Pairwise Alignments
Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056
Subject, 2844 a.a., non-ribosomal peptide synthetase from Dickeya dianthicola ME23
Score = 213 bits (541), Expect = 5e-58
Identities = 269/1014 (26%), Positives = 419/1014 (41%), Gaps = 122/1014 (12%)
Query: 456 MPLTPLQQAYLLGRSTQIALGGVAMHEFREYRGHIDTQSLHSRLLYLVEHIPALRTRIDQ 515
+P+ PLQQ L A G RG + L L +V H P L R D
Sbjct: 1546 LPVLPLQQGLLFHAQLADAAGSYNSLTRLSLRGPLSVAQLSQALEAVVRHHPQLAARFDT 1605
Query: 516 EKWIQ--WVSPCIA-------LNWQAIDLQHLSRE-QALLAVEPVRQQYQQRMHDLTRSP 565
E+ V P + L+ Q + E ALLA+E + DL P
Sbjct: 1606 EQASAPLQVLPILRDDQCYWPLDHQTLPAMPADEEADALLALEKA-----ELARDLFHQP 1660
Query: 566 WQICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHALILAALLGSEEPDITQVVQNARDTQ 625
+ L E ++ L + L+VDG + + L L + +A
Sbjct: 1661 SSMLHALLVSHADGERHTLFLNAHH-LVVDGWSTPVCLRDLFTVLYQGSRALTPHAVPYT 1719
Query: 626 SISPQFASKKAQ-DEAYWKSKLHPDCPPPALPWKQALETITTSRYARESLQIPKESVGKL 684
I Q A++ A W+S L P L + E L P+ G L
Sbjct: 1720 DIIRQLAARDADASRRRWRSVLAG--ARPTLLFGDGTHHGDVREL--ELLPEPQLEQGLL 1775
Query: 685 NRCGIENGLFLNSLLTATILDVLSYWTTEIGMRVGFPVLIPSSNAIDGNESSFVILEHE- 743
C + GL LNS++ +L + + G PV IDG + +
Sbjct: 1776 ALCK-QYGLTLNSVMQGLWGMLLCASSGADDVLFGSPVS-GRFGQIDGIGQQVGLFSNTL 1833
Query: 744 ------KSTLSLLSQASKLQREMLEALEH----------LAFSGVDLNRLL--------- 778
+ +L Q ++LQ + ++ +E+ LA +G + LL
Sbjct: 1834 PVRVRLDAARALPPQLAELQAQQIQLIEYDDVGLGEIQQLAGTGTLFDTLLVVENYPDGD 1893
Query: 779 -MNQAPQALVLPVVLTNGLSWKTLN----PEDAVTLF----DGVTQTPQVALDIRLTYDE 829
++QA QAL V G + L P + L DGV Q ++A + L ++
Sbjct: 1894 VLSQAGQALRCEAVNNRGYTHYPLTLLVLPGKRLRLLMEYRDGVAQPQRLAQRLLLLLEQ 1953
Query: 830 QKNLIISFDYALAVLETELIREM-LSALHHRLSQITSSASLAAPLEPCIDLSHYRFNSDE 888
L+ + + L+ +L E L A +R Q P+ P
Sbjct: 1954 ---LVAAPERPLSAWNLQLPEEQALLAAVNRTEQ---------PVPP------------- 1988
Query: 889 SASHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVL 948
H LA AQ RT ++ A++ L+Y Q+ Q + + +L G+ G+++
Sbjct: 1989 GTLHQA--LAAQAQ----RTPERIALVDSRHQLTYRQVRHQTRLLADRLIDAGVRPGDIV 2042
Query: 949 AICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKP-----CE 1003
A+ LPRSV + A +G W+P+D P ERL ++E+ L++ + E
Sbjct: 2043 AVALPRSVRLSLALYAILETGAAWLPLDTGYPDERLALMVEDAQPRLMITESRLQPRFAE 2102
Query: 1004 FGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQA 1063
+V+ D L + + P P+ + S L QQ AY +YTSG+TG+PK VVV +QA
