Pairwise Alignments

Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056

Subject, 4293 a.a., peptide synthase from Pseudomonas simiae WCS417

 Score =  217 bits (552), Expect = 4e-59
 Identities = 244/955 (25%), Positives = 408/955 (42%), Gaps = 79/955 (8%)

Query: 487  RGHIDTQSLHSRLLYLVEHIPALRTRIDQE--KWIQWVSPCIALNWQAIDLQHLSREQAL 544
            RG +D  ++ +    L++   ALRTR  +   +  Q V      + Q IDL  L   +  
Sbjct: 698  RGELDEDAVRTSFQQLIQRHEALRTRFYERDGQAFQRVDTKADFDLQVIDLSDLPVAERE 757

Query: 545  LAVEPVRQQYQQRMHDLTRSP--WQICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHALI 602
               + +R+   +   DL + P  W + +V+L  E+ +     +L +   +I DG +  ++
Sbjct: 758  ARAQQIREDEARTQFDLEKGPLLW-VTLVRLDDEDHQ-----LLVTLHHIIADGWSLNIL 811

Query: 603  L-------AALLGSEEPDITQVVQNARDTQSISPQF-ASKKAQDE-AYWKSKLHPDCPPP 653
            +       AA +  +  ++  +     D  +   Q+ A  + Q + AYWK++L  + P  
Sbjct: 812  MDEFSRLYAAAVQGQTLELPPLALQYADYGTWQRQWLAEGEGQRQLAYWKAQLGEEHPTL 871

Query: 654  ALPWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTE 713
            +L              +R ++++       + +    +      LL A    VL  ++ +
Sbjct: 872  SLATDHPRSVHHRHSASRHTVRLGASLSEAIRQTARTHESTPFMLLLAAFQSVLYRYSGQ 931

Query: 714  IGMRVGFPVLIPSSNAIDGNESSFVILEHEKSTLSLLSQASKLQ--REMLEALEHLAFSG 771
              +R+G P          G    F+      +TL L ++        E+L A    A   
Sbjct: 932  RDIRIGVPNANRPRQETQGLVGFFI------NTLVLRAELDGRLPFTELLAATRQAALGA 985

Query: 772  VDLNRLLMNQAPQALVLPVVLTNGLSWKTLNPED----AVTLFDGVT------QTPQVAL 821
                 L   Q  +A   P     GL     N +     A+    G+        + +   
Sbjct: 986  QAHQDLPFEQLLEAF--PQAREQGLFQVMFNHQQRDLSALRRLPGMLADELPWHSREAKF 1043

Query: 822  DIRLTYDEQKN--LIISFDYALAVLETELIREMLSALHHRLSQITSSASLAAPLEPCIDL 879
            D++L  +E +N  L +SFDYA  + E+  I+ +     + L  I      A      +  
Sbjct: 1044 DLQLHTEEDRNGRLSLSFDYADELFESATIQRLAEHYINLLHAICEQPRQAIGDLMLMQH 1103

Query: 880  SHYRFNSDESASHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKA 939
                  S+   +    +L +L  Q   +T D TA++    +L++AQL  Q  R+   L+ 
Sbjct: 1104 DEQALYSEAPCAPAQVWLPELLNQ---QTSDTTALVWDGGSLTFAQLHTQANRLAHYLRD 1160

Query: 940  RGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMD 999
            +G+     +AI   RS + ++  LA   +G  +VP+D   P ERL Y+L++    L++  
Sbjct: 1161 KGVGPDVCVAIAAERSPQLLIGLLAIIKAGGAYVPLDPDYPTERLAYMLKDSGVHLLLTQ 1220

Query: 1000 KPCEFGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQT----------AYYLYTSG 1049
                        AL+E V  A GV  V  +D L   S   Q           AY +YTSG
Sbjct: 1221 T-----------ALLEQVPAACGVC-VIAMDSLHLDSWPTQPPGLHLHGDNLAYVIYTSG 1268

Query: 1050 TTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLV 1109
            +TG+PK V + + A +  +      + L   DV+M   P+  D+SV++ F  L  G  LV
Sbjct: 1269 STGQPKGVGITHAALAERLQWMQATYPLNETDVLMQKAPISFDVSVWECFWPLITGCRLV 1328

