Fitness data for Rv2048c in Mycobacterium tuberculosis H37Rv

Polyketide synthase Pks12
SEED: Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)

All 236 fitness values, sorted by group and condition


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group condition fitness t score  
carbon source casaminos 1 mg/mL (C) -1.3 -5.6 compare
casaminos 1 mg/mL (C) -1.0 -4.1 compare
cholesterol 100uM (C) -0.3 -1.4 compare
cholesterol 100uM (C) +0.1 +0.5 compare
D,L-Malic Acid 10 mM (C) -1.3 -6.0 compare
D,L-Malic Acid 10 mM (C) -1.3 -4.8 compare
D-Glucose (C) -1.5 -7.9 compare
D-Glucose (C) -1.6 -5.8 compare
D-Trehalose 10 mM (C) -1.6 -7.5 compare
D-Trehalose 10 mM (C) -1.1 -4.4 compare
Glycerol (C) -2.1 -8.0 compare
Glycerol (C) -1.9 -9.5 compare
heptadecanoic 250 uM (C) -0.6 -2.4 compare
heptadecanoic 250 uM (C) -1.1 -4.3 compare
L-Asparagine (C) -1.7 -6.7 compare
L-Asparagine (C) -1.8 -9.5 compare
L-Aspartic Acid (C) -1.7 -8.6 compare
L-Aspartic Acid (C) -1.6 -7.5 compare
L-Glutamic (C) -1.3 -6.2 compare
L-Glutamic (C) -1.4 -6.9 compare
Palmitic 100 uM (C) -0.9 -4.6 compare
Palmitic 100 uM (C) -0.7 -3.3 compare
acetate (C) -1.0 -5.1 compare
acetate (C) -1.0 -5.7 compare
butyrate 10 mM (C) -1.5 -6.6 compare
butyrate 10 mM (C) -1.3 -4.6 compare
D-Lactate 10 mM (C) -0.6 -3.2 compare
D-Lactate 10 mM (C) -0.7 -3.6 compare
L-Lactate 10 mM (C) -1.4 -8.1 compare
L-Lactate 10 mM (C) -1.5 -5.5 compare
oleate 200uM (C) -0.5 -2.1 compare
oleate 200uM (C) -1.1 -4.3 compare
propionate (C) -1.3 -6.1 compare
propionate (C) -1.5 -8.6 compare
pyruvate (C) -1.5 -6.9 compare
pyruvate (C) -1.6 -5.6 compare
Stearic 100 uM (C) -1.4 -6.4 compare
Stearic 100 uM (C) -1.4 -5.4 compare
Valeric 10 mM (C) -0.8 -3.9 compare
Valeric 10 mM (C) -0.5 -2.6 compare
nitrogen source Ammonium chloride 10mM (N) -1.2 -4.3 compare
Ammonium chloride 10mM (N) -1.1 -4.7 compare
Glycine 10 mM (N) -1.8 -8.9 compare
Glycine 10 mM (N) -1.5 -6.2 compare
L-Alanine 10 mM (N) -1.6 -6.1 compare
L-Alanine 10 mM (N) -1.5 -6.4 compare
L-Asparagine 10 mM (N) -2.6 -9.8 compare
L-Asparagine 10 mM (N) -2.7 -8.6 compare
L-Aspartic Acid 10 mM (N) -2.6 -8.1 compare
L-Aspartic Acid 10 mM (N) -1.9 -7.5 compare
L-Glutamic 10 mM (N) -1.0 -3.4 compare
L-Glutamic 10 mM (N) -1.1 -4.1 compare
L-Glutamine 10 mM (N) -1.0 -5.5 compare
L-Glutamine 10 mM (N) -1.2 -5.0 compare
L-Serine 10 mM (N) -2.6 -9.0 compare
L-Serine 10 mM (N) -2.2 -7.8 compare
L-Valine 10 mM (N) -0.2 -1.2 compare
L-Valine 10 mM (N) -0.3 -1.3 compare
Urea 10mM (N) -0.5 -1.9 compare
Urea 10mM (N) -0.8 -2.8 compare
no stress control no stress control -0.6 -2.4 compare
no stress control -0.3 -1.9 compare
no stress control -0.8 -3.6 compare
no stress control -0.7 -3.5 compare
no stress control -0.3 -1.1 compare
no stress control -0.2 -0.7 compare
no stress control -0.2 -0.8 compare
no stress control -0.6 -2.9 compare
