Pairwise Alignments
Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056
Subject, 6131 a.a., Polyketide synthase modules and related proteins from Variovorax sp. SCN45
Score = 223 bits (567), Expect = 1e-60
Identities = 161/506 (31%), Positives = 250/506 (49%), Gaps = 44/506 (8%)
Query: 899 KLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEH 958
+L +Q D A++CG Q L+YAQL E+ R+ +L A G+T+ + + I + R+ +
Sbjct: 4183 RLIEQQVRARPDAIALVCGAQALTYAQLNERANRLAHRLIASGVTSESKVGIAVSRNADM 4242
Query: 959 IVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVL 1018
+ LA SG +VP+D P++RL Y++E+ L++M
Sbjct: 4243 VAGVLAVLKSGAAYVPLDPEYPQDRLAYMVEDSGLSLLLMQSH----------------- 4285
Query: 1019 FADGVPDVTPLDQLSRLSQS-------------QQTAYYLYTSGTTGKPKCVVVNNQATS 1065
+ +PDV P+ L RL S + AY +YTSG+TGKPK V+V ++A S
Sbjct: 4286 LLERLPDV-PMLALDRLDLSGEPAHDPEVPLHAEHLAYVIYTSGSTGKPKGVMVRHEALS 4344
Query: 1066 NVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRL 1125
+ I A +T+EDV+++VT L D++ +L+ LS GA +VL + +D +L
Sbjct: 4345 HFIRSMQAAPGMTAEDVLVAVTSLSFDIAALELYLPLSCGARIVLASQETVRDGRALAQL 4404
Query: 1126 IERHQVTIWVSVPAILEMLLSC-TQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLI 1184
+E T+ S PA +L + A LH + + GG+ ++ L L
Sbjct: 4405 VEESGATLVQSTPAGWRLLRAAGWPAAPLHGFKGLC-GGEALQSDLAEDLHGLG--VELW 4461
Query: 1185 SLGGPTETTIWSIWHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVN 1244
++ GPTETTIWS + + G +A + ++D + VPQGV G ++ GV
Sbjct: 4462 NMYGPTETTIWSSAQRVADGHPGI---GEAIAATQLRVLDADLQPVPQGVAGELYIGGVG 4518
Query: 1245 LAQGYLEDGELKQTDFVTVLDEHG-HPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGV 1303
LA+GYL L F+ D G R +RTGD + DG + + SR++ +K+RG
Sbjct: 4519 LARGYLHRPGLSAERFLA--DPFGTKGERIYRTGDMVRWSFDGRLQYLSRVDHQIKIRGF 4576
Query: 1304 RVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLP 1363
R+ L +IE QL P + VVV G +A V Q L+ ++LP
Sbjct: 4577 RIELGEIETQLLAQPEVREAVVVAKEGPGGARLVA---YVSLSSDTQPQLLKARISRALP 4633
Query: 1364 SSHIPSRFIALEALPLSANGKVDRKQ 1389
+P+ + L ALPL+ NGKVDRKQ
Sbjct: 4634 EYMVPASIMVLPALPLNMNGKVDRKQ 4659
Score = 221 bits (562), Expect = 4e-60
Identities = 188/632 (29%), Positives = 288/632 (45%), Gaps = 41/632 (6%)
Query: 767 LAFSGVDLNRLLMNQAPQALVLPVVLTNGLSWKTLNPEDAVTLFDGVTQTPQVALDIRLT 826
+ F +++ L +QAP LV V + N VT+ G T ++L
Sbjct: 2979 VVFENYPVDQALKDQAPGGLVFGEVRNR----EETNYPMTVTVHGGQT----LSLAFHFA 3030
Query: 827 YDEQKNLIISFDYALAVLETELIREMLSALHHRLSQITSSASLAAPLEPCIDLSHYRFNS 886
D+ FD A T + +L AL ++ L A E + L N
Sbjct: 3031 RDQ-------FDDAAVAEMTRHLLALLEALCGDPERVLGEVRLLADSE-AVRLRALGENL 3082
Query: 887 DESASHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGN 946
A H+ + QQ RT + A++ G+ +LSYAQL + R+ +L A G+
Sbjct: 3083 PHRA-HEAPVHRLIGQQAR-RTPEAVALVFGDVSLSYAQLEARANRLAHRLIALGVRPDT 3140
Query: 947 VLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDK------ 1000
+ I RS+E +V LA +G +VPID P ER+ Y+LE+ L++
