Pairwise Alignments

Query, 894 a.a., DNA topoisomerase (ATP-hydrolyzing) subunit A from Vibrio cholerae E7946 ATCC 55056

Subject, 752 a.a., DNA topoisomerase IV, A subunit, proteobacterial from Enterobacter asburiae PDN3

 Score =  409 bits (1050), Expect = e-118
 Identities = 267/735 (36%), Positives = 415/735 (56%), Gaps = 74/735 (10%)

Query: 1   MSDLAKEITPVNIEDELRSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN 60
           MSD+A+ +    + +   ++YL+Y+M VI+ RALP + DGLKPV RR+++AM+ LG +  
Sbjct: 1   MSDMAERLA---LHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNAT 57

Query: 61  KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGD-SAAA 119
             +KKSAR VGDV+GKYHPHGDSA Y+ +V MAQPFS RY LVDGQGN+G+ D   S AA
Sbjct: 58  AKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAA 117

Query: 120 MRYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLINGASGIAVGMA 179
           MRYTE R+SK A  LL +L + TVD+VPN+DGT Q P +LP ++PN+L+NG +GIAVGMA
Sbjct: 118 MRYTESRLSKYAEVLLGELGQGTVDWVPNFDGTMQEPKMLPARLPNILLNGTTGIAVGMA 177

Query: 180 TNIPPHNLGEVIDGCLAYIDNEAITIDELMDYIPGPDFPTAA-LISGRKGIIDAYKTGRG 238
           T+IPPHNL EV    +  I+    T+DEL+D + GPDFPT A +I+ R  I   Y+ GRG
Sbjct: 178 TDIPPHNLREVAKAAITLIEQPKATLDELLDIVQGPDFPTEAEIITSRAEIRKIYQNGRG 237

Query: 239 KVYMRSKAEIETDKNGKETIIVSEIPYQVNKARLIEKIAELVKEKKVEGISALRDESDKD 298
            V MR+   +   ++G   ++++ +P+QV+ A+++E+IA  ++ KK+  +  LRDESD +
Sbjct: 238 SVRMRA---VWNKEDG--AVVITALPHQVSGAKVLEQIASQMRNKKLPMVDDLRDESDHE 292

Query: 299 G-MRIVIECKRDAVG-EVVLNNLYANTQLQTTFGIN--MVALDNGQPKLFNLKEMLKCFV 354
              R+VI  + + V  E V+N+L+A T L+ ++ IN  M+ LD G+P + NL E+L  ++
Sbjct: 293 NPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRINLNMIGLD-GRPAVKNLLEILTEWL 351

Query: 355 DHRREVVTRRTIFELRKARERAHILEGLALALANIDEIIELIRRAATPAEAKEGLIARGW 414
             RR+ V RR    L K  +R HILEGL +A  NIDE+IE+IR   T  E K  L++R  
Sbjct: 352 TFRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIR---TEDEPKPALMSR-- 406

Query: 415 DLGNVAAMLERAGTDAARPEWLEPQYGIRDGKYFLTEQQAQAILDLRLHKLTGLEHEKIL 474
                                           + ++E QA+AIL+L+L  L  LE  KI 
Sbjct: 407 --------------------------------FGISETQAEAILELKLRHLAKLEEMKIR 434

Query: 475 DEYKQLLEEIAALMHILASTERLMEVIREELEAIRAGFSDARRT-----EITAATHDIDM 529
            E  +L +E   L  ILAS  ++  ++++EL+A    F D RR+     E   A ++ DM
Sbjct: 435 GEQNELEKERDQLQAILASERKMNTLLKKELQADADAFGDDRRSPLHEREEAKAMNEHDM 494

Query: 530 EELIAREDVVVTLSHEGYVKYQLLSDYEAQRRGGKGKSATKMKEEDYIERLLVANTHDNI 589
           +     E V + LS  G+V+     D +A             K  D  +  +   ++  +
Sbjct: 495 Q---PSEPVTIVLSQSGWVRSAKGHDIDA--------PGLSYKAGDSFKAAVKGKSNQPV 543

Query: 590 LLFSTRGKTYRMKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFSEDKFIFMAT 649
               + G++Y +    LP  S   +G+P+   L L     +  +L     ++D+ + +A+
Sbjct: 544 AFIDSTGRSYAIDPITLP--SARGQGEPLTGKLTLPPGATVDHMLME---ADDQKLLLAS 598

Query: 650 GDGTVKKTSLDQFANVRANGLIALNLRDEDSLIGVDITDGESEIML-FSKFGKVVRFKES 708
             G     + +   +    G   ++L D   ++   + + ES+++L  +  G+++ F  S
Sbjct: 599 DAGYGFICTFNDLVSRNRAGKALISLPDNAHVMAPLVIENESDMLLAITTAGRMLMFPVS 658

Query: 709 EETAVVDENGQPVLD 723
           +   +    G  +++
Sbjct: 659 DLPELSKGKGNKIIN 673



 Score = 31.2 bits (69), Expect = 2e-04
 Identities = 32/133 (24%), Positives = 58/133 (43%), Gaps = 9/133 (6%)

Query: 738 MGRTAAGVRGMKLADGDQVVSLIVPKTEGDVL-TVTENGYGKRTSLSEYP--TKGRGTQG 794
           + R  AG   + L D   V++ +V + E D+L  +T  G      +S+ P  +KG+G + 
Sbjct: 612 VSRNRAGKALISLPDNAHVMAPLVIENESDMLLAITTAGRMLMFPVSDLPELSKGKGNK- 670

Query: 795 VVSIKVSERNGSVVGAVQVAEGDEFMMITNAGTLVRTRVAEVSQVGRNTQGVTLIRTSEG 854
           +++I  +E      G   +     F++   +   +     ++       Q V   R   G
Sbjct: 671 IINIPSAEAAKGEDGLAHL-----FLLPPQSTLTIHVGKRKIKLRPEELQKVVGERGRRG 725

Query: 855 ESVVGLQRIDEIE 867
             + GLQRID +E
Sbjct: 726 SLMRGLQRIDRVE 738