no stress control -0.1 -0.4 compare
no stress control -0.5 -1.9 compare
no stress control -0.6 -2.9 compare
no stress control -0.4 -1.9 compare
no stress control -0.3 -1.2 compare
no stress control -0.8 -4.3 compare
no stress control -0.3 -1.2 compare
no stress control -0.5 -2.3 compare
no stress control -0.3 -1.3 compare
no stress control -0.3 -1.4 compare
no stress control -0.7 -2.8 compare
no stress control -0.3 -1.6 compare
no stress control -0.1 -0.2 compare
no stress control -0.8 -4.4 compare
no stress control -0.9 -3.8 compare
no stress control -0.4 -1.7 compare
pH pH 4.5 -0.5 -1.7 compare
pH 4.5 -0.5 -1.6 compare
pH 5.5 -0.3 -1.3 compare
pH 5.5 -0.4 -1.3 compare
7H9 pH 5.5 -0.3 -1.3 compare
7H9 pH 5.5 -0.5 -2.1 compare
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM -0.1 -0.3 compare
7H9 with 2,4-Dinitrophenol 0.1503 mM -0.1 -0.5 compare
7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.2 -0.8 compare
7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.2 -1.2 compare
7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.1 -0.4 compare
7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.0 +0.1 compare
7H9 with 8-hydroxy-nitroquinoline 0.03 mM -3.2 -8.6 compare
7H9 with 8-hydroxy-nitroquinoline 0.03 mM -2.1 -5.7 compare
7H9 with Amikacin di2 ug/mL -0.6 -2.4 compare
7H9 with Amikacin di2 ug/mL -0.4 -1.8 compare
7H9 with Antimycin A 0.0186 mM -0.6 -2.9 compare
7H9 with Antimycin A 0.0186 mM -0.7 -2.4 compare
7H9 with Bedaquiline 0.15 ug/mL -0.3 -1.5 compare
7H9 with Bedaquiline 0.15 ug/mL -0.1 -0.3 compare
7H9 with Benzethonium chloride 0.068 mM -1.4 -4.4 compare
7H9 with Benzethonium chloride 0.068 mM -0.8 -3.7 compare
7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM -0.4 -1.7 compare
7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM -0.2 -1.0 compare
7H9 with Cetrimonium bromide 0.015 vol% -0.8 -3.1 compare
7H9 with Chloramphenicol 0.01 mM -0.4 -2.2 compare
7H9 with Chloramphenicol 0.01 mM -0.5 -2.0 compare
7H9 with Chlorhexidine diacetate salt 0.0021 mM -0.7 -2.5 compare
7H9 with Chlorhexidine diacetate salt 0.0021 mM -0.3 -1.2 compare
7H9 with Chlorpromazine 0.054 mM -0.7 -2.9 compare
7H9 with Chlorpromazine 0.054 mM -0.7 -2.8 compare
7H9 with Ciprofloxacin Hydrochloride 0.001 mM +0.2 +0.6 compare
7H9 with Ciprofloxacin Hydrochloride 0.001 mM +0.0 +0.0 compare
7H9 with Ciprofloxacin Hydrochloride 0.0012 mM -1.0 -3.5 compare
7H9 with Ciprofloxacin Hydrochloride 0.0012 mM -0.6 -2.6 compare
7H9 with Clarithromycin 0.967 ug/mL -0.7 -3.2 compare
7H9 with Clarithromycin 0.967 ug/mL -0.5 -2.5 compare
7H9 with Clofazimine 0.072 ug/mL -1.3 -5.1 compare
7H9 with Clofazimine 0.072 ug/mL -1.3 -5.9 compare
7H9 with Clofazimine 0.45 ug/mL -2.7 -11.1 compare
7H9 with Clofazimine 0.45 ug/mL -2.7 -7.5 compare
7H9 with Cloxacillin 0.0386 mM -0.5 -2.4 compare
