Pairwise Alignments

Query, 705 a.a., bifunctional GTP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase from Vibrio cholerae E7946 ATCC 55056

Subject, 719 a.a., bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase from Brevundimonas sp. GW460-12-10-14-LB2

 Score =  503 bits (1294), Expect = e-146
 Identities = 271/699 (38%), Positives = 404/699 (57%), Gaps = 21/699 (3%)

Query: 23  LRQSYVVARDAHEGQTRSSGEPYIIHPVAVARILAEMRLDLETLQAALLHDVIEDCDVTK 82
           L ++YV A   H  Q R+SG+PY  HP+ VA IL + +LD  T+  ALLHDV+ED   T+
Sbjct: 23  LNRAYVYAMKMHGSQLRASGDPYFAHPIQVAGILTDYKLDTATIVTALLHDVVEDTSATR 82

Query: 83  EDLDAHFGSSVAELVDGVSKLDKLKFRDRKEAQAENFRKMVLAMVQDIRVILIKLADRTH 142
           +D+   FG  VA LV+GV+KL +L+ +     QAEN RK +LA+ +D+RV+L+KLADR H
Sbjct: 83  DDIAGMFGEEVAVLVEGVTKLSRLELQAEHTRQAENLRKFILAISRDVRVLLVKLADRLH 142

Query: 143 NMRTLGALRPDKKRRIARETLEIYAPLAHRLGIHNIKTELEELGFEALYPNRYRVLKEVV 202
           NMRTL  ++P+K+ RI+RETLE+YAPL   +GIH+I +ELEEL F  L P     ++  +
Sbjct: 143 NMRTLQFVKPEKRERISRETLEVYAPLGRSIGIHSIASELEELAFTHLNPTAKTAIERRL 202

Query: 203 KAARGNRKEMIQRIHSEIEGRLQEVGLPARVVGREKNLFSIYNKMKTKEQRFHTIMDIYA 262
           +A +      I  + SE+E  L E GL A V GR+K  +SI+ K++ K   F ++ DIY 
Sbjct: 203 EALKLEHGRAIDGVASEVERVLSEAGLKANVYGRQKTPYSIWRKLQRKSVGFSSLSDIYG 262

Query: 263 FRIVVDTADTCYRVLGQVHSLYKPRPARMKDYIAVPKANGYQSLHTSMVGPHGVPVEVQI 322
           FR++V+  D CYR LG +H  +   P R KD+I+ PK+N Y+SLHT++VGP G+ +E+QI
Sbjct: 263 FRVIVEAEDDCYRALGVIHREWPMVPERFKDFISTPKSNNYRSLHTTVVGPRGLRIEMQI 322

Query: 323 RTEDMDQMADKGVAAHWSYKANS--------ERGGTTAQIKAQRWMQSLLELQQSAGNSF 374
           RTEDMD++A+ GVAAHW YK +S        E+GG    ++  R +  ++E  +      
Sbjct: 323 RTEDMDRIAEDGVAAHWRYKNHSYGFDREAMEQGGGRDPLQNLRHLVQVIEHGEGGE--- 379

Query: 375 EFIENVKSDLFPDEIYVFTPKGRIVELPMGATAVDFAYAVHTDIGNTCVGARVDRTPYPL 434
           +++E+ K +++ D+++VFTPKG++V LP G   +DFAYAVHT++G+T VG +V+    P+
Sbjct: 380 DWVEHAKLEMYLDQVFVFTPKGQLVTLPRGGMPLDFAYAVHTEVGDTAVGVKVNGELKPM 439

Query: 435 SQSLKSGQTVEIISAPGARPNAAWLNYVVTSRARTKIRQVLKTMRREDSITLGRRLLNHA 494
              L++G  VEII        A W +  VT RAR+ IR+ ++T  RE+ I LGR  L+  
Sbjct: 440 RTPLQNGDVVEIIRGSKREVPADWRSLTVTGRARSAIRRHIRTSEREEFIKLGRVALDQT 499

Query: 495 LGEHSVNEIAPENISKVLSDLKIASMDDLLAAIGLGELMSIVIAR----RLLGNADELTE 550
           LG      +   ++  VL  L +AS DDL   +G G L     A      L G      E
Sbjct: 500 LGRVD-KALTDVSLKPVLELLAVASDDDLFEGLGRGRLSPTTAAEILFPALKGRLKAGPE 558

Query: 551 PSKSGGNKNKLPIRG---AEGILLTFANCCHPIPDDHIIAHVSPGRGLVVHRETCPNVRG 607
             +  G K +L +RG     G+ + F  CC P+P D I+  + P  GL VH   C  +  
Sbjct: 559 KQRIEGEKARLFVRGGGLTPGVSVHFGQCCTPVPGDRIVGILEPESGLTVHTIDCQTLAA 618

Query: 608 YQKEPDKYMAVEWTKDYDQEFI--TELKVDMHNRQGALAELTNVISKTGSNIHGLSTEER 665
           +  +   +  ++WT   + + +    ++  + N  G L ++T +I + G NI  LS   R
Sbjct: 619 FADDDSVWHDLQWTPQAETDAVAAARIRATIRNAPGVLGQVTTLIGEAGGNIINLSMAHR 678

Query: 666 DGRLYTVTVLLTTKDRVHLAGIMRKIRTMPHALKVRRRK 704
               + V V +  +D  H   IM  +R  P    V R +
Sbjct: 679 QQDFFDVDVDVEVEDAKHATMIMAALRANPSVDSVERAR 717