Pairwise Alignments
Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056
Subject, 3949 a.a., peptide synthase from Pseudomonas simiae WCS417
Score = 246 bits (628), Expect = 6e-68
Identities = 340/1443 (23%), Positives = 582/1443 (40%), Gaps = 160/1443 (11%)
Query: 35 QALNRQALTEAVRALYAKHPMLRLAITKDGQQKILPLSTFHQLKVDD-LSQWKPDEVESF 93
QAL L A++AL H LR+ + Q + + L Q + VE
Sbjct: 2201 QALQAPLLVAALQALIVHHDALRIGFVQGAAGWSAAYRGPQQHQAEQVLWQTTLNAVEEL 2260
Query: 94 VHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLY 153
+ + LDL++G + L L +G RL + + D S+R+L++DL + Y
Sbjct: 2261 EALGEE--AQRSLDLSEGPLLRAVLVDLADGSQRLLLVIHHLVVDGVSWRILLEDLQTAY 2318
Query: 154 LEAIEHRLEIIESDVVTFFQYLDAQQA-DRALAKRKEVDKKWWQERLATIPAEPSLPYQP 212
+ + ++ + + + QA R+ A +E+ WWQ +L P LP
Sbjct: 2319 RQVAQGAKVVLPAKTSAIRAWAERLQAYARSAALAQEL--AWWQTQLQGSPT--GLP--- 2371
Query: 213 VPTDAVSANSQRFA-----HWFTPVERKGLAEVARQHHLTLTQLTLALFSQVIANACQER 267
D ++ S R A H R+ L + + + L L ++V+ +
Sbjct: 2372 -GADPQASLSNRHALSVTTHLDQVFTRRLLQDAPSAYRTQINDLLLTALARVVVRWTGDA 2430
Query: 268 QFRLNVPTFHRGNR--SLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQTANQLHQLLRH 325
+ + R + +D+ T+G F++L + + T +L +Q QL +
Sbjct: 2431 SMLIRLEGHGREDLFDEIDLTRTVGWFTSL--YPVKLVPTDSLAGSLKQIKEQLRAI--P 2486
Query: 326 ESYSGVSVMRDLSRKQGGVQRSPIV-----------FTSGMEMRDEE-IFSDHVTQHLGR 373
+ G +R L + S + F + ++E +F
Sbjct: 2487 DKGLGFGALRYLGNAEAQQALSELPRPRITFNYLGQFDGSFDGGEQEGLFVPSGDGSGAE 2546
Query: 374 MNWVISQGAQVTLDAQIAPAYEGIL-LNWDVRMENFADKDITALFAHYVDLIRCVALHPE 432
+ G + ++ Q+ Y G L LNW + F + + L Y ++ + H
Sbjct: 2547 QSGEAPLGNWLEINGQV---YAGELKLNWSFSQQMFDEATVQRLADDYAAELKALIEHCG 2603
Query: 433 MMQQSVQQID---AQLGYARRESI--------QEMPLTPLQQAYLLG-----------RS 470
+ Q V D A+L A+ +S+ PL+P+QQ L
Sbjct: 2604 V-NQGVTPSDFPLARLSQAQLDSLPVTVADIEDVYPLSPMQQGMLFQSLYGEGSGDYINQ 2662
Query: 471 TQIALGGVAMHEFRE-YRGHIDTQS-LHSRLLYLVEHIPALRTRIDQEKWIQWVSPCIAL 528
+I + G+ + FR+ ++ +D+ L S L+ E L+ Q + P L
Sbjct: 2663 MRIDVEGLDVPRFRQAWQAAVDSHEILRSGFLWQTEFEQPLQVVYKQMRM-----PFAEL 2717
Query: 529 NWQAIDLQHLSREQALLAVEPVRQQYQQRMHDLTRSPWQICVVQLPIEEQEEFSSIVLTS 588
+WQ R + A++ + + + + L ++P ++ L + ++ +
Sbjct: 2718 DWQG-------RPDSSAALDSLAESARAQGFVLEQAP----LLSLTVVRTGASRYHLIYT 2766
Query: 589 FDALIVDGRTHALILAALLG--SEEPDITQVVQNARDTQSISPQFASKKAQDEAYWKSKL 646
+++DG + + + +L + EP + + RD I+ A K+ EA+WK++L
Sbjct: 2767 NHHILMDGWSGSQLFGEVLQHYAGEP-LRAPIGRYRDY--IAWLQAQDKSVSEAFWKAQL 2823
Query: 647 HPDCPPPALP-WKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILD 705
P L QA ++ + L + +L + + LN+L+ + L
Sbjct: 2824 LNLQEPTRLARGLQAAQSEALAVNGEHRLNLDASQTAQLKAFAQRHKVTLNTLVQSAWLL 2883
Query: 706 VLSYWTTEIGMRVGFPVL--------IPSSNAIDGNESSFVILEHEKSTLSLLSQASKLQ 757
+L + T + + G V I + N V + T+S Q + Q