Sbjct: 3141 KVGIATERSLEMVVGLLAILKAGGAYVPIDPEYPPERIAYMLEDSGVSLLLTQSHIAPAI 3200
Query: 1001 PCEFG-NVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVV 1059
P G I D +L D P V P L + AY +YTSG+TG+PK
Sbjct: 3201 PARQGVQTIELD-----LLDLDSGPSVDPDVPL----HGEHLAYVIYTSGSTGRPKGAAN 3251
Query: 1060 NNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVL--PAGHEEK 1117
+ + N + A+ L D V+ TP D+SV++ F L GA LV+ P H E
Sbjct: 3252 RHLSLFNRLAWMQDAYALNEADTVLQKTPFSFDVSVWEFFWPLMQGARLVVAQPGDHREP 3311
Query: 1118 DALQWNRLIERHQVTIWVSVPAILEMLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAG 1177
L LI RH V+ VP++L+ ++ SL+ I G+ + A++
Sbjct: 3312 GKLV--ELIRRHGVSTIHFVPSMLQAFVAHEGIEACTSLKRIVCSGEALPAEAQARVFER 3369
Query: 1178 SNPPRLISLGGPTETTIWSIWHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGR 1237
L +L GPTE I AD + + GRP+AG + +++D+ QG+ G
Sbjct: 3370 LPGAGLYNLYGPTEAAIDVTHWSCRADGRNHVAIGRPIAGTKTYVLDDGLNLAAQGLAGE 3429
Query: 1238 IFTSGVNLAQGYLEDGELKQTDFVT-VLDEHGHPVRAFRTGDQGYYRADGNIIFASRING 1296
++ G+ LA+GYL+ L FV + G R +RTGD +R DG + + RI+
Sbjct: 3430 LYLGGIGLARGYLDKSALTSERFVADPFSDAGE--RLYRTGDLVRWREDGELEYLGRIDH 3487
Query: 1297 YVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKPQQSASSQALRE 1356
VK+RG R+ L +IE +L P + VVV G +A + + Q+ + L++
Sbjct: 3488 QVKIRGFRIELGEIEARLLAQPGVREAVVVAQQAAGGARLVAYVSAAAASQAIDAAQLKQ 3547
Query: 1357 FAKQSLPSSHIPSRFIALEALPLSANGKVDRK 1388
++LP +P + L+ALPL+ANGKVDRK
Sbjct: 3548 QLSRALPEHMVPGVIVVLQALPLNANGKVDRK 3579
Score = 196 bits (499), Expect = 8e-53
Identities = 153/501 (30%), Positives = 238/501 (47%), Gaps = 16/501 (3%)
Query: 893 DCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICL 952
D + + +L ++ D TA+I GE+ LSYA L + R+ +L A G+ + + +
Sbjct: 1588 DAEPVHRLVERQAGLRPDATALIFGEEQLSYAGLNVRANRLAHRLVAMGVKPETRVGLAV 1647
Query: 953 PRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDA 1012
RS + +V LA SG +VP+D P +RL Y++++ L++ + E G IA
Sbjct: 1648 KRSPDMVVALLAILKSGGAYVPLDPTYPPDRLAYMVQDSGIALLLTNS--EAGERIAAPC 1705
Query: 1013 LIEPVLFADGVP-DVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQT 1071
++ D V D P + AY +YTSG+TGKPK V V + S +
Sbjct: 1706 RLD----LDKVDLDAQPSHNPAVPVHGANLAYVIYTSGSTGKPKGVAVAHGPLSMHVQSI 1761
Query: 1072 GQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQV 1131
G+A+ +T ED + + D + + L+FG+ L +P E + IERH +
Sbjct: 1762 GEAYGMTPEDRELQFASISFDGAHERTWVPLAFGSAL-MPRDEEVWSVERTCAEIERHGI 1820
Query: 1132 TIWVSVPAILEMLLSCT-QAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPT 1190
TI P L + ++ +R GG+ + ++ ++ P R+I+ GPT
Sbjct: 1821 TIACFTPGYLHQIAELMGESASRLPIRSYTVGGEAMPRTSLELVQKVLRPRRVINGYGPT 1880
Query: 1191 ETTIWSI---WHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQ 1247
ET I + + D + +P GR + +++D VP GV G ++ G LA+
Sbjct: 1881 ETVITPMIAKAEDGIGFDSAYMPIGRLIGDRTAYVLDAGLSLVPPGVAGELYLGGEGLAR 1940
Query: 1248 GYLEDGELKQTDFVT-VLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVS 1306
