Pairwise Alignments

Query, 936 a.a., 2-oxoglutarate dehydrogenase subunit E1 from Vibrio cholerae E7946 ATCC 55056

Subject, 933 a.a., alpha-ketoglutarate decarboxylase (NCBI) from Escherichia coli BW25113

 Score = 1399 bits (3621), Expect = 0.0
 Identities = 680/935 (72%), Positives = 781/935 (83%), Gaps = 3/935 (0%)

Query: 1   MHNGVMKAWLESSHLAGANATYVEDLYELYLSDPDLVSEEWKRVFDGLPAHPTNVVEQPH 60
           M N  +KAWL+SS+L+GAN +++E LYE +L+DPD V   W+  F  LP       +Q H
Sbjct: 1   MQNSALKAWLDSSYLSGANQSWIEQLYEDFLTDPDSVDANWRSTFQQLPGTGVKP-DQFH 59

Query: 61  SRVRDYFRRLAQETKHYNVQVSDPEVDAKQVKVLQLINAYRFRGHEAAKLDPLGLWNRPE 120
           S+ R+YFRRLA++   Y+  +SDP+ + KQVKVLQLINAYRFRGH+ A LDPLGLW + +
Sbjct: 60  SQTREYFRRLAKDASRYSSTISDPDTNVKQVKVLQLINAYRFRGHQHANLDPLGLWQQDK 119

Query: 121 VAELNPSFHNLTQEDMEETFNVGSFAIGKDTMKLKDIYQSLQKIYCGSVGAEYMHITDTE 180
           VA+L+PSFH+LT+ D +ETFNVGSFA GK+TMKL ++ ++L++ YCG +GAEYMHIT TE
Sbjct: 120 VADLDPSFHDLTEADFQETFNVGSFASGKETMKLGELLEALKQTYCGPIGAEYMHITSTE 179

Query: 181 QKRWIQQRLEPVVGTPVFSKEEKRTFLEELTAAEGLERYLGAKFPGAKRFSLEGGDALVP 240
           +KRWIQQR+E   G   F+ EEK+ FL ELTAAEGLERYLGAKFPGAKRFSLEGGDAL+P
Sbjct: 180 EKRWIQQRIES--GRATFNSEEKKRFLSELTAAEGLERYLGAKFPGAKRFSLEGGDALIP 237

Query: 241 MTKEMIRHAGASGMREVVIGMAHRGRLNMLVNVLGKKPQDLFDEFAGKHGEGWGTGDVKY 300
           M KEMIRHAG SG REVV+GMAHRGRLN+LVNVLGKKPQDLFDEFAGKH E  GTGDVKY
Sbjct: 238 MLKEMIRHAGNSGTREVVLGMAHRGRLNVLVNVLGKKPQDLFDEFAGKHKEHLGTGDVKY 297

Query: 301 HQGFSADFATPGGDVHLALAFNPSHLEIVNPVVMGSVRARQDRLGDEDGSKVLPITIHGD 360
           H GFS+DF T GG VHLALAFNPSHLEIV+PVV+GSVRAR DRL +   +KVLPITIHGD
Sbjct: 298 HMGFSSDFQTDGGLVHLALAFNPSHLEIVSPVVIGSVRARLDRLDEPSSNKVLPITIHGD 357

Query: 361 SAIAGQGVVAETFNMSQARGFCVGGTVRIVVNNQVGFTTSNPRDTRSTMYCTDIAKMVQA 420
           +A+ GQGVV ET NMS+ARG+ VGGTVRIV+NNQVGFTTSNP D RST YCTDI KMVQA
Sbjct: 358 AAVTGQGVVQETLNMSKARGYEVGGTVRIVINNQVGFTTSNPLDARSTPYCTDIGKMVQA 417