Sbjct: 2884 LLQHHTGQATVAFGATVAGRPAQLRGIEQQVGLFINTLPVVATPDAQMTVSQWLQQIQAQ 2943
Query: 758 REMLEALEH---------------------LAFSGVDLNRLLMNQAPQALVLPVVLTNGL 796
L EH L F ++ L AP L T G
Sbjct: 2944 NVRLREQEHTPLFEIQRWAGLGGEALFDSILVFENYPVSEALEQGAPSGL------TFGA 2997
Query: 797 SWKTLNPEDAVTLFDGVTQTPQVALDIRLTYDEQKNLIISFDYALAVLETELIREMLSAL 856
+T+ G+ T L + YD +F A E +++L AL
Sbjct: 2998 VHSLEQTHYPLTVLLGIGDT----LGMEFNYDRH-----AFSAAHIEQLAEHFQQLLQAL 3048
Query: 857 HHRLSQITSSASLAAPLEPCIDLSHYRFNSDESASHDCDFLAKLAQQLFVRTEDKTAVIC 916
+Q ++ A E L + + + H + +L + VRT D A++
Sbjct: 3049 AVDGAQRLATLPSLASTERETVLHAWNATAADYPLHLA--VHQLIEAQVVRTPDAPALVF 3106
Query: 917 GEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPID 976
Q LSYA L + R+ +L A G+ ++ + + RS+E +V LA +G +VP+D
Sbjct: 3107 AGQVLSYAALNRRANRLAHRLIAAGVGPDVLVGLAVERSIEMVVGLLAVLKAGGAYVPLD 3166
Query: 977 AASPKERLNYLLENCHADLVVMDK--------PCEFGNVIAFDALIEPVLFADGVPDVTP 1028
P++RL Y+L++ L++ P +++ +A+ P VT
Sbjct: 3167 PEYPRDRLAYMLQDSDVKLLLTQAHLLEQLPIPTGLHSLVLEQGDEWLQAYAEQNPLVTV 3226
Query: 1029 LDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTP 1088
+ AY +YTSG+TG+PK + A +N + A+ L D V+ TP
Sbjct: 3227 --------DGENLAYVIYTSGSTGQPKGAGNRHSALTNRLCWMQHAYGLEGSDTVLQKTP 3278
Query: 1089 LHHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSCT 1148
D+SV++ F L GA LV+ A + +D + LI VT VP++L+ L
Sbjct: 3279 FSFDVSVWEFFWPLMTGARLVVAAPGDHRDPARLVSLINAEHVTTLHFVPSMLQAFLQDA 3338
Query: 1149 QAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETTIWSIWHELTADD-VS 1207
G HSL+ I G+ + Q+ A L +L GPTE I + H D+
Sbjct: 3339 GVGACHSLQRIVCSGEALPVDAQQQVFAKLPHAGLYNLYGPTEAAI-DVTHWTCVDEGRD 3397
Query: 1208 VIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVLDEH 1267
+P GRP+A +++D P GV+G ++ GV LA+GY L FVT D
Sbjct: 3398 AVPIGRPIANLGCYVLDGNLEPAPVGVLGELYLGGVGLARGYHRRPALTAERFVT--DPF 3455
Query: 1268 GHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPAL--ASVVV 1325
G R +RTGD YR DG I +A RI+ VK+RG+R+ L +IE +L H + A+V+
Sbjct: 3456 GSGSRLYRTGDLARYRDDGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHACVREAAVLA 3515
Query: 1326 VDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKV 1385
VD G L A P + +Q A Q LP +P++++ L +PLS NGK+
Sbjct: 3516 VDGTHLVGYLVLQA-----PSEDWKAQVAMHLAAQ-LPDYMVPAQWVVLTQMPLSPNGKL 3569
Query: 1386 DRK 1388
DRK
Sbjct: 3570 DRK 3572
Score = 204 bits (519), Expect = 2e-55
Identities = 212/811 (26%), Positives = 342/811 (42%), Gaps = 85/811 (10%)
Query: 632 ASKKAQDEAYWKSKLHPDCPPPALPWKQALETITTSRYARESLQIPKESVGKLNRCGIEN 691
A +KA+ AYW+ L + ALP+ + + R AR + ++P L +
Sbjct: 1288 AGEKARQLAYWRDMLGGEQSVLALPFDHPRPAVQSHRGARLAFELPGALTQGLKALAKQQ 1347
Query: 692 GLFLNSLLTATILDVLSYWTTEIGMRVGFPVLIPSSNAIDGNESSFVILEHEKSTL---- 747
+ L LL A+ +L ++ + +RVG P+ + + + FV + K+ L
