Pairwise Alignments
Query, 3949 a.a., peptide synthase from Pseudomonas simiae WCS417
Subject, 2666 a.a., Non-ribosomal peptide synthase:Amino acid adenylation from Pseudomonas syringae pv. syringae B728a
Score = 2221 bits (5756), Expect = 0.0
Identities = 1264/2643 (47%), Positives = 1650/2643 (62%), Gaps = 152/2643 (5%)
Query: 1086 FVAALATQDPDAPTAPALLPVGRDQ--PLPLSYAQERQWFLWQLEPQSAAYHIPSALRLK 1143
F+A L + D P +PV R +PLS+AQ+R FLWQL+P S AY + + LRL+
Sbjct: 24 FLARLRQEGKDFSLLP--VPVSRHDVSAIPLSFAQQRLLFLWQLDPSSDAYKMTTGLRLR 81
Query: 1144 GQLDLGALQRSFDTLLARHESLRTHLRQERDRTVQII--SPQVSLQ------IAHAEVHE 1195
G L+ AL+R+FD L+ RHE LRT + D+ Q++ V+L+ +A E+ +
Sbjct: 82 GTLNESALRRAFDHLIERHEVLRTVFHTDGDQAQQVLMHDQTVALESVDLTGLADVELRD 141
Query: 1196 AQLKARVEAEIAQPFNLEQGPLLRVSLLRIAADEHVLVLVQHHIVSDGWSMQLMVEELVQ 1255
A+L +V QPF+L GPLLR L R+A DEHVL++ HHIVSDGWSM +M++E V
Sbjct: 142 AELALQVATVTGQPFDLRTGPLLRAHLFRLAGDEHVLIVSMHHIVSDGWSMDVMIQEFVH 201
Query: 1256 LYAAYSQGQVLQWPALPIQYADYAVWQRNWMEAGEKARQLAYWRDMLGGEQSVLALPFDH 1315
Y AY +G+ P LP+QYADYA+WQR+W+EAGE ARQL YWR+ LG EQ +L D
Sbjct: 202 CYQAYCEGREAALPELPLQYADYAIWQRSWLEAGEGARQLDYWRNQLGEEQPLLDAAPDF 261
Query: 1316 PRPAVQSHRGARLAFELPGALTQGLKALAKQQDVTLFMLLLASFQTLLHRYSGQEEIRVG 1375
PRPA QS++G L F+ L++ L A A+ Q +TLFML+LA F L R +GQ +IR+G
Sbjct: 262 PRPATQSYQGEHLRFDFGVDLSRRLNAFARTQGMTLFMLVLAGFSLFLSRKAGQRDIRIG 321
Query: 1376 VPIANRNRSETERLIGFFVNTQVLKADLHGQMSVEQLLQQARQRALDAQAHQDLPFEQLV 1435
VP ANR R+ETE LIGFF+NTQVL+ + ++S LL Q R + AQAHQD+PFEQLV
Sbjct: 322 VPNANRGRAETEGLIGFFINTQVLRCQVDERLSYLDLLAQIRDTSFGAQAHQDVPFEQLV 381
Query: 1436 EALQPERSLSHNPLFQVMFNHQTDVGQAQVQQQLPNLSVEGLEWESKTAHFDLDLDIQES 1495
+ L PERSL HNPLFQ FN Q V + + +L L V ++ + AHFDL LDI +
Sbjct: 382 DQLAPERSLGHNPLFQAKFN-QNVVLKQKTALRLAGLEVSEYAFDKQGAHFDLALDITDD 440
Query: 1496 TEGIWATLGYAQDLFEASTVQRMARHWQNLLQGMVADPRQTLSQLNLLDNTERQQ----- 1550
I + YA DL+ +TV+ L + ++ P+ L L L R++
Sbjct: 441 GTLIHGDMAYASDLYRRTTVEGFIPELLALFETLLDAPQAPLFSLGALAIEPRREAREPA 500
Query: 1551 --ILQRWDQSDAGFSAKRLVHELVADRAGETPEAVAVKFGEQQLTYGELDRQANRLAHAL 1608
+LQ WD+ + P A A + E+ LT +L++ AN+LAH L
Sbjct: 501 PHMLQLWDR-----------------QVERQPHAQAARSLERTLTTLQLEQAANQLAHHL 543
Query: 1609 IARGVGPEVRVAIAMPRSAEIMVAFLAVMKAGGVYVPLDIEYPRDRLLYMMQDSRARLLL 1668
I G+ VA+ M RS + + A LA+ KAGGVY+PLD++ P RL M+ +++AR+LL
Sbjct: 544 IRMGISEGQPVAVLMERSLDWLTAVLAIFKAGGVYMPLDVKAPDARLQQMLINAQARVLL 603
Query: 1669 -THSTVQQRLPIPDGLEALAVDQTQAWSANDDSAPEVVLDGDNLAYVIYTSGSTGMPKGV 1727
V+Q G + L W S P+ D+ AYVI+TSGSTG PKGV
Sbjct: 604 CAEGDVRQTSLGVAGCQGLTWTPA-LWQDLPVSRPDTRPSADSAAYVIHTSGSTGQPKGV 662
Query: 1728 AVSHGPLVAHIIATGERYETSPADCELHFMSFAFDGSHEGWMHPLINGASVLIRDDSLWL 1787
VS G L +++ E+ +P + A D H L +G ++ + ++L
Sbjct: 663 LVSQGALASYLRGLLEQLHLAPEASMALVSTIAADLGHTVLFGALCSGRTLHVLTEALGF 722
Query: 1788 -PEYTYQQMHRHHVTMAVFPPVYLQQLAEHAERDGNPPKVRVYCFGGDAVAQASYDLAWR 1846
P+ M H V + P +L L + + P+ GG+A + A + R
Sbjct: 723 DPDAFAAYMAEHQVGVLKIVPGHLAALLQAGQPADVLPQ-HALIVGGEACSPALVE-QLR 780
Query: 1847 ALKP-TYLFNGYGPTETVVTPLLWKA-----------RKGDPCGAVYA------------ 1882
LKP + N YGP+ET V L ++ +PCG+ A