Sbjct: 2103 LADVLLLDTLADERQ-SPRHPS-PPVAEQSSLVAEQQAAYVIYTSGSTGRPKGVVVGHQA 2160
Query: 1064 TSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVL--PAGHEEKDALQ 1121
N + + L + DVV+ TP D+SV++ F L GA LV+ P H + DAL
Sbjct: 2161 IVNRLWWMQHQYPLQANDVVLQKTPCSFDVSVWEFFWPLMVGARLVMAPPEAHRDPDALM 2220
Query: 1122 WNRLIERHQVTIWVSVPAILEMLLSCTQAGQ-----LHSLRLIAQGGDYIKPATIAQLRA 1176
+LI + VT VP++L +S + SLR + G+ + ++
Sbjct: 2221 --QLINDYAVTTLHFVPSMLAAWVSALETRSRAEIGCGSLRRVFCSGEALSRELALNYQS 2278
Query: 1177 GSNPPRLISLGGPTETTIWSIWHELTAD-----DVSVIPYGRPLAGNRYFIMDEIQRHVP 1231
P L +L GPTE + W + + + IP G P+ + I+D R P
Sbjct: 2279 LIAAP-LHNLYGPTEAAVDVTWQPASGEALARCQLPGIPIGLPVWNTQLRILDGALRPAP 2337
Query: 1232 QGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVLDEHGHPVRAFRTGDQGYYRADGNIIFA 1291
GV G ++ GV LAQGYL +L + FV D R +RTGD + DG + +
Sbjct: 2338 VGVPGDLYLCGVQLAQGYLRRPDLTASRFVA--DPFAAGERMYRTGDIARWLEDGTVDYL 2395
Query: 1292 SRINGYVKVRGVRVSLPDIEKQLQTHPALASVVV------VDYADTNGDTALAALFSVKP 1345
R + +K+RG R+ L +IE+ L P +A VV A +G A + + P
Sbjct: 2396 GRSDDQLKIRGQRIELGEIEQALLAQPGVAQAVVGARELGGKPARLHGADARQLVAWLVP 2455
Query: 1346 QQSASSQ--ALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRKQCQAHVQRQ 1397
Q + AL++ Q LP+ +P ++ + + PLSANGK+DRK A +Q
Sbjct: 2456 QAEITLDITALQQALSQQLPAHMVPVSYVLMTSFPLSANGKLDRKALPAPAGQQ 2509
Score = 162 bits (411), Expect = 6e-43
Identities = 150/519 (28%), Positives = 238/519 (45%), Gaps = 51/519 (9%)
Query: 902 QQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVI 961
QQ + D AV CG++ LSY +L +V ++ L A+G+ TG+V+AI +PRSV +V
Sbjct: 470 QQQVRQQPDALAVACGKERLSYRELSARVMQLARLLMAQGIGTGDVVAIGVPRSVSSLVA 529
Query: 962 SLASALSGIIWVPIDAASPKERLNYLLENCHADLV-----VMDKPCEFGNVIAF-DALIE 1015
SG ++P+D P+ERL + ++ L+ V + E V+ DA +
Sbjct: 530 IFGVLTSGAAYMPLDLDYPRERLALMCDDARPALLLTHSAVRAQMPELPQVLCLDDATLR 589
Query: 1016 PVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVI------- 1068
VT ++ L AY +YTSG+TGKPK V+ + N++
Sbjct: 590 AECTRLPAHPVTDAERREPLC-GDHLAYMIYTSGSTGKPKGVMSTHAGLLNLMMSHSSFL 648
Query: 1069 ------------GQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEE 1116
G+ +A H S S PL + G+ L +
Sbjct: 649 FGPAIARFSQQQGRRLRAGHTASFSFDSSWEPLF----------CMMMGSELHIFDEELR 698
Query: 1117 KDALQWNRLIERHQVTIWVSVPAIL-EMLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLR 1175
KDA + + + + P+ +M+ S H I GG+ P + QL
