Pairwise Alignments

Query, 705 a.a., bifunctional GTP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase from Vibrio cholerae E7946 ATCC 55056

Subject, 702 a.a., bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase from Escherichia coli ECRC101

 Score = 1055 bits (2729), Expect = 0.0
 Identities = 525/706 (74%), Positives = 610/706 (86%), Gaps = 5/706 (0%)

Query: 1   MYLFDSLKDVAQEYLTEPQIEALRQSYVVARDAHEGQTRSSGEPYIIHPVAVARILAEMR 60
           +YLF+SL  + Q YL E QI+ LRQ+Y+VARDAHEGQTRSSGEPYI HPVAVA ILAEM+
Sbjct: 1   LYLFESLNQLIQTYLPEDQIKRLRQAYLVARDAHEGQTRSSGEPYITHPVAVACILAEMK 60

Query: 61  LDLETLQAALLHDVIEDCDVTKEDLDAHFGSSVAELVDGVSKLDKLKFRDRKEAQAENFR 120
           LD ETL AALLHDVIED   T +D++  FG SVAELV+GVSKLDKLKFRD+KEAQAENFR
Sbjct: 61  LDYETLMAALLHDVIEDTPATYQDMEQLFGKSVAELVEGVSKLDKLKFRDKKEAQAENFR 120

Query: 121 KMVLAMVQDIRVILIKLADRTHNMRTLGALRPDKKRRIARETLEIYAPLAHRLGIHNIKT 180
           KM++AMVQDIRVILIKLADRTHNMRTLG+LRPDK+RRIARETLEIY+PLAHRLGIH+IKT
Sbjct: 121 KMIMAMVQDIRVILIKLADRTHNMRTLGSLRPDKRRRIARETLEIYSPLAHRLGIHHIKT 180

Query: 181 ELEELGFEALYPNRYRVLKEVVKAARGNRKEMIQRIHSEIEGRLQEVGLPARVVGREKNL 240
           ELEELGFEALYPNRYRV+KEVVKAARGNRKEMIQ+I SEIEGRLQE G+P RV GREK+L
Sbjct: 181 ELEELGFEALYPNRYRVIKEVVKAARGNRKEMIQKILSEIEGRLQEAGIPCRVSGREKHL 240

Query: 241 FSIYNKMKTKEQRFHTIMDIYAFRIVVDTADTCYRVLGQVHSLYKPRPARMKDYIAVPKA 300
           +SIY KM  KEQRFH+IMDIYAFR++V+ +DTCYRVLGQ+HSLYKPRP R+KDYIA+PKA
Sbjct: 241 YSIYCKMVLKEQRFHSIMDIYAFRVIVNDSDTCYRVLGQMHSLYKPRPGRVKDYIAIPKA 300

Query: 301 NGYQSLHTSMVGPHGVPVEVQIRTEDMDQMADKGVAAHWSYKANSERGGTTAQIKAQRWM 360
           NGYQSLHTSM+GPHGVPVEVQIRTEDMDQMA+ GVAAHW+YK + E   TTAQI+AQRWM
Sbjct: 301 NGYQSLHTSMIGPHGVPVEVQIRTEDMDQMAEMGVAAHWAYKEHGET-STTAQIRAQRWM 359

Query: 361 QSLLELQQSAGNSFEFIENVKSDLFPDEIYVFTPKGRIVELPMGATAVDFAYAVHTDIGN 420
           QSLLELQQSAG+SFEFIE+VKSDLFPDEIYVFTP+GRIVELP GAT VDFAYAVHTDIG+
Sbjct: 360 QSLLELQQSAGSSFEFIESVKSDLFPDEIYVFTPEGRIVELPAGATPVDFAYAVHTDIGH 419

Query: 421 TCVGARVDRTPYPLSQSLKSGQTVEIISAPGARPNAAWLNYVVTSRARTKIRQVLKTMRR 480
            CVGARVDR PYPLSQ L SGQTVEII+APGARPNAAWLN+VV+S+AR KIRQ+LK ++R
Sbjct: 420 ACVGARVDRQPYPLSQPLTSGQTVEIITAPGARPNAAWLNFVVSSKARAKIRQLLKNLKR 479

Query: 481 EDSITLGRRLLNHAL-GEHSVNEIAPENISKVLSDLKIASMDDLLAAIGLGELMSIVIAR 539
           +DS++LGRRLLNHAL G   +NEI  ENI + L  +K+A++DDLLA IGLG  MS+V+A+
Sbjct: 480 DDSVSLGRRLLNHALGGSRKLNEIPQENIQRELDRMKLATLDDLLAEIGLGNAMSVVVAK 539

Query: 540 RLLGNADELTEPSKSGGNKNKLPIRGAEGILLTFANCCHPIPDDHIIAHVSPGRGLVVHR 599
            L      +   ++S G+   LPI+GA+G+L+TFA CC PIP D IIAHVSPG+GLV+H 
Sbjct: 540 NLQHGDASIPPATQSHGH---LPIKGADGVLITFAKCCRPIPGDPIIAHVSPGKGLVIHH 596

Query: 600 ETCPNVRGYQKEPDKYMAVEWTKDYDQEFITELKVDMHNRQGALAELTNVISKTGSNIHG 659
           E+C N+RGYQKEP+K+MAVEW K+  QEFITE+KV+M N QGALA LT  I+ T SNI  
Sbjct: 597 ESCRNIRGYQKEPEKFMAVEWDKETAQEFITEIKVEMFNHQGALANLTAAINTTTSNIQS 656

Query: 660 LSTEERDGRLYTVTVLLTTKDRVHLAGIMRKIRTMPHALKVRRRKN 705
           L+TEE+DGR+Y+  + LT +DRVHLA IMRKIR MP  +KV R +N
Sbjct: 657 LNTEEKDGRVYSAFIRLTARDRVHLANIMRKIRVMPDVIKVTRNRN 702