Pairwise Alignments

Query, 1037 a.a., AcrB/AcrD/AcrF family protein from Vibrio cholerae E7946 ATCC 55056

Subject, 1053 a.a., Probable transmembrane drug efflux protein from Hydrogenophaga sp. GW460-11-11-14-LB1

 Score =  612 bits (1579), Expect = e-179
 Identities = 358/1060 (33%), Positives = 585/1060 (55%), Gaps = 37/1060 (3%)

Query: 6    MSEQKQTPPENNENQGVAAY-----FINNRVISWMVSLIFLIGGTAAFFNLGRLEDPAFT 60
            M++   T P  +    V+ +      ++++  +  + ++ ++ G   +F LG+ EDP FT
Sbjct: 1    MNDASSTTPAGDTGSWVSRFNLSQWALDHQAFTRYLMIVLMVLGVVGYFQLGQDEDPPFT 60

Query: 61   IKDAMVVTSY-PGATPQQVEEEVTYPLEKAIQQLTYVDEVNSISSRGLSQITVTMKNNYG 119
             + AMVV +Y PGAT +QV E+V   +EK +Q++ Y D++ S S  G + I   +K++  
Sbjct: 61   FR-AMVVRAYWPGATAEQVAEQVADRIEKTLQEVPYADKIRSYSKPGETLIIFQLKDSSP 119

Query: 120  PDDLPQIWDELRRKVNDLKGALPPGVNPPLVIDDFGDVYGILLAVTGEGYSYKELLDYVD 179
            P ++ QIW   R+KV D++G LP GV  P   D+FGDVYG++ A+ GEG+S  +     D
Sbjct: 120  PQEVQQIWYTARKKVGDMRGTLPQGVVGPFFNDEFGDVYGVIYALQGEGFSPADKKQVAD 179

Query: 180  YLRRELELIDGVSKVSVSGQQQEQVFIEISMKRISTLGISPQTVFNLLSTQNLVSDAGAI 239
             +R+ L  +  V KV + G Q E+++IEIS KR++TLG++ Q V + L  QN V  AG++
Sbjct: 180  DVRQRLLRVKDVRKVELFGVQDEKLYIEISQKRLATLGLNLQQVLDALGQQNAVESAGSV 239

Query: 240  RIGSEYIRIHPTGEFDDVEKLGDL-ILSERGAQGLIYLRDVAEVKRGYVEVPSNVITFNG 298
            +   + +++   G F+ VE+L  + I +  G Q  I L D+A++  GYV+ P  ++   G
Sbjct: 240  QTPQDVVQVRVAGAFNSVEQLRAMPIRAANGTQ--IRLGDIAKIGLGYVDPPQVLVRHEG 297

Query: 299  KLALNVGVSFAQGVNVVEVGQRFDRRLAELKYQQPIGIDIAEVYSQPKEVDKSVSGFVVS 358
            K ++ +G+S A+G +++ +G+     +A ++   P G+ +A+V  QP  V  SV+ FV  
Sbjct: 298  KDSIALGISMAKGGDIIALGKALKTTVAGIEATLPAGMTLAQVQDQPSAVTNSVNEFVKV 357

Query: 359  LGQAVAIVIIVLLFFMGL----------------RSGLLIGLILLLTVLGTFIFMQYFKI 402
            L +AV IV+ V    +GL                R GL++ + + L +  TF+ M Y+ I
Sbjct: 358  LIEAVVIVLAVSFLALGLHRRPGGRGLKRYVLDMRPGLVVFITIPLVLAITFLAMHYWGI 417

Query: 403  DLQRISLGALVIALGMLVDNAIVVVEGILIGTQKGRTRLQAATDIVTQTKWPLLGATVIA 462
             L +ISLG+L+IALG+LVD+AI+ VE ++   ++G   ++AAT     T  P+L  T+I 
Sbjct: 418  GLHKISLGSLIIALGLLVDDAIIAVEMMVRKLEEGYDMMRAATFTWDATAMPMLTGTLIT 477