Sbjct: 1348 DVTLFMLLLASFQTLLHRYSGQEEIRVGVPIANRNRSETERLIGFFVNTQVLKADLHGQM 1407
Query: 748 ---SLLSQASKLQ-----------REMLEALE-HLAFSGVDLNRLLMN------QAPQAL 786
LL QA + +++EAL+ + S L +++ N QA
Sbjct: 1408 SVEQLLQQARQRALDAQAHQDLPFEQLVEALQPERSLSHNPLFQVMFNHQTDVGQAQVQQ 1467
Query: 787 VLPVVLTNGLSWKTLNPEDAVTLFDGVTQTPQVALDIRLTYDEQKNLIISFDYALAVLET 846
LP + GL W E FD + LDI+ + + + + YA + E
Sbjct: 1468 QLPNLSVEGLEW-----ESKTAHFD-------LDLDIQ---ESTEGIWATLGYAQDLFEA 1512
Query: 847 ELIREMLSALHHRLSQITSSASLAAPLEPCIDLSHYRFNSDESASHDCDFLAK-LAQQLF 905
++ M + L + + +D + + D F AK L +L
Sbjct: 1513 STVQRMARHWQNLLQGMVADPRQTLSQLNLLDNTERQQILQRWDQSDAGFSAKRLVHELV 1572
Query: 906 V----RTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVI 961
T + AV GEQ L+Y +L Q R+ L ARG+ +AI +PRS E +V
Sbjct: 1573 ADRAGETPEAVAVKFGEQQLTYGELDRQANRLAHALIARGVGPEVRVAIAMPRSAEIMVA 1632
Query: 962 SLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDK------PCEFG-NVIAFDALI 1014
LA +G ++VP+D P++RL Y++++ A L++ P G +A D
Sbjct: 1633 FLAVMKAGGVYVPLDIEYPRDRLLYMMQDSRARLLLTHSTVQQRLPIPDGLEALAVDQTQ 1692
Query: 1015 EPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQA 1074
D P+V + AY +YTSG+TG PK V V++ I TG+
Sbjct: 1693 AWSANDDSAPEV--------VLDGDNLAYVIYTSGSTGMPKGVAVSHGPLVAHIIATGER 1744
Query: 1075 WHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDALQW-----NRLIERH 1129
+ + D + D S L GA++++ +D W + + RH
Sbjct: 1745 YETSPADCELHFMSFAFDGSHEGWMHPLINGASVLI------RDDSLWLPEYTYQQMHRH 1798
Query: 1130 QVTIWVSVPAILEMLLS-CTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGG 1188
VT+ V P L+ L + G +R+ GGD + A+ P L + G
Sbjct: 1799 HVTMAVFPPVYLQQLAEHAERDGNPPKVRVYCFGGDAVAQASYDLAWRALKPTYLFNGYG 1858
Query: 1189 PTETTIWS-IWHELTADDVSVI--PYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNL 1245
PTET + +W D + P G L +++D P GV G ++ G +
Sbjct: 1859 PTETVVTPLLWKARKGDPCGAVYAPIGTLLGNRSGYVLDAQLNLQPIGVAGELYLGGEGV 1918
Query: 1246 AQGYLEDGELKQTDFVTVLDEHGHP-VRAFRTGDQGYYRADGNIIFASRINGYVKVRGVR 1304
A+GYLE L FV D G P R +R+GD R DG + + R++ VK+RG R
Sbjct: 1919 ARGYLERPALTAERFVP--DPFGKPGSRVYRSGDLTRGRPDGGVDYLGRVDHQVKIRGFR 1976
Query: 1305 VSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKP-------QQSASSQALREF 1357
+ L +IE +L+ ++ VVV +G +A + + P QS +ALR
Sbjct: 1977 IELGEIEARLREQDSVGETVVVAQEGPSGKQLVAYVVPLDPLLIDDAVAQSTCREALRRA 2036
Query: 1358 AKQSLPSSHIPSRFIALEALPLSANGKVDRK 1388
K LP +P+ + LE +PL+ NGK+DRK
Sbjct: 2037 LKARLPDYMVPTHLMFLERMPLTPNGKLDRK 2067
Score = 199 bits (506), Expect = 8e-54
Identities = 262/1035 (25%), Positives = 444/1035 (42%), Gaps = 105/1035 (10%)
Query: 421 VDLI-RCVALHPEMMQQSVQQID------AQLGYAR-RESIQEMPLTPLQQAYLLGRSTQ 472
+DL+ R + L E QQ Q++ AQL A RE Q +PL+ Q+
Sbjct: 7 IDLVSRFLRLPLEQRQQFYQRLQSRGMSFAQLPIASIREDGQMLPLSYAQERQWFLWQLD 66
