Pairwise Alignments

Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056

Subject, 3470 a.a., non-ribosomal peptide synthetase from Pseudomonas putida KT2440

 Score =  248 bits (634), Expect = 1e-68
 Identities = 258/1001 (25%), Positives = 439/1001 (43%), Gaps = 100/1001 (9%)

Query: 445  LGYARRESIQEMPLTPLQQAYLLGRSTQIALGGVAMHEFREYRGHIDTQSLHSRLLYLVE 504
            + YA+        L P   AY +G + Q+             +G +D + L      L++
Sbjct: 47   VSYAQERQWFLWQLDPASGAYNIGAALQL-------------QGRLDIEGLRGACQALIQ 93

Query: 505  HIPALRT--RIDQEKWIQWVSPCIALNWQAIDLQHLSREQALLAVEPVRQQYQQ---RMH 559
                LRT  R D ++ +Q + P +        L  +S        + +R+  +    +  
Sbjct: 94   RHEVLRTTLRQDSDRVVQIIHPQMPFELLIEPLIGMSATS-----DALREHVEACIAKPF 148

Query: 560  DLTRSPWQICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHALILAALLGSEE-------P 612
            DL + P  + +  LP+ E +    +++ +   +  DG +  +++  L+   E       P
Sbjct: 149  DLEQGPL-LRLNLLPLGEDDH---VLVLTVHHIAADGWSMPILINDLVQCYERLSQGQAP 204

Query: 613  DITQVVQNARDTQSISPQF--ASKKAQDEAYWKSKLHPDCPPPALPWKQALETITTSRYA 670
            ++  +     D       +  A ++A+  AYWK  L  + P  +LP  ++     + R A
Sbjct: 205  NLPALPVQYADYAIWQRNWMEAGEQARQLAYWKDTLGGEQPVLSLPTNRSRPVAPSGRGA 264

Query: 671  RESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEIGMRVGFPVLIPSSNAI 730
            R  ++I    +  L       G+ L  LL A+   +L  ++ +  +RVG P+   + + +
Sbjct: 265  RVGIEIDAVLLQSLKALANAQGVTLFMLLLASFQTLLHRYSGQPQVRVGVPIANRNRSEV 324

Query: 731  DGNESSFVILEHEKSTLSLLS--------------QASKLQ----REMLEALE-HLAFSG 771
             G    FV  +  K+  +L S              QA   Q     +++EAL+   + S 
Sbjct: 325  QGLIGFFVNTQVLKADFALHSRFIDVLQQVKETALQAQAHQDLPFEQLVEALQPERSMSH 384

Query: 772  VDLNRLLMNQAPQALVLPVVLTNGLSWKTLNPEDAVTLFDGVTQTPQVALDIRLTYDEQK 831
              L +++ N   QA        +GL  + L  +   T FD       + LD R   +   
Sbjct: 385  SPLFQVMFNHQAQAASDAHAQLSGLQVRGLEWDSRTTQFD-------LTLDTR---EHAD 434

Query: 832  NLIISFDYALAVLETELIREMLSALHHRLSQITSSASLAAPLEPCIDLSHY-------RF 884
             L  S  YA  + +   I +M  A H R   I +       +     L H        ++
Sbjct: 435  GLFASLTYATDLFDVSRIEQM--ARHWRNLLIQACQDPRKRVLELALLEHDERERILGQW 492

Query: 885  NSDESASHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTT 944
            N  + A      + +L +Q   RT D  A+  GEQTLSYA+L  Q  ++   L+ RG+  
Sbjct: 493  NQTQMAYPTKLGVYRLFEQQVCRTPDAVALRFGEQTLSYAELNRQANQLAHALRERGVGP 552

Query: 945  GNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEF 1004
              ++ + +PR    +V  LA   +G  +VP+D   P ERL Y++E+    L++ ++    
Sbjct: 553  EVLVGVAMPRGPRMLVGLLAIFKAGGAYVPLDPDYPAERLAYMIEDSGLGLLLTEQAVLA 612

Query: 1005 -----GNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVV 1059
                   V +     +   +A    +  PLD       +   AY +YTSG+TG+PK V V
Sbjct: 613  RLQVPATVASLCLDTDTACYASAAAEDLPLDV-----DADHPAYVIYTSGSTGRPKGVTV 667

