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Specific Phenotypes for
Mycobacterium tuberculosis H37Rv
in carbon source experiments
Condition
Gene
Description
Fitness
Cons.
D,L-Malic Acid
Rv3667
Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase)
-1.5
D-Trehalose dihydrate
Rv1236
Probable sugar-transport integral membrane protein ABC transporter SugA
-1.8
Yes
D-Trehalose dihydrate
Rv1238
Probable sugar-transport ATP-binding protein ABC transporter SugC
-1.6
Yes
Glycerol
Rv3499c
Mce-family protein Mce4A
-1.4
Glycerol
Rv3501c
Conserved integral membrane protein YrbE4A. Possible ABC transporter.
-1.6
L-Asparagine
Rv0530A
Conserved protein
+1.5
L-Asparagine
Rv1180
Probable polyketide beta-ketoacyl synthase Pks3
+1.4
L-Asparagine
Rv2618
Conserved hypothetical protein
-1.4
L-Asparagine
Rv3145
Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A)
-1.7
L-Asparagine
Rv3146
Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B)
-1.4
L-Asparagine
Rv3149
Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E)
-1.5
L-Asparagine
Rv3150
Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)
-1.5
L-Asparagine
Rv3151
Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G)
-1.5
L-Asparagine
Rv3152
Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)
-1.2
L-Asparagine
Rv3154
Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J)
-1.3
L-Asparagine
Rv3156
Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L)
-1.4
L-Asparagine
Rv3157
Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
-1.6
L-Asparagine
Rv3158
Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N)
-1.5
L-Asparagine
Rv3342
Possible methyltransferase (methylase)
-1.6
Potassium acetate
Rv0408
Probable phosphate acetyltransferase Pta (phosphotransacetylase)
-3.2
Yes
Potassium acetate
Rv3342
Possible methyltransferase (methylase)
-1.5
Sodium D-Lactate
Rv0487
Conserved hypothetical protein
-2.3
Sodium D-Lactate
Rv1257c
Probable oxidoreductase
-3.0
Yes
Sodium L-Lactate
Rv1872c
Possible L-lactate dehydrogenase (cytochrome) LldD2
-2.5
Yes
Sodium butyrate
Rv2851c
GCN5-related N-acetyltransferase
-1.6
Sodium butyrate
Rv3575c
Transcriptional regulatory protein (probably LacI-family)
-1.6
Sodium propionate
Rv0408
Probable phosphate acetyltransferase Pta (phosphotransacetylase)
-2.0
Yes
Sodium propionate
Rv1058
Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
-1.4
Sodium propionate
Rv1183
Probable conserved transmembrane transport protein MmpL10
-1.2
Sodium propionate
Rv1193
Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
-2.3
Sodium propionate
Rv3145
Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A)
-2.8
Sodium propionate
Rv3146
Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B)
-2.4
Sodium propionate
Rv3147
Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C)
-2.7
Sodium propionate
Rv3148
Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D)
-2.9
Sodium propionate
Rv3149
Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E)
-2.6
Sodium propionate
Rv3150
Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)
-3.0
Sodium propionate
Rv3151
Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G)
-2.2
Sodium propionate
Rv3152
Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)
-2.6
Sodium propionate
Rv3153
Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I)
-2.2
Sodium propionate
Rv3154
Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J)
-2.6
Sodium propionate
Rv3156
Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L)
-2.7
Sodium propionate
Rv3157
Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
-2.6
Sodium propionate
Rv3158
Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N)
-2.2
Sodium propionate
Rv3575c
Transcriptional regulatory protein (probably LacI-family)
-1.3
Stearic acid
Rv3766
Hypothetical protein
-2.6
Valeric acid
Rv3151
Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G)
-1.3
heptadecanoic acid
Rv0171
Mce-family protein Mce1C
-1.5
heptadecanoic acid
Rv3484
Possible conserved protein CpsA
-1.4
heptadecanoic acid
Rv3766
Hypothetical protein
-2.4