7H9 with Cloxacillin 0.0386 mM -0.1 -0.3 compare
7H9 with copper (II) chloride 0.08 mM +1.3 +5.2 compare
7H9 with copper (II) chloride 0.08 mM +0.8 +3.4 compare
7H9 with Cumene hydroperoxide 0.05 mM -1.1 -3.6 compare
7H9 with Cumene hydroperoxide 0.05 mM -1.3 -4.1 compare
7H9 with Delamanid 0.236 ug/mL -0.4 -2.3 compare
7H9 with Delamanid 0.236 ug/mL -0.9 -4.3 compare
7H9 with Dibucaine 0.21 mM -0.6 -3.4 compare
7H9 with Dibucaine 0.21 mM -0.4 -1.7 compare
7H9 with Dicloxacillin 0.0069 mM -0.4 -1.6 compare
7H9 with Dicloxacillin 0.0069 mM -0.2 -0.7 compare
7H9 with Dimethyl Sulfoxide 1 vol% +0.1 +0.4 compare
7H9 with Dimethyl Sulfoxide 1 vol% -0.3 -1.8 compare
7H9 with Doxycycline hyclate 0.0035 mM -0.5 -2.4 compare
7H9 with Doxycycline hyclate 0.0035 mM -0.3 -0.9 compare
7H9 with Econazole nitrate salt 0.0082 mM -1.8 -6.2 compare
7H9 with Econazole nitrate salt 0.0082 mM -1.9 -6.9 compare
7H9 with EDTA (disodium salt) 0.2 mM +0.2 +1.0 compare
7H9 with Erythromycin 0.016 mM -1.5 -6.2 compare
7H9 with Erythromycin 0.016 mM -0.9 -3.5 compare
7H9 with Ethambutol 0.75 ug/mL -0.1 -0.4 compare
7H9 with Ethambutol 0.75 ug/mL +0.0 +0.0 compare
7H9 with Ethionamide 0.1 ug/mL -0.1 -0.6 compare
7H9 with Ethionamide 0.1 ug/mL -0.3 -1.4 compare
7H9 with Formaldehyde 0.23 mM +0.1 +0.4 compare
7H9 with Geneticin G418 0.35 mM -0.5 -2.4 compare
7H9 with Geneticin G418 0.35 mM -0.7 -3.6 compare
7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -1.1 -3.7 compare
7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.6 -2.2 compare
7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.2 -0.8 compare
7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.8 -2.9 compare
7H9 with Hydrogen peroxide 3.97 mM -0.6 -2.1 compare
7H9 with Hydrogen peroxide 3.97 mM -0.3 -1.2 compare
7H9 with Hygromycin B 0.0095 mM -0.4 -1.6 compare
7H9 with Hygromycin B 0.0095 mM -0.2 -0.7 compare
7H9 with Irgasan 0.065 mM -0.3 -1.3 compare
7H9 with Irgasan 0.065 mM -0.6 -2.6 compare
7H9 with Isoniazid 0.025 ug/mL -1.2 -4.5 compare
7H9 with Isoniazid 0.025 ug/mL -0.9 -2.9 compare
7H9 with Levofloxacin 0.3 ug/mL -0.1 -0.4 compare
7H9 with Levofloxacin 0.3 ug/mL -0.1 -0.3 compare
7H9 with Levofloxacin 0.3 ug/mL -0.3 -1.4 compare
7H9 with Linezolid 0.3 ug/mL -0.0 -0.2 compare
7H9 with Linezolid 0.3 ug/mL -0.1 -0.5 compare
7H9 with Linezolid 0.44 ug/mL -0.3 -1.7 compare
7H9 with Linezolid 0.44 ug/mL -0.2 -1.1 compare
7H9 with Lomefloxacin 0.0035 mM -0.2 -1.0 compare
7H9 with Lomefloxacin 0.0035 mM -0.3 -1.4 compare
7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.2 -0.7 compare
7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.2 -0.8 compare
7H9 with Menadione 0.005 mM -0.3 -1.1 compare
7H9 with Menadione 0.005 mM -0.1 -0.5 compare
7H9 with Meropenem 9.6 ug/mL -0.4 -2.1 compare
7H9 with Meropenem 9.6 ug/mL -0.2 -0.8 compare
7H9 with methylglyoxal 1.2 mM -0.1 -0.7 compare