Query: 1110 LPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSCTQAGQLHSLRLIAQGGDYIKPA 1169
            L    E +D  +  +L++ H VT    VP +L++ +      +  SLR +  GG+ +   
Sbjct: 1329 LAGPGEHRDPHRIAQLVQEHGVTTLHFVPPLLQLFIDEPLVAECTSLRRLFSGGEALPAE 1388

Query: 1170 TIAQLRAGSNPPRLISLGGPTETTI-WSIWHELTADDVSVIPYGRPLAGNRYFIMDEIQR 1228
               ++ A     +L +  GPTET I  + WH   A+D    P GRPL      ++DE   
Sbjct: 1389 LRNRVLAQLPAVQLHNRYGPTETAINVTHWH-CRAEDGERSPIGRPLGNVICRVLDEQLN 1447

Query: 1229 HVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVLDEHGHPVRAFRTGDQGYYRADGNI 1288
             VP GV G +   G+ LA+GYL    L    FV   D  G   R +RTGD+  + ADG I
Sbjct: 1448 PVPLGVPGELCIGGIGLARGYLGRAGLTAERFVA--DHQG--ARLYRTGDRARWSADGVI 1503

Query: 1289 IFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKPQQS 1348
             +  R++  VK+RG RV   +IE ++     +A  VV+       D  L   F+      
Sbjct: 1504 EYLGRLDQQVKLRGFRVEPEEIEARMLALEGIAQAVVL-----VRDGQLIGYFTA--HGD 1556

Query: 1349 ASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRKQCQAHVQRQSISVEP 1403
               Q ++      LP   +P+  + L+A+PLS +GK+DR+     V +    VEP
Sbjct: 1557 LDEQQVKTALAAELPEYMVPALLMRLDAMPLSPSGKLDRRALPEPVWQVREHVEP 1611



 Score =  213 bits (543), Expect = 4e-58
 Identities = 238/993 (23%), Positives = 405/993 (40%), Gaps = 58/993 (5%)

Query: 436  QSVQQIDAQLGYARRESIQEMPLTPLQQAY-----LLGRSTQIALGGVAMHEFREYRGHI 490
            Q+  Q + Q   A+ +  Q +PL+  QQ       +   S    +GG+A       RG +
Sbjct: 1685 QASGQRNQQTVIAKVDRGQPVPLSYSQQRMWFLWQMEPDSPAYNVGGMA-----RLRGVL 1739

Query: 491  DTQSLHSRLLYLVEHIPALRTRIDQEKWIQW--VSPCIALNWQAIDLQHLSREQALLAVE 548
            D     + L  L+     LRT       + +  VSP   L     D   LS       ++
Sbjct: 1740 DVGRFEAALQALIMRHETLRTTFPSVDGVAYQNVSPQTGLRMDWQDFSALSEADRQPRLQ 1799

Query: 549  PVRQQYQQRMHDLTRSPW-QICVVQLPIEEQEEFSSIVL----TSFDALIVDGRTHALIL 603
             +         +L   P  + C+V+    EQE +  + L    T   A+ +  R  + + 
Sbjct: 1800 RLADHEAHTPFNLETGPLLRACLVKAG--EQEHYLVLTLHHIVTEGWAMDIFARELSALY 1857

Query: 604  AALLGSEEPDITQVVQNARDTQSISPQF--ASKKAQDEAYWKSKLHPDCPPPALPWKQAL 661
             A +   +  +  +     D      Q+  + ++ +   YW ++L  + P   LP  +  
Sbjct: 1858 EAFIDERDSPLAPLPVQYLDYSVWQRQWLESGERQRQLDYWTAQLGNEHPLLELPGDRPR 1917

Query: 662  ETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEIGMRVGFP 721
              + + +       +  +   ++     E GL L   +TAT+  +L  ++ +  +R+G P
Sbjct: 1918 PPVQSHQGELYRFDLSDDLAARVRAFNAERGLTLFMTMTATLAVLLYRYSGQTDLRIGAP 1977

Query: 722  VLIPSSNAIDGNESSFVILEHEKSTLSLLSQASKLQREMLEALEHLAFSGVDLNRLLMNQ 781
            V    +N I       +        L           E+ E + H    G     L  + 
Sbjct: 1978 V----ANRIRPESEGLIGAFLNTQVLRCQLNGQMNVAELFEHVRHTVIEGQSHQDLPFDH 2033