Query: 1060 NNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDA 1119
             + A  N +        + + D V+++T L  D++  +L+  L  GA++VL A  + KD 
Sbjct: 668  RHGALVNFLTSMAVQPGIAASDRVLALTSLSFDIAGLELYLPLLHGASVVLLADQQNKDP 727

Query: 1120 LQWNRLIERHQVTIWVSVPAILEMLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSN 1179
                R+IE+  V++  + P+   MLL       L   R+I+ GG+ +  + +AQ R    
Sbjct: 728  FALLRVIEQQAVSVIQATPSTWRMLLDNAPPQALRGKRVIS-GGEALS-SELAQ-RLIDQ 784

Query: 1180 PPRLISLGGPTETTIWSIWHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIF 1239
               + +L GPTETTIWS   ++T  D   +  G+P+    + ++D     VP GV G +F
Sbjct: 785  AGHVWNLYGPTETTIWSGIEKVT--DSRQVWLGKPIGNTTFHVLDAQFDAVPVGVSGELF 842

Query: 1240 TSGVNLAQGYLEDGELKQTDFVTVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVK 1299
              G  LA+GYL+   L    F+   + HGH  R +RTGD   YR DG + +  RI+  +K
Sbjct: 843  IGGDGLARGYLKRPGLTAERFIP--NPHGHG-RLYRTGDLVRYRDDGVLEYMGRIDHQLK 899

Query: 1300 VRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTAL-------AALFSVKPQ-QSASS 1351
            +RG R+ L +IE  LQ   A+  V V+D     G           A+L     + Q    
Sbjct: 900  IRGFRIELGEIEASLQGFGAVREVAVIDVDGPLGKQLAGYIVPYDASLLQADAEVQETLR 959

Query: 1352 QALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRKQCQA 1392
             AL+  A +S+P   +P+  + +  +PL+ NGK+DRK   A
Sbjct: 960  LALKAHALKSMPDYMVPTHLVFIPRMPLTPNGKLDRKALPA 1000



 Score =  232 bits (592), Expect = 7e-64
 Identities = 235/942 (24%), Positives = 416/942 (44%), Gaps = 60/942 (6%)

Query: 487  RGHIDTQSLHSRLLYLVEHIPALRTRIDQEKWIQWVSPCIALNWQAIDLQHLSREQA--L 544
            RG +D  +L      LV    +LRT   Q            ++ +A  + H    Q   L
Sbjct: 1135 RGALDVAALQQAFQALVARHESLRTTFVQ------------VDGEARQVIHAPEAQGACL 1182

Query: 545  LAVEPVRQQYQQRMHDLTRSPWQIC---VVQLPIEEQEEFSSIVLTSFDALIVDGRTHAL 601
               +    + Q  +  L R P+ +    ++++ +   E  + +++ +   +I DG + A+
Sbjct: 1183 RQADVDAVELQATVEQLAREPFDLVNGPLIRVDLLRLEAQAHVLVMNLHHIITDGWSMAV 1242

Query: 602  ILAALLG-------SEEPDITQVVQNARDTQSISPQF--ASKKAQDEAYWKSKLHPDCPP 652
            ++  L+         +  ++  +     D  +   Q+  AS++A+  AYW+++L  + P 
Sbjct: 1243 LVNELVALYQGYRHGQAVELPALAVQYADYAAWQRQWLEASEQARQLAYWEAQLGGEQPV 1302

Query: 653  PALPWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTT 712
              LP         +    + SL +    V  L R     G+ L  LL A+   +L  ++T
Sbjct: 1303 LELPTDYPRPAQPSRAGGQLSLALDAPLVQALRRQAQAQGVTLFMLLLASFQTLLHRYST 1362

Query: 713  EIGMRVGFPVLIPSSNAIDGNESSFVILEHEKSTLSLLSQASKLQREMLE-ALEHLAFSG 771
            +  +RVG PV   +    +G    FV  +  K+   L  +  +L R++ + AL+  A   
Sbjct: 1363 QPDIRVGVPVANRTRGETEGVVGFFVNTQVHKAEFHLRLRFVELLRQVRQTALDAQAHQD 1422