GYL L FV D+ G R +RTGD + ADG + + RI+ VK+RG R+
Sbjct: 1941 GYLNRAGLSAERFVADPFDDRGG--RLYRTGDLVRWGADGQMEYLGRIDHQVKIRGFRIE 1998
Query: 1307 LPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSH 1366
L ++E QL P + VVV +G L S P QALRE Q LP
Sbjct: 1999 LGEVEAQLLAQPEVQEAVVVARRGASG-ARLVGYVSALPGAVIDGQALRERLGQVLPDYM 2057
Query: 1367 IPSRFIALEALPLSANGKVDR 1387
+P+ + L+ALPL+ GKVDR
Sbjct: 2058 VPAALVVLDALPLNGAGKVDR 2078
Score = 193 bits (490), Expect = 9e-52
Identities = 229/966 (23%), Positives = 397/966 (41%), Gaps = 97/966 (10%)
Query: 487 RGHIDTQSLHSRLLYLVEHIPALRTRIDQEK---WIQWVSPCIALNWQAIDLQHL--SRE 541
+G +D +L + LV +LRT Q + P +AL +DL + SR
Sbjct: 67 QGALDIDALRTAFQALVARHASLRTVFAPTHDGLAEQVIMPSLALEIPLVDLGAIEASRR 126
Query: 542 QALLAVEPVRQQYQQRMHDLTRSPW-QICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHA 600
+AL A E R DLTR P ++ V++L E +++ ++ DG +
Sbjct: 127 EALAAQEAGRVNGVP--FDLTRGPLLRVSVIRLGENEH-----VLVVVMHHIVSDGWSMQ 179
Query: 601 LILAALLGSEEPDITQVVQNARDTQSISPQF----------------ASKKAQDEAYWKS 644
+++ + R Q+ P A ++ + AYW+
Sbjct: 180 ILVDEFMAL-------YADGVRGRQAALPVLPVGYADYAAWQRHWMEAGERDRQIAYWRE 232
Query: 645 KLHPDCPPPALPWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATIL 704
+L + P LP + + A L +P+ +L + G L L A
Sbjct: 233 QLGTEHPVLQLPTDHPRKAEGGYQAAHHGLTVPQALTARLQQRAQAQGASLFMALLAGFQ 292
Query: 705 DVLSYWTTEIGMRVGFPVLIPSSNAIDGNESSFV---ILEHEKSTLSLLSQASKLQREML 761
+L T + +RVG PV + +G FV +L + L Q ++ +
Sbjct: 293 ALLHRHTAQDDIRVGVPVANRNRVETEGVVGFFVNTQVLRNRVDARMPLGQV--FEQAVH 350
Query: 762 EALEHLAFSGVDLNRLLMNQAPQ-----ALVLPVVLTNGLSWKTLNPEDAVTLFDGVT-- 814
AL A + +L+ P+ + + V+L +K + A G++
Sbjct: 351 AALGAQAHQDLPFEQLVEALQPERSMSHSPLFQVMLNFQRDFKG-SARQASQPLPGLSVQ 409
Query: 815 ------QTPQVALDIRLTYDEQKNLIISFDYALAVLETELIREM-------LSALHHRLS 861
Q Q L + DE + + F YA + + + I M L AL +
Sbjct: 410 AHALGGQAAQFELTLDAVQDEAGEVRLKFVYASGLFDADTIARMGTHYLALLEALADDPA 469
Query: 862 QITSSASLAAPLEPCIDLSHYRFNSDESASHDCDFLAKLAQQLFVRTEDKTAVICGEQTL 921
+ L + E R + + A + Q R D AV+ + +L
Sbjct: 470 RAVGDVRLLSEAESSQLEGWSRVRQADVGASARPLHAMIESQAQTRP-DAVAVVYEDASL 528
Query: 922 SYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPK 981
SY +L + R+ +L A G+ + + + RS++ +V LA +G +VP+D P+
Sbjct: 529 SYGELNARANRLAHRLIALGVKPETRVGLAVERSLDMVVGLLAILKAGGAYVPLDPQYPR 588
Query: 982 ERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQ---- 1037
+RL Y++ + L+V + + V +G+ V LD L ++
Sbjct: 589 DRLAYMVHDSAISLLVTQS-----------GVRDCVEVREGLR-VLELDTLDLRTEPTAN 636
Query: 1038 ------SQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHH 1091
+ AY +YTSG+TG+PK + ++ + ++G T + +DV
Sbjct: 637 PGVAVHADNLAYVIYTSGSTGRPKGAQLCHRNVARLLGATEPWFRFGPDDVWTMFHSYAF 696
Query: 1092 DMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSCT--Q 1149
D SV+++F L G LV+ + + L+ +VT+ P+ L+
Sbjct: 697 DFSVWEIFGALCTGGRLVVVPYWVSRSPDDFMALLRSEKVTVLNQTPSAFGQLIHAPALD 756
Query: 1150 AGQLHSLRLIAQGGDYIKPATIAQL--RAGSNPPRLISLGGPTETTIWSIWHELTADDVS 1207
