Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 873 a.a., DNA topoisomerase I from Pseudomonas simiae WCS417

 Score = 1189 bits (3077), Expect = 0.0
 Identities = 578/876 (65%), Positives = 702/876 (80%), Gaps = 4/876 (0%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           MGKSLVIVESPAKAKTINKYLG +++VKSS+GH+RDLPT+G +A+ + + AA   K A+ 
Sbjct: 1   MGKSLVIVESPAKAKTINKYLGNEYVVKSSIGHIRDLPTSG-SASASKEPAAKRGKAAAG 59

Query: 61  TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120
                  +EK R  L+ +MGVDP HGW+A Y+ILPGKEKV+ EL++LAKDAD++YLATDL
Sbjct: 60  EGPVLTPKEKARKQLVSRMGVDPDHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDL 119

Query: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180
           DREGEAIAWHLRE IGGD+ RYKRVVFNEITK AIQ+AF +PGEL++D VNAQQARRF+D
Sbjct: 120 DREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSKPGELDIDRVNAQQARRFLD 179

Query: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240
           RVVG+MVSPLLW K+ARGLSAGRVQSVAVKL+VEREREI+AF+PEE+W+++AD  TA   
Sbjct: 180 RVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEVHADLGTAKGA 239

Query: 241 DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQA 300
           + R  VA++ G AFKP+NE +A+AA+  L  + Y + KREDKPT+SKPSAPFITSTLQQA
Sbjct: 240 NVRFEVAREKGEAFKPLNEAQAMAALEKLKSSSYSIVKREDKPTSSKPSAPFITSTLQQA 299

Query: 301 ASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQP 360
           AS RLG+GVKKTMM+AQRLYEAGYITYMRTDSTNLS +AV   R YI + +G+ YLP +P
Sbjct: 300 ASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSVDAVAMARTYIEEEFGKKYLPEKP 359

Query: 361 NVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTT 420
           NVY SK+ AQEAHEAIRPSD   T   L GME DA +LY LIW QF+ACQM PAQY STT
Sbjct: 360 NVYSSKEGAQEAHEAIRPSDANTTPAKLSGMERDAERLYELIWRQFLACQMLPAQYLSTT 419

Query: 421 VSVKAAEYTLKAKGRILKFDGWTRVQRPLGK-NEDQILPPVKVGDSLKLVSLDPKQHFTK 479
           V+V A+++ L+AKGRILKFDG+TRV   + K  +D +LP +  GD+LKL++LDP QHFTK
Sbjct: 420 VTVAASDFELRAKGRILKFDGYTRVMPQIAKPGDDDVLPDMAQGDTLKLITLDPSQHFTK 479

Query: 480 PPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDE 539
           PPARY+EA+LVKE+EKRGIGRPSTYA+IISTIQDRGYV +  RRF++EKMG+IVT+RL E
Sbjct: 480 PPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTERLSE 539

Query: 540 NFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHI 599
           +F +LM+Y FTA MEE LD +A+GE +W  VLDEF+ DF + LE AE  ES  GM+ N  
Sbjct: 540 SFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFKKKLEVAESPES--GMRANQP 597

Query: 600 VMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVET 659
           VMT+I C TC RPM IRTASTGVFLGCSGY LPPKERCK T+NL   + +    E + E+
Sbjct: 598 VMTDIPCQTCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESES 657

Query: 660 AALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECDK 719
             LR K RCPIC TAMDAYL+D+K KLH+CGNNP+C G+ +EEG +++KGYEGP++ECDK
Sbjct: 658 LVLRGKHRCPICSTAMDAYLLDEKHKLHICGNNPDCNGYEIEEGTYRIKGYEGPSLECDK 717

Query: 720 CGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVLR 779
           CGS+M LK GRFGK+ GCTN  CKNTRK+LK+G+ APPK +PV  PEL CE  +  ++LR
Sbjct: 718 CGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKSGDAAPPKMDPVKMPELKCEKVNDTYILR 777

Query: 780 DGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFSR 839
           DGASGLF AAS FPK+RETRAPLV E+    + +  KY +L  AP  DPDG PAV+R+SR
Sbjct: 778 DGASGLFLAASQFPKNRETRAPLVLEIVPHKDEIDPKYHFLCEAPKKDPDGRPAVIRYSR 837

Query: 840 KEKEHYVRTETEGKPSGWMAVYQEGKWLVTDKRKNA 875
           K KE YV+TE +GKP+GW A Y  GKW V DKR+ A
Sbjct: 838 KTKEQYVQTEVDGKPTGWKAFYDGGKWKVEDKRQGA 873