Specific Phenotypes for Mycobacterium tuberculosis H37Rv in stress experiments

Condition Gene Description Fitness Cons.
2,4-Dinitrophenol Rv1071c Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) -1.2  
2-Mercaptopyridine N-oxide sodium salt Rv0877 Conserved hypothetical protein +2.3  
2-Mercaptopyridine N-oxide sodium salt Rv1205 Conserved hypothetical protein +2.3  
2-Mercaptopyridine N-oxide sodium salt Rv1901 Probable CinA-like protein CinA +1.5  
2-Mercaptopyridine N-oxide sodium salt Rv2344c Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) -1.7  
2-Mercaptopyridine N-oxide sodium salt Rv2684 Probable arsenic-transport integral membrane protein ArsA +1.1  
2-Mercaptopyridine N-oxide sodium salt Rv3842c Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase) +1.4  
2-bromo-2-nitro-1,3-propanediol Rv0877 Conserved hypothetical protein +1.5  
8-hydroxy-nitroquinoline Rv3839 Conserved hypothetical protein +1.0  
Antimycin A Rv3082c Virulence-regulating transcriptional regulator VirS (AraC/XylS family) +2.1  
Antimycin A Rv3083 Probable monooxygenase (hydroxylase) +1.4  
Bedaquiline Rv0174 Mce-family protein Mce1F -1.6  
Bedaquiline Rv0176 Probable conserved Mce associated transmembrane protein -1.6  
Bedaquiline Rv1184c Possible exported protein -2.3  
Benzethonium chloride Rv3161c Possible dioxygenase -2.0  
Ceftriaxone disodium salt hemi(heptahydrate) Rv2068c Class a beta-lactamase BlaC -1.4  
Ceftriaxone disodium salt hemi(heptahydrate) Rv2864c Possible penicillin-binding lipoprotein -1.1  
Ceftriaxone disodium salt hemi(heptahydrate) Rv3811 Conserved hypothetical protein -1.4  
Ciprofloxacin Hydrochloride Rv1634 Possible drug efflux membrane protein -1.7  
Ciprofloxacin Hydrochloride Rv2781c Possible alanine rich oxidoreductase +1.3  
Clarithromycin Rv1322 Conserved hypothetical protein -1.8  
Clarithromycin Rv1988 Probable 23S rRNA methyltransferase Erm(37) -3.2  
Clarithromycin Rv2125 Conserved hypothetical protein -1.1  
Clarithromycin Rv2368c Probable PHOH-like protein PhoH1 (phosphate starvation-inducible protein PSIH) -2.1  
Clarithromycin Rv2725c Probable GTP-binding protein HflX -3.1  
Clofazimine Rv0678 Conserved protein +2.1  
Clofazimine Rv1184c Possible exported protein -1.0  
Cumene hydroperoxide Rv1925 Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) -2.0  
Delamanid Rv2073c Probable shortchain dehydrogenase -1.7  
Delamanid Rv3547 Deazaflavin-dependent nitroreductase Ddn +2.3  
Dimethyl Sulfoxide Rv0984 Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) +1.4  
Econazole nitrate salt Rv0678 Conserved protein +2.4  
Econazole nitrate salt Rv3572 Unknown protein -1.2  
Erythromycin Rv1988 Probable 23S rRNA methyltransferase Erm(37) -2.9  
Erythromycin Rv2725c Probable GTP-binding protein HflX -1.7 Yes
Ethambutol Rv0020c Conserved protein with FHA domain, FhaA -1.5  
Ethionamide Rv1205 Conserved hypothetical protein -1.6  
Ethionamide Rv1901 Probable CinA-like protein CinA -1.7  
Ethionamide Rv3082c Virulence-regulating transcriptional regulator VirS (AraC/XylS family) +2.1  
Ethionamide Rv3083 Probable monooxygenase (hydroxylase) +2.3  
Formaldehyde Rv1633 Probable excinuclease ABC (subunit B-helicase) UvrB -2.8  
Formaldehyde Rv1638 Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA -2.4  
Hydrogen peroxide Rv1925 Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) -1.6  
Hygromycin B Rv1280c Probable periplasmic oligopeptide-binding lipoprotein OppA -1.8  
Hygromycin B Rv1281c Probable oligopeptide-transport ATP-binding protein ABC transporter OppD -1.9  