AG+ +LR + GG+ ++P ++ R G + P+L+++ G TETT+ + +T D+
Sbjct: 757 AGERLALRCVVFGGEALEPESLRPWIDRYGDSSPQLVNMYGITETTVHVTYRPITRADLE 816
Query: 1208 V---IPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVL 1264
P G + ++D +P GV G ++ +G LA+GY L FV
Sbjct: 817 DGKRSPVGIAIPDLGMHVLDGELNRLPVGVPGELYVAGAGLARGYGNRAGLSAERFVA-- 874
Query: 1265 DEHGHP-VRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASV 1323
D G R +RTGD +R DG + + RI+ VK+RG R+ L +IE QL P +
Sbjct: 875 DPFGRAGERLYRTGDLVRWRNDGQLEYLGRIDHQVKIRGFRIELGEIEGQLLAQPGVREA 934
Query: 1324 VVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIPSRFIAL-EALPLSAN 1382
+V+ D G L A S + + L+ LP +P+ ++A+ + LPL+AN
Sbjct: 935 IVL-AKDAPGGARLVAYVSPQAGRQLDVNTLKSGLGAVLPEYMVPAAWVAMPQGLPLNAN 993
Query: 1383 GKVDRK 1388
GKVDRK
Sbjct: 994 GKVDRK 999
Score = 184 bits (468), Expect = 3e-49
Identities = 172/632 (27%), Positives = 271/632 (42%), Gaps = 42/632 (6%)
Query: 820 ALDIRLTYDEQKNLIISFDYALAVLETELIREMLSALHHRLSQITSSAS--------LAA 871
A+D+++T + L I + YA A E +R L H L ++T+ A+ L A
Sbjct: 5156 AMDLQVTMGDA--LEIEYCYARASFADEAVRAQRQQLEHLLRRMTTDAARPVGELGWLDA 5213
Query: 872 PLEPCI-DLSHYRFNSDESASHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQV 930
PLE + L A D + +L + D A++ G+ +SYAQL +
Sbjct: 5214 PLETAVLALGRTEHLRALDAQADRTMVHRLIEAQARLRPDAIALLLGDDEMSYAQLNARA 5273
Query: 931 QRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLEN 990
R L+ G+ ++ + L RS++ IV+ LA +G +VP+DAA P +RL Y++ +
Sbjct: 5274 NRFAHHLRELGVGPDRLVGVALERSLDTIVVLLAVLKAGGAYVPLDAAYPADRLAYMMRD 5333
Query: 991 CHADLVVMDK------PCEFGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQTAYY 1044
A L++ + P + D L L A D +P + L AY
Sbjct: 5334 SGAMLLITQRSVLPRLPETTVPRLLLDELAPDALGAPSDADPSPATGVDNL------AYV 5387
Query: 1045 LYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSF 1104
+YTSG+TG PK V V + + T + L S + D + L
Sbjct: 5388 IYTSGSTGMPKGVAVTHGPLAMHCLATADIYGLNSHSCELHFMSFSFDGAHERWLTPLCV 5447
Query: 1105 GATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLS-CTQAGQLHSLRLIAQGG 1163
GA L L +E A Q + R+ VT PA L + + L GG
Sbjct: 5448 GAGLAL-RDNELWTAEQTYEALHRYGVTTAAFPPAYLNQIADWAAPRDDAPPVELYVFGG 5506
Query: 1164 DYIKPATIAQLRAGSNPPRLISLGGPTETTIWSIWHELTAD---DVSVIPYGRPLAGNRY 1220
+ + A ++R P LI+ GPTET + + A D + P GRP+
Sbjct: 5507 EAMPKAAYDKVRTHLKPRMLINGYGPTETVVTPLIWRTEASRTFDCAYAPIGRPVGERTA 5566
Query: 1221 FIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVLDEHGHP-VRAFRTGDQ 1279
+++D + VP+GV G ++ G LA+GYL L FV D G R +RTGD
Sbjct: 5567 YVLDADMQPVPEGVAGELYIGGYGLARGYLGRSALTAERFVA--DPFGGAGERLYRTGDL 5624
Query: 1280 GYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAA 1339
+ +DGN+ + R++ VKVRG R+ L +IE +L + VV + G +A
Sbjct: 5625 VRWMSDGNVEYLGRVDNQVKVRGFRIELGEIEARLLAVTGVREAAVVTHDGAAGRQLVAY 5684
Query: 1340 LFSVKPQ-QSASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRKQCQAHVQRQS 1398