Query: 782  APQALVLP---------VVLTNGLSWKTLNPED----AVTLFDGVTQTPQVALDIRLTYD 828
              +AL  P          V+ N   W+           V       +  +  L++ +T D
Sbjct: 2034 LVEALQPPRSAAYNPLFQVMCNVQRWEFQQSRQLAGMTVEYLANDARATKFDLNLEVT-D 2092

Query: 829  EQKNLIISFDYALAVLETELIREMLSALHHRLSQITSSASLAAPLEPCIDLSHYRFNSD- 887
                L     Y+  + +   I  M +   + L  + +         P +     R   D 
Sbjct: 2093 LDHRLGCCLTYSTDLFDEPRIARMAAHWRNLLEALIADPQQRLSELPLLGADEQRVLQDS 2152

Query: 888  ---ESASHDCDFLAK--LAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGL 942
               E+  H  D       +QQ+ VR +       G  TLSY +L  +  R+ W L+ RG+
Sbjct: 2153 LGIENGEHRLDQCIHPLFSQQVAVRGDAPALTFAGV-TLSYRELDARANRLAWMLRERGV 2211

Query: 943  TTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPC 1002
                 + + LPRS+E ++  LA   +G  +VP+D   P +RL+Y++E+    L++ D   
Sbjct: 2212 GPQVRVGLALPRSLEMVIGLLAILKAGGAYVPLDPEYPLDRLHYMIEDSGIGLLLSD-AA 2270

Query: 1003 EFGNVIAFDALIEPVLFADGVPDVT--PLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVN 1060
             F  +    A +      D +P +   P D L  +S  Q  AY +YTSG+TGKPK VVV+
Sbjct: 2271 MFEALGELPATVACWCLEDDLPVLANYPADALPFISLPQHQAYLIYTSGSTGKPKGVVVS 2330

Query: 1061 NQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDAL 1120
            +   +       + + + ++D  +    ++ D +   L   L  GA +VL A   + DA 
Sbjct: 2331 HGEIAMHCAAVIERFGMRADDCELHFYSINFDAATERLLVPLLSGAQVVLRA-QGQWDAE 2389

Query: 1121 QWNRLIERHQVTIWVSVPAILEMLLS-CTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSN 1179
            +   LI  H + I    P+    L        Q   +R+   GG+ +    + ++RA   
Sbjct: 2390 EICGLIRTHGINILGFTPSYGSQLAQWLATRQQTLPVRMCITGGEALTGEHLQRIRAAFQ 2449

Query: 1180 PPRLISLGGPTETTIW---SIWHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVG 1236
            P    +  GPTET +    S+  E   +  + +P G  +     +I+D     VPQG  G
Sbjct: 2450 PQVFFNAYGPTETVVMPLASLAPEHLEEGAASVPIGSIIGDRVAYILDADLALVPQGATG 2509

Query: 1237 RIFTSGVNLAQGYLEDGELKQTDFVT-VLDEHGHPVRAFRTGDQGYYRADGNIIFASRIN 1295
             ++  G  LAQGY +   +    FV      +G   R +RTGD    R DG + +  RI+
Sbjct: 2510 ELYVGGAGLAQGYHQRPGMTAERFVADPFARNGG--RLYRTGDLVRQRVDGLVEYLGRID 2567

Query: 1296 GYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKPQQSASSQALR 1355
              VK+RG R+ L +IE +L  H A+   VV+     +G   +A L S   +  A   AL+
Sbjct: 2568 HQVKIRGFRIELGEIETRLLEHDAVREAVVLALDAPSGKQLVAYLVS-DAEHVALRDALK 2626

Query: 1356 EFAKQSLPSSHIPSRFIALEALPLSANGKVDRK 1388
               K  LP   +P+  I L+++PL+ANGK+DR+
Sbjct: 2627 AHLKAHLPDYMVPAHLIVLDSMPLTANGKLDRR 2659



 Score =  156 bits (394), Expect = 8e-41
 Identities = 127/490 (25%), Positives = 228/490 (46%), Gaps = 16/490 (3%)

Query: 911  KTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGI 970
            + A  C +Q  +Y +L  +   +   L A G+     +A+   R+++ + + + S  +G 
Sbjct: 3702 RIAASCLDQQWTYDELNRRSNGLGHALIAAGVGLDQPVALLAERNLDLLGMIIGSFKAGA 3761

Query: 971  IWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPDVTPLD 1030
             ++P+D   P +RL  +L+     L+V  +      +   D     +L  + +P     +
Sbjct: 3762 GYLPLDPGLPSQRLRSILDLSRTPLLVCTEASREQAIELLDGFDCQLLVWEEIP--ARGE 3819

