Experiment: Ying_AminoAcid20 rep A; time point 1
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt IAI47_08240 and IAI47_08245 are separated by 176 nucleotides IAI47_08245 and IAI47_08250 are separated by 59 nucleotides IAI47_08250 and IAI47_08255 are separated by 307 nucleotides
IAI47_08240: IAI47_08240 - tRNA-Ser, at 1,744,041 to 1,744,128
_08240
IAI47_08245: IAI47_08245 - peptide-methionine (S)-S-oxide reductase MsrA, at 1,744,305 to 1,744,838
_08245
IAI47_08250: IAI47_08250 - flavin reductase family protein, at 1,744,898 to 1,745,464
_08250
IAI47_08255: IAI47_08255 - two-component system sensor histidine kinase PmrB, at 1,745,772 to 1,746,830
_08255
Position (kb)
1744
1745
1746 Strain fitness (log2 ratio)
-3
-2
-1
0
1
2
3 at 1743.974 kb on + strand at 1743.974 kb on + strand at 1743.993 kb on + strand at 1743.993 kb on + strand at 1744.135 kb on - strand at 1744.135 kb on - strand at 1744.135 kb on - strand at 1744.135 kb on - strand at 1744.219 kb on + strand at 1744.219 kb on + strand at 1744.220 kb on - strand at 1744.220 kb on - strand at 1744.220 kb on - strand at 1744.249 kb on - strand at 1744.258 kb on + strand at 1744.258 kb on + strand at 1744.258 kb on + strand at 1744.272 kb on + strand at 1744.272 kb on + strand at 1744.272 kb on + strand at 1744.273 kb on - strand at 1744.273 kb on - strand at 1744.273 kb on - strand at 1744.273 kb on - strand at 1744.273 kb on - strand at 1744.281 kb on + strand at 1744.282 kb on - strand at 1744.295 kb on - strand at 1744.302 kb on - strand at 1744.363 kb on - strand, within IAI47_08245 at 1744.376 kb on - strand, within IAI47_08245 at 1744.405 kb on + strand, within IAI47_08245 at 1744.406 kb on - strand, within IAI47_08245 at 1744.406 kb on - strand, within IAI47_08245 at 1744.406 kb on - strand, within IAI47_08245 at 1744.417 kb on + strand, within IAI47_08245 at 1744.417 kb on + strand, within IAI47_08245 at 1744.417 kb on + strand, within IAI47_08245 at 1744.418 kb on - strand, within IAI47_08245 at 1744.418 kb on - strand, within IAI47_08245 at 1744.432 kb on + strand, within IAI47_08245 at 1744.433 kb on - strand, within IAI47_08245 at 1744.587 kb on - strand, within IAI47_08245 at 1744.637 kb on - strand, within IAI47_08245 at 1744.711 kb on + strand, within IAI47_08245 at 1744.711 kb on + strand, within IAI47_08245 at 1744.711 kb on + strand, within IAI47_08245 at 1744.712 kb on - strand, within IAI47_08245 at 1744.721 kb on + strand, within IAI47_08245 at 1744.721 kb on + strand, within IAI47_08245 at 1744.722 kb on - strand, within IAI47_08245 at 1744.722 kb on - strand, within IAI47_08245 at 1744.740 kb on - strand, within IAI47_08245 at 1744.742 kb on - strand, within IAI47_08245 at 1744.742 kb on - strand, within IAI47_08245 at 1744.742 kb on - strand, within IAI47_08245 at 1744.762 kb on - strand, within IAI47_08245 at 1744.778 kb on + strand, within IAI47_08245 at 1744.778 kb on + strand, within IAI47_08245 at 1744.779 kb on - strand, within IAI47_08245 at 1744.779 kb on - strand, within IAI47_08245 at 1744.817 kb on + strand at 1744.825 kb on + strand at 1744.826 kb on - strand at 1744.826 kb on - strand at 1744.838 kb on + strand at 1744.838 kb on + strand at 1744.838 kb on + strand at 1744.839 kb on - strand at 1744.839 kb on - strand at 1744.839 kb on - strand at 1744.841 kb on + strand at 1744.841 kb on + strand at 1744.841 kb on + strand at 1744.841 kb on + strand at 1744.841 kb on + strand at 1744.841 kb on + strand at 1744.842 kb on - strand at 1744.842 kb on - strand at 1744.846 kb on + strand at 1744.847 kb on - strand at 1744.847 kb on - strand at 1744.899 kb on + strand at 1744.899 kb on + strand at 1744.899 kb on + strand at 1744.899 kb on + strand at 1744.900 kb on - strand at 1744.900 kb on - strand at 1744.900 kb on - strand at 1744.900 kb on - strand at 1744.941 kb on - strand at 1744.979 kb on - strand, within IAI47_08250 at 1744.979 kb on - strand, within IAI47_08250 at 1744.979 kb on - strand, within IAI47_08250 at 1744.980 kb on + strand, within IAI47_08250 at 1744.980 kb on + strand, within IAI47_08250 at 1744.980 kb on + strand, within IAI47_08250 at 1744.981 kb on - strand, within IAI47_08250 at 1744.981 kb on - strand, within IAI47_08250 at 1744.981 kb on - strand, within IAI47_08250 at 1745.052 kb on + strand, within IAI47_08250 at 1745.052 kb on + strand, within IAI47_08250 at 1745.052 kb on + strand, within IAI47_08250 at 1745.052 kb on + strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.053 kb on - strand, within IAI47_08250 at 1745.056 kb on + strand, within IAI47_08250 at 1745.076 kb on + strand, within IAI47_08250 at 1745.077 kb on - strand, within IAI47_08250 at 1745.170 kb on + strand, within IAI47_08250 at 1745.204 kb on + strand, within IAI47_08250 at 1745.205 kb on - strand, within IAI47_08250 at 1745.205 kb on - strand, within IAI47_08250 at 1745.205 kb on - strand, within IAI47_08250 at 1745.373 kb on + strand, within IAI47_08250 at 1745.373 kb on + strand, within IAI47_08250 at 1745.374 kb on - strand, within IAI47_08250 at 1745.374 kb on - strand, within IAI47_08250 at 1745.374 kb on - strand, within IAI47_08250 at 1745.412 kb on + strand at 1745.413 kb on - strand at 1745.425 kb on + strand at 1745.425 kb on + strand at 1745.426 kb on - strand at 1745.442 kb on + strand at 1745.442 kb on + strand at 1745.442 kb on + strand at 1745.443 kb on - strand at 1745.443 kb on - strand at 1745.469 kb on + strand at 1745.469 kb on + strand at 1745.469 kb on + strand at 1745.470 kb on - strand at 1745.470 kb on - strand at 1745.470 kb on - strand at 1745.470 kb on - strand at 1745.470 kb on - strand at 1745.479 kb on - strand at 1745.483 kb on + strand at 1745.483 kb on + strand at 1745.484 kb on - strand at 1745.495 