+ + + Q Q +RE LP +P+ L L +GK+DR+ S
Sbjct: 5685 VVADGTEMQPQWPQQIREQLGAQLPDYMVPAHVAVLPKLSRLVSGKLDRR---------S 5735
Query: 1399 ISVEPVGQPNQSQPLSPPTLSSASLSEFEQRV 1430
+ V P + + P T + L++ Q+V
Sbjct: 5736 LPVPEAENPGRVH-VPPSTPQAEQLAQIWQQV 5766
Score = 98.6 bits (244), Expect = 3e-23
Identities = 116/488 (23%), Positives = 195/488 (39%), Gaps = 54/488 (11%)
Query: 1925 QQAVLHRKPTSTSFAVSE--VVESSKAP-----LSLAQASLWKAMSKYAKFGLTHIFNLP 1977
Q+ +++K + ++ + ++ S AP LS AQ W HI
Sbjct: 5 QRRAVYQKIRAEGLSIGQFPIIAGSAAPGEAQALSYAQRRQWFLWKLDVASTAYHICG-- 62
Query: 1978 FALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFG-LEDGQPYQHVIAASNIEHYQWFWTSK 2036
L+ ++ A AF L+ RHA LRT F DG Q ++ + +E
Sbjct: 63 -GLRLQGALDIDALRTAFQALVARHASLRTVFAPTHDGLAEQVIMPSLALEI-----PLV 116
Query: 2037 DNAAQSVAR---LLAQEAEHT----FDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDE 2089
D A +R L AQEA FDL++ LR++ +R + L ++ HHIV D
Sbjct: 117 DLGAIEASRREALAAQEAGRVNGVPFDLTRGPLLRVSVIRLGEN-EHVLVVVMHHIVSDG 175
Query: 2090 WSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQR---SSAFNQTHLNYWLTKFA 2146
WS+ IL+DE +Y V+G + P+ + ++A QR + + YW +
Sbjct: 176 WSMQILVDEFMALYADGVRGRQAALPVLPVGYADYAAWQRHWMEAGERDRQIAYWREQL- 234
Query: 2147 GVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAI 2206
G DHP G G + +P++ L Q A+A+ ASLF + A
Sbjct: 235 GTEHPVLQLPTDHPRKAEGGYQAAHHG---LTVPQALTARLQQRAQAQGASLFMALLAGF 291
Query: 2207 SASVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKVQTVWQLIEQVKNS 2266
A +H A + + VG P + R E VG+F V + Q+ EQ ++
Sbjct: 292 QALLHRHTAQDDIRVGVPVANRNRVETEGVVGFFVNTQVLRNRVDARMPLGQVFEQAVHA 351
Query: 2267 INQSMPYTDIPIDLIEEGLKGVEHETEGHMFEVFIQL---------HAKNKLHGELLLTE 2317
+ + D+P + + E L+ + +F+V + A L G L +
Sbjct: 352 ALGAQAHQDLPFEQLVEALQPERSMSHSPLFQVMLNFQRDFKGSARQASQPLPG--LSVQ 409
Query: 2318 GHAIRFQQVDPDKSESGLGLQFEILEERIEQKQ-TLRVMMSYMSKHYSPAQVALLTKVTS 2376
HA+ G QFE+ + ++ + +R+ Y S + +A +
Sbjct: 410 AHAL-----------GGQAAQFELTLDAVQDEAGEVRLKFVYASGLFDADTIARMGTHYL 458
Query: 2377 GMFERFSD 2384
+ E +D
Sbjct: 459 ALLEALAD 466
Score = 83.2 bits (204), Expect = 1e-18
Identities = 90/390 (23%), Positives = 168/390 (43%), Gaps = 27/390 (6%)
Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
VE+ + A + S LGV ++ D+FF+ GG S+++ +++ R + + G +L +F
Sbjct: 2099 VEQMLAAVWASVLGVEQVGRTDNFFELGGDSILSLQIVAR-VRQAGWKLTPRQLFERQTV 2157
Query: 1921 KQLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLPFAL 1980
QLA A +P T+ + + PL QA+ +A+ + +N L
Sbjct: 2158 AQLAAVA----QPVETAGRANHGEAEGEVPLLPIQAAF------FAQAMPSRHWNQAVLL 2207
Query: 1981 KFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLE-DGQPYQHVIAASNIEHYQWFWTSKDNA 2039
+ + + + A L+ +H LR + E +G Q S + W
Sbjct: 2208 QSREPLQPASLERALAALVRQHDSLRLRYTQEAEGAWRQAYAPLSECQAQTVLWVKHARD 2267
Query: 2040 AQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDEL 2099
A + R L EA+ + D+ + PL + Q G+ L L HH+ +D S IL+++L
