Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 865 a.a., type I DNA topoisomerase from Escherichia coli ECRC100

 Score = 1262 bits (3266), Expect = 0.0
 Identities = 617/869 (71%), Positives = 727/869 (83%), Gaps = 10/869 (1%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           MGK+LVIVESPAKAKTINKYLG D++VKSSVGH+RDLPT+G  A  +  A + STK A  
Sbjct: 1   MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKS--ADSTSTKTAKK 58

Query: 61  TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120
             K+      ER AL+ +MGVDP+H W+A+Y++LPGKEKVV+EL++LA+ AD +YLATDL
Sbjct: 59  PKKD------ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112

Query: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180
           DREGEAIAWHLRE+IGGD+ RY RVVFNEITKNAI+QAF +PGELN+D VNAQQARRFMD
Sbjct: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172

Query: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240
           RVVG+MVSPLLWKK+ARGLSAGRVQSVAV+L+VEREREIKAFVPEEFW+++A T T   +
Sbjct: 173 RVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE 232

Query: 241 DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQA 300
              L V  ++   F+PVN+ +  AAV+ L KA+Y V +REDKPTTSKP APFITSTLQQA
Sbjct: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292

Query: 301 ASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQP 360
           ASTRLG+GVKKTMM+AQRLYEAGYITYMRTDSTNLS +AV  +RGYI+ ++G+ YLP  P
Sbjct: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352

Query: 361 NVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTT 420
           N Y SK+N+QEAHEAIRPSDV V A+ L+ MEADA KLY LIW QFVACQMTPA+YDSTT
Sbjct: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412

Query: 421 VSVKAAEYTLKAKGRILKFDGWTRVQRPLGK-NEDQILPPVKVGDSLKLVSLDPKQHFTK 479
           ++V A ++ LKA+GRIL+FDGWT+V   L K +ED+ILP V  GD+L LV L P QHFTK
Sbjct: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTK 472

Query: 480 PPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDE 539
           PPAR++EA+LVKELEKRGIGRPSTYASIISTIQDRGYV+V+ RRF+AEKMGEIVTDRL+E
Sbjct: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532

Query: 540 NFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHI 599
           NF +LMNYDFTA+ME  LDQ+A  E  W AVLD FF+DF++ L+ AE+D   GGM+PN +
Sbjct: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592

Query: 600 VMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLE-EDVE 658
           V+T+I CPTC R MGIRTASTGVFLGCSGY LPPKERCKTTINL  E  V+NVLE ED E
Sbjct: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652

Query: 659 TAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECD 718
           T ALRAK+RCP C TAMD+YLID KRKLHVCGNNP C+G+ +EEGEF++KGY+GP VEC+
Sbjct: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712

Query: 719 KCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVL 778
           KCGS+M LK GRFGKYM CTN+ CKNTRKIL+NGEVAPPKE+PV  PELPCE SDAYFVL
Sbjct: 713 KCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL 772

Query: 779 RDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFS 838
           RDGA+G+F AA+ FPKSRETRAPLVEEL RF +RLPEK +YL  AP  DP+G   +VRFS
Sbjct: 773 RDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFS 832

Query: 839 RKEKEHYVRTETEGKPSGWMAVYQEGKWL 867
           RK K+ YV +E +GK +GW A Y +GKW+
Sbjct: 833 RKTKQQYVSSEKDGKATGWSAFYVDGKWV 861