Query: 473 IALGGVAMHEFREYRGHIDTQSLHSRLLYLVEHIPALRTRI--DQEKWIQWVSPCIALNW 530
+ +G +D +L L+ +LRTR+ D E+ +Q V+P +
Sbjct: 67 PDSATYHIPGALRLQGRLDLAALQRAFDSLLARHESLRTRLVQDGERLLQNVAPEARIEI 126
Query: 531 QAIDLQHLSREQALLAVEPVRQQYQ-QRMHDLTRSPW-QICVVQLPIEEQEEFSSIVLTS 588
+ Q ++ EQ LLA R + + R DL P ++ ++QL +E +++
Sbjct: 127 R----QDVADEQQLLA----RVEAEIARPFDLQAGPLLRVSLLQLAEDEH-----VLVMV 173
Query: 589 FDALIVDGRTHALILAALLG-------SEEPDITQVVQNARDTQSISPQF--ASKKAQDE 639
+I DG + +++ L+ E + + + D + A +KA+
Sbjct: 174 QHHIISDGWSMQVMVEELVQFYAAHSQGREVQLPGLPIHYADYALWQRSWMEAGEKARQL 233
Query: 640 AYWKSKLHPDCPPPALPWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLL 699
AYW+ L + P LP + A + +P + V + R + G+ LL
Sbjct: 234 AYWQDLLGGEQPVLELPLDHPRPAQQSHCGASLQVHLPADLVAGIKRLAQQEGVTPFMLL 293
Query: 700 TATILDVLSYWTTEIGMRVGFPVLIPSSNAIDGNESSFVILEHEKSTLS-LLSQASKLQR 758
A+ +L ++ + +R+G P + + FV + K+ L +S A LQ+
Sbjct: 294 LASFQTLLFRYSGQSDIRIGVPNANRNRVETERLIGFFVNTQVLKADLDGQMSFAELLQQ 353
Query: 759 EMLEALEHLAFSGVDLNRLLMNQAPQALV----LPVVLTN---------------GLSWK 799
+LE A + +L++ P+ + L V+ N GL
Sbjct: 354 AKRRSLEAQAHQDLPFEQLVVALQPERSLSHNPLFQVMFNHQTDAQGGRDGQQLPGLRVA 413
Query: 800 TLNPEDAVTLFDGVTQTPQVALDIRLTYDEQKNLIISFDYALAVLETELIREMLSALHHR 859
L+ E+ T FD ++LD T++ + L + YA + E+ I + +
Sbjct: 414 QLDWENQTTHFD-------LSLD---THESAEGLWAALTYATDLFESATIERLAQHWQNL 463
Query: 860 LSQITSSASLAAPLEPCIDLSHYRFNSDESASHDCDFLAKLA-----QQLFVRTED---- 910
L A+++AP LS + D + A +A QLF
Sbjct: 464 LQ-----AAVSAPRSRLCVLSMLDAPEQQRMLKDWNAPATVAAPHAVHQLFEAQAREHPA 518
Query: 911 KTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGI 970
+ A+ +QTLSY +L Q R+ L A+G+ ++ I + RS +V LA +G
Sbjct: 519 RQALALDDQTLSYGELNRQANRLAHYLIAQGVGPEVLVGIAVERSFAMVVSLLAVLKAGG 578
Query: 971 IWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPDVTPLD 1030
+VP+D P+ERL ++L++ LV+ + D + AD
Sbjct: 579 AYVPLDPEYPRERLVHMLDDSGVRLVLTQSHLRDRLPLPADLTALDIDLADAQLAQCAEH 638
Query: 1031 QLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLH 1090
+ + AY +YTSG+TGKPK V +++ A S G + L ++D V+ L+
Sbjct: 639 NPPTAFEPRSLAYVIYTSGSTGKPKGVAISHAALSEFAGIAAEYSRLVADDRVLQFATLN 698
Query: 1091 HDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLL-SCTQ 1149
D V L+ L+ GAT+VL G + D R I +T+ A ++ L C
Sbjct: 699 FDGFVEQLYPALTLGATVVL-RGPQLWDGADLYRQIIDQGITLADLPTAYWKLFLQDCLA 757
Query: 1150 AG--QLHSLRLIAQGGDYIK-PATIAQLRAGSNPPRLISLGGPTETTIWSIWHELTADD- 1205
AG +LR + GG+ + + RAG RL++ GPTE T+ S + + D+
Sbjct: 758 AGPRPYGALRQVHIGGEAMPLDGPVLWRRAGLGHVRLLNTYGPTEATVVSSVLDCSDDNA 817
Query: 1206 ---VSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIF-TSGVNLAQGYLEDGELKQTDFV 1261
+ P GR L G +++D +P G VG ++ S LA+ YL+ L FV
Sbjct: 818 VMGATASPIGRALPGRGLYVLDPDLNLLPVGAVGELYIASAGGLARDYLQRPSLTAERFV 877
Query: 1262 ----TVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTH 1317
