Pairwise Alignments

Query, 761 a.a., 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase from Vibrio cholerae E7946 ATCC 55056

Subject, 753 a.a., methionine synthase (B12-independent) (EC 2.1.1.14) from Enterobacter asburiae PDN3

 Score =  912 bits (2357), Expect = 0.0
 Identities = 458/756 (60%), Positives = 564/756 (74%), Gaps = 14/756 (1%)

Query: 5   HILGYPRIGEKRELKFALEKYWRGEIDQAALKQVGSQIRQKNWALQKEAGLDFVTAGDFA 64
           H LG+PR+G +RELK A E YW G   +  L  VG ++R ++W  QK+AG+D +  GDFA
Sbjct: 6   HTLGFPRVGLRRELKKAQESYWAGNATREELLAVGRELRARHWDQQKQAGIDLLPVGDFA 65

Query: 65  WYDHVLTTTLLLGHVPKRHSH--GFPDLDTLFRVGRGQSQNACGCGTGSAASDMTKWFNT 122
           WYDHVLTT+LLLG+VP RH +  G  D+DTLFR+GRG++      G  +AA++MTKWFNT
Sbjct: 66  WYDHVLTTSLLLGNVPARHQNKDGSVDIDTLFRIGRGRAPT----GEPAAAAEMTKWFNT 121

Query: 123 NYHYIVPEFSSNDTFNVSWPQLFEEVNEALQAGHDVKPVLLGPISYLYLGKEVEEGFDRL 182
           NYHY+VPEF     F ++W QL +EV+EAL  GH VKPVLLGP++YL+LGK   E FDRL
Sbjct: 122 NYHYMVPEFVKGQQFRLAWTQLLDEVDEALALGHQVKPVLLGPVTYLWLGKVKGEPFDRL 181

Query: 183 TLLPRLLTAYQAILSKLAKQGVQWVQIDEPILALELEPRWQEAFKLAYQVIRGDVKLLLT 242
           +LL  +L  Y+ +LS+L K+G+QWVQIDEP L LEL   W +AFK AY  + G VKLLLT
Sbjct: 182 SLLKDILPVYKQVLSELGKRGIQWVQIDEPALVLELPQDWLDAFKPAYDALTGQVKLLLT 241

Query: 243 TYFDSVLDTLDKIVELPVDGLHVDISAAPAQLETIVNRLPSDWVLSAGVINGRNVWRADL 302
           TYF+ V   L  I  LPV GLHVD+      +  +  RLP+DW+LSAG+INGRNVWRADL
Sbjct: 242 TYFEGVTPNLKTITALPVQGLHVDLVHGKDDVAELHKRLPADWLLSAGLINGRNVWRADL 301

Query: 303 SAILARLQPVKTLLGER-LWVASSCSLLHSPVDLDLEGDLSAETRSWFAFAKQKVTEVAL 361
           +   A+   +K ++G+R LWVASSCSLLHSP+DL +E  L AE +SWFAFA QK  E+ L
Sbjct: 302 TEKYAQ---IKDIVGKRELWVASSCSLLHSPIDLSVETRLDAEVKSWFAFAVQKCEELTL 358

Query: 362 LGRALE-GDAAAILACDTYSQPIVARKSSHIVNKASVQTRINNITAALAERSAPYIERAH 420
           L  AL  GD AAI     +S PI AR+ S  V+  +V+ R+  ITA  ++R +PY  RA 
Sbjct: 359 LRDALNSGDTAAITE---WSAPIQARRHSARVHNPAVEKRLAAITARDSQRQSPYEVRAE 415

Query: 421 HQAEVLGLPFLPTTTIGSFPQTGEIRTERSAYRQGKLSEQEYVQALKGHIADAVKRQEAL 480
            Q     LP  PTTTIGSFPQT EIR  R  +++G L    Y   +  HI  A+  QE L
Sbjct: 416 AQRARFNLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANHYRTGIAEHIKQAIIEQERL 475

Query: 481 GLDVLVHGEAERNDMVEYFAENLAGFQTTQFGWVQSYGSRCVKPAIVVADIEREKPITVE 540
           GLDVLVHGEAERNDMVEYF E+L GF  TQ GWVQSYGSRCVKP +V+ D+ R + ITVE
Sbjct: 476 GLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDVSRPEAITVE 535

Query: 541 WSTYAQSLTSKQMKGMLTGPVTILCWTFPREDISRQEIAQQLALALRDEVADLQDAGINI 600
           W+ YAQSLT K +KGMLTGPVTILCW+FPRED++R+ IA+Q+ALALRDEVADL+ AGI I
Sbjct: 536 WAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGI 595

Query: 601 IQIDEPAIREGLPLKKRDHQTYLDWAVQAFKISAGSARPETQIHTHMCYSEFNEIIESVA 660
           IQIDEPA+REGLPL++ D   YL W V+AF+I+A  A+ +TQIHTHMCY EFN+I++S+A
Sbjct: 596 IQIDEPALREGLPLRRSDWDAYLQWGVEAFRINAAVAKDDTQIHTHMCYCEFNDIMDSIA 655

Query: 661 ALDADVITIETSRSNMELLKAFEEFNYPNEIGPGVYDIHSPNIPAQAWIEDLLRKAAEKI 720
           ALDADVITIETSRS+MELL++FEEF+YPNEIGPGVYDIHSPN+P+  WIE LL+KAA++I
Sbjct: 656 ALDADVITIETSRSDMELLESFEEFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRI 715

Query: 721 PAQRLWVNPDCGLKTRNWPEVEAALTNMVNAAKALR 756
           P +RLWVNPDCGLKTR WPE  AAL NMV AA+ LR
Sbjct: 716 PVERLWVNPDCGLKTRGWPETRAALANMVKAAQNLR 751