Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 860 a.a., DNA topoisomerase I (EC 5.99.1.2) from Sphingobium sp. HT1-2

 Score =  422 bits (1084), Expect = e-122
 Identities = 264/670 (39%), Positives = 379/670 (56%), Gaps = 73/670 (10%)

Query: 5   LVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKASTTDKE 64
           LVIVESPAKAKTI KYLG DF V +S GH+RDLP                          
Sbjct: 3   LVIVESPAKAKTIEKYLGGDFHVLASYGHIRDLPP------------------------- 37

Query: 65  QQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDLDREG 124
                       K   VDP +G+  +++    K K +  +   AK A  + LATD DREG
Sbjct: 38  ------------KDGSVDPDNGFAMSWENYGDKGKQLKAIADEAKKATRLILATDPDREG 85

Query: 125 EAIAWHLREIIGGDE---KRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMDR 181
           EAI+WH++E++   +   +   RV FN ITK A+  A  +P  L+ D ++A +ARR +D 
Sbjct: 86  EAISWHVQEVLRAKKALPQTVDRVTFNAITKAAVLDAMAKPRALDEDLIDAYRARRALDY 145

Query: 182 VVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQD 241
           +VGF +SP+LW+K+    SAGRVQSVA++L+VEREREI++FVP+E+W I+A+ +    Q 
Sbjct: 146 LVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIESFVPQEYWSISAE-MEQGGQG 204

Query: 242 FRLLVAQKDGLAFKPVN---ETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQ 298
           F   + +  G     +    E +A+AA A +   ++ V K E KP T  P  PF TSTLQ
Sbjct: 205 FTARLVRWKGEKIDRLTIGKEGDAMAAKADVEAGRFTVDKVETKPLTRNPPPPFTTSTLQ 264

Query: 299 QAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPS 358
           Q A+ +LG+    TM +AQ+LYE G ITYMRTD   +   A+   R  I + Y   YLP 
Sbjct: 265 QEAARKLGFSASHTMRIAQQLYEDGAITYMRTDGVQMDGSAISAARKAIAERYDGGYLPE 324

Query: 359 QPNVYGSK-QNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYD 417
           +P  Y +K +NAQEAHEAIRP++     D + G   D  +LY LI+ + +A QM  A+ +
Sbjct: 325 KPRQYQTKAKNAQEAHEAIRPTEFH--RDKVGG--GDHARLYDLIFKRALASQMASARLE 380

Query: 418 STTVSVK--AAEYTLKAKGRILKFDGWTRVQ---RPLGKNED-QILPPVKVGDSLKLVSL 471
            TT+ +   +  +TL+A G+++ F G+  +    R   +++D ++LP +  GD+     +
Sbjct: 381 RTTIDMVDGSGSHTLRATGQVVIFPGFLALYEEGRDDAEDDDSKLLPRLSEGDAPAKKKV 440

Query: 472 DPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGE 531
             +QHFT+PP RY+EA+LVK+LE+ GIGRPSTYAS +  ++DR YV+V++ RFFAE+ G 
Sbjct: 441 SAEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASTLQVLKDRDYVRVEKNRFFAEESGR 500

Query: 532 IVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLE-------- 583
           +VT  L+  F+  ++YDFTA +E++LD+I+ G   W  VL+ F+ DF             
Sbjct: 501 LVTAFLERFFERYVSYDFTAGLEDELDEISGGRAQWQEVLEAFWKDFKPKTAEIMEQKPS 560

Query: 584 --TAEQDESLGGM--KPNHIVMTNILCPTCS-RPMGIRTASTGVFLGCSGYGLPPKERCK 638
             TAE D+ L  M   P         CP C+   + +R    G F+ CS Y       CK
Sbjct: 561 DITAELDKFLEPMLFPPKADGSNPRACPLCADGQLSLRGGRFGAFIACSNY-----PECK 615

Query: 639 TTINLGDEEG 648
            T   G   G
Sbjct: 616 YTRKFGQPGG 625



 Score = 29.6 bits (65), Expect = 8e-04
 Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 2/38 (5%)

Query: 717 CDKCGSDMV-LKNGRFGKYMGCTN-DACKNTRKILKNG 752
           C  C    + L+ GRFG ++ C+N   CK TRK  + G
Sbjct: 587 CPLCADGQLSLRGGRFGAFIACSNYPECKYTRKFGQPG 624



 Score = 27.7 bits (60), Expect = 0.003
 Identities = 12/28 (42%), Positives = 16/28 (57%)

Query: 772 SDAYFVLRDGASGLFFAASNFPKSRETR 799
           +D    LR G  G F A SN+P+ + TR
Sbjct: 591 ADGQLSLRGGRFGAFIACSNYPECKYTR 618