Sbjct: 781 QLKPGCRVINHYGPSETTVGVLTYEVPASSCLDQKLKADSNPCGSELARESDSPAFPSRK 840
Query: 1883 ------------------------------------PIGTLLGNRSGYVLDAQLNLQPIG 1906
P+GT L S YVLD LN
Sbjct: 841 NVQTSSRASEASPSSLPQLPCFPQSTAHSGDPLRSVPVGTPLPGASAYVLDDVLNPVGTQ 900
Query: 1907 VAGELYLGGEGVARGYLERPALTAERFVPDPFGKPGSRVYRSGDLTRGRPDGGVDYLGRV 1966
VAGELY+GG+ VA GY+ +PALTAERFVPDPF + G+RVYRSGD R G ++++GR
Sbjct: 901 VAGELYIGGDSVALGYIGQPALTAERFVPDPFAQDGTRVYRSGDRMRRNHQGLLEFIGRA 960
Query: 1967 DHQVKIRGFRIELGEIEARLREQDSVGETVVVA---QEGPSGKQLVAYVVPLDPLLIDDA 2023
D QVK+RG+R+E E+ L SV + V+A + + QLVAY V A
Sbjct: 961 DDQVKVRGYRVEPAEVARVLLGLASVAQVSVLALPIDDDQARLQLVAYCVA--------A 1012
Query: 2024 VAQSTCREALRRALKARLPDYMVPTHLMFLERMPLTPNGKLDRKGLPRPDVSQMQQVYVA 2083
++LR L A LPDYMVP +M L+ +PLT NGKLD++ LP+P V ++Q Y A
Sbjct: 1013 GGADLSIDSLREQLTACLPDYMVPAQIMLLDSLPLTANGKLDKRALPKPGV--VKQRYTA 1070
Query: 2084 PQSELEQKIAAIWSDVLRLPRVGLHDNFFELGGDSIISIQVVSRARQAGVRFTPKDLFQH 2143
P E+E+K+AA+W+DVL+L +VG DNFFELGGDSI+S+Q+++RA++ G++ +PK LF+
Sbjct: 1071 PVGEIEEKLAAVWADVLKLEQVGSTDNFFELGGDSILSLQIIARAKRQGIKLSPKQLFEK 1130
Query: 2144 QTVQSLAAVAREGEGAVVLDQSALTGDLLLLPVQQAFFADDIPRRHHWNQSVVLQPHQAL 2203
QT+ LA+VA+ + V ++G L LLP+Q FF DIP R HWNQ+++L+P Q L
Sbjct: 1131 QTIGQLASVAKLIQKKPVAVAEQISGSLPLLPIQARFFELDIPERQHWNQALMLKPLQTL 1190
Query: 2204 QAPLLVAALQALIVHHDALRIGFVQGAAGWSAAYRGPQQHQAEQVLWQTTLNAVEELEAL 2263
+A L +AL AL+ HDALR+GF Q W A + P ++LW L+++E L L
Sbjct: 1191 EAAHLQSALTALVEQHDALRLGFTQQNGQWQATFGAP---NTCELLWTHELDSIERLPEL 1247
Query: 2264 GEEAQRSLDLSEGPLLRAVLVDLADGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQVAQ 2323
+EAQRSLDL GPLLRAVL+ L G QRLLLVIHHL+VDGVSWR+LLEDLQ AY +AQ
Sbjct: 1248 ADEAQRSLDLKNGPLLRAVLIHLPQGEQRLLLVIHHLLVDGVSWRVLLEDLQQAYLALAQ 1307
Query: 2324 GAKVVLPAKTSAIRAWAERLQAYARSAALAQELAWWQTQLQGSPTGLPGADPQASLSNRH 2383
G V L AKT++++ WAE+LQ YA L E +W LQG+ LP P+ ++ NR
Sbjct: 1308 GQPVALAAKTTSLQRWAEQLQQYATGQTLKAERDYWLQALQGADQPLPRDKPEGTMRNRD 1367
Query: 2384 ALSVTTHLDQVFTRRLLQDAPSAYRTQINDLLLTALARVVVRWTGDASMLIRLEGHGRED 2443
A ++ L + T +LL+ AP+AYRT +NDLLLTALA+V+ W+ S+LI+LEGHGRED
Sbjct: 1368 AAHASSWLSRDLTHKLLKVAPAAYRTHVNDLLLTALAQVLCEWSQQPSVLIQLEGHGRED 1427
Query: 2444 LFDEIDLTRTVGWFTSLYPVKLVPTDSLAGSLKQIKEQLRAIPDKGLGFGALRYLGNAEA 2503
LFDE DL+RTVGWF+SL+PV+L P + SL IKEQLRA+PDKG+G+G LRY+G A
Sbjct: 1428 LFDETDLSRTVGWFSSLFPVRLTPQIAPGASLSGIKEQLRAVPDKGIGYGVLRYMGEASF 1487
Query: 2504 QQALSELPRPRITFNYLGQFDGSFDGGEQEGLFVPSGDGSGAEQSGEAPLGNWLEINGQV 2563
Q L+ LP+ R+TFNYLGQFDGSF Q LFVPS D SG + PLGNWL +NGQV
Sbjct: 1488 AQQLAALPQARVTFNYLGQFDGSF-SEHQGALFVPSADSSGTALCEDGPLGNWLSLNGQV 1546
Query: 2564 YAGELKLNWSFSQQMFDEATVQRLADDYAAELKALIEHCGV-NQGVTPSDFPLARLSQAQ 2622
+ G+L+L+WSFS++++ +T+ LA Y L LIEHC +QGVTPSDFPLARL+QAQ
Sbjct: 1547 FDGQLQLDWSFSREVYHASTIDTLARRYEQALTTLIEHCTAGHQGVTPSDFPLARLTQAQ 1606
Query: 2623 LDSLPVTVADIEDVYPLSPMQQGMLFQSLYGEGSGDYINQMRIDVEGLDVPRFRQAWQAA 2682
LD LP+ I+D+YPLSPMQQGMLF SL+ EG+G+YINQ+R+++ GLDVPRFR AWQAA
Sbjct: 1607 LDGLPIAAGQIDDIYPLSPMQQGMLFHSLFDEGAGNYINQLRVNIHGLDVPRFRSAWQAA 1666
Query: 2683 VDSHEILRSGFLWQTEFEQPLQVVYKQMRMPFAELDWQGRPDSSAALDSLAESARAQGFV 2742
VD H++LRS F+ Q EQ LQVV +Q+ +PF ELD +G+P+S LD A++ R QGF