Query: 421 PIFHVNSDDPEAVAFVTRLALDYRNEFKRDVVIDLVCYRRHGHNEADEPNATQPLMYQKI 480
           PIFHVN+DDPEAVAFVTRLALD+RN FKRDV IDLVCYRRHGHNEADEP+ATQPLMYQKI
Sbjct: 418 PIFHVNADDPEAVAFVTRLALDFRNTFKRDVFIDLVCYRRHGHNEADEPSATQPLMYQKI 477

Query: 481 KKHPTPRKLYADVLTERGECDLETATQLVNEYRDALDHGEVVVKEWRPMAMHSVDWSPYL 540
           KKHPTPRK+YAD L +     LE AT++VN YRDALD G+ VV EWRPM MHS  WSPYL
Sbjct: 478 KKHPTPRKIYADKLEQEKVATLEDATEMVNLYRDALDAGDCVVAEWRPMNMHSFTWSPYL 537

Query: 541 GHDWHIPWNSEYAMERLQDLGRRVCQYPESHVLHSRVEKIYQDRLSMISGEKMLDWGMAE 600
            H+W   + ++  M+RLQ+L +R+   PE+  + SRV KIY DR +M +GEK+ DWG AE
Sbjct: 538 NHEWDEEYPNKVEMKRLQELAKRISTVPEAVEMQSRVAKIYGDRQAMAAGEKLFDWGGAE 597

Query: 601 TLAYATLLDDGKRIRISGQDSGRGTFFHRHAVLHNQNDASTYIPLSQIHAGQGPFEVFDS 660
            LAYATL+D+G  +R+SG+DSGRGTFFHRHAV+HNQ++ STY PL  IH GQG F V+DS
Sbjct: 598 NLAYATLVDEGIPVRLSGEDSGRGTFFHRHAVIHNQSNGSTYTPLQHIHNGQGAFRVWDS 657

Query: 661 VLSEEAVLAFEYGYATAEPSGLTLWEAQFGDFANGAQVVIDQFISSGEQKWGRLCGLTML 720
           VLSEEAVLAFEYGYATAEP  LT+WEAQFGDFANGAQVVIDQFISSGEQKWGR+CGL ML
Sbjct: 658 VLSEEAVLAFEYGYATAEPRTLTIWEAQFGDFANGAQVVIDQFISSGEQKWGRMCGLVML 717

Query: 721 LPHGYEGQGPEHSSARLERYLQLCAEQNMQVVVPSTPAQVYHMIRRQVVRPMRRPLVVMS 780
           LPHGYEGQGPEHSSARLERYLQLCAEQNMQV VPSTPAQVYHM+RRQ +R MRRPLVVMS
Sbjct: 718 LPHGYEGQGPEHSSARLERYLQLCAEQNMQVCVPSTPAQVYHMLRRQALRGMRRPLVVMS 777

Query: 781 PKSLLRHPLCVSSMEDLAHGTFQPAIGEIDALNPSQVKRVVFCSGKVYYDLLEQRRANEQ 840
           PKSLLRHPL VSS+E+LA+GTF PAIGEID L+P  VKRVV CSGKVYYDLLEQRR N Q
Sbjct: 778 PKSLLRHPLAVSSLEELANGTFLPAIGEIDELDPKGVKRVVMCSGKVYYDLLEQRRKNNQ 837

Query: 841 QDVAIVRIEQLYPFPLEEVQAAIANYTNVVDYVWCQEEPQNQGAWYSSQHNFRAAIPAGA 900
            DVAIVRIEQLYPFP + +Q  +  + +V D+VWCQEEP NQGAWY SQH+FR  IP GA
Sbjct: 838 HDVAIVRIEQLYPFPHKAMQEVLQQFAHVKDFVWCQEEPLNQGAWYCSQHHFREVIPFGA 897

Query: 901 DLKYAGRPASASPAVGYMSVHMKQQKALIEDALTL 935
            L+YAGRPASASPAVGYMSVH KQQ+ L+ DAL +
Sbjct: 898 SLRYAGRPASASPAVGYMSVHQKQQQDLVNDALNV 932