Pairwise Alignments

Query, 1176 a.a., hypothetical protein from Vibrio cholerae E7946 ATCC 55056

Subject, 1197 a.a., hybrid sensory histidine kinase in two-component regulatory system with EvgA (NCBI) from Escherichia coli BW25113

 Score =  218 bits (555), Expect = 2e-60
 Identities = 291/1244 (23%), Positives = 512/1244 (41%), Gaps = 182/1244 (14%)

Query: 7    LDPNEQAYVEQKSTVTIAVLKEIWMPYWGGTGQEPI-GIEHDFASGIAKELGINIEYKGF 65
            L   E  ++  K  + IAV K           Q+ + GI  D+ + + + L I +  + +
Sbjct: 44   LSNKELRWLASKKNLVIAVHKSQTATLLHTDSQQRVRGINADYLNLLKRALNIKLTLREY 103

Query: 66   DTIEALLNAVSTGKADMAIGFGQTLAREGKFLFSKPLYENVRVIWLRDKAMEEKPFASLK 125
               +  ++A++ G+ D+ +    T         S PL  ++               A+ K
Sbjct: 104  ADHQKAMDALAEGEVDIVLSHLVT---------SPPLNNDI---------------AATK 139

Query: 126  WVCIQGTSYCEILKDRGYP-------NIIMARNYSSSVEMIRQGIADATVTNYVSL---- 174
             + I   +    L D   P       NI    NY    E+I Q    AT+ ++ +L    
Sbjct: 140  PLIITFPALVTTLHDSMRPLTSPKPVNIARVANYPPD-EVIHQSFPKATIISFTNLYQAL 198

Query: 175  -------NHYLSQKRLALGKVI---FDPDLGV--------QTNRILINNNEPLLLSAINK 216
                   N Y     +    +I   F   L V        Q N  L      +L   +N+
Sbjct: 199  ASVSAGHNDYFIGSNIITSSMISRYFTHSLNVVKYYNSPRQYNFFLTRKESVILNEVLNR 258

Query: 217  VIDA----DKQGLTENKLNSADVYFLNDQANLNILRNENVNPVVRYTIQDDLF--PMSYW 270
             +DA     +  +++N L++ ++ FLN    L     + +       + ++ +  P S  
Sbjct: 259  FVDALTNEVRYEVSQNWLDTGNLAFLNKPLELTEHEKQWIKQHPNLKVLENPYSPPYSMT 318

Query: 271  DEKEKKYKGYVHDLLERISTKSILKFEFVP-AYGRDVEDMLRHGKVDLIPSFNMTYVDDR 329
            DE     +G + D+L  I+ ++ L F  +  ++       L  G  D+IP     Y +DR
Sbjct: 319  DENGS-VRGVMGDILNIITLQTGLNFSPITVSHNIHAGTQLSPGGWDIIPG--AIYSEDR 375

Query: 330  YFIHTGRYTDIQFGYIETTRPYTTPITGILD--RTGKFNAYIAVQKNLSDVKVYRSMYDL 387
                     ++ F     T PY   +    D  +T K    +A+          + MY  
Sbjct: 376  E-------NNVLFAEAFITTPYVFVMQKAPDSEQTLKKGMKVAIPYYYELHSQLKEMYPE 428

Query: 388  EQALEKGD-------ITHGLLNKVLINQM----LLDGHQDAFKLSPLTEGQDLRADMTML 436
             + ++  +       +  G L+ ++  Q+    ++D +        L  G    A ++  
Sbjct: 429  VEWIQVDNASAAFHKVKEGELDALVATQLNSRYMIDHYYPNELYHFLIPGVP-NASLSFA 487

Query: 437  VRKDARGLQNMLQKVLATFSQQEIDEIKGAYDRV--TVYFGYDKQKVLIYALIILCALLS 494
              +    L++++ K L      E+  +   + ++       +D      Y +  L  LL 
Sbjct: 488  FPRGEPELKDIINKALNAIPPSEVLRLTEKWIKMPNVTIDTWDLYSEQFYIVTTLSVLL- 546

Query: 495  IGLILTLSLSRLRGKLRSSEQVAKLSTEQLRWLTELLDAIPSMIFISDAKGEVVLTNAAY 554
            +G  L      LR   R       L   Q+ +   L D++P+  ++ + +G V+  N+A+
Sbjct: 547  VGSSLLWGFYLLRSVRRRKVIQGDLEN-QISFRKALSDSLPNPTYVVNWQGNVISHNSAF 605

