Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 987 a.a., DNA topoisomerase III, Burkholderia type (EC 5.99.1.2) from Variovorax sp. SCN45

 Score =  133 bits (334), Expect = 6e-35
 Identities = 171/705 (24%), Positives = 279/705 (39%), Gaps = 142/705 (20%)

Query: 1   MGKSLVIVESPAKAKTINKYL----GK-----------DFIVKSSVGHVRDLPTAGQTAT 45
           M K+LVI E P+ A+ I + L    GK            ++V S+VGH+ ++    +   
Sbjct: 1   MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHDEHFENDSYVVTSAVGHLVEIQAPEEFDV 60

Query: 46  PTGKAAAASTKKASTT-DKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAEL 104
             GK + A+        D +   + K R   + K                          
Sbjct: 61  KRGKWSFANLPVIPPHFDLKPVDKTKTRLNAVVK-------------------------- 94

Query: 105 QKLAKDADSVYLATDLDREGEAIAWHLREIIGGDE---KRYKRVVFNEITKNAIQQAFKQ 161
           Q   KD   +  A D  REGE I   + +  GG     K  KR+    +T  AI+  F  
Sbjct: 95  QAKRKDVTQLINACDAGREGELIFRLIEQYAGGKSGLNKPVKRLWLQSMTPQAIRDGFDA 154

Query: 162 -PGELNMDGV-NAQQARRFMDRVVGFMVSPLLWKKVARG-----LSAGRVQSVAVKLLVE 214
              E  M G+ +A ++R   D +VG   +  +    +R       + GRVQ+  + ++VE
Sbjct: 155 LRTEKQMQGLADAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVE 214

Query: 215 REREIKAFVPEEFWDINADTLTAD--------------KQDFRLLV---AQKDGLAFKPV 257
           RE +I+ FV  ++W+I+  T  A+              K +  LL       +  A +  
Sbjct: 215 REEQIRKFVSRDYWEIHG-TFAAEAGEYPGKWFNPDWKKANAPLLANGEPDPEQRADRVW 273

Query: 258 NETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQ 317
           NE EA  A+A   + +      E KPTT      F  ++LQ+ A+ R G+  K T+ LAQ
Sbjct: 274 NEQEA-RAIADAARGKPATVTEESKPTTQASPMLFDLTSLQREANGRFGFSAKTTLALAQ 332

Query: 318 RLYEA-GYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQPNVYGSKQNAQEAHEA- 375
            LYE    +TY RTDS  L                 E YLP   +  G   N+   H A 
Sbjct: 333 SLYERHKALTYPRTDSRALP----------------EDYLPVVKDTMGMLANSGMKHLAP 376

Query: 376 ----------IRPSD-------------VTVTADDLEGMEADAHKLYALIWNQFVACQMT 412
                     +RP+              +  T     G+     KLY  +  +F++    
Sbjct: 377 FAKQAVDGNYVRPNKRIFDNAKVSDHFAIIPTLQAPSGLSEAEQKLYDFVVRRFLSVFFP 436

Query: 413 PAQYDST----TVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNED-------QILPPVK 461
            A+Y  T    TV     +Y  +  G++L   GW  +     ++++       + L PVK
Sbjct: 437 SAEYQVTTRISTVEQGGKKYPFRTDGKVLVKPGWLAIYGKEAQDDEKEDDKDGKRLVPVK 496

Query: 462 VGDSLKLVSLDPKQHFTKPPARYTEAALV----------------KELEKRGIGRPSTYA 505
            G+ +K  S D K   T+PPARY+EA L+                + ++++G+G P+T A
Sbjct: 497 PGEIVKTESADTKGLKTRPPARYSEATLLGAMEGAGKTIDDDELREAMQEKGLGTPATRA 556

Query: 506 SIISTIQDRGYVKVDQRRFF-AEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGE 564
           + I  +    Y+  + R      K  +++T       ++L   + T   E KL Q+ +G 
Sbjct: 557 ATIEGLITEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSKAELTGEWEYKLAQMEKGA 616

Query: 565 VNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHIVMTNILCPTC 609
           ++  A + E        ++ A++ +      P         CP C
Sbjct: 617 LSRDAFMREIAQMTEHIVKKAKEYDR--DTVPGDYATLQTPCPNC 659