kb on + strand at 1745.496 kb on - strand at 1745.496 kb on - strand at 1745.501 kb on + strand at 1745.501 kb on + strand at 1745.501 kb on + strand at 1745.501 kb on + strand at 1745.502 kb on - strand at 1745.502 kb on - strand at 1745.502 kb on - strand at 1745.502 kb on - strand at 1745.502 kb on - strand at 1745.517 kb on + strand at 1745.518 kb on - strand at 1745.556 kb on - strand at 1745.581 kb on + strand at 1745.582 kb on - strand at 1745.582 kb on - strand at 1745.582 kb on - strand at 1745.582 kb on - strand at 1745.601 kb on - strand at 1745.611 kb on + strand at 1745.612 kb on - strand at 1745.614 kb on + strand at 1745.614 kb on + strand at 1745.614 kb on + strand at 1745.614 kb on + strand at 1745.615 kb on - strand at 1745.649 kb on + strand at 1745.652 kb on + strand at 1745.652 kb on + strand at 1745.652 kb on + strand at 1745.652 kb on + strand at 1745.652 kb on + strand at 1745.653 kb on - strand at 1745.653 kb on - strand at 1745.653 kb on - strand at 1745.653 kb on - strand at 1745.656 kb on - strand at 1745.666 kb on + strand at 1745.667 kb on - strand at 1745.667 kb on - strand at 1745.667 kb on - strand at 1745.685 kb on + strand at 1745.685 kb on + strand at 1745.710 kb on + strand at 1745.711 kb on - strand at 1745.711 kb on - strand at 1745.711 kb on - strand at 1745.711 kb on - strand at 1745.711 kb on - strand at 1745.766 kb on + strand at 1745.766 kb on + strand at 1745.767 kb on - strand at 1745.841 kb on + strand at 1745.853 kb on - strand at 1745.853 kb on - strand at 1745.909 kb on + strand, within IAI47_08255 at 1745.909 kb on + strand, within IAI47_08255 at 1745.909 kb on + strand, within IAI47_08255 at 1745.910 kb on - strand, within IAI47_08255 at 1745.910 kb on - strand, within IAI47_08255 at 1745.910 kb on - strand, within IAI47_08255 at 1745.918 kb on + strand, within IAI47_08255 at 1745.936 kb on + strand, within IAI47_08255 at 1745.937 kb on - strand, within IAI47_08255 at 1745.937 kb on - strand, within IAI47_08255 at 1745.949 kb on - strand, within IAI47_08255 at 1746.021 kb on - strand, within IAI47_08255 at 1746.021 kb on - strand, within IAI47_08255 at 1746.031 kb on + strand, within IAI47_08255 at 1746.048 kb on + strand, within IAI47_08255 at 1746.049 kb on - strand, within IAI47_08255 at 1746.057 kb on - strand, within IAI47_08255 at 1746.057 kb on - strand, within IAI47_08255 at 1746.152 kb on + strand, within IAI47_08255 at 1746.152 kb on + strand, within IAI47_08255 at 1746.152 kb on + strand, within IAI47_08255 at 1746.152 kb on + strand, within IAI47_08255 at 1746.152 kb on + strand, within IAI47_08255 at 1746.152 kb on + strand, within IAI47_08255 at 1746.152 kb on + strand, within IAI47_08255 at 1746.153 kb on - strand, within IAI47_08255 at 1746.153 kb on - strand, within IAI47_08255 at 1746.153 kb on - strand, within IAI47_08255 at 1746.187 kb on + strand, within IAI47_08255 at 1746.208 kb on + strand, within IAI47_08255 at 1746.208 kb on + strand, within IAI47_08255 at 1746.208 kb on + strand, within IAI47_08255 at 1746.208 kb on + strand, within IAI47_08255 at 1746.209 kb on - strand, within IAI47_08255 at 1746.212 kb on + strand, within IAI47_08255 at 1746.212 kb on + strand, within IAI47_08255 at 1746.212 kb on + strand, within IAI47_08255 at 1746.213 kb on - strand, within IAI47_08255 at 1746.213 kb on - strand, within IAI47_08255 at 1746.213 kb on - strand, within IAI47_08255 at 1746.213 kb on - strand, within IAI47_08255 at 1746.221 kb on + strand, within IAI47_08255 at 1746.221 kb on + strand, within IAI47_08255 at 1746.222 kb on - strand, within IAI47_08255 at 1746.317 kb on + strand, within IAI47_08255 at 1746.317 kb on + strand, within IAI47_08255 at 1746.318 kb on - strand, within IAI47_08255 at 1746.318 kb on - strand, within IAI47_08255 at 1746.320 kb on + strand, within IAI47_08255 at 1746.320 kb on + strand, within IAI47_08255 at 1746.320 kb on + strand, within IAI47_08255 at 1746.321 kb on - strand, within IAI47_08255 at 1746.321 kb on - strand, within IAI47_08255 at 1746.321 kb on - strand, within IAI47_08255 at 1746.331 kb on - strand, within IAI47_08255 at 1746.331 kb on - strand, within IAI47_08255 at 1746.331 kb on - strand, within IAI47_08255 at 1746.348 kb on + strand, within IAI47_08255 at 1746.348 kb on + strand, within IAI47_08255 at 1746.349 kb on - strand, within IAI47_08255 at 1746.349 kb on - strand, within IAI47_08255 at 1746.365 kb on + strand, within IAI47_08255 at 1746.366 kb on - strand, within IAI47_08255
Per-strain Table
Position Strand Gene LocusTag Fraction Ying_AminoAcid20 rep A; time point 1 remove 1,743,974 + -0.6 1,743,974 + +1.1 1,743,993 + +1.2 1,743,993 + -1.6 1,744,135 - +0.0 1,744,135 - -0.4 1,744,135 - -0.4 1,744,135 - +1.6 1,744,219 + +1.2 1,744,219 + -0.1 1,744,220 - +0.7 1,744,220 - +0.6 1,744,220 - +0.7 1,744,249 - -1.5 1,744,258 + +0.7 1,744,258 + -0.5 1,744,258 + +0.1 1,744,272 + -0.6 1,744,272 + -0.1 1,744,272 + +1.9 1,744,273 - -0.3 1,744,273 - +0.7 1,744,273 - +0.5 1,744,273 - -0.4 1,744,273 - -2.3 1,744,281 + +0.2 1,744,282 - -0.8 1,744,295 - +0.4 1,744,302 - -0.4 1,744,363 - IAI47_08245 0.11 -0.6 1,744,376 - IAI47_08245 0.13 +0.1 1,744,405 + IAI47_08245 0.19 +0.7 1,744,406 - IAI47_08245 0.19 +0.5 1,744,406 - IAI47_08245 0.19 +3.3 1,744,406 - IAI47_08245 0.19 +0.0 1,744,417 + IAI47_08245 0.21 -0.4 1,744,417 + IAI47_08245 0.21 +2.0 1,744,417 + IAI47_08245 0.21 -0.3 1,744,418 - IAI47_08245 0.21 +0.3 1,744,418 - IAI47_08245 0.21 -1.1 1,744,432 + IAI47_08245 0.24 +1.7 1,744,433 - IAI47_08245 0.24 +0.4 1,744,587 - IAI47_08245 0.53 -0.8 1,744,637 - IAI47_08245 0.62 -1.1 1,744,711 + IAI47_08245 0.76 -0.1 1,744,711 + IAI47_08245 0.76 +1.2 1,744,711 + IAI47_08245 0.76 +2.1 1,744,712 - IAI47_08245 0.76 -0.1 