Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 865 a.a., type I DNA topoisomerase from Serratia liquefaciens MT49

 Score = 1255 bits (3247), Expect = 0.0
 Identities = 617/871 (70%), Positives = 725/871 (83%), Gaps = 14/871 (1%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           MGK+LVIVESPAKAKTINKYLG D++VKSSVGH+RDLPT+G          +AS K A +
Sbjct: 1   MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSG----------SASKKSADS 50

Query: 61  TDKEQQKREK--ERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLAT 118
           T+ + +K+ K  E+ AL+ +MGVDPYHGW+A Y+ILPGKEKVVAEL+ LA++AD +YLAT
Sbjct: 51  TENKAKKKVKKDEKTALVNRMGVDPYHGWEAQYEILPGKEKVVAELKSLAENADHIYLAT 110

Query: 119 DLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRF 178
           DLDREGEAIAWHLRE+IGGD+KR+ RVVFNEITKNAIQ AFKQPGELN+D VNAQQARRF
Sbjct: 111 DLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQNAFKQPGELNIDRVNAQQARRF 170

Query: 179 MDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTAD 238
           MDRVVG+MVSPLLWKK+ARGLSAGRVQSVAV+L+VERER+IKAFVPEE+W+++AD L   
Sbjct: 171 MDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKG 230

Query: 239 KQDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQ 298
               ++ V       FKPVN  +  AA+  L KA+Y V  REDKPT+SKP AP+ITSTLQ
Sbjct: 231 DTALQMEVTHTHDKPFKPVNREQTHAALKLLEKARYTVLDREDKPTSSKPGAPYITSTLQ 290

Query: 299 QAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPS 358
           QAASTRL +GVKKTMM+AQRLYEAG+ITYMRTDSTNLS +A+  +RGYI +++G+ YLP 
Sbjct: 291 QAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGENFGDKYLPK 350

Query: 359 QPNVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDS 418
            PN Y SK+N+QEAHEAIRPSDV V A+ L+ MEADA KLY LIW QFVACQMTPAQYDS
Sbjct: 351 APNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDS 410

Query: 419 TTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGK-NEDQILPPVKVGDSLKLVSLDPKQHF 477
           TT+SVKAA+Y L+AKGR L+FDGWT+V   L K +ED+ LP V+VG  L+L  L P QHF
Sbjct: 411 TTLSVKAADYLLRAKGRTLRFDGWTKVMPALRKGDEDRTLPYVEVGSELELQKLIPSQHF 470

Query: 478 TKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRL 537
           TKPPARY+EA+LVKELEKRGIGRPSTYASIISTIQDRGYV+V+ RRF+AEKMGEIVTDRL
Sbjct: 471 TKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRL 530

Query: 538 DENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPN 597
           +ENF +LMNYDFTARME+ LDQ+A     W AVLDEFFA+FS  LETAE+D   GGM+PN
Sbjct: 531 EENFRELMNYDFTARMEDGLDQVANNHAEWKAVLDEFFAEFSEQLETAEKDPEEGGMRPN 590

Query: 598 HIVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLE-ED 656
            +VMT+I CPTC R MGIRTASTGVFLGCSGY L PKERCKTTINL  E  V+NVLE +D
Sbjct: 591 QMVMTSIDCPTCGRKMGIRTASTGVFLGCSGYALTPKERCKTTINLVPETEVLNVLEGDD 650

Query: 657 VETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVE 716
            ET ALRA++RC  C TAMD+YLID++RKLHVCGNNP C+G+ +EEGEF++KGY+GP VE
Sbjct: 651 AETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEEGEFRLKGYDGPVVE 710

Query: 717 CDKCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYF 776
           CDKCGS+M LK GRFGKYMGCTN+ CKNTRKIL+NG+VAPPKE+PV  PELPCE SDAYF
Sbjct: 711 CDKCGSEMHLKMGRFGKYMGCTNENCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYF 770

Query: 777 VLRDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVR 836
           VLRDGA+G+F AA+ FPKSRETRAPLVEEL RF +RLPEK +YL  AP  D +G   +VR
Sbjct: 771 VLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVTDAEGNKTMVR 830

Query: 837 FSRKEKEHYVRTETEGKPSGWMAVYQEGKWL 867
           FSRK K+ YV +E +GK +GW A Y +GKW+
Sbjct: 831 FSRKTKQQYVSSEKDGKATGWSAFYIDGKWV 861