Query: 772  VDLNRLLMNQAPQALV-----LPVVLTNGLSWKTLNPEDAVTLFDGVT-QTPQVALDIRL 825
            +   +L+    P  ++       V+  +    K    E      + V  Q      D+ L
Sbjct: 1423 LPFEQLVAALKPDRILNQNPLFQVMFNHQAEAKGAPREVPGLQIEAVDWQVHSTQFDLAL 1482

Query: 826  -TYDEQKNLIISFDYALAVLETELIREMLSALHHRLSQITSSAS-LAAPLEPCIDLSHYR 883
             T +    +  +F +A  + + + I +M     + L  I+  A+ + A L    DL    
Sbjct: 1483 DTAEHADGMTAAFTFATELYDRQTIEQMARHWRNLLQAISRDANQVVAQLPMLDDLEQQC 1542

Query: 884  FNSDESASHDCDFLAKLAQQLFV----RTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKA 939
               D +A+      A+L  QLF     R     A+I  + TLSY +L ++  R+  +L+ 
Sbjct: 1543 MLHDWNATAVAYPQARLVHQLFEDQAQRHPQAPALIFADATLSYTELDQRANRLANKLRE 1602

Query: 940  RGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMD 999
            +G+    ++ + + RS+E ++  +A   +G  +VP+D   P +RL Y++E+    L++  
Sbjct: 1603 QGVGPEVLVGVAVERSLELVIGLMAVLKAGGAYVPLDPDYPSDRLAYMIEDSGIGLLLSQ 1662

Query: 1000 KPCE----FGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPK 1055
            +           +    L +   +  G  D  P   + RL+     AY +YTSG+TG+PK
Sbjct: 1663 QALAERLPVPAAVRILCLDQDAQWLAGYADTAPEVDV-RLAN---LAYVIYTSGSTGRPK 1718

Query: 1056 CVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHE 1115
                 ++A  N +     A+ L + D V+  TP   D+SV++ F  L  GA L +    +
Sbjct: 1719 GAGNTHEALLNRLQWMQGAYGLDASDTVLQKTPFSFDVSVWEFFWPLMTGARLAVALPGD 1778

Query: 1116 EKDALQWNRLIERHQVTIWVSVPAILEMLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLR 1175
             +D  +  + I  HQV+    VP++L+  ++  +  Q  S+R +   G+ +      Q R
Sbjct: 1779 HRDPQRLCQTIIDHQVSTLHFVPSMLQAFMASAEVEQCRSVRRVVCSGEALPAVLAQQCR 1838

Query: 1176 AGSNPPRLISLGGPTETTIWSIWHELTADDVSV-IPYGRPLAGNRYFIMDEIQRHVPQGV 1234
                   L +L GPTE  I  + H    D     +P G+P+   R  I++       +GV
Sbjct: 1839 ERLPHAGLYNLYGPTEAAI-DVTHWTCGDKQGFSVPIGQPIDNLRTHILEPDLLPAARGV 1897

Query: 1235 VGRIFTSGVNLAQGYLEDGELKQTDFV-TVLDEHGHPVRAFRTGDQGYYRADGNIIFASR 1293
             G ++ +G+ LA+GY     L    FV    DE G   R +RTGD   YR DG I +A R
Sbjct: 1898 NGELYLAGIGLARGYHGRPALTAERFVPDPFDEQGG--RLYRTGDLARYRPDGVIDYAGR 1955

Query: 1294 INGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKPQQ----SA 1349
            I+  VK+RG+R+ L +IE +L  H  +   VV+     +G   +  +  +  +Q    S 
Sbjct: 1956 IDHQVKIRGLRIELGEIEARLAEHAQVREAVVLAQDGPSGKQLVGYVVPMAAEQAEPGSE 2015

Query: 1350 SSQALRE----FAKQSLPSSHIPSRFIALEALPLSANGKVDR 1387
            + Q LRE    F  Q LP   +P+  + L  LP++ANGK+ R
Sbjct: 2016 AGQRLREQLAHFLGQGLPDYMVPAHLMLLANLPVTANGKLAR 2057



 Score =  196 bits (498), Expect = 6e-53
 Identities = 248/1003 (24%), Positives = 415/1003 (41%), Gaps = 82/1003 (8%)

