Pairwise Alignments

Query, 894 a.a., DNA topoisomerase (ATP-hydrolyzing) subunit A from Vibrio cholerae E7946 ATCC 55056

Subject, 875 a.a., DNA gyrase subunit A from Paraburkholderia sabiae LMG 24235

 Score = 1032 bits (2669), Expect = 0.0
 Identities = 532/905 (58%), Positives = 667/905 (73%), Gaps = 45/905 (4%)

Query: 1   MSDLAKEITPVNIEDELRSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN 60
           M   AKE  P+++E+E+R SY++YAMSVIVGRALPDVRDGLKPVHRRVL+AM+ L NDWN
Sbjct: 1   MDQFAKETLPISLEEEMRRSYIEYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWN 60

Query: 61  KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM 120
           +AYKKSAR+VGDVIGKYHPHGDSAVYDTIVRMAQ FSLRYMLVDGQGNFGS+DGD+AAAM
Sbjct: 61  RAYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM 120

Query: 121 RYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLINGASGIAVGMAT 180
           RYTE+RM+KI HELLAD+DKETVD+ PNYDG+E  P++LP +IPNLLING+SGIAVGMAT
Sbjct: 121 RYTEIRMAKIGHELLADIDKETVDFQPNYDGSENEPSILPARIPNLLINGSSGIAVGMAT 180

Query: 181 NIPPHNLGEVIDGCLAYIDNEAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRGKV 240
           NIPPHNL E++D C   + N   TIDEL++ +P PDFPTA +I G +G+ D Y+TGRG+V
Sbjct: 181 NIPPHNLNEIVDACHHLLKNPEATIDELIEIVPAPDFPTAGIIYGVQGVRDGYRTGRGRV 240

Query: 241 YMRSKAEI-ETDKNGKETIIVSEIPYQVNKARLIEKIAELVKEKKVEGISALRDESDKDG 299
            MR+     E D+  +  IIV E+PYQVNK  L+E+IAELV EKK+EGIS +RDESDK G
Sbjct: 241 VMRATTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG 300

Query: 300 MRIVIECKRDAVGEVVLNNLYANTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRRE 359
           MR+VIE KR  V EV+LNNLY  TQLQ TFG+NMVAL +GQPKL NLKEML  F+ HRRE
Sbjct: 301 MRVVIELKRGEVPEVILNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEMLSHFLSHRRE 360

Query: 360 VVTRRTIFELRKARERAHILEGLALALANIDEIIELIRRAATPAEAKEGLIARGWDLGNV 419
           V+TRRT++ELRKARER H+LEGLA+ALANID+ I +I+ A TP  AK+ L+ R WD   V
Sbjct: 361 VLTRRTVYELRKARERGHVLEGLAVALANIDDFIAIIKAAPTPPIAKQELMDRSWDSSIV 420

Query: 420 AAMLERAGTD--------AARPEWLEPQYGIR-DGKYFLTEQQAQAILDLRLHKLTGLEH 470
             ML+RA  D        A RPE L P YG++ DG Y L++ QAQ IL +RL +LTGLE 
Sbjct: 421 REMLQRAEADNATSGGRAAYRPEGLNPAYGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ 480

Query: 471 EKILDEYKQLLEEIAALMHILASTERLMEVIREELEAIRAGFSDARRTEITAATHDIDME 530
           +KI+ EY+ ++ +IA L+ ILA  ER+  +I +EL  I++ F D RR++I     +++ E
Sbjct: 481 DKIIGEYRDVMAQIADLLDILARPERITSIIFDELVTIKSEFGDERRSKIEMNATELNTE 540

Query: 531 ELIAREDVVVTLSHEGYVKYQLLSDYEAQRRGGKGKSATKMKEEDYIERLLVANTHDNIL 590
           +LI  +D+VVT+SH GYVK Q LS+Y AQ+RGG+GK AT+MKE+D+I+ L +ANTHD+IL
Sbjct: 541 DLITPQDMVVTMSHSGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIDTLFIANTHDHIL 600

Query: 591 LFSTRGKTYRMKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFSEDKFIFMATG 650
            FS RG+ Y +KVY++P  SR +RG+PIVN+ PL+E E+IT +LPV EFS DKF+FMAT 
Sbjct: 601 CFSNRGRVYWLKVYEVPQGSRNSRGRPIVNMFPLQEGEKITVVLPVKEFSADKFVFMATA 660

Query: 651 DGTVKKTSLDQFANVRANGLIALNLRDEDSLIGVDITDGESEIMLFSKFGKVVRFKESEE 710
            GTVKKT L+ F+     G+IA+ L D D LIG  ITDGE ++MLFS  GK VRF E++ 
Sbjct: 661 LGTVKKTPLEAFSRPLKKGIIAVGLDDGDYLIGAAITDGEHDVMLFSDSGKAVRFDEND- 719

Query: 711 TAVVDENGQPVLDENGQPEIKFKGVRPMGRTAAGVRGMKLADGDQVVSLIVPKTE-GDVL 769
                                   VRPMGR A GVRGM+L DG  V++L+V   E   VL
Sbjct: 720 ------------------------VRPMGREARGVRGMQLEDGQSVIALLVAGDEQQSVL 755

Query: 770 TVTENGYGKRTSLSEYPTKGRGTQGVVSIKVSERNGSVVGAVQVAEGDEFMMITNAGTLV 829
           T TENGYGKRT ++EY   GRGT+G+++I+ SERNG VV A  V    + M+ITN G L+
Sbjct: 756 TATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVDPEAQIMLITNTGVLI 815

Query: 830 RTRVAEVSQVGRNTQGVTLIRTSEGESVVGLQRIDEIEESELPEGEEALVENDAPVAQDD 889
           RTRV+E+ ++GR TQGVTLI   EG  + GLQ+I E          EA V+ DA +  D+
Sbjct: 816 RTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAE---------AEADVDGDADLPADE 866

Query: 890 DGEQE 894
            G  E
Sbjct: 867 AGGDE 871