Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 884 a.a., DNA topoisomerase 1 from Alteromonas macleodii MIT1002

 Score = 1180 bits (3052), Expect = 0.0
 Identities = 588/879 (66%), Positives = 693/879 (78%), Gaps = 5/879 (0%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           M KSLVIVESPAKAKTINKYLGK+FIVKSSVGHVRDLPT         K  A   K  S 
Sbjct: 1   MAKSLVIVESPAKAKTINKYLGKNFIVKSSVGHVRDLPTKALGKVEP-KKPAKELKTLSE 59

Query: 61  TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120
            ++++  R  E   L+ +MGVDP   W+A+YQ+L GKEKVV EL+KLAKDAD++YLATDL
Sbjct: 60  EERQEYLRRHEYLKLVDRMGVDPEKDWKAHYQVLQGKEKVVNELKKLAKDADTIYLATDL 119

Query: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180
           DREGEAIAWHL+E++G  +K Y+RVVFNEITKNAIQ AF  PGELN+  VNAQQARRF+D
Sbjct: 120 DREGEAIAWHLQELLGKKDKTYQRVVFNEITKNAIQDAFSDPGELNISRVNAQQARRFLD 179

Query: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240
           RVVGFMVSPLLWKK+ARGLSAGRVQSVAV+L+VEREREIKAFVPEEFWD++AD  +  K 
Sbjct: 180 RVVGFMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDVHADLTSQQKA 239

Query: 241 DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQA 300
             R+LVA+  G AFKP N+ E   A+A L  A Y+V  RE KPT S+PSAPFITSTLQQA
Sbjct: 240 ALRMLVAKHQGNAFKPKNKAETDKALADLEGANYKVESRESKPTQSRPSAPFITSTLQQA 299

Query: 301 ASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQP 360
           ASTRLG+GVKKTMM+AQRLYEAGYITYMRTDSTNLS EA+++ R YI+ ++G+ YLP  P
Sbjct: 300 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQEALDSARAYISDNFGDKYLPDSP 359

Query: 361 NVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTT 420
           N YGSK+ AQEAHEAIRPS+V+++A  L  ME DA +LY LIW QFVACQMTPA+YD+TT
Sbjct: 360 NRYGSKEGAQEAHEAIRPSNVSISAASLGDMERDAQRLYELIWRQFVACQMTPAKYDATT 419

Query: 421 VSVKAAEYTLKAKGRILKFDGWTRVQRPLGK--NEDQILPPVKVGDSLKLVSLDPKQHFT 478
           + V A +Y L AKGR+LKFDGWTRVQ  L K   E+ +LP V+ GD L L +LDPKQHFT
Sbjct: 420 IKVAAGDYELTAKGRVLKFDGWTRVQPQLRKKGEEELMLPDVQKGDVLDLKALDPKQHFT 479

Query: 479 KPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLD 538
           KP AR+ EA+LVKELEKRGIGRPSTYASIISTIQDRGYV+++ +RF+AEKMGEIV DRL 
Sbjct: 480 KPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLENKRFYAEKMGEIVNDRLM 539

Query: 539 ENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNH 598
           ENFDDLM+YDFTA ME+ LD IAEG+ NW  VL++F++ F   L  AE+D   GGM+ N 
Sbjct: 540 ENFDDLMSYDFTANMEQHLDDIAEGKKNWKDVLNDFYSGFYGKLLNAEKDPEEGGMRLNQ 599

Query: 599 IVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINV-LEEDV 657
            V   + C  C R M +RTASTGVFLGCSGY LPPKERC  T+NL   + V+ V  EE++
Sbjct: 600 AVPAGVECDKCGREMNVRTASTGVFLGCSGYNLPPKERCTNTMNLTPGDEVVKVDDEEEL 659

Query: 658 ETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVEC 717
           ET ALR+KKRCP C TAMD+YL+D+ RKLHVCGN P C+G +VE G FK+KGY+GP +EC
Sbjct: 660 ETEALRSKKRCPKCGTAMDSYLVDETRKLHVCGNTPTCDGTLVETGTFKIKGYDGPIIEC 719

Query: 718 DKCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFV 777
           DKCGSDM LKNGRFGKY GCT + CKNTRK+L+NGE APPKE+PV  PELPCE SDA+F+
Sbjct: 720 DKCGSDMELKNGRFGKYFGCTKEECKNTRKLLRNGEAAPPKEDPVDLPELPCEKSDAHFM 779

Query: 778 LRDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRF 837
           LRDGASG+F AA NFPKSRETRAP VEEL RF +R+  K+ YL  AP  DPDG PA+VR+
Sbjct: 780 LRDGASGIFLAAHNFPKSRETRAPKVEELARFRDRISPKFYYLADAPQTDPDGNPAIVRY 839

Query: 838 SRKEKEHYVRTETE-GKPSGWMAVYQEGKWLVTDKRKNA 875
           SRK K+ YV +E + GK +GW A Y  GKW     +K A
Sbjct: 840 SRKTKQQYVMSENDNGKATGWSAWYDNGKWQEQAAKKPA 878