1,744,721 + IAI47_08245 0.78 -0.8 1,744,721 + IAI47_08245 0.78 -0.3 1,744,722 - IAI47_08245 0.78 -0.0 1,744,722 - IAI47_08245 0.78 +1.0 1,744,740 - IAI47_08245 0.81 +0.3 1,744,742 - IAI47_08245 0.82 -0.3 1,744,742 - IAI47_08245 0.82 -0.0 1,744,742 - IAI47_08245 0.82 +1.2 1,744,762 - IAI47_08245 0.86 +0.9 1,744,778 + IAI47_08245 0.89 -2.4 1,744,778 + IAI47_08245 0.89 -1.3 1,744,779 - IAI47_08245 0.89 +2.2 1,744,779 - IAI47_08245 0.89 +0.7 1,744,817 + +0.5 1,744,825 + -0.4 1,744,826 - -0.6 1,744,826 - +2.3 1,744,838 + -0.6 1,744,838 + +0.0 1,744,838 + +0.9 1,744,839 - -0.4 1,744,839 - +0.3 1,744,839 - +0.9 1,744,841 + -1.0 1,744,841 + +0.4 1,744,841 + +0.4 1,744,841 + +0.5 1,744,841 + -0.8 1,744,841 + +0.4 1,744,842 - -0.4 1,744,842 - +1.2 1,744,846 + +0.5 1,744,847 - +0.9 1,744,847 - +0.5 1,744,899 + +0.3 1,744,899 + -0.3 1,744,899 + +1.0 1,744,899 + -0.1 1,744,900 - +0.7 1,744,900 - -0.1 1,744,900 - -0.1 1,744,900 - -0.8 1,744,941 - -1.0 1,744,979 - IAI47_08250 0.14 +0.7 1,744,979 - IAI47_08250 0.14 -0.1 1,744,979 - IAI47_08250 0.14 +0.3 1,744,980 + IAI47_08250 0.14 +0.2 1,744,980 + IAI47_08250 0.14 -1.2 1,744,980 + IAI47_08250 0.14 -1.3 1,744,981 - IAI47_08250 0.15 -0.7 1,744,981 - IAI47_08250 0.15 -0.1 1,744,981 - IAI47_08250 0.15 -0.3 1,745,052 + IAI47_08250 0.27 +2.1 1,745,052 + IAI47_08250 0.27 -0.1 1,745,052 + IAI47_08250 0.27 -2.1 1,745,052 + IAI47_08250 0.27 -0.1 1,745,053 - IAI47_08250 0.27 +0.2 1,745,053 - IAI47_08250 0.27 +0.0 1,745,053 - IAI47_08250 0.27 -0.7 1,745,053 - IAI47_08250 0.27 -0.7 1,745,053 - IAI47_08250 0.27 +0.2 1,745,053 - IAI47_08250 0.27 -0.4 1,745,053 - IAI47_08250 0.27 +0.9 1,745,053 - IAI47_08250 0.27 +0.3 1,745,053 - IAI47_08250 0.27 +0.4 1,745,053 - IAI47_08250 0.27 -0.2 1,745,053 - IAI47_08250 0.27 +0.4 1,745,056 + IAI47_08250 0.28 -0.6 1,745,076 + IAI47_08250 0.31 +0.6 1,745,077 - IAI47_08250 0.32 -0.4 1,745,170 + IAI47_08250 0.48 -0.4 1,745,204 + IAI47_08250 0.54 -0.4 1,745,205 - IAI47_08250 0.54 +0.4 1,745,205 - IAI47_08250 0.54 +0.4 1,745,205 - IAI47_08250 0.54 +0.2 1,745,373 + IAI47_08250 0.84 -0.1 1,745,373 + IAI47_08250 0.84 -0.2 1,745,374 - IAI47_08250 0.84 +1.5 1,745,374 - IAI47_08250 0.84 +2.3 1,745,374 - IAI47_08250 0.84 -1.0 1,745,412 + +0.0 1,745,413 - +0.2 1,745,425 + -0.8 1,745,425 + -0.8 1,745,426 - -0.7 1,745,442 + -1.3 1,745,442 + -0.5 1,745,442 + -0.4 1,745,443 - +0.2 1,745,443 - +0.9 1,745,469 + +0.6 1,745,469 + -0.4 1,745,469 + +0.3 1,745,470 - +0.7 1,745,470 - +0.4 1,745,470 - +0.2 1,745,470 - -0.2 1,745,470 - -1.6 1,745,479 - +0.7 1,745,483 + +0.4 1,745,483 + +0.2 1,745,484 - +0.4 1,745,495 + +0.0 1,745,496 - +0.5 1,745,496 - +1.5 1,745,501 + +0.9 1,745,501 + +0.2 1,745,501 + +0.7 1,745,501 + -0.5 1,745,502 - -0.8 1,745,502 - -1.3 1,745,502 - -0.8 1,745,502 - -0.1 1,745,502 - +1.2 1,745,517 + +1.0 1,745,518 - -0.3 1,745,556 - +0.3 1,745,581 + -0.3 1,745,582 - -0.6 1,745,582 - +0.6 1,745,582 - -0.4 1,745,582 - +0.1 1,745,601 - -1.7 1,745,611 + +1.7 1,745,612 - -0.2 1,745,614 + +0.7 1,745,614 + +0.5 1,745,614 + -2.1 1,745,614 + +0.3 1,745,615 - -0.5 1,745,649 + +1.1 1,745,652 + +1.1 1,745,652 + -0.7 1,745,652 + -0.5 1,745,652 + -0.8 1,745,652 + -0.6 1,745,653 - -1.1 1,745,653 - +0.2 1,745,653 - +0.6 1,745,653 - +1.3 1,745,656 - -0.6 1,745,666 + -0.4 1,745,667 - +0.5 1,745,667 - -1.5 1,745,667 - +0.0 1,745,685 + -0.2 1,745,685 + +0.1 1,745,710 + -1.1 1,745,711 - -0.5 1,745,711 - +0.2 1,745,711 - +0.6 1,745,711 - -0.3 1,745,711 - +0.1 1,745,766 + +0.0 1,745,766 + +0.7 1,745,767 - +2.1 1,745,841 + +0.2 1,745,853 - -0.6 1,745,853 - -0.8 1,745,909 + IAI47_08255 0.13 +2.3 1,745,909 + IAI47_08255 0.13 -0.3 1,745,909 + IAI47_08255 0.13 -0.4 1,745,910 - IAI47_08255 0.13 +0.7 1,745,910 - IAI47_08255 0.13 -0.3 1,745,910 - IAI47_08255 0.13 -1.6 1,745,918 + IAI47_08255 0.14 -0.2 1,745,936 + IAI47_08255 0.15 -0.3 1,745,937 - IAI47_08255 0.16 -1.1 1,745,937 - IAI47_08255 0.16 +0.6 1,745,949 - IAI47_08255 0.17 +0.1 1,746,021 - IAI47_08255 0.24 -2.8 1,746,021 - IAI47_08255 0.24 -0.6 1,746,031 + IAI47_08255 0.24 +0.6 1,746,048 + IAI47_08255 0.26 +0.7 1,746,049 - IAI47_08255 0.26 -0.7 1,746,057 - IAI47_08255 0.27 +0.1 1,746,057 - IAI47_08255 0.27 +1.6 1,746,152 + IAI47_08255 0.36 -1.4 1,746,152 + IAI47_08255 0.36 +0.7 1,746,152 + IAI47_08255 0.36 -1.3 1,746,152 + IAI47_08255 0.36 -0.7 1,746,152 + IAI47_08255 0.36 -0.7 1,746,152 + IAI47_08255 0.36 -0.3 1,746,152 + IAI47_08255 0.36 +1.9 1,746,153 - IAI47_08255 0.36 -1.0 1,746,153 - IAI47_08255 0.36 -0.6 1,746,153 - IAI47_08255 0.36 -1.0 1,746,187 + IAI47_08255 0.39 -0.8 1,746,208 + IAI47_08255 0.41 -0.0 1,746,208 + IAI47_08255 0.41 -1.4 1,746,208 + IAI47_08255 0.41 +1.2 1,746,208 + IAI47_08255 0.41 +2.9 1,746,209 - IAI47_08255 0.41 +0.9 1,746,212 + IAI47_08255 0.42 -1.2 1,746,212 + IAI47_08255 0.42 +0.7 1,746,212 + IAI47_08255 0.42 -0.6 1,746,213 - IAI47_08255 0.42 -1.1 1,746,213 - IAI47_08255 0.42 -0.3 1,746,213 - IAI47_08255 0.42 -1.7 1,746,213 - IAI47_08255 0.42 -0.7 1,746,221 + IAI47_08255 0.42 +0.3 1,746,221 + IAI47_08255 0.42 -0.1 1,746,222 - IAI47_08255 0.42 -0.6 1,746,317 + IAI47_08255 0.51 +0.0 1,746,317 + IAI47_08255 0.51 -0.8 1,746,318 - IAI47_08255 0.52 -1.0 1,746,318 - IAI47_08255 0.52 -0.3 1,746,320 + IAI47_08255 0.52 -1.2 1,746,320 + IAI47_08255 0.52 -1.3 1,746,320 + IAI47_08255 0.52 +0.5 1,746,321 - IAI47_08255 0.52 +0.2 1,746,321 - IAI47_08255 0.52 +0.3 1,746,321 - IAI47_08255 0.52 -0.0 1,746,331 - IAI47_08255 0.53 +0.4 1,746,331 - IAI47_08255 0.53 -0.0 1,746,331 - IAI47_08255 0.53 -2.4 1,746,348 + IAI47_08255 0.54 -2.3 1,746,348 + IAI47_08255 0.54 +0.5 1,746,349 - IAI47_08255 0.54 +2.1 1,746,349 - IAI47_08255 0.54 +0.7 1,746,365 + IAI47_08255 0.56 +1.0 1,746,366 - IAI47_08255 0.56 -0.7
Or see this region's nucleotide sequence