Specific Phenotypes for Mycobacterium tuberculosis H37Rv in carbon source experiments

Condition Gene Description Fitness Cons.
D,L-Malic Acid Rv3667 Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase) -1.4  
D-Glucose Rv3331 Probable sugar-transport integral membrane protein SugI -3.5  
D-Trehalose dihydrate Rv1236 Probable sugar-transport integral membrane protein ABC transporter SugA -1.8 Yes
D-Trehalose dihydrate Rv1238 Probable sugar-transport ATP-binding protein ABC transporter SugC -1.6 Yes
D-Trehalose dihydrate Rv3777 Probable oxidoreductase +1.2  
Glycerol Rv0243 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) -1.6  
L-Asparagine Rv0037c Probable conserved integral membrane protein -2.1  
L-Asparagine Rv0530A Conserved protein +1.5  
L-Asparagine Rv1180 Probable polyketide beta-ketoacyl synthase Pks3 +1.4  
L-Asparagine Rv1181 Probable polyketide beta-ketoacyl synthase Pks4 +1.1  
L-Asparagine Rv2127 L-asparagine permease AnsP1 -1.8  
L-Asparagine Rv2462c Probable trigger factor (TF) protein Tig -1.6  
L-Asparagine Rv2618 Conserved hypothetical protein -1.4  
L-Asparagine Rv3145 Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A) -1.7  
L-Asparagine Rv3146 Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B) -1.4  
L-Asparagine Rv3149 Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E) -1.5  
L-Asparagine Rv3150 Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) -1.5  
L-Asparagine Rv3151 Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G) -1.5  
L-Asparagine Rv3152 Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) -1.2  
L-Asparagine Rv3154 Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J) -1.3  
L-Asparagine Rv3156 Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L) -1.4  
L-Asparagine Rv3157 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) -1.6  
L-Asparagine Rv3158 Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N) -1.4  
L-Asparagine Rv3342 Possible methyltransferase (methylase) -1.6  
L-Asparagine Rv3719 Conserved protein -1.6  
L-Asparagine Rv3720 Possible fatty acid synthase -2.1  
L-Asparagine Rv3824c Conserved polyketide synthase associated protein PapA1 +1.6  
L-Asparagine Rv3825c Polyketide synthase Pks2 +1.5  
L-Asparagine Rv3826 Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) +1.2  
L-Aspartic Acid Rv2127 L-asparagine permease AnsP1 -1.6  
L-Aspartic Acid Rv3720 Possible fatty acid synthase -1.4  
Palmitic acid Rv3259 Conserved hypothetical protein +1.3  
Potassium acetate Rv0408 Probable phosphate acetyltransferase Pta (phosphotransacetylase) -3.2 Yes
Potassium acetate Rv3342 Possible methyltransferase (methylase) -1.5  
Sodium D-Lactate Rv0487 Conserved hypothetical protein -2.3  
Sodium D-Lactate Rv1257c Probable oxidoreductase -3.0 Yes
Sodium L-Lactate Rv1872c Possible L-lactate dehydrogenase (cytochrome) LldD2 -2.5 Yes
Sodium butyrate Rv2851c GCN5-related N-acetyltransferase -1.6  
Sodium butyrate Rv3575c Transcriptional regulatory protein (probably LacI-family) -1.6  
Sodium oleate Rv3766 Hypothetical protein -3.1  
Sodium propionate Rv0280 PPE family protein PPE3 -1.8  
Sodium propionate Rv0408 Probable phosphate acetyltransferase Pta (phosphotransacetylase) -2.0 Yes
Sodium propionate Rv0409 Probable acetate kinase AckA (acetokinase) -1.4 Yes
Sodium propionate Rv1058 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) -1.4  
Sodium propionate Rv1129c Probable transcriptional regulator protein -4.6  
Sodium propionate Rv1130 Possible methylcitrate dehydratase PrpD -2.9  
Sodium propionate Rv1183 Probable conserved transmembrane transport protein MmpL10 -1.2  
Sodium propionate Rv1193 Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) -2.3  
Sodium propionate Rv3145 Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A) -2.8  
Sodium propionate Rv3146 Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B) -2.3  
Sodium propionate Rv3147 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) -2.7  
Sodium propionate Rv3148 Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D) -2.9  
Sodium propionate Rv3149 Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E) -2.6  
Sodium propionate Rv3150 Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) -3.0  
Sodium propionate Rv3151 Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G) -2.2  
Sodium propionate Rv3152 Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) -2.5  
Sodium propionate Rv3153 Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I) -2.2  
Sodium propionate Rv3154 Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J) -2.6  
Sodium propionate Rv3156 Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L) -2.7  
Sodium propionate Rv3157 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) -2.6  
Sodium propionate Rv3158 Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N) -2.2  
Sodium propionate Rv3575c Transcriptional regulatory protein (probably LacI-family) -1.3  
Stearic acid Rv0169 Mce-family protein Mce1A -1.3  
Stearic acid Rv0171 Mce-family protein Mce1C -1.3  
Stearic acid Rv0172 Mce-family protein Mce1D -1.5  
Stearic acid Rv0173 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) -1.7  
Stearic acid Rv0174 Mce-family protein Mce1F -1.6  
Stearic acid Rv0176 Probable conserved Mce associated transmembrane protein -1.6  
Stearic acid Rv3766 Hypothetical protein -2.7  
Valeric acid Rv1129c Probable transcriptional regulator protein -4.4  
Valeric acid Rv1130 Possible methylcitrate dehydratase PrpD -3.4  
Valeric acid Rv3133c Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) +1.2  
Valeric acid Rv3151 Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G) -1.3  
Valeric acid Rv3158 Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N) -1.3  
casamino acids Rv2127 L-asparagine permease AnsP1 -1.3  
cholesterol Rv0129c Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) +1.4  
cholesterol Rv0692 Conserved hypothetical protein -2.8  
cholesterol Rv0694 Possible L-lactate dehydrogenase (cytochrome) LldD1 -2.1  
cholesterol Rv0761c Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB -2.0  
cholesterol Rv0908 Probable metal cation transporter ATPase P-type CtpE +1.4  
cholesterol Rv2799 Probable membrane protein -1.5  
cholesterol Rv3494c Mce-family protein Mce4F -2.2  
cholesterol Rv3498c Mce-family protein Mce4B -1.8  
cholesterol Rv3526 Oxygenase component of 3-ketosteroid-9-alpha-hydroxylase KshA -1.9  
cholesterol Rv3537 Probable dehydrogenase -1.9  
cholesterol Rv3561 Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) -1.6  
cholesterol Rv3570c Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase. -2.6  
heptadecanoic acid Rv0171 Mce-family protein Mce1C -1.5  
heptadecanoic acid Rv0172 Mce-family protein Mce1D -1.6  
heptadecanoic acid Rv0173 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) -1.6  
heptadecanoic acid Rv0174 Mce-family protein Mce1F -1.5  
heptadecanoic acid Rv0176 Probable conserved Mce associated transmembrane protein -1.6  
heptadecanoic acid Rv1129c Probable transcriptional regulator protein -2.4  
heptadecanoic acid Rv1130 Possible methylcitrate dehydratase PrpD -2.4  
heptadecanoic acid Rv3766 Hypothetical protein -2.4