+ L E R +RTGD YRADG I + R++ VK+RG R+ L +IE L
Sbjct: 878 ADPFSTLGE-----RLYRTGDLARYRADGVIEYVGRVDHQVKIRGFRIELGEIEALLLAQ 932
Query: 1318 PALASVVVVDYADTNGDTALAALFSVKP----QQSASSQALREFAKQSLPSSHIPSRFIA 1373
A+ ++ + +A L +P +Q+A+ + L+ ++ LP +P+ I
Sbjct: 933 EAVREAFLL----AADNQLVAYLVPAQPLSAAEQAAAGETLKATLREQLPDYMVPAHLIF 988
Query: 1374 LEALPLSANGKVDRK 1388
L+ +PL+ NGK+DR+
Sbjct: 989 LDRMPLNPNGKLDRQ 1003
Score = 144 bits (362), Expect = 4e-37
Identities = 118/444 (26%), Positives = 197/444 (44%), Gaps = 22/444 (4%)
Query: 1862 EECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNAK 1921
++ + A + LGV + FF+ GGHSL+A +V+ R+ +E+ + +F P +
Sbjct: 1025 QQQVAAIWADILGVERVGLTHHFFELGGHSLLAMQVVSRIRQALKLEVPLKLLFEQPRLE 1084
Query: 1922 QLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLPFALK 1981
T+ A+ V PLS AQ W + HI P AL+
Sbjct: 1085 GFVAALATQDPDAPTAPALLPVGRDQPLPLSYAQERQWFLWQLEPQSAAYHI---PSALR 1141
Query: 1982 FLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQ 2041
+++ A +F LL RH LRTH E + Q + +++ ++ + AQ
Sbjct: 1142 LKGQLDLGALQRSFDTLLARHESLRTHLRQERDRTVQIISPQVSLQIAH----AEVHEAQ 1197
Query: 2042 SVARLLAQEAEHTFDLSQELPLRLNFVR---DEQTGTQYLSLLFHHIVLDEWSINILMDE 2098
AR+ A+ A+ F+L Q LR++ +R DE L L+ HHIV D WS+ ++++E
Sbjct: 1198 LKARVEAEIAQ-PFNLEQGPLLRVSLLRIAADEHV----LVLVQHHIVSDGWSMQLMVEE 1252
Query: 2099 LAQVYQHSVQGTRPQWQTEPLPFHEFARKQRS---SAFNQTHLNYWLTKFAGVPWAQPLF 2155
L Q+Y QG QW P+ + ++A QR+ + L YW G L
Sbjct: 1253 LVQLYAAYSQGQVLQWPALPIQYADYAVWQRNWMEAGEKARQLAYWRDMLGGEQSVLAL- 1311
Query: 2156 AADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHCLGA 2215
DHP V G + +LP + L LAK + +LF ++ A+ +H
Sbjct: 1312 PFDHP---RPAVQSHRGARLAFELPGALTQGLKALAKQQDVTLFMLLLASFQTLLHRYSG 1368
Query: 2216 PEKLLVGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKVQTVWQLIEQVKNSINQSMPYTD 2275
E++ VG P + R +E +G+F V D +V QL++Q + + + D
Sbjct: 1369 QEEIRVGVPIANRNRSETERLIGFFVNTQVLKADLHGQMSVEQLLQQARQRALDAQAHQD 1428
Query: 2276 IPIDLIEEGLKGVEHETEGHMFEV 2299
+P + + E L+ + +F+V
Sbjct: 1429 LPFEQLVEALQPERSLSHNPLFQV 1452
Score = 94.0 bits (232), Expect = 5e-22
Identities = 109/482 (22%), Positives = 197/482 (40%), Gaps = 33/482 (6%)
Query: 1901 LLSEQGIELHINDMFSFP-NAKQLAQQAVLHRKPTSTSFAVSEVVESSKA-PLSLAQASL 1958
+LS I+L ++ P +Q Q + R + ++ + E + PLS AQ
Sbjct: 1 MLSNPNIDL-VSRFLRLPLEQRQQFYQRLQSRGMSFAQLPIASIREDGQMLPLSYAQERQ 59
Query: 1959 WKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQ 2018
W HI P AL+ ++ A AF LL RH LRT + + Q
Sbjct: 60 WFLWQLDPDSATYHI---PGALRLQGRLDLAALQRAFDSLLARHESLRTRLVQDGERLLQ 116
Query: 2019 HVIAASNIEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYL 2078
+V + IE Q + Q +AR+ A+ A FDL LR++ ++ + L
Sbjct: 117 NVAPEARIEIRQ----DVADEQQLLARVEAEIAR-PFDLQAGPLLRVSLLQLAED-EHVL 170