Sbjct: 2268 AAEIER-LCDEAQRSLDIGRG-PLIRALAIEVQDGSWRLLLAIHHLAVDGVSWRILLEDL 2325
Query: 2100 AQVYQHSVQGTRPQWQTEPLPFHEFA-RKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAAD 2158
Y + + + A Q +A ++ L +W AG P P + +
Sbjct: 2326 QTAYAQCRADQAVALPAKTSSYKDMALALQAHAATHEAELVFW-QALAGTPVLLPCASRE 2384
Query: 2159 HPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFN-VMYAAISASVHCLGAPE 2217
+ +T D+ VE++L ++ +L + A A + + N ++ A+ ++ G E
Sbjct: 2385 ---AGNTTADMTS---VELRLDRARTQALLKDAPAAYRTQVNDLLLTALGRALCAWGGHE 2438
Query: 2218 KLLVGTPASGRLD----AEFFDTVGYFTTM 2243
+L+ GR D + TVG+FT++
Sbjct: 2439 SILIDLEGHGREDLFEHVDLSRTVGWFTSL 2468
Score = 67.4 bits (163), Expect = 7e-14
Identities = 80/312 (25%), Positives = 130/312 (41%), Gaps = 37/312 (11%)
Query: 36 ALNRQALTEAVRALYAKHPMLR--LAITKDG--QQKILPLSTFHQLKVDDLSQWKPDEVE 91
AL+ AL A +AL A+H LR A T DG +Q I+P S ++ + DL + E
Sbjct: 69 ALDIDALRTAFQALVARHASLRTVFAPTHDGLAEQVIMP-SLALEIPLVDLGAIEASRRE 127
Query: 92 SFVHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTS 151
+ + R+ DLT+G + +S+ L E +H L + I D S ++LVD+ +
Sbjct: 128 ALAAQEAGRVNGVPFDLTRGPLLRVSVIRLGENEHVLVVVMHHIVSDGWSMQILVDEFMA 187
Query: 152 LYLEAIEHRLEIIESDVVTFFQY-------LDAQQADRALAKRKEVDKKWWQERLATIPA 204
LY + + R + V + Y ++A + DR +A +W+E+L T
Sbjct: 188 LYADGVRGRQAALPVLPVGYADYAAWQRHWMEAGERDRQIA--------YWREQLGT--- 236
Query: 205 EPSLPYQPVPTD---AVSANSQRFAHWFTPVE--RKGLAEVARQHHLTLTQLTLALFSQV 259
P +PTD Q H T + L + A+ +L LA F +
Sbjct: 237 --EHPVLQLPTDHPRKAEGGYQAAHHGLTVPQALTARLQQRAQAQGASLFMALLAGFQAL 294
Query: 260 IANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQTAN-- 317
+ + R+ VP +R ++ E +G F N + V L + +Q +
Sbjct: 295 LHRHTAQDDIRVGVPVANRNR--VETEGVVGFFVNTQVLRNRVDARMPLGQVFEQAVHAA 352
Query: 318 ---QLHQLLRHE 326
Q HQ L E
Sbjct: 353 LGAQAHQDLPFE 364
Score = 63.9 bits (154), Expect = 8e-13
Identities = 104/481 (21%), Positives = 175/481 (36%), Gaps = 60/481 (12%)
Query: 1791 LDATVSPHVGAYLLEQFVAAIGGRTMPSSTTSSSHVSAIELTSNNPPTSNNAHAALAESE 1850
L A VSP G L + + G +P ++ V+ + P +N A E
Sbjct: 947 LVAYVSPQAGRQLDVNTLKSGLGAVLPEYMVPAAWVA---MPQGLPLNANGKVDRKALPE 1003
Query: 1851 LELSAVNS-----SAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQ 1905
E + ++ EE + + LGV + D FF+ GGHSL+A +++ R + Q
Sbjct: 1004 PERAGTDAYEAPQGTTEEALATLWAEVLGVERVGRSDSFFELGGHSLLAIQLLER-MRRQ 1062
Query: 1906 GIELHINDMFSFPNAKQLAQQAVLHRKPTSTSFAVSE--------VVESSKAPLSLAQAS 1957
G + + +F P Q AQ + + E VE L
Sbjct: 1063 GWSVEVRTLFQKPRLAQFAQALTPVGNEEAPRLDIPESLIPQGCLAVEPGMLALIELSPG 1122
Query: 1958 LWKAMSKYAKFGLTHIFNL-------------------------PFALKFLDEVNEQAFG 1992
+A+ G +I ++ F L F + F
Sbjct: 1123 HLRAIEAEVPGGAANIQDIYPLAPLQEGILFHHMMQAEGDVYVNSFLLAFDSQARLAGFV 1182
Query: 1993 EAFHWLLLRHAGLRTHFGLED-GQPYQHVIAASNIEHYQWFWTSKDNAAQSVARLLAQEA 2051
++ + ++ RH LRT E +P Q V + ++ QW + + A
Sbjct: 1183 DSLNEVVARHDILRTAVLWEGLPEPVQVVYRRAGLQ-VQWLDVGAGDDVAARLDAHVDPA 1241