Sbjct: 1667 VDHHDVLRSCFVSQR--EQSLQVVQRQVTLPFVELDARGQPES--WLDDWAQADRQQGFD 1722
Query: 2743 LEQAPLLSLTVVRTGASRYHLIYTNHHILMDGWSGSQLFGEVLQHYAGEPLRAPIGRYRD 2802
L Q PLL L V+RT +HL+YT+HHILMDGWS S+L GEVLQ Y+G+ GRYRD
Sbjct: 1723 LAQGPLLRLAVLRTADDAWHLVYTSHHILMDGWSSSRLLGEVLQRYSGQMPAKQAGRYRD 1782
Query: 2803 YIAWLQAQDKSVSEAFWKAQLLNLQEPTRLARGLQAAQSEALAVN-GEHRLNLDASQTAQ 2861
YI WLQ QD ++SE FW AQL L EPTRL LQA +S A G++ +DA T +
Sbjct: 1783 YIQWLQHQDAALSERFWTAQLAELDEPTRL---LQAFKSSAQGGGYGDYIQLIDADGTRR 1839
Query: 2862 LKAFAQRHKVTLNTLVQSAWLLLLQHHTGQATVAFGATVAGRPAQLRGIEQQVGLFINTL 2921
L AFA+ +VTLNTL+QSAWLLLLQ +TGQ++V FGATVAGRPA+L G+E+Q+GLFINTL
Sbjct: 1840 LNAFAREQRVTLNTLLQSAWLLLLQRYTGQSSVTFGATVAGRPAELPGVEEQLGLFINTL 1899
Query: 2922 PVVATPDAQMTVSQWLQQIQAQNVRLREQEHTPLFEIQRWAGLGGEALFDSILVFENYPV 2981
PV+A+P A+ TV+ W+QQ+QA+N+ LRE EHTPL++IQRWA GEALFD+ILVFENYPV
Sbjct: 1900 PVIASPRAEQTVADWVQQVQAKNLALREHEHTPLYDIQRWARNSGEALFDNILVFENYPV 1959
Query: 2982 SEALEQGAPSGLTFGAVHSLEQTHYPLTVLLGIGDTLGMEFNYDRHAFSAAHIEQLAEHF 3041
SEAL Q AP GL F + + EQ HYPLT+++ + L + F+YDR FSA I QLA HF
Sbjct: 1960 SEAL-QRAPDGLVFSDLRNQEQAHYPLTLVVEATEVLSVRFSYDRQHFSAEGILQLAAHF 2018
Query: 3042 QQLLQALAVDGAQRLATLPSLASTERETVLHAWNATAADYPLHLAVHQLIEAQVVRTPDA 3101
LLQ+L L L + AW + YP HQ IEAQ R P A
Sbjct: 2019 DHLLQSLCASATTPLGEL---------ALPTAWTQSVQRYPSEHCAHQRIEAQAERNPQA 2069
Query: 3102 PALVFAGQVLSYAALNRRANRLAHRLIAAGVGPDVLVGLAVERSIEMVVGLLAVLKAGGA 3161
AL F + LSY LN+RAN+LAH+L GVGPDV VGLA ER +EM+VGLLA+LKAGGA
Sbjct: 2070 IALSFGDEQLSYRQLNQRANQLAHKLREQGVGPDVRVGLAAERGLEMIVGLLAILKAGGA 2129
Query: 3162 YVPLDPEYPRDRLAYMLQDSDVKLLLTQAHLLEQLPIPTGLHSLVLEQGDEWLQAYAEQN 3221
YVPLDP+YP+DRL++++ DS ++LLLTQA LL +LPIP + +L+ DE L Y+ +
Sbjct: 2130 YVPLDPDYPQDRLSFLMHDSGIELLLTQASLLGKLPIPEQVQ--MLDLADE-LDDYSTAD 2186
Query: 3222 PLVTVDGENLAYVIYTSGSTGQPKGAGNRHSALTNRLCWMQHAYGLEGSDTVLQKTPFSF 3281
P+ +NLAYVIYTSGSTG+PKG H L + D F+F
Sbjct: 2187 PINQTAPDNLAYVIYTSGSTGKPKGTLLAHHNLMRLFAATDEWFEFSEKDVWTLFHSFAF 2246
Query: 3282 DVSVWEFFWPLMTGARLVVAAPGDHRDPARLVSLINAEHVTTLHFVPSMLQAFLQDAGVG 3341
D SVWE F L+ G RLV+ R P +L+ + VT L+ PS + + A
Sbjct: 2247 DFSVWEIFGALLHGGRLVIVPREVTRSPEDFHALLVEQQVTVLNQTPSAFKQLMHVACDS 2306
Query: 3342 AC-HSLQRIVCSGEALPVDAQQQVFAKLPHAG--LYNLYGPTEAAIDVTH--WTCVDEGR 3396
+ SLQ ++ GEAL V + + FA+ L N+YG TE + V++ T D
Sbjct: 2307 SLPMSLQTVIFGGEALDVASLKPWFARFGDQSPQLINMYGITETTVHVSYRPITLADTQN 2366
Query: 3397 DAVPIGRPIANLGCYVLDGNLEPAPVGVLGELYLGGVGLARGYHRRPALTAERFVTDPFG 3456
A PIG I +L YVLD + P G GEL++G GLARGYH R ALTAERFV DPF
Sbjct: 2367 PASPIGEAIPDLSWYVLDADFNPVAQGCSGELHIGHAGLARGYHNRAALTAERFVPDPFS 2426
Query: 3457 S-GSRLYRTGDLARYRDDGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHACVREAAVLA 3515
+ G RLYRTGDLARYR GVI+YAGRIDHQVK+RG RIELGEIEARL H VRE +VLA
Sbjct: 2427 NEGGRLYRTGDLARYRATGVIDYAGRIDHQVKIRGFRIELGEIEARLQAHPAVREVSVLA 2486
Query: 3516 VDGTHLVGYLVLQAPSED---WKAQVAMHLAAQLPDYMVPAQWVVLTQMPLSPNGKLDRK 3572
+DG L YLV P +D + + L A LPDYMVP ++VL MPL+ NGKLDRK
Sbjct: 2487 LDG-QLAAYLVPAEPDQDQPTLREMLKNELRAHLPDYMVPTHFIVLDSMPLTANGKLDRK 2545
Query: 3573 ALPKPEA-QGAGAYQAPQSAIEQQVAAIWRDVLGVERVGLNDNFFELGGHSLLVLMLKER 3631