Query: 2079 SLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQRS---SAFNQ 2135
++ HHI+ D WS+ ++++EL Q Y QG Q P+ + ++A QRS +
Sbjct: 171 VMVQHHIISDGWSMQVMVEELVQFYAAHSQGREVQLPGLPIHYADYALWQRSWMEAGEKA 230
Query: 2136 THLNYWLTKFAGVPWAQPL--FAADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKA 2193
L YW G QP+ DHP G +++ LP + + +LA+
Sbjct: 231 RQLAYWQDLLGG---EQPVLELPLDHP---RPAQQSHCGASLQVHLPADLVAGIKRLAQQ 284
Query: 2194 RHASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKV 2253
+ F ++ A+ + + +G P + R E +G+F V D
Sbjct: 285 EGVTPFMLLLASFQTLLFRYSGQSDIRIGVPNANRNRVETERLIGFFVNTQVLKADLDGQ 344
Query: 2254 QTVWQLIEQVKNSINQSMPYTDIPIDLIEEGLKGVEHETEGHMFEVFI--QLHAKNKLHG 2311
+ +L++Q K ++ + D+P + + L+ + +F+V Q A+ G
Sbjct: 345 MSFAELLQQAKRRSLEAQAHQDLPFEQLVVALQPERSLSHNPLFQVMFNHQTDAQGGRDG 404
Query: 2312 ELLLTEGHAIRFQQVDPDKSESGLGLQFEILEERIEQKQTLRVMMSYMSKHYSPAQVALL 2371
+ L +R Q+D + + F++ + E + L ++Y + + A + L
Sbjct: 405 QQL----PGLRVAQLDWENQTT----HFDLSLDTHESAEGLWAALTYATDLFESATIERL 456
Query: 2372 TK 2373
+
Sbjct: 457 AQ 458
Score = 74.3 bits (181), Expect = 4e-16
Identities = 91/428 (21%), Positives = 178/428 (41%), Gaps = 30/428 (7%)
Query: 37 LNRQALTEAVRALYAKHPMLRLAITKDGQQKILPLSTFHQLKVDDLSQWKPDEVESFVHT 96
L+ AL + L A+H LR + ++ + + +S L++ + E+ +
Sbjct: 1146 LDLGALQRSFDTLLARHESLRTHLRQERDRTVQIISPQVSLQIAHA-----EVHEAQLKA 1200
Query: 97 KRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLYLEA 156
+ + Q +L QG + +SL + +H L + I D S +L+V++L LY
Sbjct: 1201 RVEAEIAQPFNLEQGPLLRVSLLRIAADEHVLVLVQHHIVSDGWSMQLMVEELVQLYAAY 1260
Query: 157 IEHRLEIIESDVVTFFQYLDAQQADRALAKRK--EVDKK-----WWQERLATIPAEPSLP 209
+ + V + L Q AD A+ +R E +K +W++ L + +LP
Sbjct: 1261 SQGQ--------VLQWPALPIQYADYAVWQRNWMEAGEKARQLAYWRDMLGGEQSVLALP 1312
Query: 210 YQPVPTDAVSANSQRFAHWFTPVERKGLAEVARQHHLTLTQLTLALFSQVIANACQERQF 269
+ S R A +GL +A+Q +TL L LA F ++ + +
Sbjct: 1313 FDHPRPAVQSHRGARLAFELPGALTQGLKALAKQQDVTLFMLLLASFQTLLHRYSGQEEI 1372
Query: 270 RLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQTANQLHQLLRHESYS 329
R+ VP +R NRS + E IG F N + AD+ ++ L QQ + H+
Sbjct: 1373 RVGVPIANR-NRS-ETERLIGFFVNTQVLKADLHGQMSVEQLLQQARQRALDAQAHQDLP 1430
Query: 330 GVSVMRDLSRKQGGVQRSP---IVFTSGMEMRDEEIFSDHVTQHLGRMNWVISQGAQVTL 386
++ L + + + +P ++F ++ ++ + + W S+ A L
Sbjct: 1431 FEQLVEAL-QPERSLSHNPLFQVMFNHQTDVGQAQVQQQLPNLSVEGLEWE-SKTAHFDL 1488
Query: 387 DAQIAPAYEGILLNWDVRMENFADKDITALFAHYVDLIRCVALHPEMMQQSVQQIDAQLG 446
D I + EGI + F + + H+ +L++ + P +Q++ Q++
Sbjct: 1489 DLDIQESTEGIWATLGYAQDLFEASTVQRMARHWQNLLQGMVADP---RQTLSQLNLLDN 1545
Query: 447 YARRESIQ 454
R++ +Q
Sbjct: 1546 TERQQILQ 1553
Score = 72.8 bits (177), Expect = 1e-15
Identities = 95/396 (23%), Positives = 158/396 (39%), Gaps = 32/396 (8%)
