Pairwise Alignments
Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056
Subject, 2139 a.a., peptide synthetase from Pseudomonas simiae WCS417
Score = 302 bits (774), Expect = 4e-85
Identities = 277/1003 (27%), Positives = 454/1003 (45%), Gaps = 79/1003 (7%)
Query: 413 ITALFAHYVDLIRCVALHPEMMQQSVQQIDAQLGYARRESIQEMPLTPLQQAYLLGRSTQ 472
I +FA V C LH ++ +S + I A L A+R + P+T +QQAY LGR
Sbjct: 1085 IAQVFAKPVLAQFCTTLHQQVRAESARTIVADL--AQRHA--SFPMTEVQQAYWLGRDPS 1140
Query: 473 IALGGVAMHEFREYRGH-IDTQSLHSRLLYLVEHIPALRTRID---QEKWIQWVSPCIAL 528
+ LGGV+ H +REY +D L L L+E LR D Q + +Q V P +
Sbjct: 1141 LVLGGVSCHFYREYDVEDLDLPRLQRALQRLIERHEMLRAVFDHSGQARILQQV-PAFVI 1199
Query: 529 NWQAIDLQHLSREQALLAVEPVRQQYQQRMHDLTRSPWQICVVQLPIEEQEEFSSIVLTS 588
Q +++ +R+ R+ D + W + VQ + +I S
Sbjct: 1200 G------------QGHASLDDLREHCAHRVFDPHQ--WPLFDVQAVTHGRHTRLAI---S 1242
Query: 589 FDALIVDGRTHALILAALLGS-EEPD--ITQVVQNARDTQSISPQFASKKAQDEAYWKSK 645
D LI+D + A L EPD + + + RD Q ++ + +W+ +
Sbjct: 1243 LDNLILDALSILRFYAELDALYREPDMALAPLALSFRDYQLQCAAAPAELQAAQRFWQER 1302
Query: 646 LHPDCPP-PALPWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATIL 704
L P PP P LP ++ R+ R QI + + + GL +++L
Sbjct: 1303 L-PQLPPHPQLPLAADPASLGRPRFERLQGQIDASAWQAILAKAQQQGLTASAVLLCAFA 1361
Query: 705 DVLSYWTTEIGMRVGFPV-----LIPSSNAIDGNESSFVILEHEK-STLSLLSQASKLQR 758
+ L W+ + + + L P + I G+ +S +L + + + +A + Q+
Sbjct: 1362 ETLGRWSARPDLSLNLTLFDRRPLHPQVDQIMGDFTSLTLLGYVPVAGERWVDRARRTQQ 1421
Query: 759 EMLEALEHLAFSGVDLNR-LLMNQAPQALVLPVVLTNGLSWK--TLNPED---AVTLFDG 812
+ EALEH V L R L Q + +PVV T+ L T P D A +F G
Sbjct: 1422 SLGEALEHRCVGSVSLLRQLARGNGEQQVSMPVVFTSALGVPNGTAAPVDGPFARQVF-G 1480
Query: 813 VTQTPQVALDIRLTYDEQKNLIISFDYALAVLETELIREMLSALHHRLSQITSSASLAAP 872
+TQTPQV LD ++ + + +++D + + L+ M +A H L+ + A +AP
Sbjct: 1481 LTQTPQVWLDHQVV-EANGGIALNWDRVVGLFPEGLVETMFAAYLHSLNWLAEHAWDSAP 1539
Query: 873 LEPCIDLSHYRFNSDESASHDCDFLAKLAQQLFVR---TEDKTAVICGEQ-TLSYAQLGE 928
+ R + L Q F + T A++ GE TL Y +L +
Sbjct: 1540 PDLLPQAQAQRRAQLNAPGDRVPGDPTLHQGFFEQARQTPQSPALLWGEHGTLKYGELAD 1599
Query: 929 QVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLL 988
+ R+ L G+ G+++A+ L + + + L +G ++P+ P +R +L
Sbjct: 1600 RALRIAHSLMDAGVAPGDLVAVSLAKGPQQVACVLGILAAGAAYLPVGVDQPLQRCQRIL 1659
Query: 989 ENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTS 1048