ALP P+A Q Y APQ +EQQ+AAIW D+L VERVG NDNFFELGGHSLL + + R
Sbjct: 2546 ALPAPDASQLQATYSAPQGELEQQLAAIWADLLQVERVGRNDNFFELGGHSLLAVQMLVR 2605
Query: 3632 IRK 3634
+R+
Sbjct: 2606 VRE 2608
Score = 766 bits (1978), Expect = 0.0
Identities = 542/1474 (36%), Positives = 770/1474 (52%), Gaps = 130/1474 (8%)
Query: 9 LVSRFLRLPLEQRQQFYQRLQSRGMSFAQLPIASIREDGQMLPLSYAQERQWFLWQLDPD 68
+ RF+ L LEQRQQF RL+ G F+ LP+ R D +PLS+AQ+R FLWQLDP
Sbjct: 9 IAKRFVGLSLEQRQQFLARLRQEGKDFSLLPVPVSRHDVSAIPLSFAQQRLLFLWQLDPS 68
Query: 69 SATYHIPGALRLQGRLDLAALQRAFDSLLARHESLRTRLVQDGERLLQNVAPEARIEIRQ 128
S Y + LRL+G L+ +AL+RAFD L+ RHE LRT DG++ Q + + + +
Sbjct: 69 SDAYKMTTGLRLRGTLNESALRRAFDHLIERHEVLRTVFHTDGDQAQQVLMHDQTVALES 128
Query: 129 ----DVAD----EQQLLARVEAEIARPFDLQAGPLLRVSLLQLAEDEHVLVMVQHHIISD 180
+AD + +L +V +PFDL+ GPLLR L +LA DEHVL++ HHI+SD
Sbjct: 129 VDLTGLADVELRDAELALQVATVTGQPFDLRTGPLLRAHLFRLAGDEHVLIVSMHHIVSD 188
Query: 181 GWSMQVMVEELVQFYAAHSQGREVQLPGLPIHYADYALWQRSWMEAGEKARQLAYWQDLL 240
GWSM VM++E V Y A+ +GRE LP LP+ YADYA+WQRSW+EAGE ARQL YW++ L
Sbjct: 189 GWSMDVMIQEFVHCYQAYCEGREAALPELPLQYADYAIWQRSWLEAGEGARQLDYWRNQL 248
Query: 241 GGEQPVLELPLDHPRPAQQSHCGASLQVHLPADLVAGIKRLAQQEGVTPFMLLLASFQTL 300
G EQP+L+ D PRPA QS+ G L+ DL + A+ +G+T FML+LA F
Sbjct: 249 GEEQPLLDAAPDFPRPATQSYQGEHLRFDFGVDLSRRLNAFARTQGMTLFMLVLAGFSLF 308
Query: 301 LFRYSGQSDIRIGVPNANRNRVETERLIGFFVNTQVLKADLDGQMSFAELLQQAKRRSLE 360
L R +GQ DIRIGVPNANR R ETE LIGFF+NTQVL+ +D ++S+ +LL Q + S
Sbjct: 309 LSRKAGQRDIRIGVPNANRGRAETEGLIGFFINTQVLRCQVDERLSYLDLLAQIRDTSFG 368
Query: 361 AQAHQDLPFEQLVVALQPERSLSHNPLFQVMFNHQTDAQGGRDGQQLPGLRVAQLDWENQ 420
AQAHQD+PFEQLV L PERSL HNPLFQ FN Q + +L GL V++ ++ Q
Sbjct: 369 AQAHQDVPFEQLVDQLAPERSLGHNPLFQAKFN-QNVVLKQKTALRLAGLEVSEYAFDKQ 427
Query: 421 TTHFDLSLDTHESAEGLWAALTYATDLFESATIERLAQHWQNLLQAAVSAPRSRLCVLSM 480
HFDL+LD + + + YA+DL+ T+E L + + AP++ L L
Sbjct: 428 GAHFDLALDITDDGTLIHGDMAYASDLYRRTTVEGFIPELLALFETLLDAPQAPLFSLGA 487
Query: 481 LDAPEQQRMLKDWNAPATVAAPHAVHQLFEAQAREHPARQALALDDQTLSYGELNRQANR 540
L A E +R ++ APH + QL++ Q P QA ++TL+ +L + AN+
Sbjct: 488 L-AIEPRREARE-------PAPHML-QLWDRQVERQPHAQAARSLERTLTTLQLEQAANQ 538
Query: 541 LAHYLIAQGVGPEVLVGIAVERSFAMVVSLLAVLKAGGAYVPLDPEYPRERLVHMLDDSG 600
LAH+LI G+ V + +ERS + ++LA+ KAGG Y+PLD + P RL ML ++
Sbjct: 539 LAHHLIRMGISEGQPVAVLMERSLDWLTAVLAIFKAGGVYMPLDVKAPDARLQQMLINAQ 598
Query: 601 VRLVL-TQSHLRDRLPLPADLTALDIDLADAQLAQCAEHNPPTAFEPRSLAYVIYTSGST 659
R++L + +R A L A P T S AYVI+TSGST
Sbjct: 599 ARVLLCAEGDVRQTSLGVAGCQGL--TWTPALWQDLPVSRPDTRPSADSAAYVIHTSGST 656
Query: 660 GKPKGVAISHAALSEFAGIAAEYSRLVADDRVLQFATLNFDGFVEQLYPALTLGATV-VL 718
G+PKGV +S AL+ + E L + + +T+ D L+ AL G T+ VL
Sbjct: 657 GQPKGVLVSQGALASYLRGLLEQLHLAPEASMALVSTIAADLGHTVLFGALCSGRTLHVL 716
Query: 719 RGPQLWDGADLYRQIIDQGITLADLPTAYWKLFLQDCLAAGPRPYGALRQVHIGGEAMPL 778
+D + + + + + + LQ A P AL +GGEA
Sbjct: 717 TEALGFDPDAFAAYMAEHQVGVLKIVPGHLAALLQAGQPADVLPQHAL---IVGGEACSP 773
Query: 779 DGPVLWRRAGLGHVRLLNTYGPTEATV--------VSSVLD---------CSDD------ 815
R+ G R++N YGP+E TV SS LD C +
Sbjct: 774 ALVEQLRQLKPG-CRVINHYGPSETTVGVLTYEVPASSCLDQKLKADSNPCGSELARESD 832