Query: 1031 QLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLH 1090
                 S     AY +YTSG+TG PK V+V  +   N          L+  DV+       
Sbjct: 3820 NPGVYSAPDNLAYVIYTSGSTGLPKGVMVEQRGMLNNQLSKVPYLALSDADVIAQTASQS 3879

Query: 1091 HDMSVFDLFATLSFGATL-VLP--AGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSC 1147
             D+SV+   A   FGA + ++P    H+ +  L+    ++   +T+  SVP++++ +L+ 
Sbjct: 3880 FDISVWQFLAAPLFGARVDIVPNTIAHDPQGLLEH---VQAQGITVLESVPSLIQGMLAQ 3936

Query: 1148 TQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETTIWSIWH--ELTADD 1205
             + G L  LR +   G+ + P    Q         L++  GP E +    ++  +L +  
Sbjct: 3937 DRIG-LDGLRWMLPTGEAMPPELAHQWLQRYPEIGLVNAYGPAECSDDVAFYRVDLASTR 3995

Query: 1206 VSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVLD 1265
             + +P G P   NR +++D     VPQG VG +  +G  + +GY+ D    +T  V V +
Sbjct: 3996 GTYLPIGTPTDNNRLYLLDGALELVPQGAVGELCVAGTGVGRGYVSDP--LRTAPVFVPN 4053

Query: 1266 EHGHP-VRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVV 1324
              G P  R +RTGD    R+DG + +  R++  VK+RG R+ L +IE +L   P +    
Sbjct: 4054 PFGAPGERLYRTGDLARRRSDGVLEYVGRVDHQVKIRGYRIELGEIEARLHEQPEVRDAA 4113

Query: 1325 VVDYADTNGDTALAALFSVKPQQSASSQ--ALREFAKQSLPSSHIPSRFIALEALPLSAN 1382
            V      NG   +  L +     + S +   +++  +  LP   +P  ++ L+ LPL+AN
Sbjct: 4114 VGVQEGMNGKHLVGYLVAADEALNPSERLDRIKQRLRAELPEYMVPLHWLWLDRLPLNAN 4173

Query: 1383 GKVDRKQCQA 1392
            GK+DRK   A
Sbjct: 4174 GKLDRKALPA 4183



 Score =  143 bits (361), Expect = 6e-37
 Identities = 142/537 (26%), Positives = 227/537 (42%), Gaps = 35/537 (6%)

Query: 1841 NAHAALAESELELSAVNSSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGR 1900
            N HA   +  LE    N  A   C        L VA + A+D FF  GG+S+ AT+V+ R
Sbjct: 564  NLHAQEGDGALESELHNQIAAIWC------EQLQVATVAADDHFFLLGGNSITATQVVAR 617

Query: 1901 LLSEQGIELHINDMFSFPNAKQLAQQ-AVLHRKPTSTSFAVSEVVESSKAPLSLAQASLW 1959
            L    G+EL++  +F  P  +  A   A L +       A+  +    + P SLAQ+ LW
Sbjct: 618  LRESLGLELNLRMLFEAPTLEGFAASVAQLQQDGGVAQGAIHSLSRQEELPQSLAQSRLW 677

Query: 1960 KAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQH 2019
                       +  + +P AL+   E++E A   +F  L+ RH  LRT F   DGQ +Q 
Sbjct: 678  ITWQLDPH---SSAYTIPGALRLRGELDEDAVRTSFQQLIQRHEALRTRFYERDGQAFQR 734

Query: 2020 VIAASNIEHYQWFWTSKDNAAQSVAR---LLAQEAEHTFDLSQELPLRLNFVRDEQTGTQ 2076
            V   ++ +  Q    S    A+  AR   +   EA   FDL +   L +  VR +    Q
Sbjct: 735  VDTKADFD-LQVIDLSDLPVAEREARAQQIREDEARTQFDLEKGPLLWVTLVRLDDEDHQ 793

Query: 2077 YLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQR---SSAF 2133
             L  L HHI+ D WS+NILMDE +++Y  +VQG   +     L + ++   QR   +   
Sbjct: 794  LLVTL-HHIIADGWSLNILMDEFSRLYAAAVQGQTLELPPLALQYADYGTWQRQWLAEGE 852