Query: 463  VTAFAPIGLSEDATGEYCGTLFTVLLISLMLSWFTAISLTPFFADLFFRGQKAPASGEES 522
               F PIGL+   TGEY   +F V +++L++SW  A+   P+   +  +  K  A GE  
Sbjct: 478  AAGFLPIGLANSTTGEYTFAIFAVTVLALVISWVVAVLFVPYLGVVLLK-VKPHAEGEPH 536

Query: 523  DPYQGFIFVVYRRFLEFCMRRAWLTMGVLVLGLAASLYGFTKVKQAFFPSSTTPMFMVDV 582
            + + G  +V +R  +++C++  WLT+G  +L     + G   V+Q FFP S+ P  +VD+
Sbjct: 537  EVFDGPFYVRFRAVVDWCVQHRWLTIGATILTFVLGIAGMGSVQQQFFPDSSRPEILVDI 596

Query: 583  WMPEGTDIRATDAILLELEKWLSAQESVDSVTTTAGKGLQRFMLTYSPEKSYAAYGEITT 642
            W+PEG+ + A D +   +E  L+ +E V  VTT  G G+ RF L            ++  
Sbjct: 597  WLPEGSSMPAMDEVTRRVENRLAKEEGVRGVTTWVGSGVPRFYLPLDQIFPQTNVSQMIV 656

Query: 643  RVTDYQQLAALMARFRAHLDARYPQINYKLKQIELGPGGGAKIEARIVGSDPTVLRSIAA 702
               D +    L       L   +P++  ++K +  GP     ++ R+VGSDP VLR +A 
Sbjct: 657  LPQDLKTREHLRKALPGLLATEFPEVRGRVKLLPNGPPVPYPVQFRVVGSDPQVLRGLAD 716

Query: 703  QVMDVMYADPGAYNIRHDWRERTKVLEPQFNESQARRYGITKADVDEFLAMSFSGKTIGV 762
            +V   M  +P    +  +W E  K L  + ++++AR  G++   + +      SG T+G 
Sbjct: 717  EVKLAMRENPNMRGVNDNWNESVKRLRLEVDQAKARALGVSSQSIAQASRTLLSGTTVGQ 776

Query: 763  YRDGTTLMPIVARLPEEERVDIRNIEGMKIWSPALSEYIPLQQVTLGYEMRWEDPLIVRK 822
            YR+G  L+ IV R P EER  I ++    +   A  + IPL Q+       WE  ++ R+
Sbjct: 777  YREGDKLIDIVLRQPLEERDAITSLANAYL-PTASGQAIPLLQIARPV-FDWEPGVLWRE 834

Query: 823  NRKRMLTVMADPDLLGEETAATLQQRLQPQIEAIPLP------PGYFLEWGGEYESSGDA 876
            NR   +TV    D++     AT+  +LQP+++AI           Y +E  G  E S   
Sbjct: 835  NRDYAITVQG--DVVEGLQGATVTAQLQPKLKAISDGWASKGLGAYHIEVAGAVEESSKG 892

Query: 877  KASLFKTMPLGYLFMFLITVFLFNSVKESLIVWLTVPLAVIGVTTGLLALNTPFGFMALL 936
             AS+   +PL    +F + +    S   S++V+LT PL + GV   LL LN PFGF+ALL
Sbjct: 893  SASIVVGVPLMLFIVFTLLMLQLQSFSRSMLVFLTGPLGMAGVAGALLLLNRPFGFVALL 952

Query: 937  GFLSLSGMLLKNGIVLLDQIEIEMHSGKDPYLAVVDASLSRVRPVCMAAVTTILGMIPLL 996
            G ++L GM+ +N ++L+DQIE +   G   + A+V+A++ R+RP+ + A   +L MIPL 
Sbjct: 953  GVIALMGMIQRNSVILIDQIEQDRARGVPAWDAIVEAAVRRMRPIVLTAAAAVLAMIPLS 1012

Query: 997  PDIFFRPMAVTIMFGLGFATVLTLIVVPVLYRLFHHVKVP 1036
              +F+ PMAV IM GL  ATVLTL+ +P +Y  +  V+ P
Sbjct: 1013 RSVFWGPMAVAIMGGLIVATVLTLLALPAMYAAWFRVRRP 1052