+ L++ + + V + L A+ + PL + + AY +YTS
Sbjct: 1660 QQAGVTLMLAEHDPQLPGVKHLNP--SSALKAEPLAAPRPL-------AAGELAYVIYTS 1710
Query: 1049 GTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATL 1108
G+TG+PK V + ++A N + + + + + D ++++ L D+SV+DLF LS G L
Sbjct: 1711 GSTGQPKGVEITHRAAMNTVADINRRYDVQATDRGLALSALDFDLSVYDLFGLLSVGGAL 1770
Query: 1109 VLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSC-TQAGQLHSLRLIAQGGDYIK 1167
VL + +DA W + +++H+VT+W SVPA+L+MLL Q Q L++ GD+I
Sbjct: 1771 VLIDEDQRRDARAWLKALQQHRVTLWNSVPALLDMLLEANAQDRQRLDLKVALLSGDWIG 1830
Query: 1168 PATIAQLRAGSNPPRLISLGGPTETTIWSIWHEL--TADDVSVIPYGRPLAGNRYFIMDE 1225
+L+ + R I+LGG TE IWS E+ IPYG PL Y ++D
Sbjct: 1831 LDLPQRLQDQAPSCRFIALGGATEAAIWSNHFEVQPPLPGWRSIPYGVPLTNQAYRVVDA 1890
Query: 1226 IQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVLDEHGHPVRAFRTGDQGYYRAD 1285
+ R P V G ++ G +A+GY +L FV +RTGD G Y D
Sbjct: 1891 LGRDCPDWVTGELWIGGAGVARGYRHAPQLNAERFVD---------GWYRTGDLGRYHPD 1941
Query: 1286 GNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKP 1345
G + F R + VK+ G R+ L +IE L HP + S V + D A+ A
Sbjct: 1942 GLLEFLGRADSQVKIGGHRIELGEIEAALARHPCVNSAVAL-VVDNRLMAAVTA------ 1994
Query: 1346 QQSASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRK 1388
S ++ L + +Q LP+ P + + LE LPL++NGKVDR+
Sbjct: 1995 --STCAEVLAQHLEQCLPAYMRPEQVLVLERLPLNSNGKVDRR 2035
Score = 266 bits (681), Expect = 2e-74
Identities = 269/1012 (26%), Positives = 434/1012 (42%), Gaps = 99/1012 (9%)
Query: 458 LTPLQQAYLLGRSTQIALGGVAMHEFREYRGH-IDTQSLHSRLLYLVEHIPALRTRI--D 514
L P+Q AY +GR+ LGGVA H + E+ G +D L + + L+ P LR + D
Sbjct: 97 LAPMQHAYWIGRAPGQQLGGVAAHFYNEFDGQDVDPIRLEAAVRALLARHPMLRAQFLDD 156
Query: 515 QEKWIQWVSPCIALNWQAIDLQHLSREQALLAVEPVRQQYQQRMHDLTRSPWQICVVQLP 574
+ I SP L DL+ S EQ + +R + R L Q+ +QL
Sbjct: 157 GRQQILAHSPWPGLTVH--DLRQASAEQVQQRLAALRAELSHRQ--LAVEQGQVLDIQLS 212
Query: 575 IEEQEEFSSIVLTSFDALIVDGRTHALILAALLGS------EEP------DITQVVQNAR 622
+ + + + D L D AL L LLG + P + + + + R
Sbjct: 213 LLPN---GTRLHLNLDMLAAD----ALSLRTLLGDLVQLYRQHPLPALDYNFARYLADLR 265
Query: 623 DTQSISPQFASKKAQDEAYWKSKLHPDCPPPALPWKQALETITTSRYARESLQIPKESVG 682
Q+ + Q + Q YW +L P+LP K + + R +P
Sbjct: 266 QEQNSAEQ-RDRHQQARDYWLQRLDQLPGAPSLPIKPQGDD---RQVCRRHHWLPPSERQ 321
Query: 683 KLNRCGIENGLFLNSLLTATILDVLSYWTTEIGMRVGFPVL--IPSSNAID---GNESSF 737