Query: 2134 NQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKA 2193
             Q  L YW  +  G        A DHP S              ++L  S   ++ Q A+ 
Sbjct: 853  GQRQLAYWKAQL-GEEHPTLSLATDHPRSVHHRHSASRH---TVRLGASLSEAIRQTART 908

Query: 2194 RHASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKV 2253
              ++ F ++ AA  + ++       + +G P + R   E    VG+F    V   +    
Sbjct: 909  HESTPFMLLLAAFQSVLYRYSGQRDIRIGVPNANRPRQETQGLVGFFINTLVLRAELDGR 968

Query: 2254 QTVWQLIEQVKNSINQSMPYTDIPIDLIEEGLKGVEHETEGHMFEVFI-----QLHAKNK 2308
                +L+   + +   +  + D+P    E+ L+      E  +F+V        L A  +
Sbjct: 969  LPFTELLAATRQAALGAQAHQDLP---FEQLLEAFPQAREQGLFQVMFNHQQRDLSALRR 1025

Query: 2309 LHGEL---LLTEGHAIRFQ-QVDPDKSESG-LGLQFEILEERIEQKQTLRVMMSYMS 2360
            L G L   L       +F  Q+  ++  +G L L F+  +E  E     R+   Y++
Sbjct: 1026 LPGMLADELPWHSREAKFDLQLHTEEDRNGRLSLSFDYADELFESATIQRLAEHYIN 1082



 Score =  122 bits (307), Expect = 1e-30
 Identities = 115/499 (23%), Positives = 199/499 (39%), Gaps = 29/499 (5%)

Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
            +++ I A +R  LG+  +   DDFF  GGHSL+AT++I R      +EL +  +F     
Sbjct: 1615 LQQQIAAIWREVLGLPSIGLRDDFFALGGHSLLATQIISRTRQACDVELPLRTLFDASEL 1674

Query: 1921 KQLAQQAVLHRK--PTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLPF 1978
               A+Q  L +     +    +++V      PLS +Q  +W           +  +N+  
Sbjct: 1675 GAFAEQVGLIQASGQRNQQTVIAKVDRGQPVPLSYSQQRMWFLWQMEPD---SPAYNVGG 1731

Query: 1979 ALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIE-HYQWFWTSKD 2037
              +    ++   F  A   L++RH  LRT F   DG  YQ+V   + +   +Q F    +
Sbjct: 1732 MARLRGVLDVGRFEAALQALIMRHETLRTTFPSVDGVAYQNVSPQTGLRMDWQDFSALSE 1791

Query: 2038 NAAQSVARLLAQEAEHT-FDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILM 2096
               Q   + LA    HT F+L     LR   V+  +    YL L  HHIV + W+++I  
Sbjct: 1792 ADRQPRLQRLADHEAHTPFNLETGPLLRACLVKAGEQ-EHYLVLTLHHIVTEGWAMDIFA 1850

Query: 2097 DELAQVYQHSVQGTRPQWQTEPLPFHEFARKQR---SSAFNQTHLNYWLTKFAGVPWAQP 2153
             EL+ +Y+  +          P+ + +++  QR    S   Q  L+YW  +         
Sbjct: 1851 RELSALYEAFIDERDSPLAPLPVQYLDYSVWQRQWLESGERQRQLDYWTAQLGN------ 1904

Query: 2154 LFAADHPLSNSTG------VDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAIS 2207
                +HPL    G      V   +G      L       +      R  +LF  M A ++
Sbjct: 1905 ----EHPLLELPGDRPRPPVQSHQGELYRFDLSDDLAARVRAFNAERGLTLFMTMTATLA 1960

Query: 2208 ASVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKVQTVWQLIEQVKNSI 2267
              ++       L +G P + R+  E    +G F    V          V +L E V++++
Sbjct: 1961 VLLYRYSGQTDLRIGAPVANRIRPESEGLIGAFLNTQVLRCQLNGQMNVAELFEHVRHTV 2020

Query: 2268 NQSMPYTDIPIDLIEEGLKGVEHETEGHMFEVFIQLHAKNKLHGELLLTEGHAIRFQQVD 2327
             +   + D+P D + E L+         +F+V   +          L   G  + +   D
Sbjct: 2021 IEGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEFQQSRQL--AGMTVEYLAND 2078

