Pairwise Alignments

Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056

Subject, 1134 a.a., Non-ribosomal peptide synthetase from Hydrogenophaga sp. GW460-11-11-14-LB1

 Score =  233 bits (593), Expect = 2e-64
 Identities = 241/981 (24%), Positives = 422/981 (43%), Gaps = 74/981 (7%)

Query: 455  EMPLTPLQQAYLLGRSTQIALGGVAMHEFREYRGHIDTQSLHSRLLYLVEHIPALRTRI- 513
            +MP++  QQ     R          +     + G +D   L   L  LV    +LRTR  
Sbjct: 76   DMPISHTQQRLWFLRQMDPGSHAYNIAAALRFSGPLDEALLERVLAVLVARHESLRTRFI 135

Query: 514  ---DQEKWIQWVSPCIALNWQAIDLQHLSREQALLAVEPVRQQYQQRMHDLTRSPWQICV 570
                + +++  + P   ++   ID+ HL       A +   +   +R  DL ++P     
Sbjct: 136  SAQGEPRFV--IDPHARVHLDRIDISHLQGAARDAACKQAIESIARRPFDLAQAPLLHAG 193

Query: 571  VQLPIEEQEEFSSIVLTSFDALIVDGRTHALIL-------AALLGSEEPDITQVVQNARD 623
            +    ++Q+ F+     + D ++ DG +  + +       + L    E  + +      D
Sbjct: 194  LIREADQQQVFAF----ALDHIVSDGLSLGIFMLEFRDLYSRLATGHEVTVVEPPIQYYD 249

Query: 624  TQSISPQFASKKAQDE--AYWKSKLHPDCPPPALPWKQALETITTSRYARESLQIPKESV 681
                  +  ++ A DE  A+WK +L        LP  +    + T+  +R +LQ+     
Sbjct: 250  YAEWERRAFAQGAIDEHLAFWKRELAGLPSMLQLPTDRPRPPVQTASGSRCALQLTPAFS 309

Query: 682  GKLNRCGIENGLFLNSLLTATILDVLSYWTTEIGMRVGFPVLIPSSNAIDGNESSF---V 738
             +L   G   G  L  ++ +    ++  ++ E  + +G  +   + + ++     F   +
Sbjct: 310  DRLKAFGRAEGTTLFMVMLSAFQVLMHRYSGETDIAIGSAIANRNRSEVEHTIGFFANNL 369

Query: 739  ILEHEKSTLSLLSQASKLQREMLEALEHLAFSGVDLNRLL--------MNQAPQALVLPV 790
            +L  + S    + +     RE   AL   A   +  + L+        ++ +P   VL  
Sbjct: 370  VLRADVSGDPTVRELMTRVRE--RALRAYAHQEMPFDMLVDELGTRRELDHSPLFQVL-F 426

Query: 791  VLTN---------GLSWKTLNPEDAVTLFDGVTQTPQVALDIRLTYDEQKNLIISFDYAL 841
            VL N         GL   +++ +   + FD       +++D+   +D    L   F+Y  
Sbjct: 427  VLQNLSMTSLELPGLRCDSMDLDVTASRFD-------LSVDV---FDIVHGLRCYFEYNT 476

Query: 842  AVLETELIREMLSALHHRLSQ-ITSSASLAAPLEPCIDLSHYRFNSDESASHDCDFLAKL 900
             + +   I  ML+     L   I    +  + L    D    +   D +A+     + + 
Sbjct: 477  DLFDVSTIERMLNHYRKLLEGFIDRPDARVSELALLTDDEQRQLLLDWNATAMPYPVEQT 536

Query: 901  AQQLFV----RTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSV 956
               LF     RT D  A+   +  LSYA+L  +  R+   L+A G    +++ + + RS 
Sbjct: 537  VHGLFEAQAQRTPDAPALRFDDVVLSYAELNARANRLAHHLRALGAGRESLVGVWMERSE 596

Query: 957  EHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALI-- 1014
            + +V  L    +G  +VP+D A PK+R++Y++E+    +VV       G      A+   
Sbjct: 597  DMVVAVLGVLKAGAAYVPLDPAFPKDRIDYMMEDAALSVVVTQSALAEGLPAGIRAVCMD 656

