Pairwise Alignments
Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056
Subject, 653 a.a., DNA topoisomerase III from Escherichia coli BL21
Score = 102 bits (254), Expect = 7e-26
Identities = 133/539 (24%), Positives = 221/539 (41%), Gaps = 81/539 (15%)
Query: 87 WQANYQILPGKEKVVAELQKLAKDADSVYLATDLDREGEAIAWHLREIIG-GDEKRYK-- 143
WQ Q P K + +++ +A + A D DREG+ + + + + EKR +
Sbjct: 73 WQL--QPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQ 130
Query: 144 RVVFNEITKNAIQQAFKQPGELN-----------------MDGVNAQQARRFMDRVVGFM 186
R + N++ A+++A + + + G+N +A + R G+
Sbjct: 131 RCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQ 190
Query: 187 VSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQDFRLLV 246
LS GRVQ+ + L+V R+ EI+ FV ++F+++ A +T + F +
Sbjct: 191 GV----------LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240
Query: 247 AQKDGLAFKPVNETE--------ALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQ 298
+ A +P + E A V ++ V DK + PF S LQ
Sbjct: 241 QPSE--ACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298
Query: 299 QAASTRLGYGVKKTMMLAQRLYEA-GYITYMRTDSTNLSAEAVEN---LRGYITKHYGEA 354
A+ R G + + + Q+LYE ITY R+D L E + I+ H +
Sbjct: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD- 357
Query: 355 YLPSQPNVYGSKQN------AQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVA 408
L QP V +N +AH AI P+ +A +L EA K+Y LI Q++
Sbjct: 358 -LLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEA---KVYNLIARQYLM 412
Query: 409 CQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDQ---ILPPVKVGDS 465
A + + + A+ AK R L GW + ++E+ LP V GD
Sbjct: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472
Query: 466 LKLVSLDPKQHFTKPPARYTEAALV------------KELEK-----RGIGRPSTYASII 508
L + + T+PP +T+A L+ K+L+K G+G +T A II
Sbjct: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532
Query: 509 STIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNW 567
+ RG++ R + G+ + L E D TA E L QI+E + +
Sbjct: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQCRY 588