Query: 2328 PDKSESGLGLQFEILEERI 2346
               ++  L L+   L+ R+
Sbjct: 2079 ARATKFDLNLEVTDLDHRL 2097



 Score = 73.6 bits (179), Expect = 7e-16
 Identities = 117/521 (22%), Positives = 201/521 (38%), Gaps = 65/521 (12%)

Query: 921  LSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASP 980
            LSY  L ++ + +   L+A     G+   +  P   +++        +G+I VP   A P
Sbjct: 41   LSYRDLDQRARTIAAALQANA-DLGDRAVLLFPSGPDYVAAFFGCLYAGVIAVP---AYP 96

Query: 981  KERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQ--- 1037
             E       +  A L+ +    E   ++   +L + +   +  P V  +D+L        
Sbjct: 97   PESTR---RHHQARLLSIISDAEPRLLLTIASLADGLSQLENAPPVLSVDRLEGAGNWVA 153

Query: 1038 ----SQQTAYYLYTSGTTGKPKCVVVN--NQATSNVIGQTGQAWHLTSEDVVMSVTPLHH 1091
                    A+  YTSG+T  PK V V+  N   + V+ + G    L  +DV++S  PL+H
Sbjct: 154  PDLHPDDIAFLQYTSGSTALPKGVQVSHGNLVANEVLIRRGFGIDLNPDDVIVSWLPLYH 213

Query: 1092 DMSVFD-LFATLSFGATLVLPA-GHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSCTQ 1149
            DM +   L   +  G   VL +  +     L+W   I  +  TI         +      
Sbjct: 214  DMGLIGGLLQPIFSGVPCVLMSPAYFLGRPLRWLEAISEYGGTISGGPDFAYRLCSERVS 273

Query: 1150 AGQLHSL-----RLIAQGGDYIKPATIAQLR-----AGSNPPRLISLGGPTETTIWSIWH 1199
               L  L     R+   G + I+  T+ +        G  P    +  G  E T++    
Sbjct: 274  ETALERLDLSRWRVAYSGSEPIRLDTLERFAEKFAACGFTPNHFFASYGLAEATLFVAGG 333

Query: 1200 ELTADDVSVIPYGRPLAGNR--------------------YFIMD-EIQRHVPQGVVGRI 1238
                   ++    + LA NR                      I D      +P   VG +
Sbjct: 334  SRGQGIAAMRVDDQALAANRAEPGQGSAIMSCGTRQPEHAVLIADPHTLAELPDNHVGEL 393

Query: 1239 FTSGVNLAQGYLEDGELKQTDFVTVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYV 1298
            + +G ++A GY  + E     FV    +H    R  RTGD G+ R DG +    R+   +
Sbjct: 394  WATGPSIAHGYWRNPEATAKTFV----QHAGR-RWLRTGDLGFIR-DGEVYITGRLKDLL 447

Query: 1299 KVRGVRVSLPDIEKQLQ-----THPALASVVVVDYADTNGDTALAALFSVKPQQSASSQA 1353
             VRG  +   DIE+ ++           +   V+     G   +AA  S   Q+  + +A
Sbjct: 448  IVRGHNLYPQDIEQTIEREVEVVRKGRVAAFAVNEQGLEG-IGIAAEISRSVQKILAPEA 506

Query: 1354 LREFAKQSLPSSH--IPSRFIALE--ALPLSANGKVDRKQC 1390
            L +  +Q++  ++   PS  + L   ALP +++GK+ R  C
Sbjct: 507  LIKAIRQAVAEAYQEAPSVVVLLNPGALPKTSSGKLQRAAC 547



 Score = 73.6 bits (179), Expect = 7e-16
 Identities = 77/313 (24%), Positives = 134/313 (42%), Gaps = 24/313 (7%)

Query: 1986 VNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVI---AASNIEHYQWFWTSKDNAAQS 2042
            ++ + F +A+  ++ RH  LR  F    G+    VI    ++ IE+  W    +D     
Sbjct: 3258 LDPERFAQAWQAVIARHEALRASFCWNVGEDMLQVIHTPGSTPIEYLDWSDDPEDQQEPR 3317

Query: 2043 VARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQ--YLSLLFHHIVLDEWSINILMDELA 2100
            +  LL QE E  FDL  + P  L  +R    G +  +  +  HHI++D W  ++LM++  
Sbjct: 3318 LQALLKQEREAGFDLLNQAPFHLRLIR---VGAERYWFMMSNHHILIDAWCRSLLMNDFF 3374