Query: 816 --------NAVMGATAS---------------------------PIGRALPGRGLYVLDP 840
N + AS P+G LPG YVLD
Sbjct: 833 SPAFPSRKNVQTSSRASEASPSSLPQLPCFPQSTAHSGDPLRSVPVGTPLPGASAYVLDD 892
Query: 841 DLNLLPVGAVGELYIASAGGLARDYLQRPSLTAERFVADPFSTLGERLYRTGDLARYRAD 900
LN + GELYI +A Y+ +P+LTAERFV DPF+ G R+YR+GD R
Sbjct: 893 VLNPVGTQVAGELYI-GGDSVALGYIGQPALTAERFVPDPFAQDGTRVYRSGDRMRRNHQ 951
Query: 901 GVIEYVGRVDHQVKIRGFRIELGEIEALLLAQEAVREAFLLA-------ADNQLVAYLVP 953
G++E++GR D QVK+RG+R+E E+ +LL +V + +LA A QLVAY V
Sbjct: 952 GLLEFIGRADDQVKVRGYRVEPAEVARVLLGLASVAQVSVLALPIDDDQARLQLVAYCV- 1010
Query: 954 AQPLSAAEQAAAGETLKA-TLREQ----LPDYMVPAHLIFLDRMPLNPNGKLDRQALPKP 1008
AA G L +LREQ LPDYMVPA ++ LD +PL NGKLD++ALPKP
Sbjct: 1011 ---------AAGGADLSIDSLREQLTACLPDYMVPAQIMLLDSLPLTANGKLDKRALPKP 1061
Query: 1009 DGSAVQQAWQAPVTPRQQQVAAIWADILGVERVGLTHHFFELGGHSLLAMQVVSRI-RQA 1067
V+Q + APV ++++AA+WAD+L +E+VG T +FFELGG S+L++Q+++R RQ
Sbjct: 1062 --GVVKQRYTAPVGEIEEKLAAVWADVLKLEQVGSTDNFFELGGDSILSLQIIARAKRQG 1119
Query: 1068 LKLEVPLKLLFEQPRLEGFVAALATQDPDAPTAPALLPVGRDQPLPLSYAQERQWFLWQL 1127
+KL K LFE+ + G +A++A P A A G LPL Q R + L
Sbjct: 1120 IKLSP--KQLFEKQTI-GQLASVAKLIQKKPVAVAEQISG---SLPLLPIQARFFELDIP 1173
Query: 1128 EPQSAAYHIPSALRLK--GQLDLGALQRSFDTLLARHESLRTHLRQERDR-TVQIISPQV 1184
E Q H AL LK L+ LQ + L+ +H++LR Q+ + +P
Sbjct: 1174 ERQ----HWNQALMLKPLQTLEAAHLQSALTALVEQHDALRLGFTQQNGQWQATFGAPNT 1229
Query: 1185 SLQIAHAEVHEAQLKARVEAEIAQPFNLEQGPLLRVSLLRIAADEHVLVLVQHHIVSDGW 1244
+ E+ + + E + +L+ GPLLR L+ + E L+LV HH++ DG
Sbjct: 1230 CELLWTHELDSIERLPELADEAQRSLDLKNGPLLRAVLIHLPQGEQRLLLVIHHLLVDGV 1289
Query: 1245 SMQLMVEELVQLYAAYSQGQVLQWPALPIQYADYAVWQRNWMEAGEKARQLAYWRDMLGG 1304
S ++++E+L Q Y A +QGQ + A +A + + + YW L G
Sbjct: 1290 SWRVLLEDLQQAYLALAQGQPVALAAKTTSLQRWAEQLQQYATGQTLKAERDYWLQALQG 1349
Query: 1305 EQSVLALPFDHPRPAVQSHRGARLAFELPGALTQGLKALAKQQDVT-LFMLLLASFQTLL 1363
LP D P +++ A + L LT L +A T + LLL + +L
Sbjct: 1350 ADQ--PLPRDKPEGTMRNRDAAHASSWLSRDLTHKLLKVAPAAYRTHVNDLLLTALAQVL 1407
Query: 1364 HRYSGQEEIRVGVPIANR----NRSETERLIGFF 1393
+S Q + + + R + ++ R +G+F
Sbjct: 1408 CEWSQQPSVLIQLEGHGREDLFDETDLSRTVGWF 1441
Score = 606 bits (1563), Expect = e-176
Identities = 420/1077 (38%), Positives = 582/1077 (54%), Gaps = 58/1077 (5%)
Query: 38 LPIASIREDGQMLPLSYAQERQWFLWQLDPDSATYHIPGALRLQGRLDLAALQRAFDSLL 97
LPIA+ + D + PLS Q+ F D + Y + + G LD+ + A+ + +
Sbjct: 1610 LPIAAGQID-DIYPLSPMQQGMLFHSLFDEGAGNYINQLRVNIHG-LDVPRFRSAWQAAV 1667
Query: 98 ARHESLRTRLVQDGERLLQNVAPEAR---IEIRQDVADEQQLLARVEAEIARPFDLQAGP 154
H+ LR+ V E+ LQ V + +E+ E L +A+ + FDL GP
Sbjct: 1668 DHHDVLRSCFVSQREQSLQVVQRQVTLPFVELDARGQPESWLDDWAQADRQQGFDLAQGP 1727
Query: 155 LLRVSLLQLAEDEHVLVMVQHHIISDGWSMQVMVEELVQFYAAHSQGREVQLPGLPIHYA 214
LLR+++L+ A+D LV HHI+ DGWS ++ E++Q Y+ ++ Y
Sbjct: 1728 LLRLAVLRTADDAWHLVYTSHHILMDGWSSSRLLGEVLQRYSGQMPAKQAG------RYR 1781
Query: 215 DYALWQRSWMEAGEKARQLAYWQDLLGGEQPVLELPLDHPRPAQQSHCGASLQVHLPADL 274
DY W++ + A +W L L AQ G +Q+ + AD
Sbjct: 1782 DYI----QWLQHQDAALSERFWTAQLAELDEPTRLLQAFKSSAQGGGYGDYIQL-IDADG 1836
Query: 275 VAGIKRLAQQEGVTPFMLLLASFQTLLFRYSGQSDIRIGVPNANR--NRVETERLIGFFV 332
