Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 827 a.a., DNA topoisomerase I from Rhodanobacter sp000427505 FW510-R12

 Score =  427 bits (1097), Expect = e-123
 Identities = 310/852 (36%), Positives = 433/852 (50%), Gaps = 149/852 (17%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           M K+L+IVESPAKAKTINKYLGKDF V +S GHVRDL                       
Sbjct: 1   MAKNLLIVESPAKAKTINKYLGKDFQVLASYGHVRDL----------------------- 37

Query: 61  TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120
                  + KE A       VD  HG+   Y+++   EK V  + K AK AD +YLATDL
Sbjct: 38  -------KPKEGA-------VDTEHGFAMAYEVIERNEKHVDAIAKAAKLADDIYLATDL 83

Query: 121 DREGEAIAWHLREIIGG----DEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQAR 176
           DREGEAI+WH+ EI+        K+  RVVF+EIT  AI+ A   P +L+ D V+AQQAR
Sbjct: 84  DREGEAISWHISEILKQRGLVKGKQMHRVVFSEITPKAIKAAVAAPRQLSHDLVDAQQAR 143

Query: 177 RFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLT 236
           R +D +VGF +SP+LW+KV RGLSAGRVQS A++++VERE EI+AF   E+W I A    
Sbjct: 144 RALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFKAREYWTIEAQLKH 203

Query: 237 ADKQDFRLLVAQKDGLAFKP---VNETEALAAVAALNKA---QYEVCKREDKPTTSKPSA 290
           A+  DF   +++ +G  F+     +E +ALAA  AL +A   +  V +   K    +P+A
Sbjct: 204 AE-GDFTARLSRLNGKKFEQFDLTSEADALAARDALKQAARGRLTVSEVSSKERKRRPAA 262

Query: 291 PFITSTLQQAASTRLGYGVKKTMMLAQRLYE---------AGYITYMRTDSTNLSAEAVE 341
           PF TSTLQQ A+ +LG+   +TM +AQ LYE          G ITYMRTDST L  +AV 
Sbjct: 263 PFTTSTLQQEAARKLGFTTSRTMKVAQGLYEGVALGSEGNVGLITYMRTDSTMLGDDAVA 322

Query: 342 NLRGYITKHYGEAYLPSQPNVYGSK-QNAQEAHEAIRPSDVTVTADDLEG-MEADAHKLY 399
            LR  I + +G   LP  P +Y +K +NAQEAHEAIRP+    T   +   +  D  KLY
Sbjct: 323 ELRQLIARDFGSQALPDAPQMYKTKSKNAQEAHEAIRPTSAMHTPKSVASFLNDDQRKLY 382

Query: 400 ALIWNQFVACQMTPAQYDSTTV-----SVKAAEYTLKAKGRILKFDGWTRV-------QR 447
            LIW + VACQM  A  ++ T       V   +   +A G  +   G+  V       + 
Sbjct: 383 ELIWKRTVACQMIHATLNTVTAEFAVRGVAGGDAAFRASGTTVVDPGFLAVYEEGRDQKG 442

Query: 448 PLGKNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASI 507
               +E + LP + V + + L  +   QHFT+PP RY+EA+LVK LE+ GIGRPSTYASI
Sbjct: 443 AEDDDEGRRLPRLAVDEQVPLHDIAADQHFTEPPPRYSEASLVKTLEEYGIGRPSTYASI 502

Query: 508 ISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNW 567
           I  +Q+R YV +D RRF    +G  V+  L ++F   ++YDFTA+ME++LD ++ GE  W
Sbjct: 503 IQVLQNREYVFLDSRRFKPSDVGRAVSKFLTQHFTRYVDYDFTAKMEDELDAVSRGEEAW 562

Query: 568 TAVLDEFFADFSRDL----ETAEQDESLGGMKPNHIVMTNILCPTCSRPMGIRTASTGVF 623
             +++ F+  F + +    E+ ++ E+ G  +           P   +P+ +R    G +
Sbjct: 563 MPLMERFWQPFKQQVDEKTESVDRSEATGARELGS-------DPKSGKPVSVRLGRFGPY 615

Query: 624 LGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVETAALRAKKRCPICETAMDAYLIDDK 683
                            I   D+       E+  + A+LR  +       A    L    
Sbjct: 616 ---------------AAIGTKDD-------EDKPQFASLRPGQSMHTITLAEALELFKLP 653

Query: 684 RKLHVCGNNPNCEGFIVEEGEF-----------KVKGYEGP-TVECDKC----------- 720
           R+L   G+ PN E   V  G F            +K  + P T+E  +            
Sbjct: 654 RQL---GSAPNGEEVSVAIGRFGPFVKQGGTYASLKPEDDPYTIELPRALQIVQDKLEML 710

Query: 721 --------GSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENS 772
                   G+ + + NGR+G Y+    D  KN R         P ++EP    E  C   
Sbjct: 711 ANRVILDFGNGVQVLNGRYGAYI---TDGEKNAR--------IPKEQEPKELTEAQCLEL 759

Query: 773 DAYFVLRDGASG 784
            A   +R G  G
Sbjct: 760 LAAAPVRKGRFG 771