Query: 2101 QVYQHSVQGTRPQWQTEPLPFHEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPL-----F 2155
            ++Y    +G   Q  T P      A  QR +  N+    +W     G     P+     F
Sbjct: 3375 ELYMALGEGRDAQLATPPRYRDYIAWLQRQN-LNEAR-QWWQQNLQGFERTTPIPSDRPF 3432

Query: 2156 AADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHCLGA 2215
              +H   +S G+ +G+      +L       L +LA+A   ++     AA +  +  L  
Sbjct: 3433 LREH-AGHSGGMVVGD---CYTRLDARDGAQLRELAQAHQLTVNTFAQAAWALVLRRLSG 3488

Query: 2216 PEKLLVGTPASGR--LDAEFFDTVGYF---TTMGVQLVDFTKVQTVWQLIEQVKNSINQS 2270
               +L G   +GR     E   TVG F     + V+L +  +  +V Q + ++ +S  Q 
Sbjct: 3489 DRDVLFGVTVAGRPVEMPEMQRTVGLFINSIALRVKLPEDGQACSVRQWLSELLDSNMQL 3548

Query: 2271 MPYTDIPIDLIEE 2283
              Y  +P+  I+E
Sbjct: 3549 REYEYLPLVTIQE 3561



 Score = 67.8 bits (164), Expect = 4e-14
 Identities = 109/448 (24%), Positives = 178/448 (39%), Gaps = 52/448 (11%)

Query: 37   LNRQALTEAVRALYAKHPMLRLAI-TKDGQ--QKILPLSTFHQLKVDDLSQWKPDEVESF 93
            L+  A+  + + L  +H  LR     +DGQ  Q++   + F  L+V DLS     E E+ 
Sbjct: 701  LDEDAVRTSFQQLIQRHEALRTRFYERDGQAFQRVDTKADF-DLQVIDLSDLPVAEREAR 759

Query: 94   VHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLY 153
                R+       DL +G  + ++L  L +  H+L +    I  D  S  +L+D+ + LY
Sbjct: 760  AQQIREDEARTQFDLEKGPLLWVTLVRLDDEDHQLLVTLHHIIADGWSLNILMDEFSRLY 819

Query: 154  LEAIE-HRLEIIESDVVTFFQYLDAQQADRALAKRKEVDKKWWQERLATIPAEPSLPYQP 212
              A++   LE+           L  Q AD    +R+ + +   Q +LA   A+     + 
Sbjct: 820  AAAVQGQTLEL---------PPLALQYADYGTWQRQWLAEGEGQRQLAYWKAQLG---EE 867

Query: 213  VPTDAVSANSQRFAHWFTPVER----------KGLAEVARQHHLTLTQLTLALFSQVIAN 262
             PT +++ +  R  H      R          + + + AR H  T   L LA F  V+  
Sbjct: 868  HPTLSLATDHPRSVHHRHSASRHTVRLGASLSEAIRQTARTHESTPFMLLLAAFQSVLYR 927

Query: 263  ACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADVG---TTQTLLSLCQQTA--N 317
               +R  R+ VP  +R  +  + +  +G F N L+  A++        LL+  +Q A   
Sbjct: 928  YSGQRDIRIGVPNANRPRQ--ETQGLVGFFINTLVLRAELDGRLPFTELLAATRQAALGA 985

Query: 318  QLHQLLRHESYSGVSVMRDLSRKQGGVQRSPIVFTSGMEMRDEEIFSDHVTQHLGRMNWV 377
            Q HQ L  E           +R+QG  Q   ++F    + RD              + W 
Sbjct: 986  QAHQDLPFEQLLEAFPQ---AREQGLFQ---VMFNH--QQRDLSALRRLPGMLADELPW- 1036

Query: 378  ISQGAQVTLDAQIAPAYEGIL-LNWDVRMENFADKDITALFAHYVDLIRCVALHPEMM-- 434
             S+ A+  L         G L L++D   E F    I  L  HY++L+  +   P     
Sbjct: 1037 HSREAKFDLQLHTEEDRNGRLSLSFDYADELFESATIQRLAEHYINLLHAICEQPRQAIG 1096

Query: 435  QQSVQQIDAQLGYARRESIQEMPLTPLQ 462
               + Q D Q  Y+      E P  P Q
Sbjct: 1097 DLMLMQHDEQALYS------EAPCAPAQ 1118