Query: 436  QSVQQIDAQLGYARRESIQEMPL-----------TPLQQAYLLGRSTQIALGGVAMHEFR 484
            Q V+Q    L     + +Q +PL           +P+QQ  L      ++L G    +  
Sbjct: 2148 QMVEQQSVALHSLTEQQVQALPLEHAGVDGLYSLSPMQQGMLF-----LSLNGRPEDQLY 2202

Query: 485  EYRGHIDTQSLHSRLLY-----LVEHIPALRTRI---DQEKWIQWVSPCIALNWQAIDLQ 536
              +  +  Q L +  L      +V     LRT     D ++ +Q+V   + L  + +D +
Sbjct: 2203 INQLSVPVQGLVAERLRQAWETVVARHDVLRTGFLWQDLDEPLQYVMGQLPLPLRELDWR 2262

Query: 537  HLSREQALLAVEPVRQQYQQRMHDLTRSPWQ-ICVVQLPIEEQEEFSSIVLTSFDALIVD 595
               R     A+E +  + ++R  DL R P Q + +V+L  +  +     ++ ++  +++D
Sbjct: 2263 --GRGDCAQALEALANEERERGFDLARPPLQRMLLVRLDDQRHQ-----LIWTYHHILLD 2315

Query: 596  GRTHALILAALLGSEEPDITQVVQNARDTQSISPQFASKKAQDEAYWKSKLHPDCPPPAL 655
            G + + ++  +L          V   R+      Q        E +WK +L     P  L
Sbjct: 2316 GWSTSQLMGEVLACYSGQTLDSVVPYRNYIGWLRQ--QDPRHSETFWKQQLASLQEPTYL 2373

Query: 656  PWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEIG 715
                A     +   A  S +                 + LN+++    L +LS ++ +  
Sbjct: 2374 ADAFASGERGSGHQALYS-RFSVAQTETFKAFAQSQRITLNTVVQGAWLLLLSRYSGQRS 2432

Query: 716  MRVGF-----PVLIPSSNAIDGNESSFVILEHEKSTLSLLSQ-ASKLQREMLEALEHLAF 769
            +  G      P  +P   ++ G   + + + HE    + + Q   +LQR  LE  +H   
Sbjct: 2433 VSFGATVAGRPAALPGVQSMLGLFINTLPVIHEVDPQAQVGQWLQQLQRINLELRDHEYT 2492

Query: 770  SGVDLNRLLMNQAPQALVLPVVLTNGLSWKTLNP--EDAVTLFD----GVTQTPQVALDI 823
            +  ++ R             +V  N    +TL    +D++   D    G+T  P   +D+
Sbjct: 2493 ALGEIQRWAGRSGQPLFDSIIVFENQPLDRTLREWKDDSLQFGDVGGSGLTDFP---MDL 2549

Query: 824  RLTYDEQKNLIISFDYALAVLETEL---IREMLSALHHRLSQITSSASLAAPLEPCIDLS 880
             +  ++Q  LII + Y       E    IR  + AL   LS    +      L P   L 
Sbjct: 2550 MVIVEDQ--LIIEYMYLRQCFSEEAVAGIRANMEALLQALSLDGQARLGNLGLLPGAPLR 2607

Query: 881  HYRFNSDESASHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKAR 940
                 + ++     + +A+ AQQ      D  AV    QTLS+A+L      +   L A 
Sbjct: 2608 ALTPPAQQAPLLVHERIAQWAQQ----QGDAVAVKVDGQTLSFAELDRAANCLAHALIAE 2663

Query: 941  GLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDK 1000
            G+     + + L R+ + IV  LA   +G  +VPID A P ERL+YL+E+    L+V   
Sbjct: 2664 GVGPEVRVGVALQRTPQMIVALLAVLKAGAAYVPIDTAYPAERLSYLMEDSGVALLVSQT 2723

Query: 1001 PCEFG-----NVIAFDA-LIEPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKP 1054
                G     NV A +    +P  +    P VT         Q +  AY +YTSG+TGKP
Sbjct: 2724 AALAGLPKLANVHALNLDSFDPTQWPGHAPQVT--------LQGENLAYVIYTSGSTGKP 2775