Query: 2052 EHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTR 2111
D+ + LR D + G L + HH+ LD S +L++E+A + ++G R
Sbjct: 1242 HFRIDVRRAPMLRAIAAHDPEDGRWLLQVPSHHLALDHASEELLVEEIALI----LRGRR 1297
Query: 2112 PQWQTEPLPFHEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGE 2171
P+PF F + R A Q ++ V A P + G +L E
Sbjct: 1298 DALPV-PVPFRRFVAQARFGASPQEAEKFFTAMLGDV--ADPTAPFELLDVRGNGSELAE 1354
Query: 2172 GGWVEIKLPKSTMVSLYQLAKA---RHASLFNVMYAAISASVHCLGAPEKLLVGTPASGR 2228
+ L T L Q A+A A+LF++ +A + A + ++ GT GR
Sbjct: 1355 ---ARLLLDAGTSALLRQQARAAGVSAATLFHLAWALVLAKT---TGRDDVVFGTVLFGR 1408
Query: 2229 L 2229
+
Sbjct: 1409 M 1409
Score = 54.3 bits (129), Expect = 6e-10
Identities = 87/415 (20%), Positives = 160/415 (38%), Gaps = 63/415 (15%)
Query: 1862 EECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNAK 1921
E + A + L V + D+FF+ GGHSL+A +++ ++ G + +F P
Sbjct: 3600 ERALAAIWADVLAVERVGRNDNFFELGGHSLLAIQLLEQV-RRLGWGAEVRTLFRKPRLA 3658
Query: 1922 QLAQQAVLHR---KP-------------TSTSFAVSEVVESSKAPLSLAQASL-WKAMSK 1964
A R +P T+ S + +V+ A L+ +A++ A++
Sbjct: 3659 DFALAVTEARDFARPEIEVPANGIPEGCTALSPEMLTLVKLDDAQLARIEAAVPGGAVNI 3718
Query: 1965 YAKFGLTHI----------------FNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTH 2008
+ L + + P L F E F E+F+ ++ RH LRT
Sbjct: 3719 QDVYPLAPLQEGILFHHVLQSQGDAYITPCLLSFDSEARLLRFVESFNQVIARHDILRTA 3778
Query: 2009 FGLEDGQPYQHVIAASNIEHYQWFWTSK-----DNAAQ-SVARLL---AQEAEHTFDLSQ 2059
E + V+ QW + + A + SVA L + + D+ +
Sbjct: 3779 VHWEQLEEPVQVVQRRAELRLQWLHEIEGEGDGEGAGKCSVAERLDACVDPSRYRIDVRR 3838
Query: 2060 ELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPL 2119
+R D + L L HH+V+D ++ +++DE+A + Q R P+
Sbjct: 3839 APMIRAVAAHDAEGERWLLQLPCHHLVMDHTTVELIIDEIALIQQ-----DRHDELPVPM 3893
Query: 2120 PFHEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKL 2179
PF + + R H +++ A V F + TGV+ E++L
Sbjct: 3894 PFRRYVAQARLGVSRAEHDDFFRRMLADVEEPTAPFNVLDVQGDGTGVE-------EVRL 3946
Query: 2180 PKSTMVSLYQLAKARH-----ASLFNVMYAAISASVHCLGAPEKLLVGTPASGRL 2229
S +S +A+ A+LF++ +A + A + ++ GT GR+
Sbjct: 3947 SLSDALSAQLRREAQRQGVGTAALFHLAWALVLAKT---TGRDDVVFGTVLFGRM 3998
Score = 50.4 bits (119), Expect = 9e-09
Identities = 61/252 (24%), Positives = 102/252 (40%), Gaps = 22/252 (8%)
Query: 1983 LDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQS 2042
+D ++ F +A+ L RH LR+ F E P Q V+ + W A+S
Sbjct: 2673 VDGLDVARFRQAWQAALSRHDILRSGFLAEGKAPAQWVVRYVEVPLSVHDWRDDAGQARS 2732
Query: 2043 VARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQV 2102
+ L E FDL++ +RL VR + ++ HH++LD WS + LM E+ +
Sbjct: 2733 LDALAQDELARGFDLARPPLMRLVLVRTAEQ-RHHMLWTVHHLLLDGWSTSQLMGEVLRH 2791
Query: 2103 YQHS---VQGTRPQWQTEPLPFHEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAA-D 2158
Y G R + E L + +R YW + A V L AA
Sbjct: 2792 YDGQALPAPGGRYRDYIEWLQGRDATESER----------YWRAQIALVDAPTRLAAALP 2841
Query: 2159 HPLSNS--TGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHCLGAP 2216
