Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 869 a.a., DNA topoisomerase I from Pseudomonas putida KT2440

 Score = 1172 bits (3031), Expect = 0.0
 Identities = 575/873 (65%), Positives = 688/873 (78%), Gaps = 5/873 (0%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           MGKSLVIVESPAKAKTINKYLG  ++VKSS+GH+RDLPT+G  +    K  AA   KA+ 
Sbjct: 1   MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASA--SKEPAAKRGKAAG 58

Query: 61  TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120
                  +EK R  L+ +MGVDP HGW+A Y+ILPGKEKV+ EL++LAKDAD++YLATDL
Sbjct: 59  EAPALSPKEKARRQLVARMGVDPDHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDL 118

Query: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180
           DREGEAIAWHLRE IGGD+ RYKRVVFNEITK AIQ+AF QPGEL++D VNAQQARRF+D
Sbjct: 119 DREGEAIAWHLREAIGGDDTRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLD 178

Query: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240
           RVVG+MVSPLLW K+ARGLSAGRVQSVAVKL+VEREREI+AF+PEE+W+I+AD  TA   
Sbjct: 179 RVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEIHADLGTAKNA 238

Query: 241 DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQA 300
             R  VA++ G AFKP+NE +A+AA+  L  + Y V KRED+PT+SKPSAPFITSTLQQA
Sbjct: 239 KVRFEVAREKGEAFKPLNEAQAMAALEKLKASSYSVVKREDRPTSSKPSAPFITSTLQQA 298

Query: 301 ASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQP 360
           AS RLG+GVKKTMM+AQRLYEAGYITYMRTDSTNLSA+A++  R YI + +G+ YLP  P
Sbjct: 299 ASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADALDMARSYIEREFGKQYLPEAP 358

Query: 361 NVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTT 420
            VYGSK+ AQEAHEAIRPSDV      L GME DA +LY LIW QF+ACQM PAQY ST+
Sbjct: 359 LVYGSKEGAQEAHEAIRPSDVNTHPTKLSGMERDAERLYELIWRQFLACQMPPAQYLSTS 418

Query: 421 VSVKAAEYTLKAKGRILKFDGWTRVQRPLGK-NEDQILPPVKVGDSLKLVSLDPKQHFTK 479
           V+V A ++ L+AKGRILKFDG+TRV     K  ED +LP +  G++LKL+ +DP QHFTK
Sbjct: 419 VTVAAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMVQGEALKLIQIDPSQHFTK 478

Query: 480 PPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDE 539
           PPAR+TEA+LVKE+EKRGIGRPSTYA+IISTIQDRGYV +  RRF++EKMG+IVT+RL E
Sbjct: 479 PPARFTEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVTLHNRRFYSEKMGDIVTERLSE 538

Query: 540 NFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHI 599
           +F +LM+Y FTA MEE LD +A+GE +W  VLDEF+ DFS+ L+TAE  E   GM+ N  
Sbjct: 539 SFSNLMDYGFTADMEENLDDVAQGERDWKNVLDEFYGDFSKKLQTAESSED--GMRANQP 596

Query: 600 VMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVET 659
            MTNI C  C RPM IRTASTGVFLGCSGY LPPKERCK T+NL   + +    E + E+
Sbjct: 597 TMTNIPCKECGRPMMIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESES 656

Query: 660 AALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECDK 719
             L  K RCPIC TAMDAYL+D+K KLH+CGNNP+C G+ +EEG +++KGYEGP++ECDK
Sbjct: 657 RVLLGKHRCPICATAMDAYLLDEKHKLHICGNNPDCVGYEIEEGNYRIKGYEGPSLECDK 716

Query: 720 CGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVLR 779
           CGS+M LK GRFGK+ GCTN ACKNTRK+LK+GE APPK + V  PEL CE  D  +VLR
Sbjct: 717 CGSEMQLKTGRFGKFFGCTNPACKNTRKLLKSGEAAPPKMDKVDMPELKCEKVDDTYVLR 776

Query: 780 DGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFSR 839
           DGASGLF AAS FPK+RETRAPLV E+      +  KY +L  AP  DPDG PAV+R+SR
Sbjct: 777 DGASGLFLAASQFPKNRETRAPLVLEIVPHKHEIDPKYHFLCDAPQKDPDGRPAVIRYSR 836

Query: 840 KEKEHYVRTETEGKPSGWMAVYQEGKWLVTDKR 872
           K KE YV++E +GKP+GW A Y    W V DKR
Sbjct: 837 KTKEQYVQSEVDGKPTGWKAFYDGNAWKVEDKR 869