Query: 1055 KCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGH 1114
            K VVV++ A +      G+ + +T  D  +       D +       L+ G +++L  G 
Sbjct: 2776 KGVVVSHDALAMHCQAIGERYEMTPADCELLFMSFAFDGAHERWLTALTHGGSVLL-RGD 2834

Query: 1115 EEKDALQWNRLIERHQVTIWVSVPAILEMLLS-CTQAGQLHSLRLIAQGGDYIKPATIAQ 1173
            E     Q  + + RH V++    P  L+ L+    + G    +R+   GGD +  A+  Q
Sbjct: 2835 ELWTPEQTCQALHRHGVSVAAFPPVYLQQLIEQVREHGNPPPMRIYCFGGDAVPQASYEQ 2894

Query: 1174 LRAGSNPPRLISLGGPTETTIW-SIWHELTADDVSVI--PYGRPLAGNRYFIMDEIQRHV 1230
              A   P  +I+  GPTET +  +IW          +  P G  +     ++MD     +
Sbjct: 2895 AHAYLQPQYIINGYGPTETVVTPTIWKAAPQQPCGAVYAPIGTLVGQRSAYVMDVDLNPL 2954

Query: 1231 PQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVLDEHGHPV-RAFRTGDQGYYRADGNII 1289
            P GV G ++  G  +A+GYL    L    FV    + G+P  R +RTGD    R DG   
Sbjct: 2955 PPGVAGELYLGGTGVARGYLNRPGLTAERFVA---DPGNPGGRLYRTGDLVRQREDGTFD 3011

Query: 1290 FASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKPQQSA 1349
            +  R++  VKVRG R+ L +IE +L     +    VV     +G      +   +     
Sbjct: 3012 YLGRLDNQVKVRGFRIELGEIEARLADMDPVRQAAVVVRDGPSGKQLFGYVTLAEGHAQG 3071

Query: 1350 SSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRKQCQA 1392
             ++ LRE  KQ LP   +P++ + LE +PLS NGK+DR    A
Sbjct: 3072 IAEQLRERLKQELPEYMVPAQLMVLERMPLSPNGKLDRNALPA 3114



 Score =  127 bits (318), Expect = 4e-32
 Identities = 132/576 (22%), Positives = 236/576 (40%), Gaps = 40/576 (6%)

Query: 1858 SSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSF 1917
            +S +++ + A +   L V ++   D FF+ GGHSL+A+++IGR+  +  +E+ +  +F  
Sbjct: 1014 TSPLQQALAAIWADVLKVGQVGLSDSFFELGGHSLLASQMIGRVRQQLALEVPLRSVFEA 1073

Query: 1918 PNAKQLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLP 1977
             +    A++            A++ V       LS AQ   W           +  +N+ 
Sbjct: 1074 QDLAGFAERVAAATTGAQLP-AIAVVPRGEPLALSYAQQRQWVLWQLEPH---SAAYNIA 1129

Query: 1978 FALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIEHYQWFWTSKD 2037
             AL     ++  A  +AF  L+ RH  LRT F   DG+  Q + A    E         D
Sbjct: 1130 SALHLRGALDVAALQQAFQALVARHESLRTTFVQVDGEARQVIHAP---EAQGACLRQAD 1186

Query: 2038 NAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMD 2097
              A  +   + Q A   FDL     +R++ +R E      L +  HHI+ D WS+ +L++
Sbjct: 1187 VDAVELQATVEQLAREPFDLVNGPLIRVDLLRLEAQA-HVLVMNLHHIITDGWSMAVLVN 1245

Query: 2098 ELAQVYQHSVQGTRPQWQTEPLPFHEFARKQRS---SAFNQTHLNYWLTKFAGVPWAQPL 2154
            EL  +YQ    G   +     + + ++A  QR    ++     L YW  +  G    QP+
Sbjct: 1246 ELVALYQGYRHGQAVELPALAVQYADYAAWQRQWLEASEQARQLAYWEAQLGG---EQPV 1302

Query: 2155 FA--ADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHC 2212
                 D+P           GG + + L    + +L + A+A+  +LF ++ A+    +H 
Sbjct: 1303 LELPTDYPRPAQPS---RAGGQLSLALDAPLVQALRRQAQAQGVTLFMLLLASFQTLLHR 1359