Query: 1859 SAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFP 1918
S +E+ I A + L + + D+FF+ GG S+I+ +V+ R + G+ D+F
Sbjct: 2086 SELEQKIAAIWSDVLRLPRVGLHDNFFELGGDSIISIQVVSRA-RQAGVRFTPKDLFQHQ 2144
Query: 1919 NAKQLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLPF 1978
+ LA A R+ + L + QA + + H +N
Sbjct: 2145 TVQSLAAVA---REGEGAVVLDQSALTGDLLLLPVQQAFFADDIPR------RHHWNQSV 2195
Query: 1979 ALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIEHY--QWFWTSK 2036
L+ + A L++ H LR G G +H Q W +
Sbjct: 2196 VLQPHQALQAPLLVAALQALIVHHDALR--IGFVQGAAGWSAAYRGPQQHQAEQVLWQTT 2253
Query: 2037 DNAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILM 2096
NA + + L +EA+ + DLS+ LR V D G+Q L L+ HH+V+D S IL+
Sbjct: 2254 LNAVEEL-EALGEEAQRSLDLSEGPLLRAVLV-DLADGSQRLLLVIHHLVVDGVSWRILL 2311
Query: 2097 DELAQVYQHSVQGTRPQWQTEPLPFHEFARK----QRSSAFNQTHLNYWLTKFAGVPWAQ 2152
++L Y+ QG + + +A + RS+A Q L +W T+ G P
Sbjct: 2312 EDLQTAYRQVAQGAKVVLPAKTSAIRAWAERLQAYARSAALAQ-ELAWWQTQLQGSPTGL 2370
Query: 2153 PLFAADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFN-VMYAAISASVH 2211
P LSN + V L + L Q A + + + N ++ A++ V
Sbjct: 2371 PGADPQASLSNRHALS------VTTHLDQVFTRRLLQDAPSAYRTQINDLLLTALARVVV 2424
Query: 2212 CLGAPEKLLVGTPASGRLD----AEFFDTVGYFTTM 2243
+L+ GR D + TVG+FT++
Sbjct: 2425 RWTGDASMLIRLEGHGREDLFDEIDLTRTVGWFTSL 2460
Score = 60.5 bits (145), Expect = 6e-12
Identities = 66/292 (22%), Positives = 118/292 (40%), Gaps = 12/292 (4%)
Query: 37 LNRQALTEAVRALYAKHPMLRLAITKDGQQKILPLSTFHQLKVDDLSQWKPDEVESFVHT 96
L+ AL A +L A+H LR + +DG++ + ++ ++ ++ Q DE +
Sbjct: 84 LDLAALQRAFDSLLARHESLRTRLVQDGERLLQNVAPEARI---EIRQDVADEQQLLARV 140
Query: 97 KRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLYLEA 156
+ + + DL G + +SL L E +H L + I D S +++V++L Y
Sbjct: 141 EAE--IARPFDLQAGPLLRVSLLQLAEDEHVLVMVQHHIISDGWSMQVMVEELVQFYAAH 198
Query: 157 IEHRLEIIESDVVTFFQYLDAQQADRALAKRKEVDKKWWQERLATIPAEPSLPY-QPVPT 215
+ R + + + Y Q A K +WQ+ L LP P P
Sbjct: 199 SQGREVQLPGLPIHYADYA-LWQRSWMEAGEKARQLAYWQDLLGGEQPVLELPLDHPRPA 257
Query: 216 DAVSANSQRFAHWFTPVER-KGLAEVARQHHLTLTQLTLALFSQVIANACQERQFRLNVP 274
+ H P + G+ +A+Q +T L LA F ++ + R+ VP
Sbjct: 258 QQSHCGASLQVH--LPADLVAGIKRLAQQEGVTPFMLLLASFQTLLFRYSGQSDIRIGVP 315
Query: 275 TFHRGNRSLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQTANQLHQLLRHE 326
+R ++ E IG F N + AD+ + L QQ + + H+
Sbjct: 316 NANRNR--VETERLIGFFVNTQVLKADLDGQMSFAELLQQAKRRSLEAQAHQ 365
Score = 46.2 bits (108), Expect = 1e-07
Identities = 86/376 (22%), Positives = 140/376 (37%), Gaps = 32/376 (8%)
Query: 1361 SLPSSHIPSRFIALEALPLSANGKVDRKQCQAHVQRQSISVE--PVGQPNQSQPLSPPTL 1418
S P+ + SRF+ L PL R+Q +Q + +S P+ + + P
Sbjct: 3 SNPNIDLVSRFLRL---PLE-----QRQQFYQRLQSRGMSFAQLPIASIREDGQMLP--- 51
Query: 1419 SSASLSEFEQRVWRQHQRHGDGRNQYAT-AYRLSGKVNIARLITALSQLPNHFPVLNRRY 1477