Query: 1015 --EPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTG 1072
                 L A+   D  PL      + S   AY +YTSG+TG+PK V++ +++  N +    
Sbjct: 657  RDAAALAAEPAADPAPL------AGSGDLAYVIYTSGSTGRPKGVMLEHRSVVNFLLSMH 710

Query: 1073 QAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVT 1132
            +   +T++D  +SVT L  D++  ++   L+ G T+VL +     D ++   L+++ + T
Sbjct: 711  REPGITAQDRFVSVTTLSFDIAGLEIHGPLTVGGTVVLASRATALDGVRLAALLDQCEAT 770

Query: 1133 IWVSVPAILEMLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTET 1192
            +  + PA   +LL     G+   L+++  G    +      L  G     L ++ GPTET
Sbjct: 771  LLQATPATWRLLLESGWQGR-PGLKMLCGGEGLPRDLADKLLATGGE---LWNMYGPTET 826

Query: 1193 TIWS-IWHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLE 1251
            TIWS +W     D    I  GRP+A  + ++++      P GV G +   G  LA+GY  
Sbjct: 827  TIWSTVWR--VTDTTRAISIGRPIANTQVYVLEPSGLPAPVGVGGELCIGGDGLARGYRG 884

Query: 1252 DGELKQTDFVTVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIE 1311
              +L    FVT+      P R +RTGD   + ADG + F  R +  VKVRG R+ L +IE
Sbjct: 885  RDDLTAEKFVTLDLPGVGPTRVYRTGDVVRFLADGRMEFVGRRDHQVKVRGFRIELGEIE 944

Query: 1312 KQLQTHPALASVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIPSRF 1371
              L  H  +   VV    DT GD  L A    +P     ++A R   +  LP   +P+ F
Sbjct: 945  TVLAKHGGIKECVVHVREDTPGDQRLVAYVVSEPGTPFEAEAARATLRVQLPEYMVPNLF 1004

Query: 1372 IALEALPLSANGKVDRKQCQA 1392
            + LEALPL+ NGKVDRK   A
Sbjct: 1005 VVLEALPLTPNGKVDRKALPA 1025



 Score = 95.9 bits (237), Expect = 3e-23
 Identities = 110/476 (23%), Positives = 190/476 (39%), Gaps = 29/476 (6%)

Query: 1939 AVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWL 1998
            A+  V   +  P+S  Q  LW           +H +N+  AL+F   ++E         L
Sbjct: 67   ALERVPRQADMPISHTQQRLWFLRQMDPG---SHAYNIAAALRFSGPLDEALLERVLAVL 123

Query: 1999 LLRHAGLRTHFGLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQSVARLLAQE--AEHTFD 2056
            + RH  LRT F    G+P   +   + +   +   +    AA+  A   A E  A   FD
Sbjct: 124  VARHESLRTRFISAQGEPRFVIDPHARVHLDRIDISHLQGAARDAACKQAIESIARRPFD 183

Query: 2057 LSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQT 2116
            L+Q   L    +R E    Q  +    HIV D  S+ I M E   +Y     G       
Sbjct: 184  LAQAPLLHAGLIR-EADQQQVFAFALDHIVSDGLSLGIFMLEFRDLYSRLATGHEVTVVE 242

Query: 2117 EPLPFHEFARKQRSSAFNQ----THLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEG 2172
             P+ ++++A  +R  AF Q     HL +W  + AG+P    L   D P      V    G
Sbjct: 243  PPIQYYDYAEWERR-AFAQGAIDEHLAFWKRELAGLPSMLQL-PTDRP---RPPVQTASG 297

Query: 2173 GWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDAE 2232
                ++L  +    L    +A   +LF VM +A    +H       + +G+  + R  +E
Sbjct: 298  SRCALQLTPAFSDRLKAFGRAEGTTLFMVMLSAFQVLMHRYSGETDIAIGSAIANRNRSE 357

