Pairwise Alignments

Query, 431 a.a., Dihydrofolate synthase (EC 6.3.2.12) @ Folylpolyglutamate synthase (EC 6.3.2.17) from Variovorax sp. SCN45

Subject, 421 a.a., bifunctional tetrahydrofolate synthase/dihydrofolate synthase from Vibrio cholerae E7946 ATCC 55056

 Score =  304 bits (778), Expect = 4e-87
 Identities = 179/417 (42%), Positives = 240/417 (57%), Gaps = 15/417 (3%)

Query: 7   WLARAEQLHPKNIELGLERAKEMAQRLGLRFGCP-VITVAGTNGKGSTCAMLESILTHAG 65
           WL     +H   I+LGLER + +AQ+  L    P VITVAGTNGKGSTCA++E+IL  AG
Sbjct: 16  WLDYLAHIHTSAIDLGLERVQAVAQKAKLTKPAPTVITVAGTNGKGSTCALMEAILLQAG 75

Query: 66  YRTAVFTSPHLVRFEERLRLKGEAVDASKLIASFEVVEKARGDMPLTYFEFTTLGILHCM 125
           Y   V++SPHL+R+ ER+R+ G+ +       +F  +E+ RGD+ L+ FEF TL  L+  
Sbjct: 76  YSVGVYSSPHLIRYNERVRINGQDLADEMHTQAFAHIEQERGDISLSLFEFGTLAALYLF 135

Query: 126 IEEKPDVAILEVGLGGRLDAVNIIDTDCAVITSIDLDHMEYLGPDRESIGFEKAGIMRAG 185
            ++K DV +LEVGLGGRLDA N++D D +VITS+ LDH ++LG D   IG+EKAGI R+G
Sbjct: 136 EQQKVDVLLLEVGLGGRLDATNVVDHDVSVITSLALDHTDWLGNDIAVIGYEKAGIFRSG 195

Query: 186 KPVVVSDPMPPQSVIDHANAIGADLWRFGTDFNV-SGDKQQWGWSGRGRRYSGLAYPALR 244
           KP +   P PP +V  HA+ IGA L +    F+        W W       + L  P+L 
Sbjct: 196 KPAICGQPKPPATVAAHADDIGAKLHQVEIQFSYEKTSATTWNWRSGRFELTDLPIPSL- 254

Query: 245 GANQLINAAGVLAALEALRPQLPITAQAVRNGLAMVELPGRFQIVPGEPALVLDVAHNAH 304
               L NAA  L AL      L I+   + +GL   +L GR Q++  +P +VLDVAHN H
Sbjct: 255 ---PLPNAATALMALGC--SGLAISDINIVDGLRNAQLAGRMQVISHQPTIVLDVAHNPH 309

Query: 305 AVAALAENLDAMGFYPTTHGVFGVMADKDLAPILARIGPLIDRWYFTDLPTSRAAKAADL 364
           +   L + L       T H VFG++ DKD+A  +  + P +  WY   L   RAA AA L
Sbjct: 310 SAHYLVQQLTQRYPERTIHLVFGMLHDKDIASTVVELSPAVTHWYPASLSGPRAATAAQL 369

Query: 365 LASWQAQNTRTDASGSVHAGPMEALRAAIEQAGPADRIVVFGSFFTVGGVLENGTPR 421
                A  T+       +A P+ A  AA+ QAG  D IVV GSF TVG VLE+   R
Sbjct: 370 CQYLPADITQ-------YANPVSAFEAALTQAGAQDVIVVAGSFHTVGEVLEHWQKR 419