+ A+++ VT LL +++ LL RY+GQS + G A R E +G F+
Sbjct: 1837 TRRLNAFAREQRVTLNTLLQSAWLLLLQRYTGQSSVTFGATVAGRPAELPGVEEQLGLFI 1896
Query: 333 NTQVLKADLDGQMSFAELLQQAKRRSLEAQAHQDLPFEQLVV-ALQPERSLSHNPLFQVM 391
NT + A + + A+ +QQ + ++L + H+ P + A +L N L
Sbjct: 1897 NTLPVIASPRAEQTVADWVQQVQAKNLALREHEHTPLYDIQRWARNSGEALFDNILVFEN 1956
Query: 392 FNHQTDAQGGRDGQQLPGLRVAQLDWENQTTHFDLSLDTHESAEGLWAALTYATDLFESA 451
+ Q DG LR + H+ L+L E+ E L +Y F +
Sbjct: 1957 YPVSEALQRAPDGLVFSDLR------NQEQAHYPLTLVV-EATEVLSVRFSYDRQHFSAE 2009
Query: 452 TIERLAQHWQNLLQAAVSAPRSRLCVLSMLDAPEQQRMLKDWNAPATVAAPHAVHQLFEA 511
I +LA H+ +LLQ+ ++ + L L++ A Q + + H HQ EA
Sbjct: 2010 GILQLAAHFDHLLQSLCASATTPLGELALPTAWTQ--------SVQRYPSEHCAHQRIEA 2061
Query: 512 QAREHPARQALALDDQTLSYGELNRQANRLAHYLIAQGVGPEVLVGIAVERSFAMVVSLL 571
QA +P AL+ D+ LSY +LN++AN+LAH L QGVGP+V VG+A ER M+V LL
Sbjct: 2062 QAERNPQAIALSFGDEQLSYRQLNQRANQLAHKLREQGVGPDVRVGLAAERGLEMIVGLL 2121
Query: 572 AVLKAGGAYVPLDPEYPRERLVHMLDDSGVRLVLTQSHLRDRLPLPADLTALDIDLADAQ 631
A+LKAGGAYVPLDP+YP++RL ++ DSG+ L+LTQ+ L +LP+P + LD LAD +
Sbjct: 2122 AILKAGGAYVPLDPDYPQDRLSFLMHDSGIELLLTQASLLGKLPIPEQVQMLD--LAD-E 2178
Query: 632 LAQCAEHNPPTAFEPRSLAYVIYTSGSTGKPKGVAISHAALSEFAGIAAEYSRLVADDRV 691
L + +P P +LAYVIYTSGSTGKPKG ++H L E+ D
Sbjct: 2179 LDDYSTADPINQTAPDNLAYVIYTSGSTGKPKGTLLAHHNLMRLFAATDEWFEFSEKDVW 2238
Query: 692 LQFATLNFDGFVEQLYPALTLGATVVL------RGPQLWDGADLYRQIIDQGIT-LADLP 744
F + FD V +++ AL G +V+ R P+ D + +++Q +T L P
Sbjct: 2239 TLFHSFAFDFSVWEIFGALLHGGRLVIVPREVTRSPE-----DFHALLVEQQVTVLNQTP 2293
Query: 745 TAYWKLFLQDCLAAGPRPYGALRQVHIGGEAMPLDGPVLW-RRAGLGHVRLLNTYGPTEA 803
+A+ +L C ++ P +L+ V GGEA+ + W R G +L+N YG TE
Sbjct: 2294 SAFKQLMHVACDSSLPM---SLQTVIFGGEALDVASLKPWFARFGDQSPQLINMYGITET 2350
Query: 804 TVVSSVLDCSDDNAVMGATASPIGRALPGRGLYVLDPDLNLLPVGAVGELYIASAGGLAR 863
TV S + A ASPIG A+P YVLD D N + G GEL+I AG LAR
Sbjct: 2351 TVHVSYRPIT--LADTQNPASPIGEAIPDLSWYVLDADFNPVAQGCSGELHIGHAG-LAR 2407
Query: 864 DYLQRPSLTAERFVADPFSTLGERLYRTGDLARYRADGVIEYVGRVDHQVKIRGFRIELG 923
Y R +LTAERFV DPFS G RLYRTGDLARYRA GVI+Y GR+DHQVKIRGFRIELG
Sbjct: 2408 GYHNRAALTAERFVPDPFSNEGGRLYRTGDLARYRATGVIDYAGRIDHQVKIRGFRIELG 2467
Query: 924 EIEALLLAQEAVREAFLLAADNQLVAYLVPAQPLSAAEQAAAGETLKATLREQLPDYMVP 983
EIEA L A AVRE +LA D QL AYLVPA+P +Q E LK LR LPDYMVP
Sbjct: 2468 EIEARLQAHPAVREVSVLALDGQLAAYLVPAEP--DQDQPTLREMLKNELRAHLPDYMVP 2525
Query: 984 AHLIFLDRMPLNPNGKLDRQALPKPDGSAVQQAWQAPVTPRQQQVAAIWADILGVERVGL 1043
H I LD MPL NGKLDR+ALP PD S +Q + AP +QQ+AAIWAD+L VERVG
Sbjct: 2526 THFIVLDSMPLTANGKLDRKALPAPDASQLQATYSAPQGELEQQLAAIWADLLQVERVGR 2585
Query: 1044 THHFFELGGHSLLAMQVVSRIRQALKLEVPLKLLFEQPRLEGFVAALATQDPDAPTA 1100
+FFELGGHSLLA+Q++ R+R+ L+ EV LK +FEQP L F A L ++ ++ A
Sbjct: 2586 NDNFFELGGHSLLAVQMLVRVREQLQHEVSLKDVFEQPLLADFCATLQEKNGESDHA 2642
Score = 583 bits (1502), Expect = e-169
Identities = 397/1086 (36%), Positives = 576/1086 (53%), Gaps = 76/1086 (6%)
Query: 1109 DQPLPLSYAQERQWFLWQLEPQSAAYHIPSALRLKGQLDLGALQRSFDTLLARHESLRTH 1168
D PLS Q+ F + + Y + + G LD+ + ++ + H+ LR+
Sbjct: 1618 DDIYPLSPMQQGMLFHSLFDEGAGNYINQLRVNIHG-LDVPRFRSAWQAAVDHHDVLRSC 1676