Query: 555  RKIYHTCCEKGCVQPQPECSFLALPDQHEAEFSIIIQAPKSNCSIGEHYFHVT----RRA 610
               +     K  + P  E S     D       +  +  K N +I    F +     +R 
Sbjct: 606  EHYFTADYYKNAMLPL-ENSDSPFKDVFSNAHEVTAET-KENRTIYTQVFEIDNGIEKRC 663

Query: 611  ISH-------PINQRKYYLTLFNDITELKETEQALRQSNEQALQAVEARNHFLAVVSHEL 663
            I+H       P +    Y+  + DITE ++   AL     +A++A  A++ FLA +SHE+
Sbjct: 664  INHWHTLCNLPASDNAVYICGWQDITETRDLINALEVEKNKAIKATVAKSQFLATMSHEI 723

Query: 664  RTPIAAMLGLMEILASRLKSSESQL-LLTNAISSAERLKLHVNDILDFSKIEAQQLQLDI 722
            RTPI++++G +E+L+    S E ++  ++ A ++ + L   + +ILD  KIE+   QL  
Sbjct: 724  RTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQP 783

Query: 723  GLYNLADELGPLLRGFEASAQLKEIEFDVIWSPNSLLLANFDALRFNQIVTNLLSNAIKF 782
               ++   +      F A A  K I      +     L   D   F Q+++NLLSNA+KF
Sbjct: 784  QWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPEHYLVKIDPQAFKQVLSNLLSNALKF 843

Query: 783  TDQGRV-----VFKIDVAPEMLTIVVEDTGCGMTQTQIESLFVPFAQADSTITRRFGGTG 837
            T +G V     +  ID    ++ + + D+G G++Q + + LF  ++Q  ++  R+  G+G
Sbjct: 844  TTEGAVKITTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQ--TSAGRQQTGSG 901

Query: 838  LGMSIVANLIELMNGKIEVKSEFEQGTQIQVNLPLVTQTCDEFRGQVVAMSYRSPYMLWA 897
            LG+ I   LI+ M G + ++S    GT   + +P+      E   QV  +         A
Sbjct: 902  LGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV------EISQQVATVE--------A 947

Query: 898  KALGMRVEENEEWVEQSGHNIYPDLLLNRLREVSNLTQAQTEPAHSRLLQGHVLVADDDA 957
            KA            EQ      P  L  +L                      +L+ADD  
Sbjct: 948  KA------------EQ------PITLPEKL---------------------SILIADDHP 968

Query: 958  INRLLIKKQLSELGLSATLVSDGLQAFEKLSQHPEQYDLLITDCHMPHLDGFALTRKVKQ 1017
             NRLL+K+QL+ LG      +DG+QA  K+S   + YDLLITD +MP++DGF LTRK+++
Sbjct: 969  TNRLLLKRQLNLLGYDVDEATDGVQALHKVSM--QHYDLLITDVNMPNMDGFELTRKLRE 1026

Query: 1018 EISLFKGAVVGCTAEDSRLAAEQALQAGMDKVIYKPYTLANLRKVLSRYLTTQWVALPEQ 1077
            + S     + G TA       E+ L  GM+  ++KP TL  L+  LS+      +A P+ 
Sbjct: 1027 QNSSL--PIWGLTANAQANEREKGLSCGMNLCLFKPLTLDVLKTHLSQLHQVAHIA-PQY 1083

Query: 1078 SWLD--------AYQEEEREEMAMVVAESLAQDI-----ALLNQPDCDVKALAHRIKGAA 1124
              LD        A   +  +E+ M       +D+     AL    +       HRI GAA
Sbjct: 1084 RHLDIEALKNNTANDLQLMQEILMTFQHETHKDLPAAFQALEAGDNRTFHQCIHRIHGAA 1143

Query: 1125 GSLQLQRLADLAKTVEKQNDPQQLVADKQQLINAMHEVVEQAQQ 1168
              L LQ+L +++  +E          +  QL+N++ E + +  Q
Sbjct: 1144 NILNLQKLINISHQLEITPVSDDSKPEILQLLNSVKEHIAELDQ 1187