LS ++R W Q D + A RL G++++A L A L L R
Sbjct: 52 ----LSYAQERQWFLWQLDPDSATYHIPGALRLQGRLDLAALQRAFDSLLARHESLRTRL 107
Query: 1478 VLDEASGLTLYSAKPTPLEIHFEHVESMDEAFEHLVRWQNQPMDLAKQATLSFCLLSLGS 1537
V D L A +EI + V + + +P DL L LL L
Sbjct: 108 VQD-GERLLQNVAPEARIEIR-QDVADEQQLLARVEAEIARPFDLQAGPLLRVSLLQLAE 165
Query: 1538 EERVLGVISHQIISEQWDWRRVFECVTNGYNQIACDIDPVMEG-----EDLSLGFTPVMP 1592
+E VL ++ H IIS+ W + + E + Y + + + G D +L M
Sbjct: 166 DEHVLVMVQHHIISDGWSMQVMVEELVQFYAAHSQGREVQLPGLPIHYADYALWQRSWME 225
Query: 1593 QTPLSQALLPWLQ-PASHATWIEQSLPSANSAINTLCSRKYRIALHSSVLAE-HGLAQPD 1650
++ L W +E L A + C ++ L + ++A LAQ +
Sbjct: 226 AGEKARQLAYWQDLLGGEQPVLELPLDHPRPAQQSHCGASLQVHLPADLVAGIKRLAQQE 285
Query: 1651 KQEVLALIAALFARYLAASAKLGQFELYVPHDVERK--TRELNGSMIESQLVHIALKG-- 1706
L+ A F L + + VP+ + T L G + +Q++ L G
Sbjct: 286 GVTPFMLLLASFQTLLFRYSGQSDIRIGVPNANRNRVETERLIGFFVNTQVLKADLDGQM 345
Query: 1707 -FERPLSQLSQEILDA 1721
F L Q + L+A
Sbjct: 346 SFAELLQQAKRRSLEA 361
Score = 46.2 bits (108), Expect = 1e-07
Identities = 49/181 (27%), Positives = 77/181 (42%), Gaps = 25/181 (13%)
Query: 1752 LQLEGLRCE------KLLFAAMHPKFEVALGVGLNCQGALVLELALD---ATVSPHVGAY 1802
++L GLR E +LL A + V G + G LVL+ + A V+ H+ A
Sbjct: 3486 VKLRGLRIELGEIEARLLEHACVREAAVLAVDGTHLVGYLVLQAPSEDWKAQVAMHLAAQ 3545
Query: 1803 LLEQFVAA--IGGRTMPSSTTSSSHVSAIELTSNNPPTSNNAHAALAESELELSAVNSSA 1860
L + V A + MP S A+ P + A A A SA
Sbjct: 3546 LPDYMVPAQWVVLTQMPLSPNGKLDRKALP-----KPEAQGAGAYQAPQ---------SA 3591
Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
+E+ + A +R LGV + D+FF+ GGHSL+ + R+ G+ L ++ + P
Sbjct: 3592 IEQQVAAIWRDVLGVERVGLNDNFFELGGHSLLVLMLKERIRKVSGVGLSVSQLMLNPTV 3651
Query: 1921 K 1921
+
Sbjct: 3652 R 3652
Score = 36.2 bits (82), Expect = 1e-04
Identities = 33/117 (28%), Positives = 51/117 (43%), Gaps = 7/117 (5%)
Query: 1991 FGEAFHWLLLRHAGLRTHF--GLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQSVARLLA 2048
F +A+ + H LR+ F E QP Q V + + W + +++ ++ L
Sbjct: 2675 FRQAWQAAVDSHEILRSGFLWQTEFEQPLQVVYKQMRMPFAELDWQGRPDSSAALDSLAE 2734
Query: 2049 QEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLF--HHIVLDEWSINILMDELAQVY 2103
F L Q L L VR TG L++ HHI++D WS + L E+ Q Y
Sbjct: 2735 SARAQGFVLEQAPLLSLTVVR---TGASRYHLIYTNHHILMDGWSGSQLFGEVLQHY 2788
Score = 30.4 bits (67), Expect = 0.006
Identities = 25/115 (21%), Positives = 47/115 (40%), Gaps = 2/115 (1%)
Query: 1459 LITALSQLPNHFPVLNRRYVLDEASGLTLYSA--KPTPLEIHFEHVESMDEAFEHLVRWQ 1516
L+ AL L H L +V A Y + ++ ++ + E E L
Sbjct: 2208 LVAALQALIVHHDALRIGFVQGAAGWSAAYRGPQQHQAEQVLWQTTLNAVEELEALGEEA 2267
Query: 1517 NQPMDLAKQATLSFCLLSLGSEERVLGVISHQIISEQWDWRRVFECVTNGYNQIA 1571
+ +DL++ L L+ L + L ++ H ++ + WR + E + Y Q+A
Sbjct: 2268 QRSLDLSEGPLLRAVLVDLADGSQRLLLVIHHLVVDGVSWRILLEDLQTAYRQVA 2322