Query: 2233 FFDTVGYFTTMGVQLVDFTKVQTVWQLIEQVKNSINQSMPYTDIPIDLIEEGLKGVEHET 2292
               T+G+F    V   D +   TV +L+ +V+    ++  + ++P D++ + L       
Sbjct: 358  VEHTIGFFANNLVLRADVSGDPTVRELMTRVRERALRAYAHQEMPFDMLVDELGTRRELD 417

Query: 2293 EGHMFEVFIQLHAKNKLHGELLLTEGHAIRFQQVDPDKSESGLGLQFEILEERIEQKQTL 2352
               +F+V   L   +    EL       +R   +D D + S    +F++  +  +    L
Sbjct: 418  HSPLFQVLFVLQNLSMTSLEL-----PGLRCDSMDLDVTAS----RFDLSVDVFDIVHGL 468

Query: 2353 RVMMSYMSKHYSPAQVALL----TKVTSGMFERFSDCIAQDIALPTLKKQVRQLED 2404
            R    Y +  +  + +  +     K+  G  +R  D    ++AL T  +Q + L D
Sbjct: 469  RCYFEYNTDLFDVSTIERMLNHYRKLLEGFIDR-PDARVSELALLTDDEQRQLLLD 523



 Score = 63.2 bits (152), Expect = 2e-13
 Identities = 74/325 (22%), Positives = 127/325 (39%), Gaps = 14/325 (4%)

Query: 8   QAAYWLGRQHDCLLDGVAAHLYAEFDGQALNRQALTEAVRALYAKHPMLRLA-ITKDGQQ 66
           Q   W  RQ D             F G  L+   L   +  L A+H  LR   I+  G+ 
Sbjct: 83  QQRLWFLRQMDPGSHAYNIAAALRFSGP-LDEALLERVLAVLVARHESLRTRFISAQGEP 141

Query: 67  KIL--PLSTFHQLKVDDLSQWKPDEVESFVHTKRQRMTHQMLDLTQGNPIEISLTLLPEG 124
           + +  P +  H  ++D +S  +    ++      + +  +  DL Q   +   L    + 
Sbjct: 142 RFVIDPHARVHLDRID-ISHLQGAARDAACKQAIESIARRPFDLAQAPLLHAGLIREADQ 200

Query: 125 KHRLHIDADMIACDAQSFRLLVDDLTSLYLE-AIEHRLEIIESDVVTFFQYLDAQQADRA 183
           +       D I  D  S  + + +   LY   A  H + ++E  +    QY D  + +R 
Sbjct: 201 QQVFAFALDHIVSDGLSLGIFMLEFRDLYSRLATGHEVTVVEPPI----QYYDYAEWERR 256

Query: 184 LAKRKEVDKK--WWQERLATIPAEPSLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEVA 241
              +  +D+   +W+  LA +P+   LP         +A+  R A   TP     L    
Sbjct: 257 AFAQGAIDEHLAFWKRELAGLPSMLQLPTDRPRPPVQTASGSRCALQLTPAFSDRLKAFG 316

Query: 242 RQHHLTLTQLTLALFSQVIANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSAD 301
           R    TL  + L+ F  ++     E    +     +R NRS ++EHTIG F+N L+  AD
Sbjct: 317 RAEGTTLFMVMLSAFQVLMHRYSGETDIAIGSAIANR-NRS-EVEHTIGFFANNLVLRAD 374

Query: 302 VGTTQTLLSLCQQTANQLHQLLRHE 326
           V    T+  L  +   +  +   H+
Sbjct: 375 VSGDPTVRELMTRVRERALRAYAHQ 399



 Score = 34.7 bits (78), Expect = 9e-05
 Identities = 23/80 (28%), Positives = 36/80 (45%), Gaps = 3/80 (3%)

Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
            V+  + A +R  L    +    +FFD GGHSL+  R+   +  E G E  + ++F     
Sbjct: 1045 VQRQVAALWREVLSTQRIGLHANFFDLGGHSLLLVRLQSAMQREFGKEFPLVELF---QR 1101

Query: 1921 KQLAQQAVLHRKPTSTSFAV 1940
              +A QA     P   S A+
Sbjct: 1102 TTVAAQAERMSTPVGASGAL 1121