Sbjct: 699 KDAWALVQQFNQTPIDLMDITPSFFTQMIDSGLLEADNHQPAFIMIGGEAATP-RLWQLM 757
Query: 1176 AGSNPPRLISLGGPTETTIWSIWHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVV 1235
+ + GP+E TI ++ +T D VI G+P+A R +++D R VP GV
Sbjct: 758 RQHPQMEIHNYYGPSEYTIDTLGARVTVADQPVI--GQPVANTRVWLLDNQLRPVPVGVP 815
Query: 1236 GRIFTSGVNLAQGYLEDGELKQTDFVTVLDEHGHPVRAFRTGDQGYYRADGNIIFASRIN 1295
G ++ +G LA+GYL +L T FV G + +RTGD +R DG + F R++
Sbjct: 816 GELYIAGPGLARGYLRRPDLTATRFVACPFMPGAVM--YRTGDLMRWRHDGQLAFIGRVD 873
Query: 1296 GYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDT-ALAALFSV-----KPQQSA 1349
+KVRG RV L ++E L +++ VV+ A+ G T L SV + Q
Sbjct: 874 HQIKVRGFRVELGEVENALVALAEVSTAVVI--AEPLGATHRLIGYCSVPDAAAREQPDV 931
Query: 1350 SSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRK 1388
+++ L + A+Q LP IP+ + + LPL+ NGK+DR+
Sbjct: 932 AARLLAQLAEQ-LPDYMIPAVLMVMAELPLTVNGKIDRQ 969
Score = 45.4 bits (106), Expect = 1e-07
Identities = 77/333 (23%), Positives = 123/333 (36%), Gaps = 30/333 (9%)
Query: 1950 PLSLAQASLWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHF 2009
PL AQ +W A ++ + F + AL+ V+ A L ++ F
Sbjct: 4 PLVAAQPGIWMADQIASQ---PNAFAVAHALELCGSVDPVRLSAAIRQGLAEADTVQARF 60
Query: 2010 GL-EDGQPYQHVIAAS---NIEHYQWFWTSKDNAAQSVA-RLLAQEAEHTFDLSQELPLR 2064
GL E G+P Q + +A+ NI +W S + A L+ + E PL
Sbjct: 61 GLNERGEPVQWLPSAADAANIRQPEWLDFSDPAQGEPAAWALMRADLAAPLPADGEQPLY 120
Query: 2065 LNFVR--DEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFH 2122
+ Q + FHH+++D +S + L +A +Y G P E PF
Sbjct: 121 RQVIMRVSAQPERWFWYQRFHHLMVDGFSFDALTRRIATIYNALSAGETP----EASPFA 176
Query: 2123 EFARK-------QRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWV 2175
FA +RS A Q +W +P L AAD G
Sbjct: 177 PFAEVVAEYQAWERSPACRQA-AAFWRDHAGELPTPVSL-AADVCTPAPAGTRTLH---Q 231
Query: 2176 EIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDAEFFD 2235
+ LP + V+L Q V AA++A ++ + +L VG P R+ +
Sbjct: 232 RVTLPAAPFVALAQQRFGGKVQPAEVAMAALAAYLYRMSGEPRLSVGFPFMRRMGSAALC 291
Query: 2236 TVG-YFTTMGVQLV---DFTKVQTVWQLIEQVK 2264
G + +QL D T + L+ ++K
Sbjct: 292 ACGPVVNVLPLQLTLQPDMTLIDVTQTLLAEIK 324
Score = 39.3 bits (90), Expect = 1e-05
Identities = 102/496 (20%), Positives = 176/496 (35%), Gaps = 58/496 (11%)
Query: 1793 ATVSPHVGAYLLEQFVAAIGGRTMPSSTTSSSHVSAIELTSNNPPTSNNA--HAALAESE 1850
A P V A LL Q + +P+ + + + P T N AL + +