Query: 1169 LRQERDRTVQIISPQVSLQIAHAEVH---EAQLKARVEAEIAQPFNLEQGPLLRVSLLRI 1225
+R++++Q++ QV+L + E+ L +A+ Q F+L QGPLLR+++LR
Sbjct: 1677 FVSQREQSLQVVQRQVTLPFVELDARGQPESWLDDWAQADRQQGFDLAQGPLLRLAVLRT 1736
Query: 1226 AADEHVLVLVQHHIVSDGWSMQLMVEELVQLYAAYSQGQVLQWPALPI-QYADYAVWQRN 1284
A D LV HHI+ DGWS ++ E++Q Y+ Q PA +Y DY
Sbjct: 1737 ADDAWHLVYTSHHILMDGWSSSRLLGEVLQRYSG-------QMPAKQAGRYRDYI----Q 1785
Query: 1285 WMEAGEKARQLAYWRDMLGGEQSVLALPFDHPRPAVQSHRGARLAFELPGAL-------T 1337
W++ + A +W L D P +Q+ + + + T
Sbjct: 1786 WLQHQDAALSERFWTAQLA--------ELDEPTRLLQAFKSSAQGGGYGDYIQLIDADGT 1837
Query: 1338 QGLKALAKQQDVTLFMLLLASFQTLLHRYSGQEEIRVGVPIANRNRS--ETERLIGFFVN 1395
+ L A A++Q VTL LL +++ LL RY+GQ + G +A R E +G F+N
Sbjct: 1838 RRLNAFAREQRVTLNTLLQSAWLLLLQRYTGQSSVTFGATVAGRPAELPGVEEQLGLFIN 1897
Query: 1396 TQVLKADLHGQMSVEQLLQQARQRALDAQAHQDLPFEQLVE-ALQPERSLSHNPLFQVMF 1454
T + A + +V +QQ + + L + H+ P + A +L N L V
Sbjct: 1898 TLPVIASPRAEQTVADWVQQVQAKNLALREHEHTPLYDIQRWARNSGEALFDNIL--VFE 1955
Query: 1455 NHQTDVGQAQVQQQLPNLSVEGLEWESKTAHFDLDLDIQESTEGIWATLGYAQDLFEAST 1514
N+ ++ Q+ P+ V + AH+ L L + E+TE + Y + F A
Sbjct: 1956 NYPV----SEALQRAPDGLVFSDLRNQEQAHYPLTL-VVEATEVLSVRFSYDRQHFSAEG 2010
Query: 1515 VQRMARHWQNLLQGMVADPRQTLSQLNLLDNTERQQILQRWDQSDAGFSAKRLVHELVAD 1574
+ ++A H+ +LLQ + A L +L L W QS + ++ H+ +
Sbjct: 2011 ILQLAAHFDHLLQSLCASATTPLGELALPT---------AWTQSVQRYPSEHCAHQRIEA 2061
Query: 1575 RAGETPEAVAVKFGEQQLTYGELDRQANRLAHALIARGVGPEVRVAIAMPRSAEIMVAFL 1634
+A P+A+A+ FG++QL+Y +L+++AN+LAH L +GVGP+VRV +A R E++V L
Sbjct: 2062 QAERNPQAIALSFGDEQLSYRQLNQRANQLAHKLREQGVGPDVRVGLAAERGLEMIVGLL 2121
Query: 1635 AVMKAGGVYVPLDIEYPRDRLLYMMQDSRARLLLTHSTVQQRLPIPDGLEAL-AVDQTQA 1693
A++KAGG YVPLD +YP+DRL ++M DS LLLT +++ +LPIP+ ++ L D+
Sbjct: 2122 AILKAGGAYVPLDPDYPQDRLSFLMHDSGIELLLTQASLLGKLPIPEQVQMLDLADELDD 2181
Query: 1694 WSAND---DSAPEVVLDGDNLAYVIYTSGSTGMPKGVAVSHGPLVAHIIATGERYETSPA 1750
+S D +AP DNLAYVIYTSGSTG PKG ++H L+ AT E +E S
Sbjct: 2182 YSTADPINQTAP------DNLAYVIYTSGSTGKPKGTLLAHHNLMRLFAATDEWFEFSEK 2235
Query: 1751 DCELHFMSFAFDGSHEGWMHPLINGAS-VLIRDDSLWLPEYTYQQMHRHHVTMAVFPPVY 1809
D F SFAFD S L++G V++ + PE + + VT+ P
Sbjct: 2236 DVWTLFHSFAFDFSVWEIFGALLHGGRLVIVPREVTRSPEDFHALLVEQQVTVLNQTPSA 2295
Query: 1810 LQQLAEHAERDGNPPKVRVYCFGGDAVAQASYDLAWRAL---KPTYLFNGYGPTETVVTP 1866
+QL A P ++ FGG+A+ AS W A + L N YG TET V
Sbjct: 2296 FKQLMHVACDSSLPMSLQTVIFGGEALDVASLK-PWFARFGDQSPQLINMYGITETTVHV 2354
Query: 1867 LLWKARKGDPCGAVYAPIGTLLGNRSGYVLDAQLNLQPIGVAGELYLGGEGVARGYLERP 1926
D +PIG + + S YVLDA N G +GEL++G G+ARGY R
Sbjct: 2355 SYRPITLADTQNPA-SPIGEAIPDLSWYVLDADFNPVAQGCSGELHIGHAGLARGYHNRA 2413
Query: 1927 ALTAERFVPDPFGKPGSRVYRSGDLTRGRPDGGVDYLGRVDHQVKIRGFRIELGEIEARL 1986
ALTAERFVPDPF G R+YR+GDL R R G +DY GR+DHQVKIRGFRIELGEIEARL
Sbjct: 2414 ALTAERFVPDPFSNEGGRLYRTGDLARYRATGVIDYAGRIDHQVKIRGFRIELGEIEARL 2473
Query: 1987 REQDSVGETVVVAQEGPSGKQLVAYVVPLDPLLIDDAVAQSTCREALRRALKARLPDYMV 2046
+ +V E V+A +G QL AY+VP +P Q T RE L+ L+A LPDYMV
Sbjct: 2474 QAHPAVREVSVLALDG----QLAAYLVPAEP-----DQDQPTLREMLKNELRAHLPDYMV 2524
Query: 2047 PTHLMFLERMPLTPNGKLDRKGLPRPDVSQMQQVYVAPQSELEQKIAAIWSDVLRLPRVG 2106