R E+GL L A + L W + + P+ P +D G+ +S
Sbjct: 322 AFERQAREHGLTPAMALAAVFCEALGAWCDTPELLLNLPLFNRTPLHADVDRLVGDFTSS 381
Query: 738 VILEHEKSTL-SLLSQASKLQREMLEALEHLAFSGVDLNRLLMNQAPQALVLPVVLTNGL 796
++L + + ++A+ LQR + H AFSG+++ R L Q + ++ PVV T+ L
Sbjct: 382 ILLAWDGRVAGTFAARATALQRRFHSDVAHSAFSGLEVLRELSRQRGEQVLAPVVYTSAL 441
Query: 797 SWKTLNPEDAVTLFDG----VTQTPQVALDIRLTYDEQKNLIISFDYALAVLETELIREM 852
L E F ++Q PQV LD ++T + ++++ D + ++ M
Sbjct: 442 GLGELFAEGVQASFGQPAWIISQGPQVWLDAQVT-ELDGGILVNLDAREGLFAGGVLDGM 500
Query: 853 LSA---LHHRLSQITSSASLAAP-LEPCIDLSHYRFNSDESASHDCDFLAKLAQQLFVR- 907
A L RL +S A P L P L+ + + + + +L + F +
Sbjct: 501 FKAYTDLLQRLCFDPASWHQAPPALVPAAQLAVRQAVQGQRVALP---VKRLHEAFFAQA 557
Query: 908 --TEDKTAVICGEQ-TLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLA 964
T A++ G +SY +L E+ ++ L+ +G+ G+V+A+ LP+ E ++ L
Sbjct: 558 RLTPTLPALLQGNPPVISYGELAERALQLAAYLEDQGIRRGDVVALQLPKGPEQVIAVLG 617
Query: 965 SALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVP 1024
++PI P+ R + + A L++ P E
Sbjct: 618 ILACSATYLPIGIDQPEARCQKICDGSGARLLLKALPSE--------------------- 656
Query: 1025 DVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVM 1084
P + R AY LYTSG+TG PK V +++ A +N + + LT++D ++
Sbjct: 657 --GPALEAPRPGAISDLAYILYTSGSTGDPKGVEISHLAAANTLDDLQRRLQLTADDRIL 714
Query: 1085 SVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEML 1144
+++ L D+SVFDLFA LS GA ++ ++DAL+W L H ++ VPA+L+ML
Sbjct: 715 ALSALEFDLSVFDLFAALSTGAAVIGIEPEAQRDALRWRELALLHHASVLNCVPALLDML 774
Query: 1145 LSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETTIWSIWHELTAD 1204
L C A LR + GGD + P +L A + R ++LGG TE I S E
Sbjct: 775 LGCAAADARLPLRAVLLGGDKVAPDLAPRLWAQAPGCRFMALGGATEAAIHSTLFEAFPG 834
Query: 1205 DV---SVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFV 1261
+PYG+PL I+D P V G ++ G +A+GY D FV
Sbjct: 835 QPLQWHCLPYGKPLDNVSLRIVDHQGHDCPDWVAGELWIGGAGVAEGYRGDRVRSAERFV 894
Query: 1262 TVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALA 1321
D G R +RTGD+ Y DGN+ F R + +K+ G R+ ++E+ L P +
Sbjct: 895 ---DYQGQ--RWYRTGDRARYHPDGNVEFLGRTDFQLKLHGYRIEAGEVEQALLACPGVE 949
Query: 1322 SVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIPSRFIALEALPLSA 1381
VV+ G A + + L A++ LP+ IP+ + LPL+
Sbjct: 950 HAVVL----LAGQQLAAVVRQAHGPAQPAPIDLPGLAER-LPAYMIPTFILGCAQLPLTG 1004