P+ ++ TG + G L + M L Q+A+ ++ ++ AA + +
Sbjct: 2842 RPVQDAGRTGHSVHHGA-----LDAAAMQRLTQVARRERVTVNTMVQAAWALLLGRYTGQ 2896
Query: 2217 EKLLVGTPASGR 2228
++ G +GR
Sbjct: 2897 RHVVFGATVAGR 2908
Score = 49.3 bits (116), Expect = 2e-08
Identities = 66/271 (24%), Positives = 112/271 (41%), Gaps = 35/271 (12%)
Query: 1860 AVEECILAEFRSALGVAEMTAE-DDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFP 1918
AVEE + A + LG + D+FF+ GG S+++ +++ R G L +F
Sbjct: 4677 AVEEALAAIWHQVLGAEKKIGRHDNFFELGGDSILSLQIVTRA-QRAGWTLTPRQLFEHQ 4735
Query: 1919 NAKQLAQQAVL--------HRKP-------------TSTSFAVSEVVESSKAPLSLAQAS 1957
+ +LA A R+P FA E+ + PL+ Q
Sbjct: 4736 SIARLALVAQPVDGGHEENPREPRGRPQDFLPTDVLAGLPFAADEIEDIY--PLAPTQEG 4793
Query: 1958 LWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDG--Q 2015
++ + + GL ++ L + +V+ + F A+ ++ RHA LRT F + G +
Sbjct: 4794 MFFHSMEASGSGL-YVNQLSVEI---GQVDPERFARAWEAMVARHAMLRTAFLWQAGMKR 4849
Query: 2016 PYQHVI---AASNIEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQ 2072
P Q V+ A Q+ W + Q +A + QE D Q R++ +R +
Sbjct: 4850 PLQLVLRHAPAQAARVAQFDWRGSPDVRQRLAEHVQQELLRPVDWLQPPLARVSLIRLAE 4909
Query: 2073 TGTQYLSLLFHHIVLDEWSINILMDELAQVY 2103
Q L HHI+ D W+ + L+ E Y
Sbjct: 4910 DRHQ-LVWTHHHILSDGWTDSRLLGEWLACY 4939
Score = 38.9 bits (89), Expect = 3e-05
Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 2/106 (1%)
Query: 1847 AESELELSAVNSSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIG--RLLSE 1904
AE+ + S+ E + ++ LGV ++ D+FF+ GG SL++ +VI R L
Sbjct: 5741 AENPGRVHVPPSTPQAEQLAQIWQQVLGVGQVGETDNFFELGGDSLLSLKVIAQVRRLRN 5800
Query: 1905 QGIELHINDMFSFPNAKQLAQQAVLHRKPTSTSFAVSEVVESSKAP 1950
++ + D+ +P L +P S A++ + + P
Sbjct: 5801 PKLDFKLRDLMRWPTIGGLLHATTAAAQPDSNLIALNGEAQGTGMP 5846
Score = 38.1 bits (87), Expect = 5e-05
Identities = 40/171 (23%), Positives = 70/171 (40%), Gaps = 11/171 (6%)
Query: 35 QALNRQALTEAVRALYAKHPMLRLAITKDGQ----QKILPLSTFHQLKVDDLSQWKPDEV 90
+ L +L A+ AL +H LRL T++ + Q PLS V W
Sbjct: 2211 EPLQPASLERALAALVRQHDSLRLRYTQEAEGAWRQAYAPLSECQAQTV----LWVKHAR 2266
Query: 91 ESFVHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLT 150
++ + + LD+ +G I + +G RL + +A D S+R+L++DL
Sbjct: 2267 DAAEIERLCDEAQRSLDIGRGPLIRALAIEVQDGSWRLLLAIHHLAVDGVSWRILLEDLQ 2326
Query: 151 SLYLEAIEHRLEIIESDVVTFFQYLDAQQADRALAKRKEVDKKWWQERLAT 201
+ Y + + + + + Y D A +A A E + +WQ T
Sbjct: 2327 TAYAQCRADQAVALPAKTSS---YKDMALALQAHAATHEAELVFWQALAGT 2374
Score = 33.5 bits (75), Expect = 0.001
Identities = 32/113 (28%), Positives = 46/113 (40%), Gaps = 8/113 (7%)
Query: 1449 RLSGKVNIARLITALSQLPNHFPVLNRRYVLDEASGLTLYSAKPT-PLEIHFEHVESMDE 1507
RL G ++I L TA L L R GL P+ LEI + +++
Sbjct: 65 RLQGALDIDALRTAFQALVARHASL-RTVFAPTHDGLAEQVIMPSLALEIPLVDLGAIEA 123
Query: 1508 ------AFEHLVRWQNQPMDLAKQATLSFCLLSLGSEERVLGVISHQIISEQW 1554
A + R P DL + L ++ LG E VL V+ H I+S+ W
Sbjct: 124 SRREALAAQEAGRVNGVPFDLTRGPLLRVSVIRLGENEHVLVVVMHHIVSDGW 176