PTH + L+ MPLT NGKLDRK LP PD SQ+Q Y APQ ELEQ++AAIW+D+L++ RVG
Sbjct: 2525 PTHFIVLDSMPLTANGKLDRKALPAPDASQLQATYSAPQGELEQQLAAIWADLLQVERVG 2584
Query: 2107 LHDNFFELGGDSIISIQVVSRAR-QAGVRFTPKDLFQHQTVQSLAAVAREGEGAVVLDQS 2165
+DNFFELGG S++++Q++ R R Q + KD+F+ + A +E G Q
Sbjct: 2585 RNDNFFELGGHSLLAVQMLVRVREQLQHEVSLKDVFEQPLLADFCATLQEKNGESDHAQD 2644
Query: 2166 ALTGDL 2171
LT L
Sbjct: 2645 ELTKSL 2650
Score = 92.0 bits (227), Expect = 2e-21
Identities = 120/487 (24%), Positives = 205/487 (42%), Gaps = 36/487 (7%)
Query: 6 NIDLVSRFLR--LPLEQRQQFYQRLQSRGMSFAQL----PIASIREDGQMLPLSYAQERQ 59
++ +++R R + L +Q F ++ + S A+L P+A + LPL Q R
Sbjct: 1108 SLQIIARAKRQGIKLSPKQLFEKQTIGQLASVAKLIQKKPVAVAEQISGSLPLLPIQAR- 1166
Query: 60 WFLWQLD-PDSATYHIPGALRLQGRLDLAALQRAFDSLLARHESLRTRLVQ-DGERLLQN 117
++LD P+ ++ L+ L+ A LQ A +L+ +H++LR Q +G+
Sbjct: 1167 --FFELDIPERQHWNQALMLKPLQTLEAAHLQSALTALVEQHDALRLGFTQQNGQWQATF 1224
Query: 118 VAPEARIEIRQDVADEQQLLARVEAEIARPFDLQAGPLLRVSLLQLAEDEHVLVMVQHHI 177
AP + D + L + E R DL+ GPLLR L+ L + E L++V HH+
Sbjct: 1225 GAPNTCELLWTHELDSIERLPELADEAQRSLDLKNGPLLRAVLIHLPQGEQRLLLVIHHL 1284
Query: 178 ISDGWSMQVMVEELVQFYAAHSQGREVQLPGLPIHYADYALWQRSWMEAGEKARQLAYW- 236
+ DG S +V++E+L Q Y A +QG+ V L +A + + + YW
Sbjct: 1285 LVDGVSWRVLLEDLQQAYLALAQGQPVALAAKTTSLQRWAEQLQQYATGQTLKAERDYWL 1344
Query: 237 QDLLGGEQPVLELPLDHPRPAQQSHCGASLQVHLPADLVAGIKRLAQQEGVTPFM-LLLA 295
Q L G +QP LP D P ++ A L DL + ++A T LLL
Sbjct: 1345 QALQGADQP---LPRDKPEGTMRNRDAAHASSWLSRDLTHKLLKVAPAAYRTHVNDLLLT 1401
Query: 296 SFQTLLFRYSGQSDIRIGVPNANR----NRVETERLIGFFVNTQVLKADLDGQMSFAELL 351
+ +L +S Q + I + R + + R +G+F + + L Q++ L
Sbjct: 1402 ALAQVLCEWSQQPSVLIQLEGHGREDLFDETDLSRTVGWF--SSLFPVRLTPQIAPGASL 1459
Query: 352 QQAKRRSLEAQAHQDLPFEQLVVALQPERSLSHN----PLFQVMFNHQTDAQGGRDGQQL 407
K + +A D V+ E S + P +V FN+ G Q
Sbjct: 1460 SGIKE---QLRAVPDKGIGYGVLRYMGEASFAQQLAALPQARVTFNYLGQFDGSFSEHQ- 1515
Query: 408 PGLRVAQLDWENQTTHFDLSLDTHESAEG------LWAALTYATDLFESATIERLAQHWQ 461
L V D D L S G L +++ +++ ++TI+ LA+ ++
Sbjct: 1516 GALFVPSADSSGTALCEDGPLGNWLSLNGQVFDGQLQLDWSFSREVYHASTIDTLARRYE 1575
Query: 462 NLLQAAV 468
L +
Sbjct: 1576 QALTTLI 1582
Score = 62.4 bits (150), Expect = 2e-12
Identities = 65/257 (25%), Positives = 105/257 (40%), Gaps = 35/257 (13%)
Query: 2128 ARQAGVRFTPKDLFQHQTVQSLAAVAREGEGAVVLDQSALTGDLLLLPVQQA-----FFA 2182
A + RF L Q Q Q LA + +EG+ +L D+ +P+ A F
Sbjct: 6 AARIAKRFVGLSLEQRQ--QFLARLRQEGKDFSLLPVPVSRHDVSAIPLSFAQQRLLFLW 63
Query: 2183 DDIPRRHHWNQSVVLQPHQALQAPLLVAALQALIVHHDALRIGFVQGAAGWSAAYRGPQQ 2242
P + + L+ L L A LI H+ LR F
Sbjct: 64 QLDPSSDAYKMTTGLRLRGTLNESALRRAFDHLIERHEVLRTVFHTDG------------ 111
Query: 2243 HQAEQVLWQTTLNAVEELEALG------EEAQRSL----------DLSEGPLLRAVLVDL 2286
QA+QVL A+E ++ G +A+ +L DL GPLLRA L L
Sbjct: 112 DQAQQVLMHDQTVALESVDLTGLADVELRDAELALQVATVTGQPFDLRTGPLLRAHLFRL 171
Query: 2287 ADGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQVAQGAKVVLPAKTSAIRAWAERLQAY 2346
A L++ +HH+V DG S +++++ Y+ +G + LP +A +++
Sbjct: 172 AGDEHVLIVSMHHIVSDGWSMDVMIQEFVHCYQAYCEGREAALPELPLQYADYAIWQRSW 231
Query: 2347 ARSAALAQELAWWQTQL 2363
+ A++L +W+ QL
Sbjct: 232 LEAGEGARQLDYWRNQL 248