Sbjct: 925 AREQPDVAARLLAQLAEQLPDYMIPA---------VLMVMAELPLTVNGKIDRQALPKPQ 975
Query: 1851 LELSAVNSSAV---EECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGI 1907
+ + A E I S L + ++AE DFF GG S+ A +G LL G
Sbjct: 976 QAAAVIGREAATEQERLICQSIASLLKLEMVSAEADFFALGGDSISAMG-LGTLLRRAGW 1034
Query: 1908 ELHINDMFSFPNAKQLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAK 1967
+L +F+ ++AQ +P +T PL + + +
Sbjct: 1035 QLRPKAIFAERTPARMAQAM----QPLTTV----------AVPLRTVRHGVVDGLPIVHG 1080
Query: 1968 FGLTHIFNLPFA----LKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAA 2023
F N FA L D + +A L H L DGQ ++
Sbjct: 1081 FARLAGINQRFAHGVFLSVPDALQPAQLTQALTALAQAHPALTAL--TRDGQLVIDAASS 1138
Query: 2024 SNIEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFH 2083
+ + T+++ + R + + + RDE+ L L+ H
Sbjct: 1139 TTVSVISDTLTAQEPVDAAAERAFDAAVARLDPAAGRMMQAVLLQRDERACG--LVLVVH 1196
Query: 2084 HIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQRSSAFNQTHLNYWLT 2143
H+V+D S +L+ EL Q + ++ G RP LP E + S++ +
Sbjct: 1197 HLVVDGVSWRVLLPELRQAAEAAMAG-RP----AVLPAEECSLVDWSASLKE----QVAA 1247
Query: 2144 KFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPKS------TMVSLYQLAKARHAS 2197
+ A +P Q AA P +D +L + T L L + A
Sbjct: 1248 RRAELPLWQSALAAPLPQLGQRRLDPSRDREQTRQLARRVLDAGLTHAVLTTLPERYQAR 1307
Query: 2198 LFNVMYAAISASVHCLGAPEKLLVGTPASGRLD----AEFFDTVGYFTTMGVQLVD--FT 2251
+ ++ A+ + H + L + + GR+D + TVG+ T +D
Sbjct: 1308 VDEILLGALMLACHRRFGVQPLRLALESHGRIDTADGVDLGRTVGWLTAEYPVCIDAPAA 1367
Query: 2252 KVQTVWQLIEQVKNSI 2267
+ T W ++ VK ++
Sbjct: 1368 RAATPWAILRAVKGAL 1383
Score = 37.0 bits (84), Expect = 5e-05
Identities = 19/63 (30%), Positives = 31/63 (49%)
Query: 1862 EECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNAK 1921
E I A F L ++A+DDFF GGHSL+A R+ + + L + + + +
Sbjct: 2520 ERTIAALFAELLACETVSADDDFFALGGHSLLAMRLAAEIRRQLQRSLTVGQIMAARSVA 2579
Query: 1922 QLA 1924
+A
Sbjct: 2580 SIA 2582
Score = 35.0 bits (79), Expect = 2e-04
Identities = 60/294 (20%), Positives = 108/294 (36%), Gaps = 30/294 (10%)
Query: 2078 LSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQRSSAFNQTH 2137
L L HH+V+D WS + + +L V + P +P+ + R+ + + +
Sbjct: 1679 LFLNAHHLVVDGWSTPVCLRDLFTVLYQGSRALTP----HAVPYTDIIRQLAARDADASR 1734
Query: 2138 LNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHAS 2197
W L A L G G+ +E+ L L K +