7H9 with methylglyoxal 1.2 mM -0.1 -0.4 compare
7H9 with Moxifloxacin 0.121 ug/mL -0.1 -0.6 compare
7H9 with Moxifloxacin 0.121 ug/mL -0.3 -1.0 compare
7H9 with Nickel (II) chloride 0.6 mM -1.4 -5.8 compare
7H9 with Nickel (II) chloride 0.6 mM -2.2 -7.5 compare
7H9 with Norfloxacin 0.125 mM +0.4 +1.9 compare
7H9 with Norfloxacin 0.125 mM +0.0 +0.2 compare
7H9 with Novobiocin 0.004 mM -1.2 -4.6 compare
7H9 with Novobiocin 0.004 mM -1.4 -3.7 compare
7H9 with Ofloxacin 0.8 ug/mL +0.0 +0.1 compare
7H9 with Ofloxacin 0.8 ug/mL +0.3 +1.5 compare
7H9 with para-aminosalicylic 0.086 ug/mL +0.0 +0.1 compare
7H9 with para-aminosalicylic 0.086 ug/mL +0.2 +0.9 compare
7H9 with para-aminosalicylic 0.086 ug/mL +0.2 +1.4 compare
7H9 with Phenazine ethosulfate 0.0137 mM -0.4 -1.3 compare
7H9 with Phenazine ethosulfate 0.0137 mM -0.6 -2.7 compare
7H9 with Phenazine methosulfate 0.0054 mM -0.7 -3.2 compare
7H9 with Phenazine methosulfate 0.0054 mM -0.8 -3.4 compare
7H9 with Plumbagin 0.01 mM -1.4 -6.7 compare
7H9 with Pretomanid 0.213 ug/mL -0.3 -1.2 compare
7H9 with Pretomanid 0.213 ug/mL -0.2 -0.7 compare
7H9 with Pyrazinamide 50 ug/mL; pH 5.5 +0.0 +0.0 compare
7H9 with Pyrazinamide 50 ug/mL; pH 5.5 -0.2 -0.9 compare
7H9 with Ramoplanin 0.009 mM -0.3 -1.3 compare
7H9 with Rifampicin 0.00045 ug/mL -0.2 -1.2 compare
7H9 with Rifampicin 0.00045 ug/mL -0.1 -0.7 compare
7H9 with Rifampicin 0.014 ug/mL -0.5 -2.2 compare
7H9 with Rifampicin 0.014 ug/mL -0.6 -3.4 compare
7H9 with Sisomicin 0.07 mM +0.1 +0.2 compare
7H9 with Sisomicin 0.07 mM -0.1 -0.5 compare
7H9 with Dodecyl Sulfate 0.02 vol% -0.3 -0.8 compare
7H9 with Dodecyl Sulfate 0.02 vol% -0.6 -2.8 compare
7H9 with hypochlorite 0.4 vol% -0.4 -2.1 compare
7H9 with hypochlorite 0.4 vol% -0.5 -2.4 compare
7H9 with nitrate 4 mM -0.3 -1.6 compare
7H9 with nitrite 1.5 mM; pH 5.5 -0.6 -2.4 compare
7H9 with nitrite 1.5 mM; pH 5.5 -0.6 -2.6 compare
7H9 with nitrite 2.5 mM -0.3 -1.1 compare
7H9 with nitrite 3 mM; pH 5.5 -0.3 -1.1 compare
7H9 with nitrite 5 mM -0.1 -0.6 compare
7H9 with Spectinomycin 0.029 mM -0.3 -1.1 compare
7H9 with Spectinomycin 0.029 mM -0.4 -1.6 compare
7H9 with Streptomycin 0.178 ug/mL -0.2 -1.0 compare
7H9 with Streptomycin 0.178 ug/mL -0.2 -0.7 compare
7H9 with Sulfamethizole 0.026 mM -0.2 -0.9 compare
7H9 with Sulfamethizole 0.026 mM -0.0 -0.0 compare
7H9 with Sulfaquinoxaline 0.097 mM -0.1 -0.8 compare
7H9 with Sutezolid 0.12 ug/mL -0.0 -0.2 compare
7H9 with Tetracycline 0.0058 mM -0.8 -3.0 compare
7H9 with Tetrazolium violet 0.065 mM -0.9 -3.4 compare
7H9 with Tetrazolium violet 0.065 mM -0.8 -2.9 compare
7H9 with Thioridazine 0.028 mM -0.7 -2.5 compare
7H9 with Vancomycin Hydrochloride from Streptomyces orientalis 0.012 mM -0.1 -0.7 compare
7H9 with Zinc Pyrithione 0.00072 mM -0.1 -0.7 compare
7H9 with Zinc Pyrithione 0.00072 mM -0.3 -1.5 compare