Query: 1382 NGKVDRKQCQAHVQRQSISVEPVGQPNQSQPLSPPTLSSASLSEFEQRVWRQ 1433
NGKVDRK A + + S P Q L+PP + + R W+Q
Sbjct: 1005 NGKVDRKALHAWLAQHS--------PAQQANLTPP---CGDIEQQVARAWQQ 1045
Score = 266 bits (680), Expect = 3e-74
Identities = 159/467 (34%), Positives = 246/467 (52%), Gaps = 13/467 (2%)
Query: 3 EMTAMQAAYWLGRQHDCLLDGVAAHLYAEFDGQALNRQALTEAVRALYAKHPMLRLAITK 62
E+ MQ AYW+GR L GVAAH Y EFDGQ ++ L AVRAL A+HPMLR
Sbjct: 96 ELAPMQHAYWIGRAPGQQLGGVAAHFYNEFDGQDVDPIRLEAAVRALLARHPMLRAQFLD 155
Query: 63 DGQQKILPLSTFHQLKVDDLSQWKPDEVESFVHTKRQRMTHQMLDLTQGNPIEISLTLLP 122
DG+Q+IL S + L V DL Q ++V+ + R ++H+ L + QG ++I L+LLP
Sbjct: 156 DGRQQILAHSPWPGLTVHDLRQASAEQVQQRLAALRAELSHRQLAVEQGQVLDIQLSLLP 215
Query: 123 EGKHRLHIDADMIACDAQSFRLLVDDLTSLYLEAIEHRLEIIESDVVTFFQYLDAQQADR 182
G RLH++ DM+A DA S R L+ DL LY +H L ++ + + L +Q
Sbjct: 216 NGT-RLHLNLDMLAADALSLRTLLGDLVQLYR---QHPLPALDYNFARYLADLRQEQNSA 271
Query: 183 ALAKRKEVDKKWWQERLATIPAEPSLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEVAR 242
R + + +W +RL +P PSLP +P D R HW P ER+ AR
Sbjct: 272 EQRDRHQQARDYWLQRLDQLPGAPSLPIKPQGDDRQVC---RRHHWLPPSERQAFERQAR 328
Query: 243 QHHLTLTQLTLALFSQVIANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADV 302
+H LT A+F + + C + LN+P F+R D++ +GDF++ ++ + D
Sbjct: 329 EHGLTPAMALAAVFCEALGAWCDTPELLLNLPLFNRTPLHADVDRLVGDFTSSILLAWDG 388
Query: 303 GTTQTLLSLCQQTANQLHQLLRHESYSGVSVMRDLSRKQGGVQRSPIVFTSGMEMRDEEI 362
T + + H + H ++SG+ V+R+LSR++G +P+V+TS + + E+
Sbjct: 389 RVAGTFAARATALQRRFHSDVAHSAFSGLEVLRELSRQRGEQVLAPVVYTSALGL--GEL 446
Query: 363 FSDHVTQHLGRMNWVISQGAQVTLDAQIAPAYEGILLNWDVRMENFADKDITALFAHYVD 422
F++ V G+ W+ISQG QV LDAQ+ GIL+N D R FA + +F Y D
Sbjct: 447 FAEGVQASFGQPAWIISQGPQVWLDAQVTELDGGILVNLDAREGLFAGGVLDGMFKAYTD 506
Query: 423 LIRCVALHPEMMQQSVQQIDAQLGYARRESIQ----EMPLTPLQQAY 465
L++ + P Q+ + A R+++Q +P+ L +A+
Sbjct: 507 LLQRLCFDPASWHQAPPALVPAAQLAVRQAVQGQRVALPVKRLHEAF 553
Score = 144 bits (364), Expect = 1e-37
Identities = 123/455 (27%), Positives = 198/455 (43%), Gaps = 39/455 (8%)
Query: 4 MTAMQAAYWLGRQHDCLLDGVAAHLYAEFDGQALNRQALTEAVRALYAKHPMLRLAITKD 63
MT +Q AYWLGR +L GV+ H Y E+D + L+ L A++ L +H MLR
Sbjct: 1126 MTEVQQAYWLGRDPSLVLGGVSCHFYREYDVEDLDLPRLQRALQRLIERHEMLRAVFDHS 1185
Query: 64 GQQKIL---PLSTFHQ--LKVDDLSQWKPDEVESFVHTKRQRMTHQMLDLTQGNPIEISL 118
