Fitness data for Rv2066 in Mycobacterium tuberculosis H37Rv

Probable bifunctional protein, CobI-COBJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase
SEED: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) / Cobalt-precorrin-3b C17-methyltransferase
KEGG: precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase

Top 20 experiments with the strongest phenotypes (|fitness| ≥ 0.2)


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group condition fitness t score  
stress 7H9 with Levofloxacin 0.3 ug/mL -0.3 -2.1 compare
stress 7H9 with Isoniazid 0.025 ug/mL -0.3 -1.7 compare
no stress control no stress control -0.3 -1.5 compare
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.2 -1.3 compare
stress 7H9 with Ofloxacin 0.8 ug/mL -0.2 -1.3 compare
stress 7H9 with Isoniazid 0.025 ug/mL -0.2 -1.4 compare
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM -0.2 -1.4 compare
stress 7H9 with Clofazimine 0.072 ug/mL +0.2 +1.4 compare
stress 7H9 with Sisomicin 0.07 mM +0.2 +1.2 compare
nitrogen source L-Glutamine 10 mM (N) +0.2 +1.2 compare
stress 7H9 with Sulfamethizole 0.026 mM +0.2 +1.8 compare
nitrogen source L-Aspartic Acid 10 mM (N) +0.2 +1.2 compare
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.2 +1.7 compare
carbon source L-Glutamic (C) +0.2 +1.7 compare
carbon source L-Lactate 10 mM (C) +0.2 +1.7 compare
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.3 +1.6 compare
carbon source L-Lactate 10 mM (C) +0.3 +1.9 compare
stress 7H9 with Geneticin G418 0.35 mM +0.3 +2.3 compare
no stress control no stress control +0.3 +1.9 compare
carbon source oleate 200uM (C) +0.4 +2.3 compare