Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 907 a.a., DNA topoisomerase 1 from Xanthobacter sp. DMC5

 Score =  424 bits (1091), Expect = e-123
 Identities = 264/664 (39%), Positives = 374/664 (56%), Gaps = 76/664 (11%)

Query: 5   LVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKASTTDKE 64
           +VIVESPAKAKTINKYLG  + V +S GHVRDLP+   +  P      A  +     D +
Sbjct: 15  VVIVESPAKAKTINKYLGPGYEVIASYGHVRDLPSKDGSVDPD-----ADFRMLWDVDPK 69

Query: 65  QQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDLDREG 124
            QKR  E AA +                                K AD + LATD DREG
Sbjct: 70  AQKRLNEIAAAV--------------------------------KGADGLILATDPDREG 97

Query: 125 EAIAWHLREIIGGDE----KRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180
           EAI+WH+ E++   +    ++ +RVVFN ITK A+ +A K P  ++   V+A  ARR +D
Sbjct: 98  EAISWHVLEVLRQKKALKSQKVERVVFNAITKQAVLEAMKSPRAIDSALVDAYLARRALD 157

Query: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240
            +VGF +SP+LW+K+    SAGRVQSVA++L+ +REREI+ FV +E+W I A   T   +
Sbjct: 158 YLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIETFVRKEYWSILAKLATPRNE 217

Query: 241 DFRLLVAQKDGLAFKPVN---ETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTL 297
           +F   ++  DG     ++     EA A   AL+ A + V   E KP    P  PF TSTL
Sbjct: 218 EFEARLSGADGKKITRLSVGTAEEARAFREALDSAAFRVRSVEAKPMKRHPQPPFTTSTL 277

Query: 298 QQAASTRLGYGVKKTMMLAQRLYE--------AGYITYMRTDSTNLSAEAVENLRGYITK 349
           QQ AS +LG    +TM +AQRLYE         G ITYMRTD  +++ EAV   R  I K
Sbjct: 278 QQEASRKLGLAPARTMQIAQRLYEGVDVGGETVGLITYMRTDGVDMAPEAVAATRDAIGK 337

Query: 350 HYGEAYLPSQPNVYGSK-QNAQEAHEAIRPSDVTVTADDL-EGMEADAHKLYALIWNQFV 407
            +G+ YLP  P  Y +K +NAQEAHEAIRP+D +    D+   ++ +  KLY LIW + V
Sbjct: 338 QFGQKYLPGVPRKYTTKAKNAQEAHEAIRPTDPSRHPRDVARYLDGEQAKLYELIWIRTV 397

Query: 408 ACQMTPAQYDSTTVSVK----AAEYTLKAKGRILKFDGWTRVQRPLGKNED-----QILP 458
           A QM  A+ + TT  ++    A    L A G ++KFDG+  + R    +ED     + LP
Sbjct: 398 ASQMESAELERTTADIEAKAGARTLDLTATGTVVKFDGFLTLYREGKDDEDDDEEGRRLP 457

Query: 459 PVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVK 518
            +   ++L    +   QHFT+PP RY+EA+LVK +E+ GIGRPSTYA++++ ++DR YVK
Sbjct: 458 AMSANEALAKRDISTTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLAVLRDREYVK 517

Query: 519 VDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADF 578
           +D+++   E  G +VT  L+  F   + YDFTA +EEKLD+++  E++W  VL  F+ DF
Sbjct: 518 LDKKKLVPEDKGRLVTAFLESFFKRYVEYDFTADLEEKLDEVSAAELDWKEVLRAFWQDF 577

Query: 579 ------SRDLETAEQDESLGGMKPNHIVMTN------ILCPTC-SRPMGIRTASTGVFLG 625
                 ++DL  ++  ++L  M   HI           LCPTC +  + ++    G F+G
Sbjct: 578 HAAIEATKDLRVSQVLDALDEMLTAHIFPPREDGTDPRLCPTCGTGRLSLKMGKFGAFIG 637

Query: 626 CSGY 629
           CS Y
Sbjct: 638 CSNY 641



 Score = 32.0 bits (71), Expect = 2e-04
 Identities = 14/34 (41%), Positives = 23/34 (67%), Gaps = 2/34 (5%)

Query: 717 CDKCGSDMV-LKNGRFGKYMGCTN-DACKNTRKI 748
           C  CG+  + LK G+FG ++GC+N   C++TR +
Sbjct: 617 CPTCGTGRLSLKMGKFGAFIGCSNYPECRHTRPL 650



 Score = 26.6 bits (57), Expect = 0.007
 Identities = 15/46 (32%), Positives = 21/46 (45%), Gaps = 1/46 (2%)

Query: 754 VAPPKEEPVHFPELPCENSDAYFVLRDGASGLFFAASNFPKSRETR 799
           + PP+E+    P L          L+ G  G F   SN+P+ R TR
Sbjct: 604 IFPPREDGTD-PRLCPTCGTGRLSLKMGKFGAFIGCSNYPECRHTR 648