260 - +1.6 506,260 - -0.3 506,263 - -1.6 506,292 - +1.3 506,308 + IAI47_21245 0.11 +0.4 506,339 + IAI47_21245 0.13 -0.5 506,339 + IAI47_21245 0.13 -1.5 506,358 - IAI47_21245 0.15 -0.0 506,358 - IAI47_21245 0.15 -0.0 506,358 - IAI47_21245 0.15 +0.5 506,373 + IAI47_21245 0.17 +0.7 506,373 + IAI47_21245 0.17 -0.3 506,373 + IAI47_21245 0.17 +0.2 506,374 - IAI47_21245 0.17 -1.3 506,374 - IAI47_21245 0.17 -0.9 506,374 - IAI47_21245 0.17 +0.1 506,406 - IAI47_21245 0.20 -0.5 506,468 + IAI47_21245 0.25 -1.3 506,468 + IAI47_21245 0.25 +0.5 506,484 + IAI47_21245 0.27 +1.5 506,484 + IAI47_21245 0.27 +0.7 506,485 - IAI47_21245 0.27 +0.4 506,580 + IAI47_21245 0.36 -0.9 506,580 + IAI47_21245 0.36 +0.4 506,580 + IAI47_21245 0.36 +0.7 506,581 - IAI47_21245 0.36 -0.2 506,685 + IAI47_21245 0.45 +0.3 506,686 - IAI47_21245 0.46 -0.3 506,686 - IAI47_21245 0.46 -0.1 506,755 + IAI47_21245 0.52 +0.7 506,756 - IAI47_21245 0.52 +1.0 506,788 + IAI47_21245 0.55 -0.3 506,788 + IAI47_21245 0.55 -2.0 506,788 + IAI47_21245 0.55 +0.2 506,789 - IAI47_21245 0.55 -0.9 506,798 + IAI47_21245 0.56 -0.1 506,799 - IAI47_21245 0.56 -0.9 506,799 - IAI47_21245 0.56 -0.8 506,799 - IAI47_21245 0.56 +0.5 506,799 - IAI47_21245 0.56 +0.2 506,799 - IAI47_21245 0.56 -0.5 506,814 + IAI47_21245 0.57 -0.2 506,814 + IAI47_21245 0.57 -1.1 506,814 + IAI47_21245 0.57 +0.6 506,814 + IAI47_21245 0.57 +0.4 506,815 - IAI47_21245 0.57 -1.2 506,815 - IAI47_21245 0.57 -0.4 506,815 - IAI47_21245 0.57 +1.6 506,815 - IAI47_21245 0.57 +0.2 506,921 + IAI47_21245 0.67 +1.0 506,921 + IAI47_21245 0.67 +1.3 506,921 + IAI47_21245 0.67 -1.4 506,921 + IAI47_21245 0.67 -1.3 506,921 + IAI47_21245 0.67 -0.9 506,922 - IAI47_21245 0.67 +0.5 506,922 - IAI47_21245 0.67 -0.9 506,922 - IAI47_21245 0.67 +1.9 506,922 - IAI47_21245 0.67 +1.5 506,994 + IAI47_21245 0.74 -0.5 506,995 - IAI47_21245 0.74 +0.5 506,995 - IAI47_21245 0.74 -2.3 507,042 + IAI47_21245 0.79 -0.6 507,043 - IAI47_21245 0.79 -0.5 507,116 - IAI47_21245 0.85 +0.7 507,116 - IAI47_21245 0.85 -1.0 507,122 + IAI47_21245 0.86 -0.1 507,122 + IAI47_21245 0.86 -1.5 507,123 - IAI47_21245 0.86 -0.3 507,123 - IAI47_21245 0.86 -0.7 507,142 + IAI47_21245 0.88 -0.2 507,142 + IAI47_21245 0.88 -1.8 507,259 + -1.0 507,260 - -1.0 507,260 - +0.7 507,273 + +1.1 507,273 + +1.2 507,273 + -0.8 507,279 + +0.6 507,279 + +0.3 507,279 + +0.0 