Pairwise Alignments

Query, 301 a.a., 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methyl glutaryl-CoA lyase from Xanthobacter sp. DMC5

Subject, 514 a.a., 2-isopropylmalate synthase from Methanococcus maripaludis S2

 Score = 74.7 bits (182), Expect = 4e-18
 Identities = 72/287 (25%), Positives = 125/287 (43%), Gaps = 20/287 (6%)

Query: 1   MARPASVRIVEVGPRDGLQNEPGIVPL-DAKVALIDALADAGLKMIEAGSFVSPKWVPQM 59
           M  P  VR+ +   RDG Q  PG+  + D K+ +   L++ G+  IEAG  VS +   + 
Sbjct: 18  MKLPEKVRVFDTTLRDGEQT-PGVSLMPDQKMDIAKNLSEIGVDAIEAGFPVSSEGEQES 76

Query: 60  ADTAEVLGAINRRAGVRYTVLAPNLKGLELALACGIEEVAVFTAASEAFTSKNINCTIAE 119
                 LG      G+   V     K +++A+ CG++ +  F A S       +  +  +
Sbjct: 77  IKNITSLGLDAEICGLARAVK----KDIDVAIDCGVDSIHTFIATSPLHREYKLKMSKEK 132

Query: 120 SLERFTPLIDLARARGVAVRGYVSCALGCPYQGEVPVAKVVEVSEALTAMGCYEVSVSDT 179
            ++     I+  +  GV V      A     + E+   K  EV +     G   ++V DT
Sbjct: 133 IIDIAVESIEYIKEHGVIVEFSAEDAT----RTELDYLK--EVYKKAVEAGADRINVPDT 186

Query: 180 IGVGTPDKAQAVTGAVAERIGLERTAIHFHDTYGQALANVLACLDIGVASVDSAVAGLGG 239
           +GV  P+    +   +   I +   ++H H+ +G A++N +A ++ G   V   V GLG 
Sbjct: 187 VGVMVPNSMSYLIKELKNDIKVP-ISVHCHNDFGIAVSNSVAAVEAGAEQVHCTVNGLG- 244

Query: 240 CPYAKGASGNLATEDLVYMLNGL-GIETGVDLDRLAAAGRAITAALG 285
                  +GN + E+ V  LN + GI T V+   L    + ++   G
Sbjct: 245 -----ERAGNASLEETVMTLNMVYGINTNVNTKMLTKLSKLVSHYTG 286