Pairwise Alignments

Query, 738 a.a., GTP diphosphokinase from Vibrio cholerae E7946 ATCC 55056

Subject, 738 a.a., Bifunctional (p)ppGpp synthase/hydrolase SpoT from Methylophilus sp. DMC18

 Score =  395 bits (1016), Expect = e-114
 Identities = 221/678 (32%), Positives = 373/678 (55%), Gaps = 33/678 (4%)

Query: 64  ILITLSMDRPTLVAALLFPIATSGVLDNESLEEGYGREVVKLIHGVEEMAAIGQLNVTMH 123
           IL  L +D PTL+AALL  +     +D+ ++ E +G++V  L+ G+ ++  + +L   M 
Sbjct: 80  ILAKLHLDLPTLLAALLHDVVEDTEVDSAAIAERFGKQVADLVDGLTKLDKV-ELQTAMQ 138

Query: 124 GSEASAQVDNVRRMLLAMVDDFRCVVIKLAERICNLREVKNEPDEVRRVAAKECANIYAP 183
                AQ +N R+MLLAM  D R +++KLA+R+ N++ +     E ++  A+E  +IYAP
Sbjct: 139 -----AQAENFRKMLLAMSQDVRVILVKLADRLHNMQTLDAMRPEKQKRIARETLDIYAP 193

Query: 184 LANRLGIGQLKWEIEDYAFRYQQPDTYKQIAKQLSERRIVREQYIRDFVSDLRAEMKQSG 243
           +ANRLG+  +  E+ED + +Y  P+ Y  I K +   R  R++ I   +  ++ ++ Q G
Sbjct: 194 IANRLGLNPIYHELEDLSLKYLYPNRYHVIDKAIRLARGNRKEVISKILEAIQNQLLQYG 253

Query: 244 INAEVSGRPKHIYSIWRKMQKKSLAFDELFDVRAVRIIADKLQDCYAALGIVHTKYKHLP 303
           I  +V GR KH++SI++KM +KS+   ++ D+   R+I      CY ALG +H  YK +P
Sbjct: 254 IEYDVQGREKHLFSIYKKMSEKSMKLSQINDIYGFRVIVKDNAACYLALGALHALYKPIP 313

Query: 304 NEFDDYVANPKPNGYQSIHTVILGPEGKTIEIQIRTKQMHEESELGVAAHWKYKEGSSAA 363
             F DY+A PK NGYQS+HT + GP G  IE+QIR+++MH  ++ GVAAHW YK   +  
Sbjct: 314 GRFKDYIAIPKANGYQSLHTTLFGPFGTPIEVQIRSQEMHNIADAGVAAHWLYKTTDAHL 373

Query: 364 RSGYDEKITWLRKLLDWQEEMSDSGEMLDELRSQVFDDRVYAFTPKGDVVDLPMGATPLD 423
                +   WL++L++ Q E  DS E L+  +  +F D VY FTPKG+++ LP G+T +D
Sbjct: 374 TKLQQQTHQWLQRLVEIQTESDDSHEFLENFKVDLFPDEVYVFTPKGNIMALPRGSTAVD 433

Query: 424 FAYHIHSEVGHRCIGAKVAGRIVPFTHKLQMGDQVEIITAKEPNPSRDWLNPSLGFVHSG 483
           FAY +HS+VG+ C+  K+   + P   +++ GD VEIITA    P+  WLN    +V +G
Sbjct: 434 FAYAVHSDVGNSCVAVKINNELAPLRSEMRNGDHVEIITAPLAKPNPAWLN----YVVTG 489

Query: 484 RARAKINAWFRKQSREKNLEAGREILEIELAKI----GANLKHAEAYALKRFNVNSVDEM 539
           +AR+ I  + +    E++ + G  +L + L  +    G          +  +   +   +
Sbjct: 490 KARSHIRHYLKTVKVEESAQLGERMLNVALRAMHIEPGDISDKQWQKVMNDYGSKTRQAI 549

Query: 540 YVGIGSGDLRINQIVNHINALVNKPTAEEEDKLALEKLQENKTLTPNRPHKDAVVVEGVD 599
              IG G  R + +V H   L+  P AE EDK         K L       D + + G +
Sbjct: 550 LTDIGLGK-RNSLMVAH--QLLAHP-AETEDK-------TGKVL-------DTITIRGSE 591

Query: 600 NLMTHLARCCQPIPGDEIRGYITQGRGISVHRSDCEQLEELSLHAPERIIDTVWGSGFVG 659
            +    A CC+PIPGD I G+I + +G+ +H  DC  + +  L  PE+ +D  W +    
Sbjct: 592 GMAVQFAPCCRPIPGDPILGFINKDKGLVIHTHDCPAIRKFRLD-PEKWLDVEWDADPKK 650

Query: 660 SYLLTVRVEAMERSGLLKDITTLLANEKVKVASMKSRSDYKRQIIIMDFDLEVNNVEALA 719
            + + +R+  ++  G+L  I   ++N +  + ++   +    Q   ++F L+V+N   LA
Sbjct: 651 LFSVNLRITVVDERGMLAKIAATISNAEANIDNVSVETSDGSQYSNVNFTLQVHNRVHLA 710

Query: 720 RVSKRIEQIKDVMLVKRL 737
            + + + +I+ ++ + R+
Sbjct: 711 TLIRNLRKIQQIVRINRV 728