Hygromycin B Rv1819c Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA +3.3  
Hygromycin B Rv2416c Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase -2.7  
Isoniazid Rv0038 Conserved protein +1.4  
Isoniazid Rv0158 Probable transcriptional regulatory protein (possibly TetR-family) -1.3  
Isoniazid Rv0279c PE-PGRS family protein PE_PGRS4 +1.5  
Isoniazid Rv0877 Conserved hypothetical protein +3.2  
Isoniazid Rv1090 Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) +1.7  
Isoniazid Rv1091 PE-PGRS family protein PE_PGRS22 +1.5  
Isoniazid Rv1170 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) +2.8  
Isoniazid Rv1205 Conserved hypothetical protein -1.8  
Isoniazid Rv1901 Probable CinA-like protein CinA -1.4  
Isoniazid Rv2388c Probable oxygen-independent coproporphyrinogen III oxidase HemN (coproporphyrinogenase) (coprogen oxidase) +1.1  
Isoniazid Rv2404c Probable GTP-binding protein LepA (GTP-binding elongation factor) +3.2  
Isoniazid Rv2431c PE family protein PE25 +1.0  
Isoniazid Rv2433c Hypothetical protein +1.7  
Isoniazid Rv2434c Probable conserved transmembrane protein +1.9  
Isoniazid Rv2681 Conserved hypothetical alanine rich protein +1.7  
Levofloxacin Rv1087 PE-PGRS family protein PE_PGRS21 +1.4  
Levofloxacin Rv1090 Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) +1.7  
Levofloxacin Rv1091 PE-PGRS family protein PE_PGRS22 +1.6  
Levofloxacin Rv1108c Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit) -1.7 Yes
Levofloxacin Rv1277 Conserved hypothetical protein -1.7  
Levofloxacin Rv3585 DNA repair protein RadA (DNA repair protein SMS) -1.0 Yes
Linezolid Rv1644 Possible 23S rRNA methyltransferase TsnR +1.6  
Malondialdehyde tetrabutylammonium salt Rv0861c DNA helicase Ercc3 -1.8  
Menadione Rv1117 Conserved protein -1.4  
Meropenem Rv1019 Probable transcriptional regulatory protein (probably TetR-family) -1.6  
Meropenem Rv1194c Conserved protein -1.3  
Meropenem Rv1195 PE family protein PE13 -1.2  
Meropenem Rv2068c Class a beta-lactamase BlaC -2.9  
Meropenem Rv2525c Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system. -1.4  
Meropenem Rv2864c Possible penicillin-binding lipoprotein -1.6  
Meropenem Rv3811 Conserved hypothetical protein -1.7  
Meropenem Rv3814c Possible acyltransferase -1.3  
Moxifloxacin Rv0146 Possible S-adenosylmethionine-dependent methyltransferase -2.4  
Moxifloxacin Rv1020 Probable transcription-repair coupling factor Mfd (TRCF) -1.2 Yes
Moxifloxacin Rv1091 PE-PGRS family protein PE_PGRS22 +1.6  
Nickel (II) chloride hexahydrate Rv0450c Probable conserved transmembrane transport protein MmpL4 -2.0  
Norfloxacin Rv1634 Possible drug efflux membrane protein -1.4  
Novobiocin sodium salt Rv2922c Probable chromosome partition protein Smc -1.8  
Ofloxacin Rv1020 Probable transcription-repair coupling factor Mfd (TRCF) -1.0  
Pretomanid Rv1634 Possible drug efflux membrane protein +3.0  
Pretomanid Rv1901 Probable CinA-like protein CinA -1.3  
Pretomanid Rv2073c Probable shortchain dehydrogenase -1.5  
Pretomanid Rv3547 Deazaflavin-dependent nitroreductase Ddn +4.6  
Pyrazinamide Rv2043c Pyrazinamidase/nicotinamidase PncA (PZase) +2.4  
Rifampicin Rv1280c Probable periplasmic oligopeptide-binding lipoprotein OppA -1.6  
Rifampicin Rv1433 Possible conserved exported protein -2.1  
Rifampicin Rv2525c Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system. -1.7  
Rifampicin Rv2672 Possible secreted protease -1.4  
Rifampicin Rv2721c Possible conserved transmembrane alanine and glycine rich protein +1.4  