Query: 2213 LGAPEKLLVGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKVQTVWQLIEQVKNSINQSMP 2272
                  + VG P + R   E    VG+F    V   +F       +L+ QV+ +   +  
Sbjct: 1360 YSTQPDIRVGVPVANRTRGETEGVVGFFVNTQVHKAEFHLRLRFVELLRQVRQTALDAQA 1419

Query: 2273 YTDIPIDLIEEGLKGVEHETEGHMFEVFIQLHAKNK--------LHGELLLTEGHAIRFQ 2324
            + D+P + +   LK      +  +F+V     A+ K        L  E +  + H+ +F 
Sbjct: 1420 HQDLPFEQLVAALKPDRILNQNPLFQVMFNHQAEAKGAPREVPGLQIEAVDWQVHSTQFD 1479

Query: 2325 -QVDPDKSESGLGLQFEILEERIEQKQTLRVMMSY---------MSKHYSPAQVALLTKV 2374
              +D  +   G+   F    E +  +QT+  M  +            +   AQ+ +L  +
Sbjct: 1480 LALDTAEHADGMTAAFTFATE-LYDRQTIEQMARHWRNLLQAISRDANQVVAQLPMLDDL 1538

Query: 2375 TSGMFERFSDCIAQDIALPTLKKQVRQLEDEACRSP 2410
                     D  A  +A P  +   +  ED+A R P
Sbjct: 1539 EQQCM--LHDWNATAVAYPQARLVHQLFEDQAQRHP 1572



 Score = 99.0 bits (245), Expect = 1e-23
 Identities = 96/374 (25%), Positives = 157/374 (41%), Gaps = 23/374 (6%)

Query: 1950 PLSLAQASLWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHF 2009
            P+S AQ   W         G    +N+  AL+    ++ +    A   L+ RH  LRT  
Sbjct: 46   PVSYAQERQWFLWQLDPASGA---YNIGAALQLQGRLDIEGLRGACQALIQRHEVLRTTL 102

Query: 2010 GLEDGQPYQHVIAASN----IEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRL 2065
              +  +  Q +         IE       + D   + V   +A+     FDL Q   LRL
Sbjct: 103  RQDSDRVVQIIHPQMPFELLIEPLIGMSATSDALREHVEACIAKP----FDLEQGPLLRL 158

Query: 2066 NFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFA 2125
            N +   +     L L  HHI  D WS+ IL+++L Q Y+   QG  P     P+ + ++A
Sbjct: 159  NLLPLGEDD-HVLVLTVHHIAADGWSMPILINDLVQCYERLSQGQAPNLPALPVQYADYA 217

Query: 2126 RKQRS---SAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGV-DLGEGGWVEIKLPK 2181
              QR+   +      L YW     G    QP+ +   P + S  V   G G  V I++  
Sbjct: 218  IWQRNWMEAGEQARQLAYWKDTLGG---EQPVLSL--PTNRSRPVAPSGRGARVGIEIDA 272

Query: 2182 STMVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFT 2241
              + SL  LA A+  +LF ++ A+    +H      ++ VG P + R  +E    +G+F 
Sbjct: 273  VLLQSLKALANAQGVTLFMLLLASFQTLLHRYSGQPQVRVGVPIANRNRSEVQGLIGFFV 332

Query: 2242 TMGVQLVDFTKVQTVWQLIEQVKNSINQSMPYTDIPIDLIEEGLKGVEHETEGHMFEVFI 2301
               V   DF        +++QVK +  Q+  + D+P + + E L+     +   +F+V  
Sbjct: 333  NTQVLKADFALHSRFIDVLQQVKETALQAQAHQDLPFEQLVEALQPERSMSHSPLFQVMF 392

Query: 2302 --QLHAKNKLHGEL 2313
              Q  A +  H +L
Sbjct: 393  NHQAQAASDAHAQL 406



 Score = 77.8 bits (190), Expect = 3e-17
 Identities = 89/383 (23%), Positives = 166/383 (43%), Gaps = 26/383 (6%)

Query: 1778 GLNCQGALVLELALDATVSPHVGAYLLEQFVAAIGGRTMPSSTTSSSHV--SAIELTSNN 1835
            G    G +V   A  A      G  L EQ +A   G+ +P     +  +  + + +T+N 
Sbjct: 1995 GKQLVGYVVPMAAEQAEPGSEAGQRLREQ-LAHFLGQGLPDYMVPAHLMLLANLPVTANG 2053