 Score = 64.7 bits (156), Expect = 3e-13
 Identities = 100/474 (21%), Positives = 184/474 (38%), Gaps = 61/474 (12%)

Query: 1785 LVLELALDATVSPHVGAYLLEQFVAAIGGRTMPSSTTSSSHVSAIELTSNNPPTSNNAHA 1844
            + L  AL A +  H+  Y++   +  +   +MP +        A+       P +N  H 
Sbjct: 2619 VALRDALKAHLKAHLPDYMVPAHLIVLD--SMPLTANGKLDRRALPQPD---PEANRQHY 2673

Query: 1845 ALAESELELSAVNSSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSE 1904
                +ELE +          + A + + L V ++  +D+FF+ GG S+++ +V+ R   +
Sbjct: 2674 VAPRNELEST----------LAAIWCAVLNVQQVGLDDNFFELGGDSILSIQVVSRA-RQ 2722

Query: 1905 QGIELHINDMFSFPNAKQLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSK 1964
             GI     D+F     + LA  A    + T+      + + +  + L+  Q   +   + 
Sbjct: 2723 AGIHFSPRDLFQHQTVQTLAAVATRSEQVTA-----EQGLLTGSSGLTPIQHWFFDTETP 2777

Query: 1965 YAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQ--------P 2016
              +      +N    LK L  ++ Q   +A   +L  H  LR  F   D Q        P
Sbjct: 2778 NRQH-----WNQALVLKPLQLLDPQRLEQALLAVLEHHDALRLSFSKRDAQWHAEHRAVP 2832

Query: 2017 YQHVIAASNIEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQ 2076
               V+  + +           + A   A  L  + + + DL     LR   V D   G Q
Sbjct: 2833 QGGVLMQAQVR----------DMAHCTA--LFTDTQRSLDLEHGPLLRALLV-DGPEGQQ 2879

Query: 2077 YLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQRSSAFNQT 2136
             L +  HH+V+D  S  +L+++L  VY+    G       +     ++A + ++ A +++
Sbjct: 2880 RLLIAIHHLVVDGVSWRVLLEDLQTVYRQLNDGQSVSLPAKTSALRDWAARLQAYAGSES 2939

Query: 2137 ---HLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKA 2193
                L+ W  + AG   A P+      L N       +   V ++L       L Q A +
Sbjct: 2940 LREELSVWQHQLAGPDAALPVARPQGSLRNR------DADTVSVRLDAEHTRQLLQQAPS 2993

Query: 2194 RHASLFNVMYAAISASVHCLGAPEK-LLVGTPASGRL----DAEFFDTVGYFTT 2242
             + +  N +     A V C  +     L+     GR     D +   +VG+FT+
Sbjct: 2994 AYRTQVNDLLLTALARVLCRWSGHACALIQLEGHGRETLFDDIDLTRSVGWFTS 3047



 Score = 40.4 bits (93), Expect = 7e-06
 Identities = 37/125 (29%), Positives = 58/125 (46%), Gaps = 16/125 (12%)

Query: 35   QALNRQALTEAVRALYAKHPMLRLAITKDGQQ-----KILPLS-TFHQLKVDDLSQWKPD 88
            Q L+ Q L +A+ A+   H  LRL+ +K   Q     + +P      Q +V D++     
Sbjct: 2792 QLLDPQRLEQALLAVLEHHDALRLSFSKRDAQWHAEHRAVPQGGVLMQAQVRDMAHC--- 2848

Query: 89   EVESFVHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDD 148
                F  T+R       LDL  G  +   L   PEG+ RL I    +  D  S+R+L++D
Sbjct: 2849 -TALFTDTQRS------LDLEHGPLLRALLVDGPEGQQRLLIAIHHLVVDGVSWRVLLED 2901

Query: 149  LTSLY 153
            L ++Y
Sbjct: 2902 LQTVY 2906



 Score = 39.7 bits (91), Expect = 1e-05
 Identities = 19/65 (29%), Positives = 35/65 (53%)

Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
            +E  + A +   L V  +  +D+FF+ GGHSL+AT++  R+      ++ +  MF     
Sbjct: 4201 LEATLAAIWAEVLKVERVGVQDNFFELGGHSLLATQIASRVQKTLQRDVPLRAMFECSTV 4260

Query: 1921 KQLAQ 1925
             +LA+
Sbjct: 4261 AELAE 4265