Pairwise Alignments

Query, 894 a.a., DNA topoisomerase (ATP-hydrolyzing) subunit A from Vibrio cholerae E7946 ATCC 55056

Subject, 881 a.a., DNA gyrase subunit A (EC 5.99.1.3) from Variovorax sp. SCN45

 Score =  991 bits (2562), Expect = 0.0
 Identities = 513/883 (58%), Positives = 647/883 (73%), Gaps = 43/883 (4%)

Query: 1   MSDLAKEITPVNIEDELRSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN 60
           M+  AKE  P+++E+E+RSSYLDYAMSVIVGRALPD RDGLKPVHRRVLFAM+ L NDWN
Sbjct: 1   MTSFAKETLPISLEEEMRSSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWN 60

Query: 61  KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM 120
           + YKKSAR+VGDVIGKYHPHGD +VYDTIVR+AQ FS+R+MLVDGQGNFGS+DGD+AAAM
Sbjct: 61  RPYKKSARIVGDVIGKYHPHGDQSVYDTIVRLAQDFSMRHMLVDGQGNFGSVDGDNAAAM 120

Query: 121 RYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLINGASGIAVGMAT 180
           RYTE+R++KIAHE+LAD+DKETVD+  NYDG+E+ P VLP+++PNLL+NG+ GIAVGMAT
Sbjct: 121 RYTEIRLAKIAHEMLADIDKETVDFQDNYDGSEKEPKVLPSQLPNLLVNGSGGIAVGMAT 180

Query: 181 NIPPHNLGEVIDGCLAYIDNEAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRGKV 240
           NIPPHNL EV+D CL  + N   +IDELM+ +P PDFPTA +I G  G+ D Y+TGRGKV
Sbjct: 181 NIPPHNLNEVVDACLYLLRNPEASIDELMEIVPAPDFPTAGIIYGINGVKDGYRTGRGKV 240

Query: 241 YMRSKAEIE-TDKNGKETIIVSEIPYQVNKARLIEKIAELVKEKKVEGISALRDESDKDG 299
            MR+K   E  D+  ++ IIV E+PYQVNK  L E++AELV EKK+EGIS ++DESDK G
Sbjct: 241 VMRAKCHFEDIDRGQRQAIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSG 300

Query: 300 MRIVIECKRDAVGEVVLNNLYANTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRRE 359
           MR+VIE KR  V EVVLNNLY  TQLQ TFGINMVAL +GQPKL NLK++++ F+ HRRE
Sbjct: 301 MRLVIELKRGEVPEVVLNNLYKQTQLQDTFGINMVALVDGQPKLCNLKDLIQVFLQHRRE 360

Query: 360 VVTRRTIFELRKARERAHILEGLALALANIDEIIELIRRAATPAEAKEGLIARGWDLGNV 419
           VVTRRT+F LRKARER H+LEGLA+ALANIDE I +IR + TP  AK  L+ R WD   V
Sbjct: 361 VVTRRTVFNLRKARERGHVLEGLAVALANIDEFIRIIRESPTPPVAKAELMTRSWDSKLV 420

Query: 420 AAMLERAGTDAA-------RPEWLEPQYGI-RDGKYFLTEQQAQAILDLRLHKLTGLEHE 471
             ML R+  D         RPE LE +YG+  DG Y L++ QAQ IL +RL +LTGLE +
Sbjct: 421 REMLTRSRADGGVINADDYRPEGLEREYGMGGDGLYRLSDTQAQEILQMRLQRLTGLEQD 480

Query: 472 KILDEYKQLLEEIAALMHILASTERLMEVIREELEAIRAGFSD----ARRTEITAATHDI 527
           KI+ EYK ++ EI  L+ ILA  ER+  +I EEL  I+  F      ARR+ +  + +D+
Sbjct: 481 KIVAEYKDVMAEIDDLLDILAKPERVSTIIGEELGTIKQEFGQSKIGARRSLVEHSAYDL 540

Query: 528 DMEELIAREDVVVTLSHEGYVKYQLLSDYEAQRRGGKGKSATKMKEEDYIERLLVANTHD 587
             E+LI   D+VVTLSH GY+K Q L +Y AQ+RGG+GK AT  K++D+I++L +ANTHD
Sbjct: 541 STEDLITPTDMVVTLSHSGYIKSQPLGEYRAQKRGGRGKQATATKDDDWIDQLFIANTHD 600

Query: 588 NILLFSTRGKTYRMKVYQLPLASRTARGKPIVNLLPLEENERITAILPVT----EFSEDK 643
            IL FS RG+ Y +KV+++P  SR +RG+PIVN+ PL+E E+I   L +T     F  D+
Sbjct: 601 YILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEGEKINVALALTGEKRNFPADQ 660

Query: 644 FIFMATGDGTVKKTSLDQFANVRANGLIALNLRDEDSLIGVDITDGESEIMLFSKFGKVV 703
           ++FMAT  GTVKKT+LD+F N R  G+IA+NL + D LIG  +TDG+ ++MLFS  GK V
Sbjct: 661 YVFMATSMGTVKKTALDEFNNPRKGGIIAVNLDEGDYLIGAALTDGKHDVMLFSDGGKAV 720

Query: 704 RFKESEETAVVDENGQPVLDENGQPEIKFKGVRPMGRTAAGVRGMKLADGDQVVSLIVPK 763
           RF E +                         VRP+GR A GVRGM L  G  V++++V +
Sbjct: 721 RFDEED-------------------------VRPLGRNARGVRGMSLEAGQGVIAMLVAE 755

Query: 764 TE-GDVLTVTENGYGKRTSLSEYPTKGRGTQGVVSIKVSERNGSVVGAVQVAEGDEFMMI 822
            E   VLT TENGYGKRTS++EY   GRGT+G+++I+ SERNG VV A  V   DE M+I
Sbjct: 756 DEQQSVLTATENGYGKRTSITEYTRHGRGTKGMIAIQQSERNGKVVAATLVHSDDEIMLI 815

Query: 823 TNAGTLVRTRVAEVSQVGRNTQGVTLIRTSEGESVVGLQRIDE 865
           T+ G LVRTRVAE+ ++GR TQGVTLI   EG  + GLQRI E
Sbjct: 816 TDKGVLVRTRVAEIRELGRATQGVTLIGLDEGAKLSGLQRIVE 858



 Score = 42.7 bits (99), Expect = 1e-07
 Identities = 27/108 (25%), Positives = 54/108 (50%), Gaps = 3/108 (2%)

Query: 768 VLTVTENGYGKRTSLSEYPTKGRGTQGVVSIKVSERNGSVVGAVQVAEGDEFMMITNAGT 827
           V   T  G  K+T+L E+    +G  G++++ + E +  ++GA       + M+ ++ G 
Sbjct: 662 VFMATSMGTVKKTALDEFNNPRKG--GIIAVNLDEGD-YLIGAALTDGKHDVMLFSDGGK 718

Query: 828 LVRTRVAEVSQVGRNTQGVTLIRTSEGESVVGLQRIDEIEESELPEGE 875
            VR    +V  +GRN +GV  +    G+ V+ +   ++ ++S L   E
Sbjct: 719 AVRFDEEDVRPLGRNARGVRGMSLEAGQGVIAMLVAEDEQQSVLTATE 766