507,279 + -0.5 507,279 + -0.7 507,279 + +0.1 507,279 + -2.5 507,279 + -0.7 507,279 + -0.6 507,279 + -1.2 507,280 - +2.0 507,280 - +0.4 507,280 - -0.5 507,280 - +0.3 507,280 - +0.4 507,280 - +1.2 507,280 - -1.6 507,280 - -2.9 507,296 - -0.0 507,308 + +0.9 507,308 + -0.7 507,309 - -1.0 507,310 + +0.2 507,310 + +0.1 507,310 + +0.2 507,310 + -0.3 507,311 - -0.2 507,340 + -0.9 507,341 - +0.1 507,346 + +0.9 507,346 + -1.3 507,347 - +0.9 507,347 - +1.5 507,347 - +0.0 507,354 + +0.1 507,354 + +0.7 507,354 + -1.3 507,355 - -0.5 507,355 - +0.3 507,355 - -1.2 507,355 - +0.3 507,356 + +1.3 507,356 + -0.5 507,356 + +1.3 507,356 + -1.3 507,356 + -0.2 507,356 + +0.9 507,357 - -0.2 507,357 - +1.4 507,357 - -1.3 507,372 + -0.1 507,372 + -0.2 507,397 + -0.9 507,398 - -2.0 507,398 - +0.9 507,398 - -0.3 507,398 - -0.3 507,398 - -0.7 507,398 - -1.9 507,451 + -1.2 507,451 + +1.7 507,452 - +0.7 507,452 - +0.5 507,452 - -1.0 507,452 - +0.7 507,521 + IAI47_21250 0.19 +1.5 507,522 - IAI47_21250 0.19 +0.4 507,531 + IAI47_21250 0.20 -0.2 507,532 - IAI47_21250 0.20 +0.2 507,534 - IAI47_21250 0.20 -0.4 507,611 + IAI47_21250 0.30 -1.2 507,611 + IAI47_21250 0.30 +0.4 507,612 - IAI47_21250 0.30 -0.3 507,612 - IAI47_21250 0.30 -0.4 507,641 + IAI47_21250 0.34 +0.4 507,641 + IAI47_21250 0.34 +0.7 507,691 + IAI47_21250 0.41 -0.9 507,758 - IAI47_21250 0.49 +1.0 507,803 - IAI47_21250 0.55 -0.3 507,881 + IAI47_21250 0.65 +0.1 507,881 + IAI47_21250 0.65 -0.9 507,882 - IAI47_21250 0.65 -0.4 507,921 + IAI47_21250 0.70 +0.7 507,922 - IAI47_21250 0.71 +1.3 507,922 - IAI47_21250 0.71 +0.2 508,018 + IAI47_21250 0.83 +1.3 508,019 - IAI47_21250 0.83 -0.9 508,019 - IAI47_21250 0.83 +0.7 508,019 - IAI47_21250 0.83 +0.7 508,083 + +1.1 508,083 + +0.7 508,131 + +0.0 508,131 + +0.6 508,131 + -0.1 508,132 - +0.3 508,132 - +0.2 508,146 + +1.3 508,146 + -0.0 508,146 + +0.7 508,147 - +0.6 508,186 + +0.7 508,186 + -1.3 508,186 + -0.9 508,187 - -0.3 508,187 - -0.3 508,187 - +0.8 508,187 - +0.4 508,187 - -1.1 508,193 + -2.1 508,193 + +0.9 508,194 - -0.4 508,194 - +0.2 508,214 + IAI47_21255 0.11 -0.5 508,215 - IAI47_21255 0.11 +2.7 508,217 + IAI47_21255 0.11 -0.9 508,217 + IAI47_21255 0.11 -1.3 508,218 - IAI47_21255 0.12 +0.1 508,218 - IAI47_21255 0.12 +0.2 508,239 + IAI47_21255 0.15 -0.1 508,264 + IAI47_21255 0.20 -1.6
Or see this region's nucleotide sequence