Sisomicin sulfate salt Rv0051 Probable conserved transmembrane protein +1.5  
Sisomicin sulfate salt Rv0169 Mce-family protein Mce1A +1.4  
Sisomicin sulfate salt Rv0171 Mce-family protein Mce1C +1.2  
Sisomicin sulfate salt Rv0176 Probable conserved Mce associated transmembrane protein +1.6  
Sisomicin sulfate salt Rv0660c Possible antitoxin MazE2 +1.5  
Sisomicin sulfate salt Rv1258c Probable conserved integral membrane transport protein -1.5  
Sisomicin sulfate salt Rv1808 PPE family protein PPE32 -1.3  
Sisomicin sulfate salt Rv1809 PPE family protein PPE33 -1.4  
Sisomicin sulfate salt Rv1819c Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA +2.7  
Sodium Dodecyl Sulfate Rv0711 Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) -1.3  
Sodium Dodecyl Sulfate Rv1429 Conserved protein +2.2  
Sodium Dodecyl Sulfate Rv2616 Conserved protein -1.6  
Sodium Dodecyl Sulfate Rv3651 Conserved hypothetical protein +1.9  
Sodium hypochlorite Rv0438c Probable molybdopterin biosynthesis protein MoeA2 +1.9 Yes
Sodium hypochlorite Rv0864 Probable molybdenum cofactor biosynthesis protein C 2 MoaC2 +1.8  
Sodium hypochlorite Rv1858 Probable molybdenum-transport integral membrane protein ABC transporter ModB +1.8  
Sodium hypochlorite Rv1859 Probable molybdenum-transport ATP-binding protein ABC transporter ModC +1.7  
Sodium hypochlorite Rv2453c Probable molybdopterin-guanine dinucleotide biosynthesis protein A MobA +1.6  
Sodium nitrate Rv0281 Possible S-adenosylmethionine-dependent methyltransferase -1.1  
Sodium nitrate Rv1077 Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) -1.6  
Sodium nitrate Rv1088 PE family protein PE9 -1.8  
Sodium nitrate Rv1334 Possible hydrolase -1.6  
Sodium nitrite Rv1074c Probable beta-ketoacyl CoA thiolase FadA3 variable  
Sodium nitrite Rv1077 Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) variable  
Sodium nitrite Rv1079 Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase) variable  
Sodium nitrite Rv1334 Possible hydrolase variable  
Sodium nitrite Rv1638 Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA -1.3  
Sodium nitrite Rv3272 Conserved hypothetical protein variable  
Spectinomycin dihydrochloride pentahydrate Rv1258c Probable conserved integral membrane transport protein -2.5  
Streptomycin sulfate salt Rv1258c Probable conserved integral membrane transport protein -2.6  
Streptomycin sulfate salt Rv1280c Probable periplasmic oligopeptide-binding lipoprotein OppA -1.6  
Streptomycin sulfate salt Rv1819c Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA +2.2  
Streptomycin sulfate salt Rv3919c Probable glucose-inhibited division protein B Gid +2.7  
Sutezolid Rv1644 Possible 23S rRNA methyltransferase TsnR +1.4  
copper (II) chloride dihydrate Rv0092 Cation transporter P-type ATPase a CtpA +1.7  
copper (II) chloride dihydrate Rv0450c Probable conserved transmembrane transport protein MmpL4 +1.8  
copper (II) chloride dihydrate Rv1386 PE family protein PE15 +2.5  
copper (II) chloride dihydrate Rv1387 PPE family protein PPE20 +2.6  
methylglyoxal Rv0818 Transcriptional regulatory protein -2.4  
methylglyoxal Rv1020 Probable transcription-repair coupling factor Mfd (TRCF) -1.0  
methylglyoxal Rv1117 Conserved protein -3.1  
methylglyoxal Rv1633 Probable excinuclease ABC (subunit B-helicase) UvrB -2.7 Yes
methylglyoxal Rv1637c Conserved protein -2.2  
methylglyoxal Rv1638 Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA -2.8 Yes
methylglyoxal Rv2259 S-nitrosomycothiol reductase MscR -1.7