Query: 1836 PPTSNNAHAALAESELELSAVNSSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIAT 1895
                N   A    +  ++     +A+E+ + + + + L + ++  +D+FF  GG S+IA 
Sbjct: 2054 KLARNLLPAPDFNAARQVYVAPRTALEQQLASIWETVLNLPQVGMQDNFFALGGDSIIAI 2113

Query: 1896 RVIGRLLSEQGIELHINDMFSFPNAKQLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQ 1955
            +V+ +   + G+++   D+F     +QLA +    +     S A+  + E     L L  
Sbjct: 2114 QVVSQ-ARQLGLDIAPRDLFLLQTIEQLAARVGQWQMVEQQSVALHSLTEQQVQALPLEH 2172

Query: 1956 A---SLWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFG-------EAFHWLLLRHAGL 2005
            A    L+             +   P    ++++++    G       +A+  ++ RH  L
Sbjct: 2173 AGVDGLYSLSPMQQGMLFLSLNGRPEDQLYINQLSVPVQGLVAERLRQAWETVVARHDVL 2232

Query: 2006 RTHFGLED-GQPYQHVIAASNIEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLR 2064
            RT F  +D  +P Q+V+    +   +  W  + + AQ++  L  +E E  FDL++    R
Sbjct: 2233 RTGFLWQDLDEPLQYVMGQLPLPLRELDWRGRGDCAQALEALANEERERGFDLARPPLQR 2292

Query: 2065 LNFVR-DEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQ-HSVQGTRPQ-----W--Q 2115
            +  VR D+Q     L   +HHI+LD WS + LM E+   Y   ++    P      W  Q
Sbjct: 2293 MLLVRLDDQ--RHQLIWTYHHILLDGWSTSQLMGEVLACYSGQTLDSVVPYRNYIGWLRQ 2350

Query: 2116 TEPLPFHEFARKQRSSAFNQTHL 2138
             +P     F ++Q +S    T+L
Sbjct: 2351 QDPRHSETFWKQQLASLQEPTYL 2373



 Score = 62.8 bits (151), Expect = 1e-12
 Identities = 75/300 (25%), Positives = 117/300 (39%), Gaps = 23/300 (7%)

Query: 37  LNRQALTEAVRALYAKHPMLRLAITKDGQ---QKILPLSTFHQLKVDDLSQWKPDEVESF 93
           L+ + L  A +AL  +H +LR  + +D     Q I P   F +L ++ L           
Sbjct: 79  LDIEGLRGACQALIQRHEVLRTTLRQDSDRVVQIIHPQMPF-ELLIEPLIGMSATSDALR 137

Query: 94  VHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLY 153
            H   +    +  DL QG  + ++L  L E  H L +    IA D  S  +L++DL   Y
Sbjct: 138 EHV--EACIAKPFDLEQGPLLRLNLLPLGEDDHVLVLTVHHIAADGWSMPILINDLVQCY 195

Query: 154 LEAIEHRLEIIESDVVTFFQYLDAQQADRALAKRKEVDK-------KWWQERLATIPAEP 206
                   E +          L  Q AD A+ +R  ++         +W++ L       
Sbjct: 196 --------ERLSQGQAPNLPALPVQYADYAIWQRNWMEAGEQARQLAYWKDTLGGEQPVL 247

Query: 207 SLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEVARQHHLTLTQLTLALFSQVIANACQE 266
           SLP       A S    R       V  + L  +A    +TL  L LA F  ++     +
Sbjct: 248 SLPTNRSRPVAPSGRGARVGIEIDAVLLQSLKALANAQGVTLFMLLLASFQTLLHRYSGQ 307

Query: 267 RQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQTANQLHQLLRHE 326
            Q R+ VP  +R NRS +++  IG F N  +  AD       + + QQ      Q   H+
Sbjct: 308 PQVRVGVPIANR-NRS-EVQGLIGFFVNTQVLKADFALHSRFIDVLQQVKETALQAQAHQ 365



 Score = 44.7 bits (104), Expect = 3e-07
 Identities = 55/220 (25%), Positives = 86/220 (39%), Gaps = 26/220 (11%)