GQ +IL P Q +DDL R+ H++ D Q ++
Sbjct: 1186 GQARILQQVPAFVIGQGHASLDDL---------------REHCAHRVFDPHQWPLFDVQA 1230
Query: 119 TLLPEGKH-RLHIDADMIACDAQSFRLLVDDLTSLYLEAIEHRLEIIESDVVTFFQYLDA 177
+ G+H RL I D + DA S +L +LY E ++ + + F+ D
Sbjct: 1231 --VTHGRHTRLAISLDNLILDALSILRFYAELDALYREP-----DMALAPLALSFR--DY 1281
Query: 178 QQADRALAKRKEVDKKWWQERLATIPAEPSLPYQPVPTDAVSANSQRFAHWFTPVERKGL 237
Q A + +++WQERL +P P LP P +R + +
Sbjct: 1282 QLQCAAAPAELQAAQRFWQERLPQLPPHPQLPLAADPASLGRPRFERLQGQIDASAWQAI 1341
Query: 238 AEVARQHHLTLTQLTLALFSQVIANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLI 297
A+Q LT + + L F++ + LN+ F R ++ +GDF++L +
Sbjct: 1342 LAKAQQQGLTASAVLLCAFAETLGRWSARPDLSLNLTLFDRRPLHPQVDQIMGDFTSLTL 1401
Query: 298 FSADVGTTQTLLSLCQQTANQLHQLLRHESYSGVSVMRDLSRKQGGVQRS-PIVFTSGME 356
+ + ++T L + L H VS++R L+R G Q S P+VFTS +
Sbjct: 1402 LGYVPVAGERWVDRARRTQQSLGEALEHRCVGSVSLLRQLARGNGEQQVSMPVVFTSALG 1461
Query: 357 MRDEEIFSDHVTQHLGRMNWVISQGAQVTLDAQIAPAYEGILLNWDVRMENFADKDITAL 416
+ + + V R + ++Q QV LD Q+ A GI LNWD + F + + +
Sbjct: 1462 VPNGT--AAPVDGPFARQVFGLTQTPQVWLDHQVVEANGGIALNWDRVVGLFPEGLVETM 1519
Query: 417 FAHYVDLIRCVALH------PEMMQQSVQQIDAQL 445
FA Y+ + +A H P+++ Q+ Q AQL
Sbjct: 1520 FAAYLHSLNWLAEHAWDSAPPDLLPQAQAQRRAQL 1554
Score = 49.3 bits (116), Expect = 7e-09
Identities = 32/90 (35%), Positives = 47/90 (52%), Gaps = 2/90 (2%)
Query: 1845 ALAESELELSAVNSSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSE 1904
A A+S + L SA E I ++ L V ++ D+FF GG SL+ATR + L S
Sbjct: 2043 AAAQSRVALDEQPLSAGEHVIAELWQHLLKVPNVSRHDNFFRLGGDSLLATRFLEMLRSR 2102
Query: 1905 QGIELHINDMFSFPNAKQLAQQAVLHRKPT 1934
G+EL + +F + ++AQ L R PT
Sbjct: 2103 LGVELPMGQLFGAASLLEVAQ--TLERLPT 2130
Score = 41.6 bits (96), Expect = 1e-06
Identities = 36/136 (26%), Positives = 62/136 (45%), Gaps = 6/136 (4%)
Query: 1829 IELTSNNPPTSNNAHAALAESELELSAVNSSA---VEECILAEFRSALGVAEMTAEDDFF 1885
+ LT N HA LA+ A + +E+ + ++ LG +E+ E +FF
Sbjct: 1000 LPLTGNGKVDRKALHAWLAQHSPAQQANLTPPCGDIEQQVARAWQQLLGCSEVCREHNFF 1059
Query: 1886 DFGGHSLIATRVIGRLLSEQGI-ELHINDMFSFPNAKQLAQQAVLHRKPTSTSFAVSEVV 1944
GG SL ATR++ RLL+E G+ I +F+ P Q + S V+++
Sbjct: 1060 ALGGDSLSATRLV-RLLAEHGLGGARIAQVFAKPVLAQFCTTLHQQVRAESARTIVADLA 1118
Query: 1945 E-SSKAPLSLAQASLW 1959
+ + P++ Q + W
Sbjct: 1119 QRHASFPMTEVQQAYW 1134