Sbjct: 1735 RR----------WRSVLAGARPTLLFGDGTHHGDVRELELLPEPQLEQGLLALCKQYGLT 1784
Query: 2198 LFNVMYAAISASVHCLGAPEKLLVGTPASGRLDA--EFFDTVGYFTTMGVQLVDFTKVQT 2255
L +VM + + +L G+P SGR VG F+ V +
Sbjct: 1785 LNSVMQGLWGMLLCASSGADDVLFGSPVSGRFGQIDGIGQQVGLFSNTLPVRVRLDAARA 1844
Query: 2256 VWQLIEQVKNSINQSMPYTDIPIDLIEEGLKGVEHETEGHMFEVFIQLHAKNKLHGELLL 2315
+ + +++ Q + Y D+ + I++ L G G +F+ L +N G++L
Sbjct: 1845 LPPQLAELQAQQIQLIEYDDVGLGEIQQ-LAGT-----GTLFDTL--LVVENYPDGDVLS 1896
Query: 2316 TEGHAIRFQQVDPDKSESGLGLQFEILEERIEQKQTLRVMMSYMSKHYSPAQVA 2369
G A+R + V + G L + + LR++M Y P ++A
Sbjct: 1897 QAGQALRCEAV------NNRGYTHYPLTLLVLPGKRLRLLMEYRDGVAQPQRLA 1944
Score = 33.1 bits (74), Expect = 7e-04
Identities = 42/166 (25%), Positives = 71/166 (42%), Gaps = 8/166 (4%)
Query: 36 ALNRQALTEAVRALYAKHPMLRLAITKDGQQKI-LPLSTFHQLKVDDLSQWKPDEVESFV 94
AL LT+A+ AL HP L A+T+DGQ I ST + D L+ +P + +
Sbjct: 1102 ALQPAQLTQALTALAQAHPAL-TALTRDGQLVIDAASSTTVSVISDTLTAQEPVDAAA-- 1158
Query: 95 HTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLYL 154
+ LD G ++ L E L + + D S+R+L+ +L
Sbjct: 1159 -ERAFDAAVARLDPAAGRMMQAVLLQRDERACGLVLVVHHLVVDGVSWRVLLPELRQAAE 1217
Query: 155 EAIEHRLEIIESDVVTFFQYLDAQQADRALAKRKEVDKKWWQERLA 200
A+ R ++ ++ + + A ++ A+R E+ WQ LA
Sbjct: 1218 AAMAGRPAVLPAEECSLVDW-SASLKEQVAARRAEL--PLWQSALA 1260
Score = 30.0 bits (66), Expect = 0.006
Identities = 57/297 (19%), Positives = 108/297 (36%), Gaps = 30/297 (10%)
Query: 42 LTEAVRALYAKHPMLRLAITKDGQQKILPLSTFHQLKVDDLSQWKPD-----------EV 90
L++A+ A+ HP +LA D +Q PL L+ DD W D E
Sbjct: 1585 LSQALEAVVRHHP--QLAARFDTEQASAPLQVLPILR-DDQCYWPLDHQTLPAMPADEEA 1641
Query: 91 ESFVHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLT 150
++ + ++ + + + ++ +H L ++A + D S + + DL
Sbjct: 1642 DALLALEKAELARDLFHQPSSMLHALLVSHADGERHTLFLNAHHLVVDGWSTPVCLRDLF 1701
Query: 151 SLYLEAIEHRLEIIESDVVTFFQYLDAQQADRALAKRKEVDKKWWQERLATIPAEPSLPY 210
++ + L + L A+ AD + ++ W+ LA A P+L +
Sbjct: 1702 TVLYQG-SRALTPHAVPYTDIIRQLAARDADAS--------RRRWRSVLAG--ARPTLLF 1750
Query: 211 QPVPTDAVSANSQRFAHWFT-PVERKGLAEVARQHHLTLTQLTLALFSQVIANACQERQF 269
D R P +GL + +Q+ LTL + L+ ++ +
Sbjct: 1751 G----DGTHHGDVRELELLPEPQLEQGLLALCKQYGLTLNSVMQGLWGMLLCASSGADDV 1806
Query: 270 RLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQTANQLHQLLRHE 326
P R + I +G FSN L + + L + Q QL+ ++
Sbjct: 1807 LFGSPVSGRFGQIDGIGQQVGLFSNTLPVRVRLDAARALPPQLAELQAQQIQLIEYD 1863