Query: 1386 DRKQCQAHVQRQSISVEPVGQPNQSQPLSPPTLSSASLSEFEQRVWRQHQRH-GDGRNQY 1444
            +RK   A +++Q +++  V +     P  P  +S A     ++R W   Q     G    
Sbjct: 15   ERKALAALLKQQGVNLYGVTRIFARDPADPTPVSYA-----QERQWFLWQLDPASGAYNI 69

Query: 1445 ATAYRLSGKVNIARLITALSQLPNHFPVLNRRYVLDEASGLTLYSAKPT-PLEIHFEHVE 1503
              A +L G+++I  L  A   L     VL  R  L + S   +    P  P E+  E + 
Sbjct: 70   GAALQLQGRLDIEGLRGACQALIQRHEVL--RTTLRQDSDRVVQIIHPQMPFELLIEPLI 127

Query: 1504 SM----DEAFEHLVRWQNQPMDLAKQATLSFCLLSLGSEERVLGVISHQIISEQWDWRRV 1559
             M    D   EH+     +P DL +   L   LL LG ++ VL +  H I ++ W    +
Sbjct: 128  GMSATSDALREHVEACIAKPFDLEQGPLLRLNLLPLGEDDHVLVLTVHHIAADGWSMPIL 187

Query: 1560 FECVTNGYNQIACDIDPVMEGEDLSLGFTPVMPQTPLSQA 1599
               +   Y             E LS G  P +P  P+  A
Sbjct: 188  INDLVQCY-------------ERLSQGQAPNLPALPVQYA 214



 Score = 34.3 bits (77), Expect = 4e-04
 Identities = 59/244 (24%), Positives = 90/244 (36%), Gaps = 50/244 (20%)

Query: 1336 ALAALFS--VKPQQSASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRKQCQAH 1393
            ALAA+++  +K  Q   S +  E    SL +S +  R     AL +      + +     
Sbjct: 1020 ALAAIWADVLKVGQVGLSDSFFELGGHSLLASQMIGRVRQQLALEVPLRSVFEAQDLAGF 1079

Query: 1394 VQR----------QSISVEPVGQPNQSQPLSPPTLSSASLSEFEQRVWR--QHQRHGDGR 1441
             +R           +I+V P G+P              +LS  +QR W   Q + H    
Sbjct: 1080 AERVAAATTGAQLPAIAVVPRGEP-------------LALSYAQQRQWVLWQLEPHSAAY 1126

Query: 1442 NQYATAYRLSGKVNIARLITALSQLPNHFPVLNRRYV-----------LDEASGLTLYSA 1490
            N  A+A  L G +++A L  A   L      L   +V             EA G  L  A
Sbjct: 1127 N-IASALHLRGALDVAALQQAFQALVARHESLRTTFVQVDGEARQVIHAPEAQGACLRQA 1185

Query: 1491 KPTPLEIHFEHVESMDEAFEHLVRWQNQPMDLAKQATLSFCLLSLGSEERVLGVISHQII 1550
                +E+            E L R   +P DL     +   LL L ++  VL +  H II
Sbjct: 1186 DVDAVELQ--------ATVEQLAR---EPFDLVNGPLIRVDLLRLEAQAHVLVMNLHHII 1234

Query: 1551 SEQW 1554
            ++ W
Sbjct: 1235 TDGW 1238



 Score = 31.6 bits (70), Expect = 0.003
 Identities = 24/109 (22%), Positives = 47/109 (43%), Gaps = 2/109 (1%)

Query: 1824 SHVSAIELTSNNPPTSNNAHAALAESELELSAVNSSAVEECILAEFRSALGVAEMTAEDD 1883
            + +  +E    +P    + +A  A   L       + +E  I   ++  L V ++   D+
Sbjct: 3091 AQLMVLERMPLSPNGKLDRNALPAMQALREHVAPRNELELAIARIWQDVLKVEQVGITDN 3150

Query: 1884 FFDFGGHSLIATRVI--GRLLSEQGIELHINDMFSFPNAKQLAQQAVLH 1930
            FF+ GG S+++ +V+   R L + G  L + D+       +L   A  H
Sbjct: 3151 FFELGGDSILSMQVVAKARGLKKIGFTLRLRDLIQKSTIAELTAVAGKH 3199